当前位置： SCI文献检索 > Marine Drugs期刊下所有文献 > Structure of fucoidan from brown seaweed Turbinaria ornata as studied by electrospray ionization mass spectrometry (ESIMS) and small angle X-ray scattering (SAXS) techniques.

Structure of fucoidan from brown seaweed Turbinaria ornata as studied by electrospray ionization mass spectrometry (ESIMS) and small angle X-ray scattering (SAXS) techniques.

Abstract：

:The purpose of this study is to elucidate both the chemical and conformational structure of an unfractionated fucoidan extracted from brown seaweed Turbinaria ornata collected at Nha-trang bay, Vietnam. Electrospray ionization mass spectrometry (ESI-MS) was used for determining the chemical structure and small angle X-ray scattering (SAXS) provided conformational of the structure at the molecular level. The results showed that the fucoidan has a sulfate content of 25.6% and is mainly composed of fucose and galactose residues (Fuc:Gal ≈ 3:1). ESIMS analysis suggested that the fucoidan has a backbone of 3-linked α-l-Fucp residues with branches, →4)-Galp(1→ at C-4 of the fucan chain. Sulfate groups are attached mostly at C-2 and sometimes at C-4 of both fucose and galactose residues. A molecular model of the fucoidan was built based on obtained chemical structure and scattering curves estimated from molecular model and observed SAXS measurement were fitted. The results indicated that fucoidan under study has a rod-like bulky chain conformation.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Thanh TT,Tran VT,Yuguchi Y,Bui LM,Nguyen TT

doi

10.3390/md11072431

subject

Has Abstract

pub_date

2013-07-12 00:00:00

pages

2431-43

issue

7

issn

1660-3397

pii

md11072431

journal_volume

11

pub_type

杂志文章

相关文献

Marine Drugs文献大全
  • Astaxanthin Promotes Nrf2/ARE Signaling to Inhibit HG-Induced Renal Fibrosis in GMCs.

    abstract：:Oxidative stress is the main cause of diabetic nephropathy (DN) progression. Nuclear factor-erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling is a crucial cellular defense system to cope with oxidative stress. Astaxanthin (AST) is a fat-soluble xanthophyll carotenoid with remarkable anti...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md16040117

    authors： Xie X,Chen Q,Tao J

    更新日期：2018-04-05 00:00:00

  • Marine myxobacteria as a source of antibiotics--comparison of physiology, polyketide-type genes and antibiotic production of three new isolates of Enhygromyxa salina.

    abstract：:Three myxobacterial strains, designated SWB004, SWB005 and SWB006, were obtained from beach sand samples from the Pacific Ocean and the North Sea. The strains were cultivated in salt water containing media and subjected to studies to determine their taxonomic status, the presence of genes for the biosynthesis of polyk...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md8092466

    authors： Schäberle TF,Goralski E,Neu E,Erol O,Hölzl G,Dörmann P,Bierbaum G,König GM

    更新日期：2010-09-03 00:00:00

  • Integrating Molecular Networking and 1H NMR Spectroscopy for Isolation of Bioactive Metabolites from the Persian Gulf Sponge Axinella sinoxea.

    abstract：:The geographic position, highly fluctuating sea temperatures and hypersalinity make Persian Gulf an extreme environment. Although this unique environment has high biodiversity dominated by invertebrates, its potential in marine biodiscovery has largely remained untapped. Herein, we aimed at a detailed analysis of the ...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md18070366

    authors： Mohsenian Kouchaksaraee R,Moridi Farimani M,Li F,Nazemi M,Tasdemir D

    更新日期：2020-07-16 00:00:00

  • Gliotoxin isolated from marine fungus Aspergillus sp. induces apoptosis of human cervical cancer and chondrosarcoma cells.

    abstract：:Gliotoxin, a secondary metabolite produced by marine fungus Aspergillus sp., possesses various biological activities including anticancer activity. However, the mechanism underlying gliotoxin-induced cytotoxicity on human cervical cancer (Hela) and human chondrosarcoma (SW1353) cells remains unclear. In this study, we...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md12010069

    authors： Nguyen VT,Lee JS,Qian ZJ,Li YX,Kim KN,Heo SJ,Jeon YJ,Park WS,Choi IW,Je JY,Jung WK

    更新日期：2013-12-24 00:00:00

  • Fucoidan and Fucosylated Chondroitin Sulfate Stimulate Hematopoiesis in Cyclophosphamide-Induced Mice.

    abstract：:Application of cytostatics in cancer patients' chemotherapy results in a number of side effects, including the inhibition of various parts of hematopoiesis. Two sulfated polysaccharides, fucoidan from the seaweed Chordaria flagelliformis (PS-Fuc) and fucosylated chondroitin sulfate from the sea cucumber Massinium magn...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md15100301

    authors： Anisimova N,Ustyuzhanina N,Bilan M,Donenko F,Usov A,Kiselevskiy M,Nifantiev N

    更新日期：2017-09-30 00:00:00

  • Production of New Antibacterial 4-Hydroxy-α-Pyrones by a Marine Fungus Aspergillus niger Cultivated in Solid Medium.

    abstract：:Four 4-hydroxy-α-pyrones including three new ones named nipyrones A-C (1-3) together with one known analogue germicidin C (4) were discovered from a marine sponge-derived fungus Aspergillus niger cultivated in a solid rice culture. Their structures and absolute configurations were elucidated through a combination of s...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md17060344

    authors： Ding L,Ren L,Li S,Song J,Han Z,He S,Xu S

    更新日期：2019-06-10 00:00:00

  • The Marine-Derived Fungus Clonostachys rosea, Source of a Rare Conjugated 4-Me-6E,8E-hexadecadienoic Acid Reducing Viability of MCF-7 Breast Cancer Cells and Gene Expression of Lipogenic Enzymes.

    abstract：:A marine-derived strain of Clonostachys rosea isolated from sediments of the river Loire estuary (France) was investigated for its high lipid production. The fungal strain was grown on six different culture media to explore lipid production changes. An original branched conjugated fatty acid, mainly present in triglyc...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md13084934

    authors： Dias AC,Ruiz N,Couzinet-Mossion A,Bertrand S,Duflos M,Pouchus YF,Barnathan G,Nazih H,Wielgosz-Collin G

    更新日期：2015-08-06 00:00:00

  • Pyrogallol-Phloroglucinol-6,6-Bieckol from Ecklonia cava Attenuates Tubular Epithelial Cell (TCMK-1) Death in Hypoxia/Reoxygenation Injury.

    abstract：:The hypoxia/reoxygenation (H/R) injury causes serious complications after the blood supply to the kidney is stopped during surgery. The main mechanism of I/R injury is the release of high-mobility group protein B1 (HMGB1) from injured tubular epithelial cells (TEC, TCMK-1 cell), which triggers TLR4 or RAGE signaling, ...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md17110602

    authors： Son M,Oh S,Choi CH,Park KY,Son KH,Byun K

    更新日期：2019-10-24 00:00:00

  • Anticancer Activity of Fascaplysin against Lung Cancer Cell and Small Cell Lung Cancer Circulating Tumor Cell Lines.

    abstract：:Lung cancer is a leading cause of tumor-associated mortality. Fascaplysin, a bis-indole of a marine sponge, exhibit broad anticancer activity as specific CDK4 inhibitor among several other mechanisms, and is investigated as a drug to overcome chemoresistance after the failure of targeted agents or immunotherapy. The c...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md16100383

    authors： Rath B,Hochmair M,Plangger A,Hamilton G

    更新日期：2018-10-14 00:00:00

  • Targets and effects of yessotoxin, okadaic acid and palytoxin: a differential review.

    abstract：:In this review, we focus on processes, organs and systems targeted by the marine toxins yessotoxin (YTX), okadaic acid (OA) and palytoxin (PTX). The effects of YTX and their basis are analyzed from data collected in the mollusc Mytilus galloprovincialis, the annelid Enchytraeus crypticus, Swiss CD1 mice and invertebra...

    journal_title：Marine drugs

    pub_type： 杂志文章,评审

    doi：10.3390/md8030658

    authors： Franchini A,Malagoli D,Ottaviani E

    更新日期：2010-03-16 00:00:00

  • Blood-Brain Barrier Permeable Chitosan Oligosaccharides Interfere with β-Amyloid Aggregation and Alleviate β-Amyloid Protein Mediated Neurotoxicity and Neuroinflammation in a Dose- and Degree of Polymerization-Dependent Manner.

    abstract：:It is proven that β-amyloid (Aβ) aggregates containing cross-β-sheet structures led to oxidative stress, neuroinflammation, and neuronal loss via multiple pathways. Therefore, reduction of Aβ neurotoxicity via inhibiting aggregation of Aβ or dissociating toxic Aβ aggregates into nontoxic forms might be effective thera...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md18100488

    authors： Zhu L,Li R,Jiao S,Wei J,Yan Y,Wang ZA,Li J,Du Y

    更新日期：2020-09-25 00:00:00

  • Ubiquitin-Proteasome Modulating Dolabellanes and Secosteroids from Soft Coral Clavularia flava.

    abstract：:We performed a high-content screening (HCS) assay aiming to discover bioactive molecules with proteasome inhibitory activity. By structural elucidation, we identified six compounds purified from soft coral Clavularia flava, which potentiates proteasome inhibition. Chemical structure elucidation revealed they are dolab...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md18010039

    authors： Chiu CY,Ling XH,Wang SK,Duh CY

    更新日期：2020-01-03 00:00:00

  • The Mediterranean red alga Asparagopsis: a source of compounds against Leishmania.

    abstract：:Crude extracts and column fractions from the red algae Asparagopsis taxiformis and A. armata from the Strait of Messina (Italy) were screened for the production of antimicrobial compounds. Extracts from both species revealed remarkable antiprotozoal activity against Leishmania, revealing such algae as a great source o...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md7030361

    authors： Genovese G,Tedone L,Hamann MT,Morabito M

    更新日期：2009-08-11 00:00:00

  • Comparative Analysis of Culture Conditions for the Optimization of Carotenoid Production in Several Strains of the Picoeukaryote Ostreococcus.

    abstract：:Microalgae are promising sources for the sustainable production of compounds of interest for biotechnologies. Compared to higher plants, microalgae have a faster growth rate and can be grown in industrial photobioreactors. The microalgae biomass contains specific metabolites of high added value for biotechnology such ...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md16030076

    authors： Guyon JB,Vergé V,Schatt P,Lozano JC,Liennard M,Bouget FY

    更新日期：2018-02-28 00:00:00

  • Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegans.

    abstract：:Two novel biscembranoids, sarelengans A and B (1 and 2), five new cembranoids, sarelengans C-G (3-7), along with two known cembranoids (8 and 9) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 wer...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md15040085

    authors： Li W,Zou YH,Ge MX,Lou LL,Xu YS,Ahmed A,Chen YY,Zhang JS,Tang GH,Yin S

    更新日期：2017-03-23 00:00:00

  • Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.

    abstract：:Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological...

    journal_title：Marine drugs

    pub_type： 杂志文章,评审

    doi：10.3390/md14010001

    authors： García-Vilas JA,Martínez-Poveda B,Quesada AR,Medina MÁ

    更新日期：2015-12-22 00:00:00

  • Theonellamide G, a potent antifungal and cytotoxic bicyclic glycopeptide from the Red Sea marine sponge Theonella swinhoei.

    abstract：:In our search for bioactive metabolites from marine organisms, we have investigated the polar fraction of the organic extract of the Red Sea sponge Theonella swinhoei. Successive chromatographic separations and final HPLC purification of the potent antifungal fraction afforded a new bicyclic glycopeptide, theonellamid...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md12041911

    authors： Youssef DT,Shaala LA,Mohamed GA,Badr JM,Bamanie FH,Ibrahim SR

    更新日期：2014-04-01 00:00:00

  • Physicochemical and Functional Properties of Type I Collagens in Red Stingray (Dasyatis akajei) Skin.

    abstract：:Collagen is widely used in the pharmaceutical, tissue engineering, nutraceutical, and cosmetic industries. In this study, acid-soluble collagen (ASC) and pepsin-soluble collagen (PSC) were extracted from the skin of red stingray, and its physicochemical and functional properties were investigated. The yields of ASC an...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md17100558

    authors： Chen J,Li J,Li Z,Yi R,Shi S,Wu K,Li Y,Wu S

    更新日期：2019-09-28 00:00:00

  • The antihyperlipidemic mechanism of high sulfate content ulvan in rats.

    abstract：:Numerous studies have suggested that hyperlipidemia is closely linked to cardiovascular disease. The aim of this study was to investigate the possible antihyperlipidemia mechanism of HU (high sulfate content of ulvan) in high-cholesterol fed rats. Wistar rats were made hyperlipidemic by feeding with a high-cholesterol...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md13063407

    authors： Qi H,Sheng J

    更新日期：2015-05-29 00:00:00

  • Plakinamine P, A Steroidal Alkaloid with Bactericidal Activity against Mycobacterium tuberculosis.

    abstract：:Tuberculosis is the leading cause of death due to infectious disease worldwide. There is an urgent need for more effective compounds against this pathogen to control the disease. Investigation of the anti-mycobacterial activity of a deep-water sponge of the genus Plakina revealed the presence of a new steroidal alkalo...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md17120707

    authors： Rodrigues Felix C,Roberts JC,Winder PL,Gupta R,Diaz MC,Pomponi SA,Wright AE,Rohde KH

    更新日期：2019-12-16 00:00:00

  • Structure Elucidation and in Vitro Toxicity of New Azaspiracids Isolated from the Marine Dinoflagellate Azadinium poporum.

    abstract：:Two strains of Azadinium poporum, one from the Korean West coast and the other from the North Sea, were mass cultured for isolation of new azaspiracids. Approximately 0.9 mg of pure AZA-36 (1) and 1.3 mg of pure AZA-37 (2) were isolated from the Korean (870 L) and North Sea (120 L) strains, respectively. The structure...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md13116687

    authors： Krock B,Tillmann U,Potvin É,Jeong HJ,Drebing W,Kilcoyne J,Al-Jorani A,Twiner MJ,Göthel Q,Köck M

    更新日期：2015-10-30 00:00:00

  • Clinical trial: marine lipid suppositories as laxatives.

    abstract：UNLABELLED:Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from ...

    journal_title：Marine drugs

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.3390/md10092047

    authors： Ormarsson OT,Geirsson T,Bjornsson ES,Jonsson T,Moller P,Loftsson T,Stefansson E

    更新日期：2012-09-01 00:00:00

  • Magnetotactic bacteria as potential sources of bioproducts.

    abstract：:Magnetotactic bacteria (MTB) produce intracellular organelles called magnetosomes which are magnetic nanoparticles composed of magnetite (Fe3O4) or greigite (Fe3S4) enveloped by a lipid bilayer. The synthesis of a magnetosome is through a genetically controlled process in which the bacterium has control over the compo...

    journal_title：Marine drugs

    pub_type： 杂志文章,评审

    doi：10.3390/md13010389

    authors： Araujo AC,Abreu F,Silva KT,Bazylinski DA,Lins U

    更新日期：2015-01-16 00:00:00

  • Identification of Novel Gymnodimines and Spirolides from the Marine Dinoflagellate Alexandrium ostenfeldii.

    abstract：:Cyclic imine toxins are neurotoxic, macrocyclic compounds produced by marine dinoflagellates. Mass spectrometric screenings of extracts from natural plankton assemblages revealed a high chemical diversity among this toxin class, yet only few toxins are structurally known. Here we report the structural characterization...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md16110446

    authors： Zurhelle C,Nieva J,Tillmann U,Harder T,Krock B,Tebben J

    更新日期：2018-11-14 00:00:00

  • Sarcophyolides B-E, new cembranoids from the soft coral Sarcophyton elegans.

    abstract：:Four new cembrane-type diterpenoids, sarcophyolides B-E (1-4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1-4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocraso...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md11093186

    authors： Xi Z,Bie W,Chen W,Liu D,van Ofwegen L,Proksch P,Lin W

    更新日期：2013-08-26 00:00:00

  • Spongionella secondary metabolites protect mitochondrial function in cortical neurons against oxidative stress.

    abstract：:The marine habitat provides a large number of structurally-diverse bioactive compounds for drug development. Marine sponges have been studied over many years and are found to be a rich source of these bioactive chemicals. This study is focused on the evaluation of the activity of six diterpene derivatives isolated fro...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md12020700

    authors： Leirós M,Sánchez JA,Alonso E,Rateb ME,Houssen WE,Ebel R,Jaspars M,Alfonso A,Botana LM

    更新日期：2014-01-27 00:00:00

  • Brown Algae Padina sanctae-crucis Børgesen: A Potential Nutraceutical.

    abstract：:Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and h...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md15100251

    authors： Nogueira RBSS,Tomaz ACA,Pessoa DR,Xavier AL,Pita JCLR,Sobral MV,Pontes MLC,Pessôa HLF,Diniz MFFM,Miranda GEC,Vieira MAR,Marques MOM,Souza MFV,Cunha EVL

    更新日期：2017-09-26 00:00:00

  • 5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34.

    abstract：:Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 1-4 were characterized using comprehens...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md15080260

    authors： Fang F,Zhao J,Ding L,Huang C,Naman CB,He S,Wu B,Zhu P,Luo Q,Gerwick WH,Yan X,Wang Q,Zhang Z,Cui W

    更新日期：2017-08-19 00:00:00

  • Natural product research in the Australian marine invertebrate Dicathais orbita.

    abstract：:The predatory marine gastropod Dicathais orbita has been the subject of a significant amount of biological and chemical research over the past five decades. Natural products research on D. orbita includes the isolation and identification of brominated indoles and choline esters as precursors of Tyrian purple, as well ...

    journal_title：Marine drugs

    pub_type： 杂志文章,评审

    doi：10.3390/md11041370

    authors： Benkendorff K

    更新日期：2013-04-23 00:00:00

  • Protective Effect of Pyrogallol-Phloroglucinol-6,6-Bieckol from Ecklonia cava on Monocyte-Associated Vascular Dysfunction.

    abstract：:Ecklonia cava (E. cava) can alleviate vascular dysfunction in diseases associated with poor circulation. E. cava contains various polyphenols with different functions, but few studies have compared the effects of these polyphenols. Here, we comparatively investigated four major compounds present in an ethanoic extract...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md16110441

    authors： Oh S,Son M,Lee HS,Kim HS,Jeon YJ,Byun K

    更新日期：2018-11-09 00:00:00