Metabolomic Insights into Marine Phytoplankton Diversity.


:The democratization of sequencing technologies fostered a leap in our knowledge of the diversity of marine phytoplanktonic microalgae, revealing many previously unknown species and lineages. The evolutionary history of the diversification of microalgae can be inferred from the analysis of their genome sequences. However, the link between the DNA sequence and the associated phenotype is notoriously difficult to assess, all the more so for marine phytoplanktonic microalgae for which the lab culture and, thus, biological experimentation is very tedious. Here, we explore the potential of a high-throughput untargeted metabolomic approach to explore the phenotypic-genotypic gap in 12 marine microalgae encompassing 1.2 billion years of evolution. We identified species- and lineage-specific metabolites. We also provide evidence of a very good correlation between the molecular divergence, inferred from the DNA sequences, and the metabolomic divergence, inferred from the complete metabolomic profiles. These results provide novel insights into the potential of chemotaxonomy in marine phytoplankton and support the hypothesis of a metabolomic clock, suggesting that DNA and metabolomic profiles co-evolve.


Mar Drugs


Marine drugs


Marcellin-Gros R,Piganeau G,Stien D




Has Abstract


2020-01-25 00:00:00










  • Theonellamide G, a potent antifungal and cytotoxic bicyclic glycopeptide from the Red Sea marine sponge Theonella swinhoei.

    abstract::In our search for bioactive metabolites from marine organisms, we have investigated the polar fraction of the organic extract of the Red Sea sponge Theonella swinhoei. Successive chromatographic separations and final HPLC purification of the potent antifungal fraction afforded a new bicyclic glycopeptide, theonellamid...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Youssef DT,Shaala LA,Mohamed GA,Badr JM,Bamanie FH,Ibrahim SR

    更新日期:2014-04-01 00:00:00

  • Development of pedigree classification using microsatellite and mitochondrial markers for Giant grouper broodstock (Epinephelus lanceolatus) management in Taiwan.

    abstract::Most giant groupers in the market are derived from inbred stock. Inbreeding can cause trait depression, compromising the animals' fitness and disease resistance, obligating farmers to apply increased amounts of drugs. In order to solve this problem, a pedigree classification method is needed. Here, microsatellite and ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Kuo HC,Hsu HH,Chua CS,Wang TY,Chen YM,Chen TY

    更新日期:2014-04-30 00:00:00

  • Nocapyrones: α- and γ-pyrones from a marine-derived Nocardiopsis sp.

    abstract::One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2-4 were found t...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Kim Y,Ogura H,Akasaka K,Oikawa T,Matsuura N,Imada C,Yasuda H,Igarashi Y

    更新日期:2014-07-08 00:00:00

  • Bioactivity of Spongian Diterpenoid Scaffolds from the Antarctic Sponge Dendrilla antarctica.

    abstract::The Antarctic sponge Dendrilla antarctica is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted in the generation of a small chemical library containing diterpenoid secondary metabolites with bioactivity in an infectious disease screening campaign focused...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bory A,Shilling AJ,Allen J,Azhari A,Roth A,Shaw LN,Kyle DE,Adams JH,Amsler CD,McClintock JB,Baker BJ

    更新日期:2020-06-23 00:00:00

  • Anti-Diabetic Activity of 2,3,6-Tribromo-4,5-Dihydroxybenzyl Derivatives from Symphyocladia latiuscula through PTP1B Downregulation and α-Glucosidase Inhibition.

    abstract::The marine alga, Symphyocladia latiuscula (Harvey) Yamada, is a good source of bromophenols with numerous biological activities. This study aims to characterize the anti-diabetic potential of 2,3,6-tribromo-4,5-dihydroxybenzyl derivatives isolated from S. latiuscula via their inhibition of tyrosine phosphatase 1B (PTP...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Paudel P,Seong SH,Park HJ,Jung HA,Choi JS

    更新日期:2019-03-14 00:00:00

  • Cyclic marinopyrrole derivatives as disruptors of Mcl-1 and Bcl-x(L) binding to Bim.

    abstract::A series of novel cyclic marinopyrroles were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-x(L), was evaluated using ELISA assays. Both atropisomers of marinopyrrole A (1) show similar potency. A tetrabromo congener 9 is t...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Cheng C,Liu Y,Balasis ME,Simmons NL,Li J,Song H,Pan L,Qin Y,Nicolaou KC,Sebti SM,Li R

    更新日期:2014-03-07 00:00:00

  • Shrimp lipids: a source of cancer chemopreventive compounds.

    abstract::Shrimp is one of the most popular seafoods worldwide, and its lipids have been studied for biological activity in both, muscle and exoskeleton. Free fatty acids, triglycerides, carotenoids, and other lipids integrate this fraction, and some of these compounds have been reported with cancer chemopreventive activities. ...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: López-Saiz CM,Suárez-Jiménez GM,Plascencia-Jatomea M,Burgos-Hernández A

    更新日期:2013-10-16 00:00:00

  • Virescenosides From the Holothurian-Associated Fungus Acremonium Striatisporum Kmm 4401.

    abstract::Ten new diterpene glycosides virescenosides Z9-Z18 (1-10) together with three known analogues (11-13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassiu...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Zhuravleva OI,Antonov AS,Oleinikova GK,Khudyakova YV,Popov RS,Denisenko VA,Pislyagin EA,Chingizova EA,Afiyatullov SS

    更新日期:2019-10-29 00:00:00

  • Design, synthesis and biological evaluation of tasiamide analogues as tumor inhibitors.

    abstract::Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus w...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Zhang W,Sun T,Ma Z,Li Y

    更新日期:2014-04-22 00:00:00

  • Regional susceptibility to domoic acid in primary astrocyte cells cultured from the brain stem and hippocampus.

    abstract::Domoic acid is a marine biotoxin associated with harmful algal blooms and is the causative agent of amnesic shellfish poisoning in marine animals and humans. It is also an excitatory amino acid analog to glutamate and kainic acid which acts through glutamate receptors eliciting a very rapid and potent neurotoxic respo...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Gill SS,Hou Y,Ghane T,Pulido OM

    更新日期:2008-02-14 00:00:00

  • Phylogenetic identification of fungi isolated from the marine sponge Tethya aurantium and identification of their secondary metabolites.

    abstract::Fungi associated with the marine sponge Tethya aurantium were isolated and identified by morphological criteria and phylogenetic analyses based on internal transcribed spacer (ITS) regions. They were evaluated with regard to their secondary metabolite profiles. Among the 81 isolates which were characterized, members o...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wiese J,Ohlendorf B,Blümel M,Schmaljohann R,Imhoff JF

    更新日期:2011-01-01 00:00:00

  • Astaxanthin Attenuates Fish Oil-Related Hepatotoxicity and Oxidative Insult in Juvenile Pacific White Shrimp (Litopenaeus vannamei).

    abstract::The present study investigated the effect of dietary astaxanthin (AX) on the growth performance, antioxidant parameters, and repair of hepatopancreas damage in Pacific white shrimp (Litopenaeus vannamei). To evaluate the hepatopancreas protective function of AX in shrimps, we compared the effect of five isonitrogenous...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Yu Y,Liu Y,Yin P,Zhou W,Tian L,Liu Y,Xu D,Niu J

    更新日期:2020-04-17 00:00:00

  • Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole.

    abstract::Mycothiazole, a polyketide metabolite isolated from the marine sponge Cacospongia mycofijiensis, is a potent inhibitor of metabolic activity and mitochondrial electron transport chain complex I in sensitive cells, but other cells are relatively insensitive to the drug. Sensitive cell lines (IC(50) 0.36-13.8 nM) includ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Meyer KJ,Singh AJ,Cameron A,Tan AS,Leahy DC,O'Sullivan D,Joshi P,La Flamme AC,Northcote PT,Berridge MV,Miller JH

    更新日期:2012-04-01 00:00:00

  • Reclamation of Marine Chitinous Materials for the Production of α-Glucosidase Inhibitors via Microbial Conversion.

    abstract::Six kinds of chitinous materials have been used as sole carbon/nitrogen (C/N) sources for producing α-glucosidase inhibitors (aGI) by Paenibacillus sp. TKU042. The aGI productivity was found to be highest in the culture supernatants using demineralized crab shell powder (deCSP) and demineralized shrimp shell powder (d...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Nguyen VB,Wang SL

    更新日期:2017-11-07 00:00:00

  • Cephalopods as vectors of harmful algal bloom toxins in marine food webs.

    abstract::Here we summarize the current knowledge on the transfer and accumulation of harmful algal bloom (HAB)-related toxins in cephalopods (octopods, cuttlefishes and squids). These mollusks have been reported to accumulate several HAB-toxins, namely domoic acid (DA, and its isomers), saxitoxin (and its derivatives) and paly...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Lopes VM,Lopes AR,Costa P,Rosa R

    更新日期:2013-09-06 00:00:00

  • Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations.

    abstract::Genome mining has become an increasingly powerful, scalable, and economically accessible tool for the study of natural product biosynthesis and drug discovery. However, there remain important biological and practical problems that can complicate or obscure biosynthetic analysis in genomic and metagenomic sequencing pr...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Miller IJ,Chevrette MG,Kwan JC

    更新日期:2017-06-06 00:00:00

  • Astaxanthin attenuates early acute kidney injury following severe burns in rats by ameliorating oxidative stress and mitochondrial-related apoptosis.

    abstract::Early acute kidney injury (AKI) is a devastating complication in critical burn patients, and it is associated with severe morbidity and mortality. The mechanism of AKI is multifactorial. Astaxanthin (ATX) is a natural compound that is widely distributed in marine organisms; it is a strong antioxidant and exhibits othe...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Guo SX,Zhou HL,Huang CL,You CG,Fang Q,Wu P,Wang XG,Han CM

    更新日期:2015-04-13 00:00:00

  • Gliotoxin Inhibits Proliferation and Induces Apoptosis in Colorectal Cancer Cells.

    abstract::The discovery of new bioactive compounds from marine natural sources is very important in pharmacological research. Here we developed a Wnt responsive luciferase reporter assay to screen small molecule inhibitors of cancer associated constitutive Wnt signaling pathway. We identified that gliotoxin (GTX) and some of it...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Chen J,Wang C,Lan W,Huang C,Lin M,Wang Z,Liang W,Iwamoto A,Yang X,Liu H

    更新日期:2015-10-02 00:00:00

  • The Positive Role of Curcumin-Loaded Salmon Nanoliposomes on the Culture of Primary Cortical Neurons.

    abstract::Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Hasan M,Latifi S,Kahn CJF,Tamayol A,Habibey R,Passeri E,Linder M,Arab-Tehrany E

    更新日期:2018-06-25 00:00:00

  • A kinetic study of accumulation and elimination of microcystin-LR in yellow perch (Perca flavescens) tissue and implications for human fish consumption.

    abstract::Fish consumption is a potential route of human exposure to the hepatotoxic microcystins, especially in lakes and reservoirs that routinely experience significant toxic Microcystis blooms. Understanding the rates of uptake and elimination for microcystins as well as the transfer efficiency into tissues of consumers are...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Dyble J,Gossiaux D,Landrum P,Kashian DR,Pothoven S

    更新日期:2011-12-01 00:00:00

  • Soft coral-derived lemnalol alleviates monosodium urate-induced gouty arthritis in rats by inhibiting leukocyte infiltration and iNOS, COX-2 and c-Fos protein expression.

    abstract::An acute gout attack manifests in the joint as dramatic inflammation. To date, the clinical use of medicinal agents has typically led to undesirable side effects. Numerous efforts have failed to create an effective and safe agent for the treatment of gout. Lemnalol-an extract from Formosan soft coral-has documented an...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lee HP,Huang SY,Lin YY,Wang HM,Jean YH,Wu SF,Duh CY,Wen ZH

    更新日期:2013-01-10 00:00:00

  • Penicibrocazines A-E, five new sulfide diketopiperazines from the marine-derived endophytic fungus Penicillium brocae.

    abstract::Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A-E (1-5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of th...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Meng LH,Zhang P,Li XM,Wang BG

    更新日期:2015-01-07 00:00:00

  • Structures and Bioactivities of Psolusosides B1, B2, J, K, L, M, N, O, P, and Q from the Sea Cucumber Psolus fabricii. The First Finding of Tetrasulfated Marine Low Molecular Weight Metabolites.

    abstract::Ten new di-, tri- and tetrasulfated triterpene glycosides, psolusosides B1 (1), B2 (2), J (3), K (4), L (5), M (6), N (7), O (8), P (9), and Q (10), were isolated from the sea cucumber Psolus fabricii collected in the Sea of Okhotsk near the Kurile Islands. Structures of these glycosides were established by two-dimens...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Silchenko AS,Kalinovsky AI,Avilov SA,Kalinin VI,Andrijaschenko PV,Dmitrenok PS,Popov RS,Chingizova EA

    更新日期:2019-11-06 00:00:00

  • Pectenotoxin-2 from marine sponges: a potential anti-cancer agent-a review.

    abstract::Pectenotoxin-2 (PTX-2), which was first identified as a cytotoxic entity in marine sponges, has been reported to display significant cytotoxicity to human cancer cells where it inhibits mitotic separation and cytokinesis through the depolymerization of actin filaments. In the late stage of endoreduplication, the effec...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Kim GY,Kim WJ,Choi YH

    更新日期:2011-01-01 00:00:00

  • Correction: Zhang, G.; Cheng, G.; Jia, P.; Jiao, S.; Feng, C.; Hu, T.; Liu, H.; Du, Y. The Positive Correlation of the Enhanced Immune Response to PCV2 Subunit Vaccine by Conjugation of Chitosan Oligosaccharide with the Deacetylation Degree. Marine Drugs

    abstract::The authors wish to correct Figure 1 in this paper [1] to be as follows:[...]. ...

    journal_title:Marine drugs

    pub_type: 杂志文章,已发布勘误


    authors: Zhang G,Cheng G,Jia P,Jiao S,Feng C,Hu T,Liu H,Du Y

    更新日期:2017-09-20 00:00:00

  • New Invasive Nemertean Species (Cephalothrix Simula) in England with High Levels of Tetrodotoxin and a Microbiome Linked to Toxin Metabolism.

    abstract::The marine nemertean Cephalothrix simula originates from the Pacific Ocean but in recent years has been discovered in northern Europe. The species has been associated with high levels of the marine neurotoxin Tetrodotoxin, traditionally associated with Pufferfish Poisoning. This study reports the first discovery of tw...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Turner AD,Fenwick D,Powell A,Dhanji-Rapkova M,Ford C,Hatfield RG,Santos A,Martinez-Urtaza J,Bean TP,Baker-Austin C,Stebbing P

    更新日期:2018-11-16 00:00:00

  • Targets and effects of yessotoxin, okadaic acid and palytoxin: a differential review.

    abstract::In this review, we focus on processes, organs and systems targeted by the marine toxins yessotoxin (YTX), okadaic acid (OA) and palytoxin (PTX). The effects of YTX and their basis are analyzed from data collected in the mollusc Mytilus galloprovincialis, the annelid Enchytraeus crypticus, Swiss CD1 mice and invertebra...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Franchini A,Malagoli D,Ottaviani E

    更新日期:2010-03-16 00:00:00

  • Chemoecological screening reveals high bioactivity in diverse culturable Portuguese marine cyanobacteria.

    abstract::Marine cyanobacteria, notably those from tropical regions, are a rich source of bioactive secondary metabolites. Tropical marine cyanobacteria often grow to high densities in the environment, allowing direct isolation of many secondary metabolites from field-collected material. However, in temperate environments cultu...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Leão PN,Ramos V,Gonçalves PB,Viana F,Lage OM,Gerwick WH,Vasconcelos VM

    更新日期:2013-04-22 00:00:00

  • Structure elucidation of new acetylated saponins, Lessoniosides A, B, C, D, and E, and non-acetylated saponins, Lessoniosides F and G, from the viscera of the sea cucumber Holothuria lessoni.

    abstract::Sea cucumbers produce numerous compounds with a wide range of chemical structural diversity. Among these, saponins are the most diverse and include sulfated, non-sulfated, acetylated and methylated congeners with different aglycone and sugar moieties. In this study, MALDI and ESI tandem mass spectrometry, in the posit...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bahrami Y,Franco CM

    更新日期:2015-01-16 00:00:00

  • Sea Cucumber Glycosides: Chemical Structures, Producing Species and Important Biological Properties.

    abstract::Sea cucumbers belonging to echinoderm are traditionally used as tonic food in China and other Asian countries. They produce abundant biologically active triterpene glycosides. More than 300 triterpene glycosides have been isolated and characterized from various species of sea cucumbers, which are classified as holosta...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Mondol MAM,Shin HJ,Rahman MA,Islam MT

    更新日期:2017-10-17 00:00:00