Abstract：
:The red seaweed Pyropia yezoensis is an ideal research model for dissecting the molecular mechanisms underlying its robust acclimation to abiotic stresses in intertidal zones. Glycine betaine (GB) was an important osmolyte in maintaining osmotic balance and stabilizing the quaternary structure of complex proteins under abiotic stresses (drought, salinity, etc.) in plants, animals, and bacteria. However, the existence and possible functions of GB in Pyropia remain elusive. In this study, we observed the rapid accumulation of GB in desiccated Pyropia blades, identifying its essential roles in protecting Pyropia cells against severe osmotic stress. Based on the available genomic and transcriptomic information of Pyropia, we computationally identified genes encoding the three key enzymes in the GB biosynthesis pathway: phosphoethanolamine N-methyltransferase (PEAMT), choline dehydrogenase (CDH), and betaine aldehyde dehydrogenase (BADH). Pyropia had an extraordinarily expanded gene copy number of CDH (up to seven) compared to other red algae. Phylogeny analysis revealed that in addition to the one conservative CDH in red algae, the other six might have originated from early gene duplication events. In dehydration stress, multiple CDH paralogs and PEAMT genes were coordinating up-regulated and shunted metabolic flux into GB biosynthesis. An elaborate molecular mechanism might be involved in the transcriptional regulation of these genes.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Mao Y,Chen N,Cao M,Chen R,Guan X,Wang Ddoi
10.3390/md17010070subject
Has Abstractpub_date
2019-01-21 00:00:00issue
1issn
1660-3397pii
md17010070journal_volume
17pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Protamine sulfate (PS) is a polycationic protein drug obtained from the sperm of fish, and is used to reverse the anticoagulant effect of unfractionated heparin (UFH). However, the interactions between PS, UFH, and platelets are still not clear. We measured the platelet numbers and collagen-induced aggregation, P-sele...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17090539
更新日期：2019-09-17 00:00:00
abstract：:The 7-Acetylsinumaximol B (7-AB), a bioactive cembranoid, was originally discovered from aquaculture soft coral Sinularia sandensis. The current study investigated the anti-proliferative property of 7-AB towards the NCI-N87 human gastric cancer cell line. An MTT cell proliferative assay was applied to evaluate cell su...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16040104
更新日期：2018-03-26 00:00:00
abstract：:Fucosterol from edible brown seaweeds has various biological activities, including anti-inflammatory, anti-adipogenic, antiphotoaging, anti-acetylcholinesterase, and anti-beta-secretase 1 activities. However, little is known about its effects on soluble amyloid beta peptide (sAβ)-induced endoplasmic reticulum (ER) str...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100368
更新日期：2018-10-05 00:00:00
abstract：:Most giant groupers in the market are derived from inbred stock. Inbreeding can cause trait depression, compromising the animals' fitness and disease resistance, obligating farmers to apply increased amounts of drugs. In order to solve this problem, a pedigree classification method is needed. Here, microsatellite and ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12052397
更新日期：2014-04-30 00:00:00
abstract：:Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus Penicillium griseofulvum. The structure of viridicatol was unambiguously established by X-ray diffraction analysis. In this study, a mouse model of ovalbumin-induced food allergy and the rat basophil leukemia (RBL)-2H3 cell model were establ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18100517
更新日期：2020-10-16 00:00:00
abstract：:In this study, we aimed to illustrate the potential bio-effects of 3-bromo-4,5-dihydroxybenzaldehyde (3-BDB) on the antioxidant/cytoprotective enzyme heme oxygenase-1 (HO-1) in keratinocytes. The antioxidant effects of 3-BDB were examined via reverse transcription PCR, Western blotting, HO-1 activity assay, and immuno...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17040234
更新日期：2019-04-19 00:00:00
abstract：:Bioassay-guided evaluation shows that a deep sea-derived fungus, Spiromastix sp. MCCC 3A00308, possesses lipid-lowering activity. Chromatographic separation of a culture broth resulted in the isolation of 15 known depsidone-based analogues, labeled spiromastixones A-O (1-15). Each of these compounds was tested for its...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13106352
更新日期：2015-10-14 00:00:00
abstract：:Ieodomycin B, which shows in vitro antimicrobial activity, was isolated from a marine Bacillus species. A novel asymmetric total synthetic approach to ieodomycin B using commercially available geraniol was achieved. The approach involves the generation of 1,3-trans-dihydroxyl at C-3 and C-5 positions via a Crimmins-mo...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15010017
更新日期：2017-01-18 00:00:00
abstract：:Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferat...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15110342
更新日期：2017-11-01 00:00:00
abstract：:Six new bis(indole) alkaloids (1-6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A-D (1-4) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md19010003
更新日期：2020-12-23 00:00:00
abstract：:Microalgae oil is an optimal feedstock for nutraceutical, pharmaceutical and biodiesel production, but its high levels of chlorophyll limit its large-scale application. To date, few effective approaches have been developed to remove chlorophyll from microalgae oil. The main purpose of this study was to present a prepr...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14090162
更新日期：2016-09-07 00:00:00
abstract：:An alginate lyase-producing bacterial strain, Pseudoalteromonas sp. SM0524, was screened from marine rotten kelp. In an optimized condition, the production of alginate lyase from Pseudoalteromonas sp. SM0524 reached 62.6 U/mL, suggesting that strain SM0524 is a good producer of alginate lyases. The bifunctional algina...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9010109
更新日期：2011-01-21 00:00:00
abstract：:Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer ce...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md13116884
更新日期：2015-11-13 00:00:00
abstract：:Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), bearing some interes...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11093297
更新日期：2013-08-28 00:00:00
abstract：:Mycosporine-like amino acids (MAAs) have gained considerable attention as highly active photoprotective candidates for human sunscreens. However, more studies are necessary to evaluate the extraction efficiency of these metabolites in solvents compatible with cosmetics and their subsequent analysis by HPLC. In the pre...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18010027
更新日期：2019-12-28 00:00:00
abstract：:The predatory marine gastropod Dicathais orbita has been the subject of a significant amount of biological and chemical research over the past five decades. Natural products research on D. orbita includes the isolation and identification of brominated indoles and choline esters as precursors of Tyrian purple, as well ...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md11041370
更新日期：2013-04-23 00:00:00
abstract：:Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and h...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15100251
更新日期：2017-09-26 00:00:00
abstract：:Ecklonia cava (E. cava) can alleviate vascular dysfunction in diseases associated with poor circulation. E. cava contains various polyphenols with different functions, but few studies have compared the effects of these polyphenols. Here, we comparatively investigated four major compounds present in an ethanoic extract...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110441
更新日期：2018-11-09 00:00:00
abstract：:N,N-Didesmethylgrossularine-1 (DDMG-1), a compound with a rare alpha-carboline structure, was isolated from an Indonesian ascidian Polycarpa aurata as responsible for the observed inhibitory activity against TNF-alpha production in lipopolysaccharide-stimulated murine macrophage-like RAW264.7 cells. DDMG-1 inhibited t...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md7040589
更新日期：2009-11-17 00:00:00
abstract：:Bacteria belonging to the Vibrionaceae family are widespread in the marine environment. Today, 128 species of vibrios are known. Several of them are infamous for their pathogenicity or symbiotic relationships. Despite their ability to interact with eukaryotes, the vibrios are greatly underexplored for their ability to...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md9091440
更新日期：2011-01-01 00:00:00
abstract：:Lipid A is a fundamental Gram-negative outer membrane component and the essential element of lipopolysaccharide (endotoxin), a potent immunostimulatory molecule. This work describes the metabolic adaptation of the lipid A acyl structure by Psychrobacter cryohalolentis at various temperatures in its facultative psychro...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13084701
更新日期：2015-07-30 00:00:00
abstract：:Diabetic retinopathy is a common diabetic eye disease caused by changes in retinal ganglion cells (RGCs). It is an ocular manifestation of systemic disease, which affects up to 80% of all patients who have had diabetes for 10 years or more. The genetically diabetic db/db mouse, as a model of type-2 diabetes, shows dia...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11030960
更新日期：2013-03-21 00:00:00
abstract：:Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was first recognized in a human case study of temporal lobe epilepsy after the 1987 amnesic shellfish-poisoning event in Quebec, and was characterized as a chronic...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md12031185
更新日期：2014-03-06 00:00:00
abstract：:A marine-derived strain of Clonostachys rosea isolated from sediments of the river Loire estuary (France) was investigated for its high lipid production. The fungal strain was grown on six different culture media to explore lipid production changes. An original branched conjugated fatty acid, mainly present in triglyc...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13084934
更新日期：2015-08-06 00:00:00
abstract：:The dinoflagellate Dinophysis spp. is responsible for diarrhetic shellfish poisoning (DSP). In the bivalves exposed to the toxic bloom of the dinoflagellate, dinophysistoxin 3 (DTX3), the 7-OH acylated form of either okadaic acid (OA) or DTX1, is produced. We demonstrated in vitro acylation of OA with palmitoyl CoA in...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11020300
更新日期：2013-01-29 00:00:00
abstract：:Mexico is one of the three areas of the world with the greatest terrestrial and cultural biological diversity. The diversity of Mexican medicinal flora has been studied for a long time and several bioactive compounds have been isolated. The investigation of marine resources, and particularly the potential of Mexican m...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md18010059
更新日期：2020-01-16 00:00:00
abstract：:Omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs), such as eicosapentaenoic acid (EPA) (20:5n-3) and docosahexaenoic acid (DHA) (22:6n-3), are considered essential for human health. Microorganisms are the primary producers of omega-3 fatty acids in marine ecosystems, representing a sustainable source of these ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18020099
更新日期：2020-02-01 00:00:00
abstract：:Application of cytostatics in cancer patients' chemotherapy results in a number of side effects, including the inhibition of various parts of hematopoiesis. Two sulfated polysaccharides, fucoidan from the seaweed Chordaria flagelliformis (PS-Fuc) and fucosylated chondroitin sulfate from the sea cucumber Massinium magn...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15100301
更新日期：2017-09-30 00:00:00
abstract：:The immunotoxic potential of domoic acid (DA), a well-characterized neurotoxin, has not been fully investigated. Phagocytosis and lymphocyte proliferation were evaluated following in vitro and in vivo exposure to assay direct vs indirect effects. Mice were injected intraperitoneally with a single dose of DA (2.5 micro...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md6040636
更新日期：2008-01-01 00:00:00
abstract：:Topical administration of drugs into the vagina can provide local therapy of vaginal infections, preventing the possible systemic side effects of the drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, and thus it can be utilized in ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18020096
更新日期：2020-01-31 00:00:00
