Clinical trial: marine lipid suppositories as laxatives.

Abstract:

UNLABELLED:Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from omega-3 fish oil. Our purpose was to evaluate the safety of marine lipid suppositories and ointment in healthy volunteers and to explore the laxative effect of the suppositories. Thirty healthy volunteers were randomized either to a study group administrating 30% FFA suppositories and applying 30% FFA ointment to the perianal region twice per day for two weeks, or to a control group using placebo suppositories and ointment in a double blinded manner. RESULTS:No serious toxic effects or irritation were observed. In the study group 93% felt the urge to defecate after administration of the suppositories as compared to 37% in the control group (P = 0.001). Subsequently 90% in the study group defecated, compared to 33% in the control group (P = 0.001). CONCLUSION:The marine lipid suppositories and ointment were well tolerated with no significant toxic side effects observed during the study period. The suppositories have a distinct laxative effect and we aim to explore this effect in further clinical trials.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Ormarsson OT,Geirsson T,Bjornsson ES,Jonsson T,Moller P,Loftsson T,Stefansson E

doi

10.3390/md10092047

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

2047-54

issue

9

issn

1660-3397

pii

marinedrugs-10-02047

journal_volume

10

pub_type

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