Abstract：
:Six new polyoxygenated cembrane-based diterpenoids, stellatumolides A⁻C (1⁻3), stellatumonins A and B (4 and 5), and stellatumonone (6), were isolated together with ten known related compounds (7⁻16) from the ethyl acetate (EtOAc) extract of soft coral Sarcophyton stellatum. The structures of the new compounds were established by extensive spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy and data comparison with related structures. Compounds 8 and 14 were isolated from a natural source for the first time. The isolated metabolites were shown to be not cytotoxic against a limited panel of cancer cells. Compound 9 showed anti-inflammatory activity by reducing the expression of proinflammatory cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) proteins in lipopolysaccharide (LPS)-stimulated mouse leukaemic monocyte macrophage (RAW 264.7) cells.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Ahmed AF,Chen YW,Huang CY,Tseng YJ,Lin CC,Dai CF,Wu YC,Sheu JHdoi
10.3390/md16060210subject
Has Abstractpub_date
2018-06-14 00:00:00issue
6issn
1660-3397pii
md16060210journal_volume
16pub_type
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