Algal lectins as potential HIV microbicide candidates.


:The development and use of topical microbicides potentially offers an additional strategy to reduce the spread of the Human Immunodeficiency Virus (HIV). Carbohydrate-binding agents (CBAs) that show specificity for high mannose carbohydrates on the surface of the heavily glycosylated envelope of HIV are endowed with potent anti-HIV activity. In fact, a number of algal lectins such as cyanovirin-N, microvirin, microcystis viridis lectin, scytovirin, Oscillatoria agardhii agglutinin and griffithsin are considered as potential microbicide candidates to prevent the sexual transmission of HIV through topical applications. They not only inhibit infection of cells by cell-free virus but they can also efficiently prevent virus transmission from virus-infected cells to uninfected CD4(+) target T-lymphocytes and DC-SIGN-directed capture of HIV-1 and transmission to CD4(+) T lymphocytes. This review focuses on the structural properties and carbohydrate specificity of these algal lectins, their antiviral activity against HIV and several other enveloped viruses, their safety profile and viral resistance patterns.


Mar Drugs


Marine drugs


Huskens D,Schols D




Has Abstract


2012-07-01 00:00:00












  • Indole diterpenoids and isocoumarin from the fungus, Aspergillus flavus, isolated from the prawn, Penaeus vannamei.

    abstract::Two new indole-diterpenoids (1 and 2) and a new isocoumarin (3), along with the known β-aflatrem (4), paspalinine (5), leporin B (6), α-cyclopiazonic acid (7), iso-α-cyclopiazonic acid (8), ditryptophenaline (9), aflatoxin B1 (10), 7-O-acetylkojic acid (11) and kojic acid (12), were isolated from the fermentation brot...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Sun K,Li Y,Guo L,Wang Y,Liu P,Zhu W

    更新日期:2014-06-30 00:00:00

  • Azaspiracid shellfish poisoning: a review on the chemistry, ecology, and toxicology with an emphasis on human health impacts.

    abstract::Azaspiracids (AZA) are polyether marine toxins that accumulate in various shellfish species and have been associated with severe gastrointestinal human intoxications since 1995. This toxin class has since been reported from several countries, including Morocco and much of western Europe. A regulatory limit of 160 micr...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Twiner MJ,Rehmann N,Hess P,Doucette GJ

    更新日期:2008-05-07 00:00:00

  • Non-traditional vectors for paralytic shellfish poisoning.

    abstract::Paralytic shellfish poisoning (PSP), due to saxitoxin and related compounds, typically results from the consumption of filter-feeding molluscan shellfish that concentrate toxins from marine dinoflagellates. In addition to these microalgal sources, saxitoxin and related compounds, referred to in this review as STXs, ar...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Deeds JR,Landsberg JH,Etheridge SM,Pitcher GC,Longan SW

    更新日期:2008-06-10 00:00:00

  • Evidence of accelerated evolution and ectodermal-specific expression of presumptive BDS toxin cDNAs from Anemonia viridis.

    abstract::Anemonia viridis is a widespread and extensively studied Mediterranean species of sea anemone from which a large number of polypeptide toxins, such as blood depressing substances (BDS) peptides, have been isolated. The first members of this class, BDS-1 and BDS-2, are polypeptides belonging to the β-defensin fold fami...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Nicosia A,Maggio T,Mazzola S,Cuttitta A

    更新日期:2013-10-30 00:00:00

  • Angiotensin-I Converting Enzyme (ACE) Inhibitory and Anti-Hypertensive Effect of Protein Hydrolysate from Actinopyga lecanora (Sea Cucumber) in Rats.

    abstract::Food protein hydrolysates are known to exhibit angiotensin converting enzyme (ACE) inhibitory properties and can be used as a novel functional food for prevention of hypertension. This study evaluated the ACE inhibitory potentials of Actinopyga lecanora proteolysate (ALP) in vivo. The pre-fed rats with ALP at various ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Sadegh Vishkaei M,Ebrahimpour A,Abdul-Hamid A,Ismail A,Saari N

    更新日期:2016-09-30 00:00:00

  • Chitosan-Based Nanomedicine to Fight Genital Candida Infections: Chitosomes.

    abstract::Vaginal infections are associated with high recurrence, which is often due to a lack of efficient treatment of complex vaginal infections comprised of several types of pathogens, especially fungi and bacteria. Chitosan, a mucoadhesive polymer with known antifungal effect, could offer a great improvement in vaginal the...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Andersen T,Mishchenko E,Flaten GE,Sollid JU,Mattsson S,Tho I,Škalko-Basnet N

    更新日期:2017-03-04 00:00:00

  • Temperature-Dependence of Lipid A Acyl Structure in Psychrobacter cryohalolentis and Arctic Isolates of Colwellia hornerae and Colwellia piezophila.

    abstract::Lipid A is a fundamental Gram-negative outer membrane component and the essential element of lipopolysaccharide (endotoxin), a potent immunostimulatory molecule. This work describes the metabolic adaptation of the lipid A acyl structure by Psychrobacter cryohalolentis at various temperatures in its facultative psychro...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Sweet CR,Watson RE,Landis CA,Smith JP

    更新日期:2015-07-30 00:00:00

  • Chemoecological screening reveals high bioactivity in diverse culturable Portuguese marine cyanobacteria.

    abstract::Marine cyanobacteria, notably those from tropical regions, are a rich source of bioactive secondary metabolites. Tropical marine cyanobacteria often grow to high densities in the environment, allowing direct isolation of many secondary metabolites from field-collected material. However, in temperate environments cultu...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Leão PN,Ramos V,Gonçalves PB,Viana F,Lage OM,Gerwick WH,Vasconcelos VM

    更新日期:2013-04-22 00:00:00

  • Regional susceptibility to domoic acid in primary astrocyte cells cultured from the brain stem and hippocampus.

    abstract::Domoic acid is a marine biotoxin associated with harmful algal blooms and is the causative agent of amnesic shellfish poisoning in marine animals and humans. It is also an excitatory amino acid analog to glutamate and kainic acid which acts through glutamate receptors eliciting a very rapid and potent neurotoxic respo...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Gill SS,Hou Y,Ghane T,Pulido OM

    更新日期:2008-02-14 00:00:00

  • Isoaaptamine Induces T-47D Cells Apoptosis and Autophagy via Oxidative Stress.

    abstract::Aaptos is a genus of marine sponge which belongs to Suberitidae and is distributed in tropical and subtropical oceans. Bioactivity-guided fractionation of Aaptos sp. methanolic extract resulted in the isolation of aaptamine, demethyloxyaaptamine, and isoaaptamine. The cytotoxic activity of the isolated compounds was e...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wu CF,Lee MG,El-Shazly M,Lai KH,Ke SC,Su CW,Shih SP,Sung PJ,Hong MC,Wen ZH,Lu MC

    更新日期:2018-01-09 00:00:00

  • Optimization of Growth and Carotenoid Production by Haloferax mediterranei Using Response Surface Methodology.

    abstract::Haloferax mediterranei produces C50 carotenoids that have strong antioxidant properties. The response surface methodology (RSM) tool helps to accurately analyze the most suitable conditions to maximize C50 carotenoids production by haloarchaea. The effects of temperature (15⁻50 °C), pH (4-10), and salinity (5⁻28% NaCl...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Montero-Lobato Z,Ramos-Merchante A,Fuentes JL,Sayago A,Fernández-Recamales Á,Martínez-Espinosa RM,Vega JM,Vílchez C,Garbayo I

    更新日期:2018-10-09 00:00:00

  • Ω3 Supplementation and intermittent hypobaric hypoxia induce cardioprotection enhancing antioxidant mechanisms in adult rats.

    abstract::Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing infarct size and reinforcing antioxidant defenses. The aim of this work was to determine the combin...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Herrera EA,Farías JG,González-Candia A,Short SE,Carrasco-Pozo C,Castillo RL

    更新日期:2015-02-04 00:00:00

  • Functional Characterization and Evolutionary Analysis of Glycine-Betaine Biosynthesis Pathway in Red Seaweed Pyropia yezoensis.

    abstract::The red seaweed Pyropia yezoensis is an ideal research model for dissecting the molecular mechanisms underlying its robust acclimation to abiotic stresses in intertidal zones. Glycine betaine (GB) was an important osmolyte in maintaining osmotic balance and stabilizing the quaternary structure of complex proteins unde...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Mao Y,Chen N,Cao M,Chen R,Guan X,Wang D

    更新日期:2019-01-21 00:00:00

  • Effects of long chain fatty acid synthesis and associated gene expression in microalga Tetraselmis sp.

    abstract::With the depletion of global fish stocks, caused by high demand and effective fishing techniques, alternative sources for long chain omega-3 fatty acids are required for human nutrition and aquaculture feeds. Recent research has focused on land-based cultivation of microalgae, the primary producers of omega-3 fatty ac...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Adarme-Vega TC,Thomas-Hall SR,Lim DK,Schenk PM

    更新日期:2014-06-04 00:00:00

  • Gentisyl Alcohol Inhibits Proliferation and Induces Apoptosis via Mitochondrial Dysfunction and Regulation of MAPK and PI3K/AKT Pathways in Epithelial Ovarian Cancer Cells.

    abstract::Ovarian cancer is one of the prevalent gynecological cancers occurring in women. In particular, the efficiency of standard therapeutic methods decreases when recurrence and chemoresistance ensue. To assist standard anti-cancer agents in the cure of ovarian cancer, development and application of new compounds such as s...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ham J,Lim W,Kim K,Heo YM,Ryu SM,Lee D,Kim JJ,Song G

    更新日期:2019-06-03 00:00:00

  • Bioactive cembrane-based diterpenoids from the soft coral Sinularia triangular.

    abstract::Chemical examination of the Taiwanese soft coral Sinularia triangular led to the isolation of five cembrane-based diterpenoids 1-5, including two new metabolites, triangulenes A (1) and B (2). The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly mass spec...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Su JH,Wen ZH

    更新日期:2011-01-01 00:00:00

  • Identification and characterization of an anti-fibrotic benzopyran compound isolated from mangrove-derived Streptomyces xiamenensis.

    abstract::An anti-fibrotic compound produced by Streptomycesn xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis. The compound, N-[[3,4-dihydro-3S-hydroxy-2S-methyl-2-(4'R-methyl-3'S-pentenyl)-2H-1-benzopyran-6-yl]carbonyl]-threonine (1), was isolated from crude extracts...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Xu MJ,Liu XJ,Zhao YL,Liu D,Xu ZH,Lang XM,Ao P,Lin WH,Yang SL,Zhang ZG,Xu J

    更新日期:2012-03-01 00:00:00

  • Cnidarians as a source of new marine bioactive compounds--an overview of the last decade and future steps for bioprospecting.

    abstract::Marine invertebrates are rich sources of bioactive compounds and their biotechnological potential attracts scientific and economic interest worldwide. Although sponges are the foremost providers of marine bioactive compounds, cnidarians are also being studied with promising results. This diverse group of marine invert...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Rocha J,Peixe L,Gomes NC,Calado R

    更新日期:2011-01-01 00:00:00

  • Pinnatoxins' Deleterious Effects on Cholinergic Networks: From Experimental Models to Human Health.

    abstract::Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine invertebrates, including bivalves. No human intoxication has been repo...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Delcourt N,Lagrange E,Abadie E,Fessard V,Frémy JM,Vernoux JP,Peyrat MB,Maignien T,Arnich N,Molgó J,Mattei C

    更新日期:2019-07-20 00:00:00

  • Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole.

    abstract::Mycothiazole, a polyketide metabolite isolated from the marine sponge Cacospongia mycofijiensis, is a potent inhibitor of metabolic activity and mitochondrial electron transport chain complex I in sensitive cells, but other cells are relatively insensitive to the drug. Sensitive cell lines (IC(50) 0.36-13.8 nM) includ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Meyer KJ,Singh AJ,Cameron A,Tan AS,Leahy DC,O'Sullivan D,Joshi P,La Flamme AC,Northcote PT,Berridge MV,Miller JH

    更新日期:2012-04-01 00:00:00

  • Posidonia oceanica (L.) Delile Ethanolic Extract Modulates Cell Activities with Skin Health Applications.

    abstract::Seagrasses are high plants sharing adaptive metabolic features with both terrestrial plants and marine algae, resulting in a phytocomplex possibly endowed with interesting biological properties. The aim of this study is to evaluate the in vitro activities on skin cells of an ethanolic extract obtained from the leaves ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Cornara L,Pastorino G,Borghesi B,Salis A,Clericuzio M,Marchetti C,Damonte G,Burlando B

    更新日期:2018-01-10 00:00:00

  • Laminariales Host Does Impact Lipid Temperature Trajectories of the Fungal Endophyte Paradendryphiella salina (Sutherland.).

    abstract::Kelps are colonized by a wide range of microbial symbionts. Among them, endophytic fungi remain poorly studied, but recent studies evidenced yet their high diversity and their central role in algal defense against various pathogens. Thus, studying the metabolic expressions of kelp endophytes under different conditions...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Vallet M,Meziane T,Thiney N,Prado S,Hubas C

    更新日期:2020-07-22 00:00:00

  • Phytoene Accumulation in the Novel Microalga Chlorococcum sp. Using the Pigment Synthesis Inhibitor Fluridone.

    abstract::Carotenoids are lipophilic pigments found in plants and algae, as well as some bacteria, archaea, and fungi that serve two functions-(1) as light harvesting molecules-primary carotenoids, and (2) as antioxidants, acting against reactive oxygen species⁻secondary carotenoids. Because of their strong antioxidant properti...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Laje K,Seger M,Dungan B,Cooke P,Polle J,Holguin FO

    更新日期:2019-03-22 00:00:00

  • Pyrogallol-Phloroglucinol-6,6-Bieckol from Ecklonia cava Attenuates Tubular Epithelial Cell (TCMK-1) Death in Hypoxia/Reoxygenation Injury.

    abstract::The hypoxia/reoxygenation (H/R) injury causes serious complications after the blood supply to the kidney is stopped during surgery. The main mechanism of I/R injury is the release of high-mobility group protein B1 (HMGB1) from injured tubular epithelial cells (TEC, TCMK-1 cell), which triggers TLR4 or RAGE signaling, ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Son M,Oh S,Choi CH,Park KY,Son KH,Byun K

    更新日期:2019-10-24 00:00:00

  • Bioactive Bis(indole) Alkaloids from a Spongosorites sp. Sponge.

    abstract::Six new bis(indole) alkaloids (1-6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A-D (1-4) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Park JS,Cho E,Hwang JY,Park SC,Chung B,Kwon OS,Sim CJ,Oh DC,Oh KB,Shin J

    更新日期:2020-12-23 00:00:00

  • Leucine aminopeptidase, beta-glucosidase and alkaline phosphatase activity rates and their significance in nutrient cycles in some coastal Mediterranean sites.

    abstract::In aquatic microbial ecology, knowledge of the processes involved in the turnover of organic matter is of utmost importance to understand ecosystem functioning. Microorganisms are major players in the cycling of nutrients (nitrogen, phosphorus) and carbon, thanks to their enzymatic activities (leucine aminopeptidase, ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Caruso G

    更新日期:2010-03-29 00:00:00

  • Mechanisms of toxicity of 3-alkylpyridinium polymers from marine sponge Reniera sarai.

    abstract::Polymeric 3-alkylpyridinium salts (poly-APS) present in the marine sponge Reniera sarai show a broad spectrum of biological activities. They are lytic to erythrocytes and various other mammalian cells, enabling the transfection of the latter with alien DNA. Furthermore, they show inhibitory effects to marine bacteria ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Turk T,Frangez R,Sepcić K

    更新日期:2007-11-13 00:00:00

  • Development of pedigree classification using microsatellite and mitochondrial markers for Giant grouper broodstock (Epinephelus lanceolatus) management in Taiwan.

    abstract::Most giant groupers in the market are derived from inbred stock. Inbreeding can cause trait depression, compromising the animals' fitness and disease resistance, obligating farmers to apply increased amounts of drugs. In order to solve this problem, a pedigree classification method is needed. Here, microsatellite and ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Kuo HC,Hsu HH,Chua CS,Wang TY,Chen YM,Chen TY

    更新日期:2014-04-30 00:00:00

  • Discovery of new eunicellin-based diterpenoids from a Formosan soft coral Cladiella sp.

    abstract::A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Chen TH,Lu MC,Chang YC,Su YD,Chen YH,Lin NC,Fang LS,Wu YC,Sung PJ

    更新日期:2013-11-14 00:00:00

  • Anticancer Activity of Fascaplysin against Lung Cancer Cell and Small Cell Lung Cancer Circulating Tumor Cell Lines.

    abstract::Lung cancer is a leading cause of tumor-associated mortality. Fascaplysin, a bis-indole of a marine sponge, exhibit broad anticancer activity as specific CDK4 inhibitor among several other mechanisms, and is investigated as a drug to overcome chemoresistance after the failure of targeted agents or immunotherapy. The c...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Rath B,Hochmair M,Plangger A,Hamilton G

    更新日期:2018-10-14 00:00:00