Abstract：
:The striking rise of methicillin-resistant Staphylococcus aureus (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant Myoporum bontioides A. Gray, which led to the isolation of two new sesquiterpene alkaloids (1 and 2) and six known furanosesquiterpenes (3⁻8). Their structures were elucidated on the basis of extensive analysis of their 1D, 2D NMR and mass spectroscopic data. These two new alkaloids (1 and 2) displayed potent anti-MRSA activity with MIC value of 6.25 μg/mL. This is the first report of sesquiterpene alkaloids from the plants of Myoporum genus and their anti-MRSA activity.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Dong LM,Huang LL,Dai H,Xu QL,Ouyang JK,Jia XC,Gu WX,Tan JWdoi
10.3390/md16110438subject
Has Abstractpub_date
2018-11-08 00:00:00issue
11issn
1660-3397pii
md16110438journal_volume
16pub_type
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