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Chemoecological screening reveals high bioactivity in diverse culturable Portuguese marine cyanobacteria.

Abstract：

:Marine cyanobacteria, notably those from tropical regions, are a rich source of bioactive secondary metabolites. Tropical marine cyanobacteria often grow to high densities in the environment, allowing direct isolation of many secondary metabolites from field-collected material. However, in temperate environments culturing is usually required to produce enough biomass for investigations of their chemical constituents. In this work, we cultured a selection of novel and diverse cyanobacteria isolated from the Portuguese coast, and tested their organic extracts in a series of ecologically-relevant bioassays. The majority of the extracts showed activity in at least one of the bioassays, all of which were run in very small scale. Phylogenetically related isolates exhibited different activity profiles, highlighting the value of microdiversity for bioprospection studies. Furthermore, LC-MS analyses of selected active extracts suggested the presence of previously unidentified secondary metabolites. Overall, the screening strategy employed here, in which previously untapped cyanobacterial diversity was combined with multiple bioassays, proved to be a successful strategy and allowed the selection of several strains for further investigations based on their bioactivity profiles.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Leão PN,Ramos V,Gonçalves PB,Viana F,Lage OM,Gerwick WH,Vasconcelos VM

doi

10.3390/md11041316

subject

Has Abstract

pub_date

2013-04-22 00:00:00

pages

1316-35

issue

4

issn

1660-3397

pii

md11041316

journal_volume

11

pub_type

杂志文章

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