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Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.

Abstract：

:Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological activities potentially beneficial to human health. (+)-Aeroplysinin-1 is a secondary metabolite isolated from marine sponges with a wide spectrum of bio-activities. (+)-Aeroplysinin-1 has potent antibiotic effects on Gram-positive bacteria and several dinoflagellate microalgae causing toxic blooms. In preclinical studies, (+)-aeroplysinin-1 has been shown to have promising anti-inflammatory, anti-angiogenic and anti-tumor effects. Due to its versatility, (+)-aeroplysinin-1 might have a pharmaceutical interest for the treatment of different pathologies.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

García-Vilas JA,Martínez-Poveda B,Quesada AR,Medina MÁ

doi

10.3390/md14010001

subject

Has Abstract

pub_date

2015-12-22 00:00:00

pages

1

issue

1

issn

1660-3397

pii

md14010001

journal_volume

14

pub_type

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