Bioprospecting Red Sea Coastal Ecosystems for Culturable Microorganisms and Their Antimicrobial Potential.

abstract：:Early acute kidney injury (AKI) is a devastating complication in critical burn patients, and it is associated with severe morbidity and mortality. The mechanism of AKI is multifactorial. Astaxanthin (ATX) is a natural compound that is widely distributed in marine organisms; it is a strong antioxidant and exhibits othe...

journal_title：Marine drugs

authors： Guo SX,Zhou HL,Huang CL,You CG,Fang Q,Wu P,Wang XG,Han CM

更新日期：2015-04-13 00:00:00

abstract：:In 2011, a Diarrhetic Shellfish Poisoning (DSP) outbreak occurred in British Columbia (BC), Canada that was associated with cooked mussel consumption. This is the first reported DSP outbreak in BC. Investigation of ill individuals, traceback of product and laboratory testing for toxins were used in this investigation....

journal_title：Marine drugs

authors： Taylor M,McIntyre L,Ritson M,Stone J,Bronson R,Bitzikos O,Rourke W,Galanis E,Outbreak Investigation Team.

更新日期：2013-05-21 00:00:00

abstract：:Chlorophenols (CPs) are environmental pollutants that are produced through various anthropogenic activities and introduced in the environment. Living organisms, including humans, are exposed to these toxic xenobiotics and suffer from adverse health effects. More specifically, 2,4-dichlorophenol (2,4-DCP) is released i...

journal_title：Marine drugs

authors： Nikolaivits E,Agrafiotis A,Termentzi A,Machera K,Le Goff G,Álvarez P,Chavanich S,Benayahu Y,Ouazzani J,Fokialakis N,Topakas E

更新日期：2019-09-30 00:00:00

abstract：:A chemical study of the ethyl acetate (EtOAc) extract from the deep-sea-derived fungus Penicilliumthomii YPGA3 led to the isolation of a new austalide meroterpenoid (1) and seven known analogues (28), two new labdane-type diterpenoids (9 and 10) and a known derivative (11). The structures of new compounds 1, 9, and 10...

journal_title：Marine drugs

authors： Cheng Z,Liu W,Fan R,Han S,Li Y,Cui X,Zhang J,Wu Y,Lv X,Zhang Y,Luo Z,Alias SA,Xu W,Li Q

更新日期：2020-03-16 00:00:00

abstract：:Tisochrysis lutea is a marine haptophyte rich in omega-3 polyunsaturated fatty acids (e.g., docosahexaenoic acid (DHA)) and carotenoids (e.g., fucoxanthin). Because of the nutraceutical applications of these compounds, this microalga is being used in aquaculture to feed oyster and shrimp larvae. In our earlier report,...

journal_title：Marine drugs

authors： Gangadhar KN,Rodrigues MJ,Pereira H,Gaspar H,Malcata FX,Barreira L,Varela J

更新日期：2020-11-19 00:00:00

abstract：:Numerous studies have suggested that hyperlipidemia is closely linked to cardiovascular disease. The aim of this study was to investigate the possible antihyperlipidemia mechanism of HU (high sulfate content of ulvan) in high-cholesterol fed rats. Wistar rats were made hyperlipidemic by feeding with a high-cholesterol...

journal_title：Marine drugs

authors： Qi H,Sheng J

更新日期：2015-05-29 00:00:00

abstract：:Ten new di-, tri- and tetrasulfated triterpene glycosides, psolusosides B1 (1), B2 (2), J (3), K (4), L (5), M (6), N (7), O (8), P (9), and Q (10), were isolated from the sea cucumber Psolus fabricii collected in the Sea of Okhotsk near the Kurile Islands. Structures of these glycosides were established by two-dimens...

journal_title：Marine drugs

authors： Silchenko AS,Kalinovsky AI,Avilov SA,Kalinin VI,Andrijaschenko PV,Dmitrenok PS,Popov RS,Chingizova EA

更新日期：2019-11-06 00:00:00

abstract：:PT-peptide is derived from the anti-lipopolysaccharide factor of the swimming crab Portunus trituberculatus. The peptide, consisting of 34 amino acids, contains a lipopolysaccharide binding domain. In this study, we investigated the effect of PT-peptide encapsulated in raw milk-derived extracellular vesicles (EVs), de...

journal_title：Marine drugs

authors： Lee BH,Chen BR,Huang CT,Lin CH

更新日期：2019-04-26 00:00:00

abstract：:The effect of carrageenans on tomato chlorotic dwarf viroid (TCDVd) replication and symptom expression was studied. Three-week-old tomato plants were spray-treated with iota(ɩ)-, lambda(λ)-, and kappa(κ)-carrageenan at 1 g·L-1 and inoculated with TCDVd after 48 h. The λ-carrageenan significantly suppressed viroid symp...

journal_title：Marine drugs

authors： Sangha JS,Kandasamy S,Khan W,Bahia NS,Singh RP,Critchley AT,Prithiviraj B

更新日期：2015-05-08 00:00:00

abstract：:A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and catalytic properties. Homology models of the three-dimensional α-PsGal structure, ...

journal_title：Marine drugs

authors： Bakunina I,Slepchenko L,Anastyuk S,Isakov V,Likhatskaya G,Kim N,Tekutyeva L,Son O,Balabanova L

更新日期：2018-09-24 00:00:00

abstract：:Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels. Recently we reported a high-throughput method to identify 215 conotoxin transcripts from the Chinese tubular cone snail, C. betulinus. Here, based ...

journal_title：Marine drugs

authors： Huang Y,Peng C,Yi Y,Gao B,Shi Q

更新日期：2017-07-18 00:00:00

abstract：:Seaweed is a rich source of bioactive sulfated polysaccharides. We obtained six sulfated polysaccharide-rich fractions (UF-0.3, UF-0.5, UF-0.6, UF-0.7, UF-1.0, and UF-2.0) from the green seaweed Udotea flabellum (UF) by proteolytic digestion followed by sequential acetone precipitation. Biochemical analysis of these f...

journal_title：Marine drugs

authors： Presa FB,Marques MLM,Viana RLS,Nobre LTDB,Costa LS,Rocha HAO

更新日期：2018-04-20 00:00:00

abstract：:A novel, cold-adapted, and acid-base stable manganese superoxide dismutase (Ps-Mn-SOD) was cloned from hadal sea cucumber Paelopatides sp. The dimeric recombinant enzyme exhibited approximately 60 kDa in molecular weight, expressed activity from 0 °C to 70 °C with an optimal temperature of 0 °C, and resisted wide pH v...

journal_title：Marine drugs

authors： Li Y,Kong X,Zhang H

更新日期：2019-02-01 00:00:00

abstract：:Pseudomonas aeruginosa biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one of the main components of its biofilm. Targeting this major biof...

journal_title：Marine drugs

authors： Daboor SM,Raudonis R,Cohen A,Rohde JR,Cheng Z

更新日期：2019-05-24 00:00:00

abstract：:Chemical interactions play a fundamental role in the ecology of marine foodwebs. Dimethyl sulfide (DMS) is a ubiquitous marine trace gas that acts as a bioactive compound by eliciting foraging behavior in a range of marine taxa including the copepod Temora longicornis. Production of DMS can rapidly increase following ...

journal_title：Marine drugs

authors： Breckels MN,Bode NW,Codling EA,Steinke M

更新日期：2013-07-15 00:00:00

abstract：:Fucosterol from edible brown seaweeds has various biological activities, including anti-inflammatory, anti-adipogenic, antiphotoaging, anti-acetylcholinesterase, and anti-beta-secretase 1 activities. However, little is known about its effects on soluble amyloid beta peptide (sAβ)-induced endoplasmic reticulum (ER) str...

journal_title：Marine drugs

authors： Oh JH,Choi JS,Nam TJ

更新日期：2018-10-05 00:00:00

abstract：:Peridinin and fucoxanthin, which are natural carotenoids isolated from a symbiotic dinoflagellate, Symbiodinium sp., and a brown alga, Petalonia fascia, respectively, were compared for inhibitory effects on delayed-type hypersensitivity in mice. The number of eosinophils at the site of inflammation and in peripheral b...

journal_title：Marine drugs

authors： Onodera K,Konishi Y,Taguchi T,Kiyoto S,Tominaga A

更新日期：2014-03-27 00:00:00

abstract：:Cold-adapted enzymes produced by psychrophilic organisms have elevated catalytic activities at low temperatures compared to their mesophilic counterparts. This is largely due to amino acids changes in the protein sequence that often confer increased molecular flexibility in the cold. Comparison of structural changes b...

journal_title：Marine drugs

authors： Yang G,Mozzicafreddo M,Ballarini P,Pucciarelli S,Miceli C

更新日期：2021-01-27 00:00:00

abstract：:The marine alga, Symphyocladia latiuscula (Harvey) Yamada, is a good source of bromophenols with numerous biological activities. This study aims to characterize the anti-diabetic potential of 2,3,6-tribromo-4,5-dihydroxybenzyl derivatives isolated from S. latiuscula via their inhibition of tyrosine phosphatase 1B (PTP...

journal_title：Marine drugs

authors： Paudel P,Seong SH,Park HJ,Jung HA,Choi JS

更新日期：2019-03-14 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is a disease closely associated with obesity and diabetes. A prevalence of type 2 diabetes and a high body mass index in cryptogenic cirrhosis may imply that obesity leads to cirrhosis. Here, we examined the effects of an extract of Ecklonia cava, a brown algae, on the activation of...

journal_title：Marine drugs

authors： Yokogawa K,Matsui-Yuasa I,Tamura A,Terada M,Kojima-Yuasa A

更新日期：2011-12-01 00:00:00

abstract：:Protamine sulfate (PS) is a polycationic protein drug obtained from the sperm of fish, and is used to reverse the anticoagulant effect of unfractionated heparin (UFH). However, the interactions between PS, UFH, and platelets are still not clear. We measured the platelet numbers and collagen-induced aggregation, P-sele...

journal_title：Marine drugs

authors： Miklosz J,Kalaska B,Kaminski K,Rusak M,Szczubialka K,Nowakowska M,Pawlak D,Mogielnicki A

更新日期：2019-09-17 00:00:00

abstract：:To date, a number of mannose-specific lectins have been isolated and characterized from seaweeds, especially from red algae. In fact, man-specific seaweed lectins consist of different structural scaffolds harboring a single or a few carbohydrate-binding sites which specifically recognize mannose-containing glycans. De...

journal_title：Marine drugs

authors： Barre A,Simplicien M,Benoist H,Van Damme EJM,Rougé P

更新日期：2019-07-26 00:00:00

abstract：:The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter str...

journal_title：Marine drugs

authors： Schulz S,Dickschat JS,Kunze B,Wagner-Dobler I,Diestel R,Sasse F

更新日期：2010-12-22 00:00:00

abstract：:A member of the marine streptomycete clade MAR4, Streptomyces sp. CNQ-509, has genetic potential for the biosynthesis of hybrid isoprenoids and produces several meroterpenoids such as naphterpin, nitropyrrolin and marinophenazine. Our research on the strain CNQ-509 led to the isolation of two new naphterpin derivative...

journal_title：Marine drugs

authors： Park JS,Kwon HC

更新日期：2018-03-12 00:00:00

abstract：:The mucus produced by many marine organisms is a complex mixture of proteins and polysaccharides forming a weak watery gel. It is essential for vital processes including locomotion, navigation, structural support, heterotrophic feeding and defence against a multitude of environmental stresses, predators, parasites, an...

journal_title：Marine drugs

authors： Stabili L,Schirosi R,Parisi MG,Piraino S,Cammarata M

更新日期：2015-08-19 00:00:00

abstract：:The search for new biological sources of commercial value is a major goal for the sustainable management of natural resources. The huge amount of fishery by-catch or processing by-products continuously produced needs to be managed to avoid environmental problems and keep resource sustainability. Fishery by-products ca...

journal_title：Marine drugs

authors： Caruso G,Floris R,Serangeli C,Di Paola L

更新日期：2020-12-07 00:00:00

abstract：:The marine environment is known as a rich source of chemical structures with numerous beneficial health effects. Among marine organisms, marine algae have been identified as an under-exploited plant resource, although they have long been recognized as valuable sources of structurally diverse bioactive compounds. Prese...

journal_title：Marine drugs

authors： Pangestuti R,Kim SK

更新日期：2011-01-01 00:00:00

abstract：:For a long time, fucoidan has been well known for its pharmacological activities, and recently low molecular weight fucoidan (LMF) has been used in food supplements and pharmaceutical products. In the present study, LMF was extracted from Laminaria japonica by enzyme hydrolysis. The toxicity of LMF in mouse and rat mo...

journal_title：Marine drugs

authors： Hwang PA,Yan MD,Lin HT,Li KL,Lin YC

更新日期：2016-06-24 00:00:00

abstract：:Astaxanthin captured peroxynitrite to form nitroastaxanthins. 15-Nitroastaxanthin was a major reaction product of astaxanthin with peroxynitrite. Here, the anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of 15-nitroastaxanthin were investigated. In addition to astaxanthin, 15-nitroastaxanthin s...

journal_title：Marine drugs

authors： Maoka T,Tokuda H,Suzuki N,Kato H,Etoh H

更新日期：2012-06-01 00:00:00

abstract：:The nutritional and pharmaceutical values of long-chain polyunsaturated fatty acids (LC-PUFAs) such as arachidonic, eicosapentaenoic and docosahexaenoic acids have been well recognized. These LC-PUFAs are physiologically important compounds in bacteria and eukaryotes. Although little is known about the biosynthetic me...

journal_title：Marine drugs

authors： Yoshida K,Hashimoto M,Hori R,Adachi T,Okuyama H,Orikasa Y,Nagamine T,Shimizu S,Ueno A,Morita N

更新日期：2016-05-12 00:00:00