Abstract：
:Astaxanthin captured peroxynitrite to form nitroastaxanthins. 15-Nitroastaxanthin was a major reaction product of astaxanthin with peroxynitrite. Here, the anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of 15-nitroastaxanthin were investigated. In addition to astaxanthin, 15-nitroastaxanthin showed excellent singlet oxygen quenching activity. Furthermore, 15-nitroastaxanthin showed inhibitory effects of in vitro Epstein-Barr virus early antigen activation and two-stage carcinogensis on mouse skin papillomas. These activities were slightly higher than those of astaxanthin. Similar results were obtained for the 15-nitrolutein, a major reaction product of lutein with peroxynitrite.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Maoka T,Tokuda H,Suzuki N,Kato H,Etoh Hdoi
10.3390/md10061391subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1391-9issue
6issn
1660-3397pii
marinedrugs-10-01391journal_volume
10pub_type
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