Abstract：
:Proteins from different fish species and different raw materials such as fish fillets and by-products have shown promising cardioprotective effects in rodents and humans, including effects on cholesterol metabolism. Blue whiting is used mainly to produce fish meal for the feed industry and during this production, a water-soluble protein fraction, containing small peptides that are easily absorbed and may hold bioactive properties, is isolated. The effects of water-soluble fish protein on cholesterol metabolism were investigated in twelve male obese Zucker fa/fa rats. Rats were fed diets with water-soluble protein from blue whiting (BWW) as 1/3 of the total protein and the remaining 2/3 as casein (BWW group) or with casein as the sole protein source (control group). After 5 weeks intervention, the BWW group had lower serum total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol concentrations and lower cholesteryl ester concentration compared to controls. Hepatic concentrations of cholesterol, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, and LDL receptors were also lower in the BWW group. The groups had a similar concentration of serum total bile acids and similar fecal excretions of cholesterol and bile acids. To conclude, the BWW diet led to lower concentrations of serum and liver cholesterol in obese Zucker fa/fa rats, probably due to lower hepatic cholesterol synthesis.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Drotningsvik A,Vikøren LA,Mjøs SA,Oterhals Å,Pampanin D,Flesland O,Gudbrandsen OAdoi
10.3390/md16050149subject
Has Abstractpub_date
2018-05-01 00:00:00issue
5issn
1660-3397pii
md16050149journal_volume
16pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, was previously reported by us to induce erythroid differentiation and G1 phase arrest of K562 chronic myelogenous leukemia cells. In this study, we investigated the effect of smenospongine on the cell cycles of other le...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md20080023
更新日期：2008-01-01 00:00:00
abstract：:Natural anionic polysaccharides fucosylated chondroitin sulfates (FCS) from sea cucumbers attract great attention nowadays due to their ability to influence various biological processes, such as blood coagulation, thrombosis, angiogenesis, inflammation, bacterial and viral adhesion. To determine pharmacophore fragment...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13020770
更新日期：2015-02-02 00:00:00
abstract：:There is an urgent need for novel strategies to fight drug resistance and multi-drug resistance. As an alternative to the classic antibiotic therapy, attenuation of the bacteria virulence affecting their Quorum sensing (QS) system is a promising approach. Quorum sensing (QS) is a genetic regulation system that allows ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15030059
更新日期：2017-02-28 00:00:00
abstract：:Being able to quantify ichthyotoxic metabolites from microalgae allows for the determination of ecologically-relevant concentrations that can be simulated in laboratory experiments, as well as to investigate bioaccumulation and degradation. Here, the ichthyotoxin karmitoxin, produced by Karlodinium armiger, was quanti...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15090278
更新日期：2017-08-31 00:00:00
abstract：:The 7-Acetylsinumaximol B (7-AB), a bioactive cembranoid, was originally discovered from aquaculture soft coral Sinularia sandensis. The current study investigated the anti-proliferative property of 7-AB towards the NCI-N87 human gastric cancer cell line. An MTT cell proliferative assay was applied to evaluate cell su...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16040104
更新日期：2018-03-26 00:00:00
abstract：:Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was first recognized in a human case study of temporal lobe epilepsy after the 1987 amnesic shellfish-poisoning event in Quebec, and was characterized as a chronic...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md12031185
更新日期：2014-03-06 00:00:00
abstract：:Gliotoxin, a secondary metabolite produced by marine fungus Aspergillus sp., possesses various biological activities including anticancer activity. However, the mechanism underlying gliotoxin-induced cytotoxicity on human cervical cancer (Hela) and human chondrosarcoma (SW1353) cells remains unclear. In this study, we...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12010069
更新日期：2013-12-24 00:00:00
abstract：:Like many fields of the biosciences, actinomycete natural products research has been revolutionised by next-generation DNA sequencing (NGS). Hundreds of new genome sequences from actinobacteria are made public every year, many of them as a result of projects aimed at identifying new natural products and their biosynth...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14040078
更新日期：2016-04-13 00:00:00
abstract：:The marine alga, Symphyocladia latiuscula (Harvey) Yamada, is a good source of bromophenols with numerous biological activities. This study aims to characterize the anti-diabetic potential of 2,3,6-tribromo-4,5-dihydroxybenzyl derivatives isolated from S. latiuscula via their inhibition of tyrosine phosphatase 1B (PTP...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030166
更新日期：2019-03-14 00:00:00
abstract：:A new sesquiterpenoid 9,10-diolhinokiic acid (1) and a new diterpenoid roussoellol C (2), together with 4 known compounds, were isolated from the extracts of laboratory cultures of marine-derived fungus Talaromyces purpurogenus. 9,10-diolhinokiic acid is the first thujopsene-type sesquiterpenoid containing a 9,10-diol...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16050150
更新日期：2018-05-02 00:00:00
abstract：:With the depletion of global fish stocks, caused by high demand and effective fishing techniques, alternative sources for long chain omega-3 fatty acids are required for human nutrition and aquaculture feeds. Recent research has focused on land-based cultivation of microalgae, the primary producers of omega-3 fatty ac...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12063381
更新日期：2014-06-04 00:00:00
abstract：:The genus Streptomyces produces secondary metabolic compounds that are rich in biological activity. Many of these compounds are genetically encoded by large secondary metabolism biosynthetic gene clusters (smBGCs) such as polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS) which are modular and can...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16020067
更新日期：2018-02-20 00:00:00
abstract：:In our current investigation, we evaluated the effect of Chlorella pyrenoidosa protein hydrolysate (CPPH) and Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) on calcium absorption and gut microbiota composition, as well as their in vivo regulatory mechanism in SD rats fed low-calcium diets. Potent ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17060348
更新日期：2019-06-11 00:00:00
abstract：:Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A⁻E (1⁻5) and agallochols A⁻D (6⁻9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10), were isolated from the mangrove plants Xylocarpus granatum, Xylocarpus moluccensis, and...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16120488
更新日期：2018-12-06 00:00:00
abstract：:Collagen is the major fibrillar protein in most living organisms. Among the different types of collagen, type I collagen is the most abundant one in tissues of marine invertebrates. Due to the health-related risk factors and religious constraints, use of mammalian derived collagen has been limited. This triggers the s...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md18090471
更新日期：2020-09-18 00:00:00
abstract：:In this study, sulfated polysaccharide-rich extracts were isolated from 22 tropical seaweeds (4 red, 11 brown, and 7 green) found in northeastern Brazil, and evaluated for the role of anticoagulant agents. Fifteen of the extracts showed anticoagulant activity, including all the extracts from green seaweeds. Udoteaflab...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17010005
更新日期：2018-12-21 00:00:00
abstract：:This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop-CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13041739
更新日期：2015-03-30 00:00:00
abstract：:Agar, alginate, and carrageenans are high-value seaweed hydrocolloids, which are used as gelation and thickening agents in different food, pharmaceutical, and biotechnological applications. The annual global production of these hydrocolloids has recently reached 100,000 tons with a gross market value just above US$ 1....
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md13063340
更新日期：2015-05-27 00:00:00
abstract：:A green extraction process using only water was proposed for the simultaneous extraction of alginate and bioactive compounds from Laminaria ochroleuca. Operation was carried out during non-isothermal heating up to maximal temperatures over the range of 70 °C to 100 °C. Once separated, the alginate and the crude extrac...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18070336
更新日期：2020-06-27 00:00:00
abstract：:The present survey deals with the initial stage of the calcification process in bone and other hard tissues, with special reference to the organic-inorganic relationship and the transformation that the early inorganic particles undergo as the process moves towards completion. Electron microscope studies clearly exclud...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12074231
更新日期：2014-07-23 00:00:00
abstract：:Marine cyanobacteria, notably those from tropical regions, are a rich source of bioactive secondary metabolites. Tropical marine cyanobacteria often grow to high densities in the environment, allowing direct isolation of many secondary metabolites from field-collected material. However, in temperate environments cultu...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11041316
更新日期：2013-04-22 00:00:00
abstract：:Three new polyoxygenated steroids, michosterols A-C (1-3), and four known compounds (4-7) were isolated from the ethyl acetate (EtOAc) extract of the soft coral Lobophytum michaelae, collected off the coast of Taitung. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and compa...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16030093
更新日期：2018-03-13 00:00:00
abstract：:In the last decades, research has focused on the capabilities of microbes to secrete exopolysaccharides (EPS), because these polymers differ from the commercial ones derived essentially from plants or algae in their numerous valuable qualities. These biopolymers have emerged as new polymeric materials with novel and u...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md12053005
更新日期：2014-05-22 00:00:00
abstract：:Cancer represents a set of more than 100 diseases, including malignant tumors from different locations. Strategies inducing differentiation have had limited success in the treatment of established cancers. Marine sponges are a biological reservoir of bioactive molecules, especially lectins. Several animal and plant le...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10040727
更新日期：2012-04-01 00:00:00
abstract：:Cyanobacteria are a diverse group of Gram-negative bacteria that produce an array of secondary compounds with selective bioactivity against vertebrates, invertebrates, plants, microalgae, fungi, bacteria, viruses and cell lines. The aim of this study was to assess the toxic effects of aqueous, methanolic and hexane cr...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md803471
更新日期：2010-03-05 00:00:00
abstract：:Haloferax mediterranei produces C50 carotenoids that have strong antioxidant properties. The response surface methodology (RSM) tool helps to accurately analyze the most suitable conditions to maximize C50 carotenoids production by haloarchaea. The effects of temperature (15⁻50 °C), pH (4-10), and salinity (5⁻28% NaCl...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100372
更新日期：2018-10-09 00:00:00
abstract：:Fucoidan is a polysaccharide built from L-fucose molecules. The main source of this polysaccharide is the extracellular matrix of brown seaweed (Phaeophyta), but it can be also isolated from invertebrates such as sea urchins (Echinoidea) and sea cucumbers (Holothuroidea). Interest in fucoidan is related to its broad b...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17080458
更新日期：2019-08-05 00:00:00
abstract：:The development and use of topical microbicides potentially offers an additional strategy to reduce the spread of the Human Immunodeficiency Virus (HIV). Carbohydrate-binding agents (CBAs) that show specificity for high mannose carbohydrates on the surface of the heavily glycosylated envelope of HIV are endowed with p...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md10071476
更新日期：2012-07-01 00:00:00
abstract：:A glycopeptide fraction (GPF) from internal organs of green sea urchins (Strongylocentrotus droebachiensis Müller, Strongylocentrotidae) has been reported to be an effective bronchitis treatment. In this study, we evaluated the pharmacokinetic and tissue distribution of GPF, following single and repeated intranasal (i...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17100577
更新日期：2019-10-11 00:00:00
abstract：:Many cytotoxic compounds of therapeutic interest have been isolated from marine invertebrates, and some of them have been reported to be of microbial origin. Pyridoacridine alkaloids are the main compounds extracted from the ascidian Cystodytes dellechiajei. Here we describe the in vitro antiproliferative activity aga...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md503052
更新日期：2007-07-19 00:00:00
