Cnidarians as a source of new marine bioactive compounds--an overview of the last decade and future steps for bioprospecting.

Abstract:

:Marine invertebrates are rich sources of bioactive compounds and their biotechnological potential attracts scientific and economic interest worldwide. Although sponges are the foremost providers of marine bioactive compounds, cnidarians are also being studied with promising results. This diverse group of marine invertebrates includes over 11,000 species, 7500 of them belonging to the class Anthozoa. We present an overview of some of the most promising marine bioactive compounds from a therapeutic point of view isolated from cnidarians in the first decade of the 21st century. Anthozoan orders Alcyonacea and Gorgonacea exhibit by far the highest number of species yielding promising compounds. Antitumor activity has been the major area of interest in the screening of cnidarian compounds, the most promising ones being terpenoids (monoterpenoids, diterpenoids, sesquiterpenoids). We also discuss the future of bioprospecting for new marine bioactive compounds produced by cnidarians.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Rocha J,Peixe L,Gomes NC,Calado R

doi

10.3390/md9101860

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

1860-86

issue

10

issn

1660-3397

pii

marinedrugs-09-01860

journal_volume

9

pub_type

杂志文章,评审
  • Preparation and characterization of antioxidant nanoparticles composed of chitosan and fucoidan for antibiotics delivery.

    abstract::In this study, we developed novel chitosan/fucoidan nanoparticles (CS/F NPs) using a simple polyelectrolyte self-assembly method and evaluated their potential to be antioxidant carriers. As the CS/F weight ratio was 5/1, the CS/F NPs were spherical and exhibited diameters of approximately 230-250 nm, as demonstrated b...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md12084379

    authors: Huang YC,Li RY

    更新日期:2014-07-31 00:00:00

  • Applying a Chemogeographic Strategy for Natural Product Discovery from the Marine Cyanobacterium Moorena bouillonii.

    abstract::The tropical marine cyanobacterium Moorena bouillonii occupies a large geographic range across the Indian and Western Tropical Pacific Oceans and is a prolific producer of structurally unique and biologically active natural products. An ensemble of computational approaches, including the creation of the ORCA (Objectiv...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md18100515

    authors: Leber CA,Naman CB,Keller L,Almaliti J,Caro-Diaz EJE,Glukhov E,Joseph V,Sajeevan TP,Reyes AJ,Biggs JS,Li T,Yuan Y,He S,Yan X,Gerwick WH

    更新日期:2020-10-14 00:00:00

  • Microginins from a Microcystis sp. Bloom Material Collected from the Kishon Reservoir, Israel.

    abstract::During blooms, cyanobacteria produce diverse modified peptides. Among these are the microginins, which inhibit zinc-containing metalloproteases. Ten microginins, microginins KR767 (1), KR801(2), KR835 (3), KR785 (4), KR604 (5), KR638 (6), KR781 (7), KR815 (8), FR3 (9), and FR4 (10), were isolated from the extract of a...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16030078

    authors: Lodin-Friedman A,Carmeli S

    更新日期:2018-03-02 00:00:00

  • New Cyclotetrapeptides and a New Diketopiperzine Derivative from the Marine Sponge-Associated Fungus Neosartorya glabra KUFA 0702.

    abstract::Two new cyclotetrapeptides, sartoryglabramides A (5) and B (6), and a new analog of fellutanine A (8) were isolated, together with six known compounds including ergosta-4, 6, 8 (14), 22-tetraen-3-one, ergosterol 5, 8-endoperoxide, helvolic acid, aszonalenin (1), (3R)-3-(1H-indol-3-ylmethyl)-3,4-dihydro-1H-1,4-benzodia...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md14070136

    authors: May Zin WW,Buttachon S,Dethoup T,Fernandes C,Cravo S,Pinto MM,Gales L,Pereira JA,Silva AM,Sekeroglu N,Kijjoa A

    更新日期:2016-07-20 00:00:00

  • Synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and its inhibition of liver cancer characteristics in vitro and in vivo.

    abstract::Nanoparticle drug delivery (NDDS) is a novel system in which the drugs are delivered to the site of action by small particles in the nanometer range. Natural or synthetic polymers are used as vectors in NDDS, as they provide targeted, sustained release and biodegradability. Here, we used the chitosan and hepatoma cell...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md11093517

    authors: Cheng M,Gao X,Wang Y,Chen H,He B,Xu H,Li Y,Han J,Zhang Z

    更新日期:2013-09-17 00:00:00

  • Synthesis and Evaluation of Spumigin Analogues Library with Thrombin Inhibitory Activity.

    abstract::Spumigins are marine natural products derived from cyanobacteria Nodulariaspumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation of spumigins showed that spumigins with a (2S,4S)-4-methylproline...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16110413

    authors: Žula A,Będziak I,Kikelj D,Ilaš J

    更新日期:2018-10-27 00:00:00

  • Anti-Thrombin, Anti-Adhesive, Anti-Migratory, and Anti-Proliferative Activities of Sulfated Galactans from the Tropical Green Seaweed, Udotea flabellum.

    abstract::In this study, sulfated polysaccharide-rich extracts were isolated from 22 tropical seaweeds (4 red, 11 brown, and 7 green) found in northeastern Brazil, and evaluated for the role of anticoagulant agents. Fifteen of the extracts showed anticoagulant activity, including all the extracts from green seaweeds. Udoteaflab...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17010005

    authors: Mendes Marques ML,Presa FB,Viana RLS,Costa MSSP,Amorim MOR,Bellan DL,Alves MGCF,Costa LS,Trindade ES,Rocha HAO

    更新日期:2018-12-21 00:00:00

  • Seaweed hydrocolloid production: an update on enzyme assisted extraction and modification technologies.

    abstract::Agar, alginate, and carrageenans are high-value seaweed hydrocolloids, which are used as gelation and thickening agents in different food, pharmaceutical, and biotechnological applications. The annual global production of these hydrocolloids has recently reached 100,000 tons with a gross market value just above US$ 1....

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md13063340

    authors: Rhein-Knudsen N,Ale MT,Meyer AS

    更新日期:2015-05-27 00:00:00

  • Butenolide Derivatives with α-Glucosidase Inhibitions from the Deep-Sea-Derived Fungus Aspergillus terreus YPGA10.

    abstract::Three new butenolide derivatives, namely aspernolides N-P (1-3), together with six known analogues (4-9), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 1-3 were determined on the basis of comprehensive analyses of the nuclear...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17060332

    authors: Cheng Z,Li Y,Liu W,Liu L,Liu J,Yuan W,Luo Z,Xu W,Li Q

    更新日期:2019-06-03 00:00:00

  • Synthesis of Alkyl-Glycerolipids Standards for Gas Chromatography Analysis: Application for Chimera and Shark Liver Oils.

    abstract::Natural O-alkyl-glycerolipids, also known as alkyl-ether-lipids (AEL), feature a long fatty alkyl chain linked to the glycerol unit by an ether bond. AEL are ubiquitously found in different tissues but, are abundant in shark liver oil, breast milk, red blood cells, blood plasma, and bone marrow. Only a few AEL are com...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16040101

    authors: Pinault M,Guimaraes C,Couthon H,Thibonnet J,Fontaine D,Chantôme A,Chevalier S,Besson P,Jaffrès PA,Vandier C

    更新日期:2018-03-23 00:00:00

  • Marine Bacteria, A Source for Alginolytic Enzyme to Disrupt Pseudomonas aeruginosa Biofilms.

    abstract::Pseudomonas aeruginosa biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one of the main components of its biofilm. Targeting this major biof...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17050307

    authors: Daboor SM,Raudonis R,Cohen A,Rohde JR,Cheng Z

    更新日期:2019-05-24 00:00:00

  • Asymmetric Synthesis and Cytotoxicity Evaluation of Right-Half Models of Antitumor Renieramycin Marine Natural Products.

    abstract::A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure⁻activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity against human prostate ca...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17010003

    authors: Matsubara T,Yokoya M,Sirimangkalakitti N,Saito N

    更新日期:2018-12-20 00:00:00

  • Total Synthesis of Pulmonarin B and Design of Brominated Phenylacetic Acid/Tacrine Hybrids: Marine Pharmacophore Inspired Discovery of New ChE and Aβ Aggregation Inhibitors.

    abstract::A marine natural product, pulmonarin B (1), and a series of related tacrine hybrid analogues were synthesized and evaluated as cholinesterase (ChE) inhibitors. The in vitro ChE assay results revealed that 1 showed moderate dual acetylcholinesterase (AChE)/ butyrylcholinesterase (BChE) inhibitory activity, while the hy...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16090293

    authors: Cheng ZQ,Song JL,Zhu K,Zhang J,Jiang CS,Zhang H

    更新日期:2018-08-21 00:00:00

  • Blood-Brain Barrier Permeable Chitosan Oligosaccharides Interfere with β-Amyloid Aggregation and Alleviate β-Amyloid Protein Mediated Neurotoxicity and Neuroinflammation in a Dose- and Degree of Polymerization-Dependent Manner.

    abstract::It is proven that β-amyloid (Aβ) aggregates containing cross-β-sheet structures led to oxidative stress, neuroinflammation, and neuronal loss via multiple pathways. Therefore, reduction of Aβ neurotoxicity via inhibiting aggregation of Aβ or dissociating toxic Aβ aggregates into nontoxic forms might be effective thera...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md18100488

    authors: Zhu L,Li R,Jiao S,Wei J,Yan Y,Wang ZA,Li J,Du Y

    更新日期:2020-09-25 00:00:00

  • Recently confirmed apoptosis-inducing lead compounds isolated from marine sponge of potential relevance in cancer treatment.

    abstract::Despite intense efforts to develop non-cytotoxic anticancer treatments, effective agents are still not available. Therefore, novel apoptosis-inducing drug leads that may be developed into effective targeted cancer therapies are of interest to the cancer research community. Targeted cancer therapies affect specific abe...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md9091580

    authors: Essack M,Bajic VB,Archer JA

    更新日期:2011-01-01 00:00:00

  • Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A-D.

    abstract::Six regioisomers associated with the tricyclic core of thiaplakortones A-D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic core scaffolds presen...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13095784

    authors: Schwartz BD,Coster MJ,Skinner-Adams TS,Andrews KT,White JM,Davis RA

    更新日期:2015-09-15 00:00:00

  • Fabrication and Characterization of Core-Shell Electrospun Fibrous Mats Containing Medicinal Herbs for Wound Healing and Skin Tissue Engineering.

    abstract::Nanofibrous structures mimicking the native extracellular matrix have attracted considerable attention for biomedical applications. The present study aims to design and produce drug-eluting core-shell fibrous scaffolds for wound healing and skin tissue engineering. Aloe vera extracts were encapsulated inside polymer f...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17010027

    authors: Zahedi E,Esmaeili A,Eslahi N,Shokrgozar MA,Simchi A

    更新日期:2019-01-05 00:00:00

  • Antiviral lead compounds from marine sponges.

    abstract::Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. They are usually produced by functional enzyme c...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md8102619

    authors: Sagar S,Kaur M,Minneman KP

    更新日期:2010-10-11 00:00:00

  • Magnetotactic bacteria as potential sources of bioproducts.

    abstract::Magnetotactic bacteria (MTB) produce intracellular organelles called magnetosomes which are magnetic nanoparticles composed of magnetite (Fe3O4) or greigite (Fe3S4) enveloped by a lipid bilayer. The synthesis of a magnetosome is through a genetically controlled process in which the bacterium has control over the compo...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md13010389

    authors: Araujo AC,Abreu F,Silva KT,Bazylinski DA,Lins U

    更新日期:2015-01-16 00:00:00

  • Anti-MRSA Sesquiterpenes from the Semi-Mangrove Plant Myoporum bontioides A. Gray.

    abstract::The striking rise of methicillin-resistant Staphylococcus aureus (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant Myoporum bontioides A. Gray, w...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16110438

    authors: Dong LM,Huang LL,Dai H,Xu QL,Ouyang JK,Jia XC,Gu WX,Tan JW

    更新日期:2018-11-08 00:00:00

  • Bioaccessibility of Marine Carotenoids.

    abstract::The benefit of carotenoids to human health is undeniable and consequently, their use for this purpose is growing rapidly. Additionally, the nutraceutical properties of carotenoids have attracted attention of the food industry, especially in a new market area, the 'cosmeceuticals.' Marine organisms (microalgae, seaweed...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md16100397

    authors: Viera I,Pérez-Gálvez A,Roca M

    更新日期:2018-10-22 00:00:00

  • Discovery of new eunicellin-based diterpenoids from a Formosan soft coral Cladiella sp.

    abstract::A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md11114585

    authors: Chen TH,Lu MC,Chang YC,Su YD,Chen YH,Lin NC,Fang LS,Wu YC,Sung PJ

    更新日期:2013-11-14 00:00:00

  • Evaluation of Rapid, Early Warning Approaches to Track Shellfish Toxins Associated with Dinophysis and Alexandrium Blooms.

    abstract::Marine biotoxin-contaminated seafood has caused thousands of poisonings worldwide this century. Given these threats, there is an increasing need for improved technologies that can be easily integrated into coastal monitoring programs. This study evaluates approaches for monitoring toxins associated with recurrent toxi...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16010028

    authors: Hattenrath-Lehmann TK,Lusty MW,Wallace RB,Haynes B,Wang Z,Broadwater M,Deeds JR,Morton SL,Hastback W,Porter L,Chytalo K,Gobler CJ

    更新日期:2018-01-13 00:00:00

  • Lipidomic Approaches towards Deciphering Glycolipids from Microalgae as a Reservoir of Bioactive Lipids.

    abstract::In recent years, noteworthy research has been performed around lipids from microalgae. Among lipids, glycolipids (GLs) are quite abundant in microalgae and are considered an important source of fatty acids (FAs). GLs are rich in 16- and 18-carbon saturated and unsaturated fatty acids and often contain polyunsaturated ...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md14050101

    authors: da Costa E,Silva J,Mendonça SH,Abreu MH,Domingues MR

    更新日期:2016-05-19 00:00:00

  • Characteristics of a Novel Manganese Superoxide Dismutase of a Hadal Sea Cucumber (Paelopatides sp.) from the Mariana Trench.

    abstract::A novel, cold-adapted, and acid-base stable manganese superoxide dismutase (Ps-Mn-SOD) was cloned from hadal sea cucumber Paelopatides sp. The dimeric recombinant enzyme exhibited approximately 60 kDa in molecular weight, expressed activity from 0 °C to 70 °C with an optimal temperature of 0 °C, and resisted wide pH v...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17020084

    authors: Li Y,Kong X,Zhang H

    更新日期:2019-02-01 00:00:00

  • Primary screening of the bioactivity of brackishwater cyanobacteria: toxicity of crude extracts to Artemia salina larvae and Paracentrotus lividus embryos.

    abstract::Cyanobacteria are a diverse group of Gram-negative bacteria that produce an array of secondary compounds with selective bioactivity against vertebrates, invertebrates, plants, microalgae, fungi, bacteria, viruses and cell lines. The aim of this study was to assess the toxic effects of aqueous, methanolic and hexane cr...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md803471

    authors: Lopes VR,Fernández N,Martins RF,Vasconcelos V

    更新日期:2010-03-05 00:00:00

  • Improved Astaxanthin Production with Corynebacterium glutamicum by Application of a Membrane Fusion Protein.

    abstract::Astaxanthin is one of the strongest natural antioxidants and a red pigment occurring in nature. This C40 carotenoid is used in a broad range of applications such as a colorant in the feed industry, an antioxidant in cosmetics or as a supplement in human nutrition. Natural astaxanthin is on the rise and, hence, alterna...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17110621

    authors: Henke NA,Wendisch VF

    更新日期:2019-10-31 00:00:00

  • Mangrove Tirucallane- and Apotirucallane-Type Triterpenoids: Structure Diversity of the C-17 Side-Chain and Natural Agonists of Human Farnesoid/Pregnane⁻X⁻Receptor.

    abstract::Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A⁻E (1⁻5) and agallochols A⁻D (6⁻9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10), were isolated from the mangrove plants Xylocarpus granatum, Xylocarpus moluccensis, and...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16120488

    authors: Jiang ZP,Luan ZL,Liu RX,Zhang Q,Ma XC,Shen L,Wu J

    更新日期:2018-12-06 00:00:00

  • Production, Characterization and Biocompatibility Evaluation of Collagen Membranes Derived from Marine Sponge Chondrosia reniformis Nardo, 1847.

    abstract::Collagen is involved in the formation of complex fibrillar networks, providing the structural integrity of tissues. Its low immunogenicity and mechanical properties make this molecule a biomaterial that is extremely suitable for tissue engineering and regenerative medicine (TERM) strategies in human health issues. Her...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16040111

    authors: Pozzolini M,Scarfì S,Gallus L,Castellano M,Vicini S,Cortese K,Gagliani MC,Bertolino M,Costa G,Giovine M

    更新日期:2018-03-29 00:00:00

  • Structure Elucidation and in Vitro Toxicity of New Azaspiracids Isolated from the Marine Dinoflagellate Azadinium poporum.

    abstract::Two strains of Azadinium poporum, one from the Korean West coast and the other from the North Sea, were mass cultured for isolation of new azaspiracids. Approximately 0.9 mg of pure AZA-36 (1) and 1.3 mg of pure AZA-37 (2) were isolated from the Korean (870 L) and North Sea (120 L) strains, respectively. The structure...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13116687

    authors: Krock B,Tillmann U,Potvin É,Jeong HJ,Drebing W,Kilcoyne J,Al-Jorani A,Twiner MJ,Göthel Q,Köck M

    更新日期:2015-10-30 00:00:00