Abstract:
:Four new compounds (1-4), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of 1 and 2 were determined by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compound 9 showed moderate cytotoxicity against human colon cancer HCT116 cell line with IC50 value of 15.6 μM. In addition, 3 and 5 had significant antifouling activity against Bugula neritina larval settlement with EC50 values of 13.7 and 22.6 μM, respectively. The NMR data of 6, 8, and 9 were assigned for the first time.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Xu X,Zhang X,Nong X,Wang J,Qi Sdoi
10.3390/md15020043subject
Has Abstractpub_date
2017-02-17 00:00:00issue
2issn
1660-3397pii
md15020043journal_volume
15pub_type
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