当前位置： SCI文献检索 > Marine Drugs期刊下所有文献 > Astaxanthin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells via Inhibition of Nf-Κb P65 and Wnt/Β-Catenin in Vitro.

Astaxanthin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells via Inhibition of Nf-Κb P65 and Wnt/Β-Catenin in Vitro.

Abstract：

:Hepatocellular carcinoma (HCC) is a malignant tumor that can cause systemic invasion; however, the exact etiology and molecular mechanism are unknown. Astaxanthin (ASX), a powerful antioxidant, has efficient anti-oxidant, anti-inflammatory, and other activities, and has great research prospects in cancer therapy. We selected the human hepatoma cell lines, LM3 and SMMC-7721, to study the anti-tumor effect and related mechanisms of ASX. The cell lines were treated with different concentrations of ASX, and its solvent DMSO as a control, for different time periods and the results were determined using CCK8, qRT-PCR, WB, apoptotic staining, and flow cytometry. ASX induced significant apoptosis of HCC cells, and its effect may have been caused by NF-κB p65 and Wnt/β-catenin down-regulation via negative activation of PI3K/Akt and ERK. Antitumor research on ASX has provided us with a potential therapy for patients with hepatomas.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Li J,Dai W,Xia Y,Chen K,Li S,Liu T,Zhang R,Wang J,Lu W,Zhou Y,Yin Q,Abudumijiti H,Chen R,Zheng Y,Wang F,Lu J,Zhou Y,Guo C

doi

10.3390/md13106064

subject

Has Abstract

pub_date

2015-09-24 00:00:00

pages

6064-81

issue

10

issn

1660-3397

pii

md13106064

journal_volume

13

pub_type

杂志文章

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