Abstract：
:24-methyl-cholesta-5,24(28)-diene-3β,19-diol-7β-monoacetate (MeCDDA) is a natural steroid compound isolated from a wild-type soft coral (Nephthea erecta). The present study aimed to investigate the anti-small cell lung cancer (SCLC) effects of MeCDDA in vitro and in vivo, as well as to elucidate its underlying mechanism. Our results indicated that H1688 and H146 cells show relevant sensitivity to MeCDDA, and the exposure to MeCDDA in SCLC cells caused dose-dependent growth inhibitory responses. In addition, MeCDDA treatment promoted cell apoptosis and increased the activities of caspases in H1688 cells, reducing the mitochondrial membrane potential and stimulating the release of cytochrome c into the cytosol. Along with the increase in Bax expression and reduction in Bcl-2, the MeCDDA treatment also significantly decreased Akt and mTOR phosphorylation. Finally, MeCDDA treatment in the mouse xenograft model of H1688 cells exhibited significant inhibition of tumor growth, corroborating MeCDDA as a potential pre-clinical candidate for the treatment of SCLC. Overall, our results demonstrate that the cytotoxic effects of MeCDDA towards H1688 and H146 cells, possibly through the activation of the mitochondrial apoptotic pathway and inhibition of the PI3K/Akt/mTOR pathway, merit further studies for its possible clinical application in chemotherapy.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Chung TW,Su JH,Lin CC,Li YR,Chao YH,Lin SH,Chan HLdoi
10.3390/md15070210subject
Has Abstractpub_date
2017-07-01 00:00:00issue
7issn
1660-3397pii
md15070210journal_volume
15pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:The red macroalga Agarophyton chilensis is a well-known producer of eicosanoids such as hydroxyeicosatetraenoic acids, but the alga produces almost no prostaglandins, unlike the closely related A. vermiculophyllum. This indicates that the related two algae would have different enzyme systems or substrate composition. ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020096
更新日期：2019-02-02 00:00:00
abstract：:The development and use of topical microbicides potentially offers an additional strategy to reduce the spread of the Human Immunodeficiency Virus (HIV). Carbohydrate-binding agents (CBAs) that show specificity for high mannose carbohydrates on the surface of the heavily glycosylated envelope of HIV are endowed with p...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md10071476
更新日期：2012-07-01 00:00:00
abstract：:Many marine bacteria produce exopolysaccharides (EPS) as a strategy for growth, adhering to solid surfaces, and to survive adverse conditions. There is growing interest in isolating new EPS producing bacteria from marine environments, particularly from extreme marine environments such as deep-sea hydrothermal vents ch...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md8061779
更新日期：2010-06-03 00:00:00
abstract：:Sea cucumbers belonging to echinoderm are traditionally used as tonic food in China and other Asian countries. They produce abundant biologically active triterpene glycosides. More than 300 triterpene glycosides have been isolated and characterized from various species of sea cucumbers, which are classified as holosta...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md15100317
更新日期：2017-10-17 00:00:00
abstract：:In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Starting from this scaf...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12063091
更新日期：2014-05-27 00:00:00
abstract：:Being able to quantify ichthyotoxic metabolites from microalgae allows for the determination of ecologically-relevant concentrations that can be simulated in laboratory experiments, as well as to investigate bioaccumulation and degradation. Here, the ichthyotoxin karmitoxin, produced by Karlodinium armiger, was quanti...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15090278
更新日期：2017-08-31 00:00:00
abstract：UNLABELLED:Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from ...
journal_title：Marine drugs
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3390/md10092047
更新日期：2012-09-01 00:00:00
abstract：:The herein presented complete structure of the core oligosaccharide of lipopolysaccharide (LPS) P. shigelloides Polish Collection of Microorganisms (PCM) 2231 (serotype O17) was investigated by (1)H, (13)C NMR spectroscopy, mass spectrometry, chemical analyses and serological methods. The core oligosaccharide is compo...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11020440
更新日期：2013-02-06 00:00:00
abstract：:The review is devoted to the chemical diversity of steroids produced by soft corals and their determined and potential activities. There are about 200 steroids that belong to different types of steroids such as secosteroids, spirosteroids, epoxy- and peroxy-steroids, steroid glycosides, halogenated steroids, polyoxyge...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md18120613
更新日期：2020-12-02 00:00:00
abstract：:Natural anionic polysaccharides fucosylated chondroitin sulfates (FCS) from sea cucumbers attract great attention nowadays due to their ability to influence various biological processes, such as blood coagulation, thrombosis, angiogenesis, inflammation, bacterial and viral adhesion. To determine pharmacophore fragment...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13020770
更新日期：2015-02-02 00:00:00
abstract：:A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11114585
更新日期：2013-11-14 00:00:00
abstract：:Chlorophenols (CPs) are environmental pollutants that are produced through various anthropogenic activities and introduced in the environment. Living organisms, including humans, are exposed to these toxic xenobiotics and suffer from adverse health effects. More specifically, 2,4-dichlorophenol (2,4-DCP) is released i...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17100564
更新日期：2019-09-30 00:00:00
abstract：:We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal absorption, distribution, metabolism, and excretion of Jaspine B in rats. The oral bioavailability of Jaspine B was 6.2%, but it decreased to 1.6% in bile-depleted rats and increased to 41.2% (normal) and 23.5% (bile-depleted)...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15090279
更新日期：2017-09-01 00:00:00
abstract：:Chemical investigation of the marine soft coral Sarcophyton tenuispiculatum resulted in the isolation of a 1,4-dihydrobenzoquinone, sarcotenuhydroquinone (1), three new cembranoids, sarcotenusenes A‒C (2‒4), and ten previously reported metabolites 5-14. The chemical structures of all isolated metabolites were determin...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md19010008
更新日期：2020-12-27 00:00:00
abstract：:Anemonia viridis is a widespread and extensively studied Mediterranean species of sea anemone from which a large number of polypeptide toxins, such as blood depressing substances (BDS) peptides, have been isolated. The first members of this class, BDS-1 and BDS-2, are polypeptides belonging to the β-defensin fold fami...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11114213
更新日期：2013-10-30 00:00:00
abstract：:So far, the Futuna Islands located in the Central Indo-Pacific Ocean have not been inventoried for their diversity in marine sponges and associated chemical diversity. As part of the Tara Pacific expedition, the first chemical investigation of the sponge Narrabeena nigra collected around the Futuna Islands yielded 18 ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17060319
更新日期：2019-05-30 00:00:00
abstract：:Marine organisms produce secondary metabolites that may be valuable for the development of novel drug leads as such and can also provide structural scaffolds for the design and synthesis of novel bioactive compounds. The marine alkaloids, clathrodin and oroidin, which were originally isolated from sponges of the genus...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12020940
更新日期：2014-02-14 00:00:00
abstract：:When the aquaculture water environment deteriorates or the temperature rises, shrimp are susceptible to viral or bacterial infections, causing a large number of deaths. This study comprehensively evaluated the effects of the oral administration of a chitosan-gentamicin conjugate (CS-GT) after Litopenaeus vannamei were...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18080419
更新日期：2020-08-10 00:00:00
abstract：:Oxylipins such as polyunsaturated aldehydes (PUAs) and hydroxyacids (HEPEs) are signaling molecules derived from the oxidation of polyunsaturated fatty acids. They are common in diatoms that constitute a major group of microalgae in freshwater and oceanic ecosystems. Although HEPEs represent the most common oxylipins ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030144
更新日期：2019-03-01 00:00:00
abstract：:Polymeric 3-alkylpyridinium salts (poly-APS) present in the marine sponge Reniera sarai show a broad spectrum of biological activities. They are lytic to erythrocytes and various other mammalian cells, enabling the transfection of the latter with alien DNA. Furthermore, they show inhibitory effects to marine bacteria ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：
更新日期：2007-11-13 00:00:00
abstract：:The marine opisthobranch Scaphander lignarius has been analyzed in the systematic search for novel bioactive compounds in Arctic marine organisms using bioassay guided fractionation. A number of highly cytotoxic fractions were shown to contain mainly polyunsaturated fatty acids (PUFAs). Selected PUFAs were isolated an...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10122676
更新日期：2012-12-01 00:00:00
abstract：:Ciguatoxins (CTXs) are marine toxins that cause ciguatera fish poisoning, a debilitating disease dominated by sensory and neurological disturbances that include cold allodynia and various painful symptoms as well as long-lasting pruritus. Although CTXs are known as the most potent mammalian sodium channel activator to...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15090269
更新日期：2017-08-30 00:00:00
abstract：:Six kinds of chitinous materials have been used as sole carbon/nitrogen (C/N) sources for producing α-glucosidase inhibitors (aGI) by Paenibacillus sp. TKU042. The aGI productivity was found to be highest in the culture supernatants using demineralized crab shell powder (deCSP) and demineralized shrimp shell powder (d...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15110350
更新日期：2017-11-07 00:00:00
abstract：:Bone defects in human, caused by fractures/nonunions or trauma, gain increasing impact and have become a medical challenge in the present-day aging population. Frequently, those fractures require surgical intervention which ideally relies on autografts or suboptimally on allografts. Therefore, it is pressing and likew...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md11030718
更新日期：2013-03-08 00:00:00
abstract：:Kelps are colonized by a wide range of microbial symbionts. Among them, endophytic fungi remain poorly studied, but recent studies evidenced yet their high diversity and their central role in algal defense against various pathogens. Thus, studying the metabolic expressions of kelp endophytes under different conditions...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18080379
更新日期：2020-07-22 00:00:00
abstract：:Vaginal infections are associated with high recurrence, which is often due to a lack of efficient treatment of complex vaginal infections comprised of several types of pathogens, especially fungi and bacteria. Chitosan, a mucoadhesive polymer with known antifungal effect, could offer a great improvement in vaginal the...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15030064
更新日期：2017-03-04 00:00:00
abstract：:Like many fields of the biosciences, actinomycete natural products research has been revolutionised by next-generation DNA sequencing (NGS). Hundreds of new genome sequences from actinobacteria are made public every year, many of them as a result of projects aimed at identifying new natural products and their biosynth...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14040078
更新日期：2016-04-13 00:00:00
abstract：:In our search for quorum-sensing (QS) disrupting molecules, 75 fungal isolates were recovered from reef organisms (endophytes), saline lakes and mangrove rhizosphere. Their QS inhibitory activity was evaluated in Chromobacterium violaceum CVO26. Four strains of endophytic fungi stood out for their potent activity at c...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12115503
更新日期：2014-11-19 00:00:00
abstract：:The purpose of this study is to elucidate both the chemical and conformational structure of an unfractionated fucoidan extracted from brown seaweed Turbinaria ornata collected at Nha-trang bay, Vietnam. Electrospray ionization mass spectrometry (ESI-MS) was used for determining the chemical structure and small angle X...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11072431
更新日期：2013-07-12 00:00:00
abstract：:Mouse bioassay is the official testing method to quantify paralytic shellfish toxins (PSTs) in bivalves. A number of alternative analytical methods have been reported. Some methods have been evaluated by a single laboratory validation. Among the different types of methods, chemical analyses are capable of identifying ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9030466
更新日期：2011-03-22 00:00:00
