Abstract：
:In our search for bioactive metabolites from marine organisms, we have investigated the polar fraction of the organic extract of the Red Sea sponge Theonella swinhoei. Successive chromatographic separations and final HPLC purification of the potent antifungal fraction afforded a new bicyclic glycopeptide, theonellamide G. The structure of the peptide was determined using extensive 1D and 2D NMR and high-resolution mass spectral determinations. The absolute configuration of theonellamide G was determined by chemical degradation and 2D NMR spectroscopy. Theonellamide G showed potent antifungal activity towards wild and amphotericin B-resistant strains of Candida albicans with IC₅₀ of 4.49 and 2.0 μM, respectively. Additionally, it displayed cytotoxic activity against the human colon adenocarcinoma cell line (HCT-16) with IC₅₀ of 6.0 μM. These findings provide further insight into the chemical diversity and biological activities of this class of compounds.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Youssef DT,Shaala LA,Mohamed GA,Badr JM,Bamanie FH,Ibrahim SRdoi
10.3390/md12041911subject
Has Abstractpub_date
2014-04-01 00:00:00pages
1911-23issue
4issn
1660-3397pii
md12041911journal_volume
12pub_type
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