Abstract:
:To investigate a high cholesterol diet in Alzheimer's disease (AD) mice, they were fed with (2% cholesterol) in five groups with a control group, AD mice group, AD mice plus Meretrix lusoria group, AD mice plus Geloina eros group, and, AD mice plus Corbicula fluminea group for three months, and treated with the fatty acid profiles of clams by gas chromatography (GC). The results showed that treatment with clams for three months reduced Fas/L and Caspase-3 in the Meretrix lusoria and Geloina eros groups, but Fas-associated death domain (FADD) and Caspase-8 were strongly reduced in the Geloina eros group. For the mitochondria-dependent apoptotic pathway, the reduction of apoptosis proteins were observed in the hearts of clams-treated AD mice. BAK and Caspase-9 was reduced in the Meretrix lusoria group, but Caspase-3 and Cytochrome-c were reduced in Geloina eros group. Enhancement of survival proteins p-AKT, p-IGF1R, p-PI3K, Bcl-XL, Bcl2, and the longevity SIRT1 signaling proteins, p-AMPK-α, SIRT1, PGC1-α, p-FOXO3 were observed in clams-treated mice and even more strongly enhanced in the Meretrix lusoria, Geloina eros and Corbicula fluminea groups. This study observed that the ingestion of clams caused a reduction of apoptosis proteins and enhancement of survival and SIRT1 signaling proteins in the hearts.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Hsieh YL,Teng HJ,Yeh YH,Hsieh CH,Huang CYdoi
10.3390/md16080263subject
Has Abstractpub_date
2018-08-01 00:00:00issue
8issn
1660-3397pii
md16080263journal_volume
16pub_type
杂志文章相关文献
Marine Drugs文献大全abstract::Four new compounds (1-4), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of 1 and 2 w...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15020043
更新日期:2017-02-17 00:00:00
abstract::Seagrasses are high plants sharing adaptive metabolic features with both terrestrial plants and marine algae, resulting in a phytocomplex possibly endowed with interesting biological properties. The aim of this study is to evaluate the in vitro activities on skin cells of an ethanolic extract obtained from the leaves ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16010021
更新日期:2018-01-10 00:00:00
abstract::Ecklonia cava (E. cava) can alleviate vascular dysfunction in diseases associated with poor circulation. E. cava contains various polyphenols with different functions, but few studies have compared the effects of these polyphenols. Here, we comparatively investigated four major compounds present in an ethanoic extract...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16110441
更新日期:2018-11-09 00:00:00
abstract::α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype. However, TxID is susceptible to modification due to it containing a methionine (Met) residue that easily forms m...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16060215
更新日期:2018-06-20 00:00:00
abstract::Three new butenolide derivatives, namely aspernolides N-P (1-3), together with six known analogues (4-9), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 1-3 were determined on the basis of comprehensive analyses of the nuclear...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17060332
更新日期:2019-06-03 00:00:00
abstract::Sea cucumbers belonging to echinoderm are traditionally used as tonic food in China and other Asian countries. They produce abundant biologically active triterpene glycosides. More than 300 triterpene glycosides have been isolated and characterized from various species of sea cucumbers, which are classified as holosta...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md15100317
更新日期:2017-10-17 00:00:00
abstract::Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus Penicillium griseofulvum. The structure of viridicatol was unambiguously established by X-ray diffraction analysis. In this study, a mouse model of ovalbumin-induced food allergy and the rat basophil leukemia (RBL)-2H3 cell model were establ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18100517
更新日期:2020-10-16 00:00:00
abstract::Two previously unreported citrinin dimer derivatives, penicitol D (1) and 1-epi-citrinin H1 (2), were isolated from the culture of a deep sea-derived fungus Penicillium citrinum NLG-S01-P1, together with 11 biogenetic related compounds (3⁻13). A plausible biogenetic pathway for compounds 2⁻4 was proposed. Their struct...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17010046
更新日期:2019-01-10 00:00:00
abstract::Fucoidan is a polysaccharide built from L-fucose molecules. The main source of this polysaccharide is the extracellular matrix of brown seaweed (Phaeophyta), but it can be also isolated from invertebrates such as sea urchins (Echinoidea) and sea cucumbers (Holothuroidea). Interest in fucoidan is related to its broad b...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md17080458
更新日期:2019-08-05 00:00:00
abstract::D. salina is one of the recognized natural sources to produce beta-carotene, and an useful model for studying the role of inhibitors and enhancers of carotenogenesis. However there is little information in D. salina regarding whether the isoprenoid substrate can be influenced by stress factors (carotenogenic) or selec...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md7010045
更新日期:2009-01-01 00:00:00
abstract::Long chain polyunsaturated fatty acids (LC-PUFAs) are important mediators in improving and maintaining human health over the total lifespan. One topic we especially focus on in this review is omega-3 LC-PUFA docosahexaenoic acid (DHA). Adequate DHA levels are essential during neurodevelopment and, in addition, benefic...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12126190
更新日期:2014-12-18 00:00:00
abstract::A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and catalytic properties. Homology models of the three-dimensional α-PsGal structure, ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16100349
更新日期:2018-09-24 00:00:00
abstract::Natural marine products have shown an interesting array of diverse and novel chemical structures with potent biological activities. Our study reports the antiproliferative assays of crude extracts, fraction and pure compound (4R,9S,14S)-4α-acetoxy-9β,14α-dihydroxydolast-1(15),7-diene (1) obtained from brown alga Canis...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md9112369
更新日期:2011-01-01 00:00:00
abstract::Oxylipins such as polyunsaturated aldehydes (PUAs) and hydroxyacids (HEPEs) are signaling molecules derived from the oxidation of polyunsaturated fatty acids. They are common in diatoms that constitute a major group of microalgae in freshwater and oceanic ecosystems. Although HEPEs represent the most common oxylipins ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030144
更新日期:2019-03-01 00:00:00
abstract::Most giant groupers in the market are derived from inbred stock. Inbreeding can cause trait depression, compromising the animals' fitness and disease resistance, obligating farmers to apply increased amounts of drugs. In order to solve this problem, a pedigree classification method is needed. Here, microsatellite and ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12052397
更新日期:2014-04-30 00:00:00
abstract::Diverse indoles and bis-indoles extracted from marine sources have been identified as promising anticancer leads. Herein, we designed and synthesized novel bis-indole series 7a-f and 9a-h as Topsentin and Nortopsentin analogs. Our design is based on replacing the heterocyclic spacer in the natural leads by a more flex...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18040190
更新日期:2020-04-02 00:00:00
abstract::The democratization of sequencing technologies fostered a leap in our knowledge of the diversity of marine phytoplanktonic microalgae, revealing many previously unknown species and lineages. The evolutionary history of the diversification of microalgae can be inferred from the analysis of their genome sequences. Howev...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18020078
更新日期:2020-01-25 00:00:00
abstract::Collagen is involved in the formation of complex fibrillar networks, providing the structural integrity of tissues. Its low immunogenicity and mechanical properties make this molecule a biomaterial that is extremely suitable for tissue engineering and regenerative medicine (TERM) strategies in human health issues. Her...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040111
更新日期:2018-03-29 00:00:00
abstract::An alginate lyase-producing bacterial strain, Pseudoalteromonas sp. SM0524, was screened from marine rotten kelp. In an optimized condition, the production of alginate lyase from Pseudoalteromonas sp. SM0524 reached 62.6 U/mL, suggesting that strain SM0524 is a good producer of alginate lyases. The bifunctional algina...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md9010109
更新日期:2011-01-21 00:00:00
abstract::Pseudomonas stutzeri 273 is a marine bacterium producing exopolysaccharide 273 (EPS273) with high anti-biofilm activity against P. aeruginosa PAO1. Here, the complete genome of P.stutzeri 273 was sequenced and the genome contained a circular 5.03 Mb chromosome. With extensive analysis of the genome, a genetic locus co...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15070218
更新日期:2017-07-10 00:00:00
abstract::In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the cultur...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16070229
更新日期:2018-07-06 00:00:00
abstract::The mucus produced by many marine organisms is a complex mixture of proteins and polysaccharides forming a weak watery gel. It is essential for vital processes including locomotion, navigation, structural support, heterotrophic feeding and defence against a multitude of environmental stresses, predators, parasites, an...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13085276
更新日期:2015-08-19 00:00:00
abstract::A potent marine toxin, tetrodotoxin (TTX), found in a great variety of marine and some terrestrial species, leaves intriguing questions about its origin and distribution in marine ecosystems. TTX-producing bacteria were found in the cultivable microflora of many TTX-bearing hosts, thereby providing strong support for ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18030177
更新日期:2020-03-23 00:00:00
abstract::The structures, names, bioactivities and references of 138 briarane-type diterpenoids, including 87 new compounds, are summarized in this review. All the briarane-type compounds mentioned in this review article were obtained from gorgonian corals including the genus Briareum, Dichotella, Junceella and Verrucella. Some...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12042164
更新日期:2014-04-10 00:00:00
abstract::Genome mining has become an increasingly powerful, scalable, and economically accessible tool for the study of natural product biosynthesis and drug discovery. However, there remain important biological and practical problems that can complicate or obscure biosynthetic analysis in genomic and metagenomic sequencing pr...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md15060165
更新日期:2017-06-06 00:00:00
abstract::The marine genus Pseudoalteromonas is known for its versatile biotechnological potential with respect to the production of antimicrobials and enzymes of industrial interest. We have sequenced the genomes of three Pseudoalteromonas sp. strains isolated from different deep sea sponges on the Illumina MiSeq platform. The...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15060184
更新日期:2017-06-19 00:00:00
abstract::Two new guaiazulene-based analogues, ochracenoids A (1) and B (2), along with four known analogues (3-6), were isolated from the gorgonian Anthogorgia ochracea collected from the South China Sea. The planar structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configuration ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12031569
更新日期:2014-03-14 00:00:00
abstract::The present study is focused on the intestinal absorption of sea cucumber saponins. We determined the pharmacokinetic characteristics and bioavailability of Echinoside A and Holotoxin A₁; the findings indicated that the bioavailability of Holotoxin A₁ was lower than Echinoside A. We inferred that the differences in ch...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14060114
更新日期:2016-06-17 00:00:00
abstract::The study of spatial distribution of secondary metabolites within microbial cells facilitates the screening of candidate strains from marine environments for functional metabolites and allows for the subsequent assessment of the production of metabolites, such as antibiotics. This paper demonstrates the first applicat...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12052827
更新日期:2014-05-13 00:00:00
abstract::Four 4-hydroxy-α-pyrones including three new ones named nipyrones A-C (1-3) together with one known analogue germicidin C (4) were discovered from a marine sponge-derived fungus Aspergillus niger cultivated in a solid rice culture. Their structures and absolute configurations were elucidated through a combination of s...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17060344
更新日期:2019-06-10 00:00:00