Bioactive cembrane-based diterpenoids from the soft coral Sinularia triangular.


:Chemical examination of the Taiwanese soft coral Sinularia triangular led to the isolation of five cembrane-based diterpenoids 1-5, including two new metabolites, triangulenes A (1) and B (2). The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly mass spectroscopy and 2D NMR ((1)H-(1)H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 3 and 5 exhibited moderate cytotoxicity to human tumor cell lines CCRF-CEM and DLD-1. Furthermore, 3-5 displayed significant in vitro anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Metabolites 4 and 5 also effectively reduced the expression of the COX-2 protein in the macrophages.


Mar Drugs


Marine drugs


Su JH,Wen ZH




Has Abstract


2011-01-01 00:00:00












  • Hyperoxia elevates adrenic acid peroxidation in marine fish and is associated with reproductive pheromone mediators.

    abstract::The development of oxidative stress in the marine ecosystem is a concurring concern in fish reproductive behavior. Marine fish being rich in polyunsaturated fatty acids (PUFA) are precursors of prostaglandin pheromone mediators but also vulnerable to lipid peroxidation. It is yet to be determined if hypoxia or hyperox...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Chung ML,Galano JM,Oger C,Durand T,Lee JC

    更新日期:2015-04-14 00:00:00

  • Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation.

    abstract::Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-β peptide oligomers, which promote excessive mitochondrial reactive oxygen species (mROS) production and induce a sustained increase in cytoplasmic Ca2...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: García F,Lobos P,Ponce A,Cataldo K,Meza D,Farías P,Estay C,Oyarzun-Ampuero F,Herrera-Molina R,Paula-Lima A,Ardiles ÁO,Hidalgo C,Adasme T,Muñoz P

    更新日期:2020-06-26 00:00:00

  • New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens.

    abstract::A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambi...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ebada SS,Müller WEG,Lin W,Proksch P

    更新日期:2019-02-06 00:00:00

  • Penicillinolide A: a new anti-inflammatory metabolite from the marine fungus Penicillium sp. SF-5292.

    abstract::In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lee DS,Ko W,Quang TH,Kim KS,Sohn JH,Jang JH,Ahn JS,Kim YC,Oh H

    更新日期:2013-11-12 00:00:00

  • Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.

    abstract::Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: García-Vilas JA,Martínez-Poveda B,Quesada AR,Medina MÁ

    更新日期:2015-12-22 00:00:00

  • Antiproliferative Activity of Glycosaminoglycan-Like Polysaccharides Derived from Marine Molluscs.

    abstract::Despite the increasing availability of new classes of cancer treatment, such as immune- and targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic drugs with improved pharmacological profiles that can also overcome drug resistant forms of cancer. In this study, we have identifi...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Aldairi AF,Ogundipe OD,Pye DA

    更新日期:2018-02-15 00:00:00

  • Potential Bioactive Compounds from Seaweed for Diabetes Management.

    abstract::Diabetes mellitus is a group of metabolic disorders of the endocrine system characterised by hyperglycaemia. Type II diabetes mellitus (T2DM) constitutes the majority of diabetes cases around the world and are due to unhealthy diet, sedentary lifestyle, as well as rise of obesity in the population, which warrants the ...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Sharifuddin Y,Chin YX,Lim PE,Phang SM

    更新日期:2015-08-21 00:00:00

  • Antiviral lead compounds from marine sponges.

    abstract::Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. They are usually produced by functional enzyme c...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Sagar S,Kaur M,Minneman KP

    更新日期:2010-10-11 00:00:00

  • Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review.

    abstract::Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increa...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Shah SAA,Akhter N,Auckloo BN,Khan I,Lu Y,Wang K,Wu B,Guo YW

    更新日期:2017-11-10 00:00:00

  • Marine-Inspired Bis-indoles Possessing Antiproliferative Activity against Breast Cancer; Design, Synthesis, and Biological Evaluation.

    abstract::Diverse indoles and bis-indoles extracted from marine sources have been identified as promising anticancer leads. Herein, we designed and synthesized novel bis-indole series 7a-f and 9a-h as Topsentin and Nortopsentin analogs. Our design is based on replacing the heterocyclic spacer in the natural leads by a more flex...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Eldehna WM,Hassan GS,Al-Rashood ST,Alkahtani HM,A Almehizia A,Al-Ansary GH

    更新日期:2020-04-02 00:00:00

  • Identification and characterization of an anti-fibrotic benzopyran compound isolated from mangrove-derived Streptomyces xiamenensis.

    abstract::An anti-fibrotic compound produced by Streptomycesn xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis. The compound, N-[[3,4-dihydro-3S-hydroxy-2S-methyl-2-(4'R-methyl-3'S-pentenyl)-2H-1-benzopyran-6-yl]carbonyl]-threonine (1), was isolated from crude extracts...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Xu MJ,Liu XJ,Zhao YL,Liu D,Xu ZH,Lang XM,Ao P,Lin WH,Yang SL,Zhang ZG,Xu J

    更新日期:2012-03-01 00:00:00

  • Bromopyrrole alkaloids as lead compounds against protozoan parasites.

    abstract::In the present study, 13 bromopyrrole alkaloids, including the oroidin analogs hymenidin (2), dispacamide B (3) and dispacamide D (4), stevensine (5) and spongiacidin B (6), their derivatives lacking the imidazole ring bromoaldisin (7), longamide B (8) and longamide A (9), the dimeric oroidin derivatives sceptrin (10)...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Scala F,Fattorusso E,Menna M,Taglialatela-Scafati O,Tierney M,Kaiser M,Tasdemir D

    更新日期:2010-07-14 00:00:00

  • Combination of trabectedin and gemcitabine for advanced soft tissue sarcomas: results of a phase I dose escalating trial of the German Interdisciplinary Sarcoma Group (GISG).

    abstract:BACKGROUND:Evaluation of the potential efficacy and safety of combination therapies for advanced soft tissue sarcomas (STS) has increased substantially after approval of trabectedin and pazopanib. Trabectedin's introduction in Europe in 2007 depended mainly on its activity in so-called L-sarcomas (liposarcoma and leiom...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Kasper B,Reichardt P,Pink D,Sommer M,Mathew M,Rauch G,Hohenberger P

    更新日期:2015-01-13 00:00:00

  • Inhibitory effect of N,N-didesmethylgrossularine-1 on inflammatory cytokine production in lipopolysaccharide-stimulated RAW 264.7 cells.

    abstract::N,N-Didesmethylgrossularine-1 (DDMG-1), a compound with a rare alpha-carboline structure, was isolated from an Indonesian ascidian Polycarpa aurata as responsible for the observed inhibitory activity against TNF-alpha production in lipopolysaccharide-stimulated murine macrophage-like RAW264.7 cells. DDMG-1 inhibited t...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Oda T,Lee JS,Sato Y,Kabe Y,Sakamoto S,Handa H,Mangindaan RE,Namikoshi M

    更新日期:2009-11-17 00:00:00

  • New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum Asbestinum.

    abstract::Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Gutiérrez M,Santamaría R,Gómez-Reyes JF,Guzmán HM,Ávila-Román J,Motilva V,Talero E

    更新日期:2020-01-27 00:00:00

  • Astaxanthin attenuates the apoptosis of retinal ganglion cells in db/db mice by inhibition of oxidative stress.

    abstract::Diabetic retinopathy is a common diabetic eye disease caused by changes in retinal ganglion cells (RGCs). It is an ocular manifestation of systemic disease, which affects up to 80% of all patients who have had diabetes for 10 years or more. The genetically diabetic db/db mouse, as a model of type-2 diabetes, shows dia...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Dong LY,Jin J,Lu G,Kang XL

    更新日期:2013-03-21 00:00:00

  • Azaspiracid shellfish poisoning: a review on the chemistry, ecology, and toxicology with an emphasis on human health impacts.

    abstract::Azaspiracids (AZA) are polyether marine toxins that accumulate in various shellfish species and have been associated with severe gastrointestinal human intoxications since 1995. This toxin class has since been reported from several countries, including Morocco and much of western Europe. A regulatory limit of 160 micr...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Twiner MJ,Rehmann N,Hess P,Doucette GJ

    更新日期:2008-05-07 00:00:00

  • Posidonia oceanica (L.) Delile Ethanolic Extract Modulates Cell Activities with Skin Health Applications.

    abstract::Seagrasses are high plants sharing adaptive metabolic features with both terrestrial plants and marine algae, resulting in a phytocomplex possibly endowed with interesting biological properties. The aim of this study is to evaluate the in vitro activities on skin cells of an ethanolic extract obtained from the leaves ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Cornara L,Pastorino G,Borghesi B,Salis A,Clericuzio M,Marchetti C,Damonte G,Burlando B

    更新日期:2018-01-10 00:00:00

  • 4-Acetoxydolastane diterpene from the Brazilian brown alga Canistrocarpus cervicornis as antileishmanial agent.

    abstract::Natural marine products have shown an interesting array of diverse and novel chemical structures with potent biological activities. Our study reports the antiproliferative assays of crude extracts, fraction and pure compound (4R,9S,14S)-4α-acetoxy-9β,14α-dihydroxydolast-1(15),7-diene (1) obtained from brown alga Canis...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Dos Santos AO,Britta EA,Bianco EM,Ueda-Nakamura T,Filho BP,Pereira RC,Nakamura CV

    更新日期:2011-01-01 00:00:00

  • The Inhibitory Effect of Protamine on Platelets is Attenuated by Heparin without Inducing Thrombocytopenia in Rodents.

    abstract::Protamine sulfate (PS) is a polycationic protein drug obtained from the sperm of fish, and is used to reverse the anticoagulant effect of unfractionated heparin (UFH). However, the interactions between PS, UFH, and platelets are still not clear. We measured the platelet numbers and collagen-induced aggregation, P-sele...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Miklosz J,Kalaska B,Kaminski K,Rusak M,Szczubialka K,Nowakowska M,Pawlak D,Mogielnicki A

    更新日期:2019-09-17 00:00:00

  • Comparative Analysis of Culture Conditions for the Optimization of Carotenoid Production in Several Strains of the Picoeukaryote Ostreococcus.

    abstract::Microalgae are promising sources for the sustainable production of compounds of interest for biotechnologies. Compared to higher plants, microalgae have a faster growth rate and can be grown in industrial photobioreactors. The microalgae biomass contains specific metabolites of high added value for biotechnology such ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Guyon JB,Vergé V,Schatt P,Lozano JC,Liennard M,Bouget FY

    更新日期:2018-02-28 00:00:00

  • Fucoxanthin-Containing Cream Prevents Epidermal Hyperplasia and UVB-Induced Skin Erythema in Mice.

    abstract::Microalgae represent a source of bio-active compounds such as carotenoids with potent anti-inflammatory and antioxidant properties. We aimed to investigate the effects of fucoxanthin (FX) in both in vitro and in vivo skin models. Firstly, its anti-inflammatory activity was evaluated in LPS-stimulated THP-1 macrophages...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Rodríguez-Luna A,Ávila-Román J,González-Rodríguez ML,Cózar MJ,Rabasco AM,Motilva V,Talero E

    更新日期:2018-10-10 00:00:00

  • Marine-Derived Anticancer Agents: Clinical Benefits, Innovative Mechanisms, and New Targets.

    abstract::The role of the marine environment in the development of anticancer drugs has been widely reviewed, particularly in recent years. However, the innovation in terms of clinical benefits has not been duly emphasized, although there are important breakthroughs associated with the use of marine-derived anticancer agents th...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Pereira RB,Evdokimov NM,Lefranc F,Valentão P,Kornienko A,Pereira DM,Andrade PB,Gomes NGM

    更新日期:2019-06-02 00:00:00

  • Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL).

    abstract::Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer ce...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Elmallah MI,Micheau O

    更新日期:2015-11-13 00:00:00

  • Targets and effects of yessotoxin, okadaic acid and palytoxin: a differential review.

    abstract::In this review, we focus on processes, organs and systems targeted by the marine toxins yessotoxin (YTX), okadaic acid (OA) and palytoxin (PTX). The effects of YTX and their basis are analyzed from data collected in the mollusc Mytilus galloprovincialis, the annelid Enchytraeus crypticus, Swiss CD1 mice and invertebra...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Franchini A,Malagoli D,Ottaviani E

    更新日期:2010-03-16 00:00:00

  • Mangrove Tirucallane- and Apotirucallane-Type Triterpenoids: Structure Diversity of the C-17 Side-Chain and Natural Agonists of Human Farnesoid/Pregnane⁻X⁻Receptor.

    abstract::Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A⁻E (1⁻5) and agallochols A⁻D (6⁻9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10), were isolated from the mangrove plants Xylocarpus granatum, Xylocarpus moluccensis, and...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Jiang ZP,Luan ZL,Liu RX,Zhang Q,Ma XC,Shen L,Wu J

    更新日期:2018-12-06 00:00:00

  • Structure of fucoidan from brown seaweed Turbinaria ornata as studied by electrospray ionization mass spectrometry (ESIMS) and small angle X-ray scattering (SAXS) techniques.

    abstract::The purpose of this study is to elucidate both the chemical and conformational structure of an unfractionated fucoidan extracted from brown seaweed Turbinaria ornata collected at Nha-trang bay, Vietnam. Electrospray ionization mass spectrometry (ESI-MS) was used for determining the chemical structure and small angle X...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Thanh TT,Tran VT,Yuguchi Y,Bui LM,Nguyen TT

    更新日期:2013-07-12 00:00:00

  • Sequence Analysis, Kinetic Constants, and Anion Inhibition Profile of the Nacrein-Like Protein (CgiNAP2X1) from the Pacific Oyster Magallana gigas (Ex-Crassostrea gigas).

    abstract::The carbonic anhydrase (CA, EC superfamily of metalloenzymes catalyzes the hydration of carbon dioxide to bicarbonate and protons. The catalytically active form of these enzymes incorporates a metal hydroxide derivative, the formation of which is the rate-determining step of catalytic reaction, being affected...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Perfetto R,Del Prete S,Vullo D,Sansone G,Barone CMA,Rossi M,Supuran CT,Capasso C

    更新日期:2017-08-28 00:00:00

  • Bioactive peptides and depsipeptides with anticancer potential: sources from marine animals.

    abstract::Biologically active compounds with different modes of action, such as, antiproliferative, antioxidant, antimicrotubule, have been isolated from marine sources, specifically algae and cyanobacteria. Recently research has been focused on peptides from marine animal sources, since they have been found as secondary metabo...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Suarez-Jimenez GM,Burgos-Hernandez A,Ezquerra-Brauer JM

    更新日期:2012-05-01 00:00:00

  • Indole diterpenoids and isocoumarin from the fungus, Aspergillus flavus, isolated from the prawn, Penaeus vannamei.

    abstract::Two new indole-diterpenoids (1 and 2) and a new isocoumarin (3), along with the known β-aflatrem (4), paspalinine (5), leporin B (6), α-cyclopiazonic acid (7), iso-α-cyclopiazonic acid (8), ditryptophenaline (9), aflatoxin B1 (10), 7-O-acetylkojic acid (11) and kojic acid (12), were isolated from the fermentation brot...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Sun K,Li Y,Guo L,Wang Y,Liu P,Zhu W

    更新日期:2014-06-30 00:00:00