Natural Products from Cyanobacteria: Focus on Beneficial Activities.


:Cyanobacteria are photosynthetic microorganisms that colonize diverse environments worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their adaptation capacities and the diversity of natural products that they synthesize, support cyanobacterial success in colonization of their respective ecological niches. Although cyanobacteria are well-known for their toxin production and their relative deleterious consequences, they also produce a large variety of molecules that exhibit beneficial properties with high potential in various fields (e.g., a synthetic analog of dolastatin 10 is used against Hodgkin's lymphoma). The present review focuses on the beneficial activities of cyanobacterial molecules described so far. Based on an analysis of 670 papers, it appears that more than 90 genera of cyanobacteria have been observed to produce compounds with potentially beneficial activities in which most of them belong to the orders Oscillatoriales, Nostocales, Chroococcales, and Synechococcales. The rest of the cyanobacterial orders (i.e., Pleurocapsales, Chroococcidiopsales, and Gloeobacterales) remain poorly explored in terms of their molecular diversity and relative bioactivity. The diverse cyanobacterial metabolites possessing beneficial bioactivities belong to 10 different chemical classes (alkaloids, depsipeptides, lipopeptides, macrolides/lactones, peptides, terpenes, polysaccharides, lipids, polyketides, and others) that exhibit 14 major kinds of bioactivity. However, no direct relationship between the chemical class and the respective bioactivity of these molecules has been demonstrated. We further selected and specifically described 47 molecule families according to their respective bioactivities and their potential uses in pharmacology, cosmetology, agriculture, or other specific fields of interest. With this up-to-date review, we attempt to present new perspectives for the rational discovery of novel cyanobacterial metabolites with beneficial bioactivity.


Mar Drugs


Marine drugs


Demay J,Bernard C,Reinhardt A,Marie B




Has Abstract


2019-05-30 00:00:00










  • Seasonal Changes in Mycosporine-Like Amino Acid Production Rate with Respect to Natural Phytoplankton Species Composition.

    abstract::After in situ incubation at the site for a year, phytoplanktons in surface water were exposed to natural light in temperate lakes (every month); thereafter, the net production rate of photoprotective compounds (mycosporine-like amino acids, MAAs) was calculated using (13)C labeled tracer. This is the first report desc...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ha SY,Lee Y,Kim MS,Kumar KS,Shin KH

    更新日期:2015-11-06 00:00:00

  • Aurantoside K, a new antifungal tetramic acid glycoside from a Fijian marine sponge of the genus Melophlus.

    abstract::A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (¹H NMR, ¹H-¹H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant acti...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Kumar R,Subramani R,Feussner KD,Aalbersberg W

    更新日期:2012-01-01 00:00:00

  • Phylogenetic identification of fungi isolated from the marine sponge Tethya aurantium and identification of their secondary metabolites.

    abstract::Fungi associated with the marine sponge Tethya aurantium were isolated and identified by morphological criteria and phylogenetic analyses based on internal transcribed spacer (ITS) regions. They were evaluated with regard to their secondary metabolite profiles. Among the 81 isolates which were characterized, members o...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wiese J,Ohlendorf B,Blümel M,Schmaljohann R,Imhoff JF

    更新日期:2011-01-01 00:00:00

  • Virescenosides From the Holothurian-Associated Fungus Acremonium Striatisporum Kmm 4401.

    abstract::Ten new diterpene glycosides virescenosides Z9-Z18 (1-10) together with three known analogues (11-13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassiu...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Zhuravleva OI,Antonov AS,Oleinikova GK,Khudyakova YV,Popov RS,Denisenko VA,Pislyagin EA,Chingizova EA,Afiyatullov SS

    更新日期:2019-10-29 00:00:00

  • Mannose-Specific Lectins from Marine Algae: Diverse Structural Scaffolds Associated to Common Virucidal and Anti-Cancer Properties.

    abstract::To date, a number of mannose-specific lectins have been isolated and characterized from seaweeds, especially from red algae. In fact, man-specific seaweed lectins consist of different structural scaffolds harboring a single or a few carbohydrate-binding sites which specifically recognize mannose-containing glycans. De...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Barre A,Simplicien M,Benoist H,Van Damme EJM,Rougé P

    更新日期:2019-07-26 00:00:00

  • Thalassospiramide G, a new γ-amino-acid-bearing peptide from the marine bacterium Thalassospira sp.

    abstract::In the chemical investigation of marine unicellular bacteria, a new peptide, thalassospiramide G (1), along with thalassospiramides A and D (2-3), was discovered from a large culture of Thalassospira sp. The structure of thalassospiramide G, bearing γ-amino acids, such as 4-amino-5-hydroxy-penta-2-enoic acid (AHPEA),...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Um S,Pyee Y,Kim EH,Lee SK,Shin J,Oh DC

    更新日期:2013-02-26 00:00:00

  • Plakofuranolactone as a Quorum Quenching Agent from the Indonesian Sponge Plakortis cf. lita.

    abstract::There is an urgent need for novel strategies to fight drug resistance and multi-drug resistance. As an alternative to the classic antibiotic therapy, attenuation of the bacteria virulence affecting their Quorum sensing (QS) system is a promising approach. Quorum sensing (QS) is a genetic regulation system that allows ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Costantino V,Della Sala G,Saurav K,Teta R,Bar-Shalom R,Mangoni A,Steindler L

    更新日期:2017-02-28 00:00:00

  • Characterization of a New Trioxilin and a Sulfoquinovosyl Diacylglycerol with Anti-Inflammatory Properties from the Dinoflagellate Oxyrrhis marina.

    abstract::Two new compounds-a trioxilin and a sulfoquinovosyl diacylglycerol (SQDG)-were isolated from the methanolic extract of the heterotrophic dinoflagellate Oxyrrhis marina cultivated by feeding on dried yeasts. The trioxilin was identified as (4Z,8E,13Z,16Z,19Z) -7(S),10(S),11(S)-trihydroxydocosapentaenoic acid (1), and t...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Yoon EY,Yang AR,Park J,Moon SJ,Jeong EJ,Rho JR

    更新日期:2017-02-27 00:00:00

  • Phytoene Accumulation in the Novel Microalga Chlorococcum sp. Using the Pigment Synthesis Inhibitor Fluridone.

    abstract::Carotenoids are lipophilic pigments found in plants and algae, as well as some bacteria, archaea, and fungi that serve two functions-(1) as light harvesting molecules-primary carotenoids, and (2) as antioxidants, acting against reactive oxygen species⁻secondary carotenoids. Because of their strong antioxidant properti...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Laje K,Seger M,Dungan B,Cooke P,Polle J,Holguin FO

    更新日期:2019-03-22 00:00:00

  • Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms.

    abstract::Fucoxanthin is a marine carotenoid exhibiting several health benefits. The anti-cancer effect of fucoxanthin and its deacetylated metabolite, fucoxanthinol, is well documented. In view of its potent anti-carcinogenic activity, the need to understand the underlying mechanisms has gained prominence. Towards achieving th...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Kumar SR,Hosokawa M,Miyashita K

    更新日期:2013-12-16 00:00:00

  • Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole.

    abstract::Mycothiazole, a polyketide metabolite isolated from the marine sponge Cacospongia mycofijiensis, is a potent inhibitor of metabolic activity and mitochondrial electron transport chain complex I in sensitive cells, but other cells are relatively insensitive to the drug. Sensitive cell lines (IC(50) 0.36-13.8 nM) includ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Meyer KJ,Singh AJ,Cameron A,Tan AS,Leahy DC,O'Sullivan D,Joshi P,La Flamme AC,Northcote PT,Berridge MV,Miller JH

    更新日期:2012-04-01 00:00:00

  • Astaxanthin from Shrimp Cephalothorax Stimulates the Immune Response by Enhancing IFN-γ, IL-10, and IL-2 Secretion in Splenocytes of Helicobacter Pylori-Infected Mice.

    abstract::Infection with Helicobacter pylori is a critical cause of gastrointestinal diseases. A crucial host response associated with H. pylori infection includes gastric inflammation, which is characterized by a sustained recruitment of T-helper (Th) cells to the site of infection and distinct patterns of cytokine production....

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Davinelli S,Melvang HM,Andersen LP,Scapagnini G,Nielsen ME

    更新日期:2019-06-26 00:00:00

  • Ascidian Toxins with Potential for Drug Development.

    abstract::Ascidians (tunicates) are invertebrate chordates, and prolific producers of a wide variety of biologically active secondary metabolites from cyclic peptides to aromatic alkaloids. Several of these compounds have properties which make them candidates for potential new drugs to treat diseases such as cancer. Many of the...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Watters DJ

    更新日期:2018-05-13 00:00:00

  • From Marine Venoms to Drugs: Efficiently Supported by a Combination of Transcriptomics and Proteomics.

    abstract::The potential of marine natural products to become new drugs is vast; however, research is still in its infancy. The chemical and biological diversity of marine toxins is immeasurable and as such an extraordinary resource for the discovery of new drugs. With the rapid development of next-generation sequencing (NGS) an...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Xie B,Huang Y,Baumann K,Fry BG,Shi Q

    更新日期:2017-03-30 00:00:00

  • Sequence Analysis, Kinetic Constants, and Anion Inhibition Profile of the Nacrein-Like Protein (CgiNAP2X1) from the Pacific Oyster Magallana gigas (Ex-Crassostrea gigas).

    abstract::The carbonic anhydrase (CA, EC superfamily of metalloenzymes catalyzes the hydration of carbon dioxide to bicarbonate and protons. The catalytically active form of these enzymes incorporates a metal hydroxide derivative, the formation of which is the rate-determining step of catalytic reaction, being affected...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Perfetto R,Del Prete S,Vullo D,Sansone G,Barone CMA,Rossi M,Supuran CT,Capasso C

    更新日期:2017-08-28 00:00:00

  • The Marine Fungi Rhodotorula sp. (Strain CNYC4007) as a Potential Feed Source for Fish Larvae Nutrition.

    abstract::Fish oil is used in the production of feed for cultured fish owing to its high polyunsaturated fatty acid content (PUFA). The over-exploitation of fisheries and events like "El Niño" are reducing the fish oil supply. Some marine microorganisms are considered potentially as alternative fatty acid sources. This study as...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Barra M,Llanos-Rivera A,Cruzat F,Pino-Maureira N,González-Saldía RR

    更新日期:2017-12-01 00:00:00

  • Preparation of calibration standards of N1-H paralytic shellfish toxin analogues by large-scale culture of cyanobacterium Anabaena circinalis (TA04).

    abstract::Mouse bioassay is the official testing method to quantify paralytic shellfish toxins (PSTs) in bivalves. A number of alternative analytical methods have been reported. Some methods have been evaluated by a single laboratory validation. Among the different types of methods, chemical analyses are capable of identifying ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Watanabe R,Suzuki T,Oshima Y

    更新日期:2011-03-22 00:00:00

  • Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells.

    abstract::The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula). Kalkitoxin exhibited N-methyl-D-aspartate (NMDA)-mediated neurotoxicity and acted as an inhibitory ligand for voltage-sensitive sodium channels in cultured rat cerebellar granule ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Morgan JB,Liu Y,Coothankandaswamy V,Mahdi F,Jekabsons MB,Gerwick WH,Valeriote FA,Zhou YD,Nagle DG

    更新日期:2015-03-20 00:00:00

  • Biotechnological Production of Docosahexaenoic Acid Using Aurantiochytrium limacinum: Carbon Sources Comparison And Growth Characterization.

    abstract::Aurantiochytrium limacinum, a marine heterotrophic protist/microalga has shown interesting yields of docosahexaenoic acid (DHA) when cultured with different carbon sources: glucose, pure and crude glycerol. A complete study in a lab-scale fermenter allowed for the characterization and comparison of the growth kinetic ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Abad S,Turon X

    更新日期:2015-12-05 00:00:00

  • Soft coral-derived lemnalol alleviates monosodium urate-induced gouty arthritis in rats by inhibiting leukocyte infiltration and iNOS, COX-2 and c-Fos protein expression.

    abstract::An acute gout attack manifests in the joint as dramatic inflammation. To date, the clinical use of medicinal agents has typically led to undesirable side effects. Numerous efforts have failed to create an effective and safe agent for the treatment of gout. Lemnalol-an extract from Formosan soft coral-has documented an...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lee HP,Huang SY,Lin YY,Wang HM,Jean YH,Wu SF,Duh CY,Wen ZH

    更新日期:2013-01-10 00:00:00

  • Hydrothermal Processing of Laminaria ochroleuca for the Production of Crude Extracts Used to Formulate Polymeric Nanoparticles.

    abstract::A green extraction process using only water was proposed for the simultaneous extraction of alginate and bioactive compounds from Laminaria ochroleuca. Operation was carried out during non-isothermal heating up to maximal temperatures over the range of 70 °C to 100 °C. Once separated, the alginate and the crude extrac...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Flórez-Fernández N,Álvarez-Viñas M,Guerreiro F,Torres MD,Grenha A,Domínguez H

    更新日期:2020-06-27 00:00:00

  • Effect of Methionine Oxidation and Substitution of α-Conotoxin TxID on α3β4 Nicotinic Acetylcholine Receptor.

    abstract::α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype. However, TxID is susceptible to modification due to it containing a methionine (Met) residue that easily forms m...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ren J,Li R,Ning J,Zhu X,Zhangsun D,Wu Y,Luo S

    更新日期:2018-06-20 00:00:00

  • Design, synthesis and evaluation of new marine alkaloid-derived pentacyclic structures with anti-tumoral potency.

    abstract::This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1-11 were evaluated for their in vitro cytotoxic activity...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Boucle S,Melin C,Clastre M,Guillard J

    更新日期:2015-01-19 00:00:00

  • Briarane diterpenoids isolated from gorgonian corals between 2011 and 2013.

    abstract::The structures, names, bioactivities and references of 138 briarane-type diterpenoids, including 87 new compounds, are summarized in this review. All the briarane-type compounds mentioned in this review article were obtained from gorgonian corals including the genus Briareum, Dichotella, Junceella and Verrucella. Some...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Sheu JH,Chen YH,Chen YH,Su YD,Chang YC,Su JH,Weng CF,Lee CH,Fang LS,Wang WH,Wen ZH,Wu YC,Sung PJ

    更新日期:2014-04-10 00:00:00

  • Spongionella secondary metabolites protect mitochondrial function in cortical neurons against oxidative stress.

    abstract::The marine habitat provides a large number of structurally-diverse bioactive compounds for drug development. Marine sponges have been studied over many years and are found to be a rich source of these bioactive chemicals. This study is focused on the evaluation of the activity of six diterpene derivatives isolated fro...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Leirós M,Sánchez JA,Alonso E,Rateb ME,Houssen WE,Ebel R,Jaspars M,Alfonso A,Botana LM

    更新日期:2014-01-27 00:00:00

  • Penicibrocazines A-E, five new sulfide diketopiperazines from the marine-derived endophytic fungus Penicillium brocae.

    abstract::Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A-E (1-5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of th...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Meng LH,Zhang P,Li XM,Wang BG

    更新日期:2015-01-07 00:00:00

  • Terrosamycins A and B, Bioactive Polyether Ionophores from Streptomyces sp. RKND004 from Prince Edward Island Sediment.

    abstract::Terrosamycins A (1) and B (2), two polycyclic polyether natural products, were purified from the fermentation broth of Streptomyces sp. RKND004 isolated from Prince Edward Island sediment. The one strain-many compounds (OSMAC) approach coupled with UPLC-HRMS-based metabolomics screening led to the identification of th...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Sproule A,Correa H,Decken A,Haltli B,Berrué F,Overy DP,Kerr RG

    更新日期:2019-06-11 00:00:00

  • Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine.

    abstract::Three major forms of the nicotinic agonist toxin anabaseine (cyclic iminium, cyclic imine and the monocationic open-chain ammonium-ketone) co-exist in almost equal concentrations at physiological pH. We asked the question: Which of these forms is pharmacologically active? First, we investigated the pH dependence of an...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Andrud K,Xing H,Gabrielsen B,Bloom L,Mahnir V,Lee S,Green BT,Lindstrom J,Kem W

    更新日期:2019-10-29 00:00:00

  • 7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.

    abstract::The 7-Acetylsinumaximol B (7-AB), a bioactive cembranoid, was originally discovered from aquaculture soft coral Sinularia sandensis. The current study investigated the anti-proliferative property of 7-AB towards the NCI-N87 human gastric cancer cell line. An MTT cell proliferative assay was applied to evaluate cell su...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Tsai TC,Lai KH,Su JH,Wu YJ,Sheu JH

    更新日期:2018-03-26 00:00:00

  • Cereus sinensis Polysaccharide and Its Immunomodulatory Properties in Human Monocytic Cells.

    abstract::In this study, the extraction conditions of the crude polysaccharide from Cereus sinensis were optimized by response surface methodology. The optimum extraction conditions were: a ratio of raw material to water volume of 1:80 (g/mL); an extraction temperature of 72 °C; and an extraction time of 3 h. Then, a purified p...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wu J,Zhou X,Zhang M,Yao Y,Han J,Liu K

    更新日期:2017-05-18 00:00:00