Fucosterol from an Edible Brown Alga Ecklonia stolonifera Prevents Soluble Amyloid Beta-Induced Cognitive Dysfunction in Aging Rats.

abstract：:The present study is focused on the intestinal absorption of sea cucumber saponins. We determined the pharmacokinetic characteristics and bioavailability of Echinoside A and Holotoxin A₁; the findings indicated that the bioavailability of Holotoxin A₁ was lower than Echinoside A. We inferred that the differences in ch...

journal_title：Marine drugs

authors： Li S,Wang Y,Jiang T,Wang H,Yang S,Lv Z

更新日期：2016-06-17 00:00:00

abstract：:Marine cyanobacteria, notably those from tropical regions, are a rich source of bioactive secondary metabolites. Tropical marine cyanobacteria often grow to high densities in the environment, allowing direct isolation of many secondary metabolites from field-collected material. However, in temperate environments cultu...

journal_title：Marine drugs

authors： Leão PN,Ramos V,Gonçalves PB,Viana F,Lage OM,Gerwick WH,Vasconcelos VM

更新日期：2013-04-22 00:00:00

abstract：:The skin, the largest organ in humans, is exposed to major sources of outdoor air pollution, such as fine particulate matter with a diameter ≤ 2.5 µm (PM2.5). Diphlorethohydroxycarmalol (DPHC), a marine-based compound, possesses multiple activities including antioxidant effects. In the present study, we evaluated the ...

journal_title：Marine drugs

authors： Zhen AX,Piao MJ,Hyun YJ,Kang KA,Madushan Fernando PDS,Cho SJ,Ahn MJ,Hyun JW

更新日期：2019-02-01 00:00:00

abstract：:An alginate lyase-producing bacterial strain, Pseudoalteromonas sp. SM0524, was screened from marine rotten kelp. In an optimized condition, the production of alginate lyase from Pseudoalteromonas sp. SM0524 reached 62.6 U/mL, suggesting that strain SM0524 is a good producer of alginate lyases. The bifunctional algina...

journal_title：Marine drugs

authors： Li JW,Dong S,Song J,Li CB,Chen XL,Xie BB,Zhang YZ

更新日期：2011-01-21 00:00:00

abstract：:Red algae of the genus Plocamium have been a rich source of halogenated monoterpenes. Herein, a new cyclic monoterpene, costatone C (7), was isolated from the extract of P. angustum collected in New Zealand, along with the previously reported (1E,5Z)-1,6-dichloro-2-methylhepta-1,5-dien-3-ol (8). Elucidation of the pla...

journal_title：Marine drugs

authors： Bracegirdle J,Sohail Z,Fairhurst MJ,Gerth ML,Zuccarello GC,Ali Hashmi M,Keyzers RA

更新日期：2019-07-19 00:00:00

abstract：:Impaired wound healing is a major clinical problem in patients with diabetes and is the leading cause of lower limb amputation. This study is aimed to observe the effects of small molecule oligopeptides isolated from sea cucumber (SCCOPs) on the wound healing process in diabetic mice. Ninety db/db male mice were divid...

journal_title：Marine drugs

authors： Li D,Li L,Xu T,Wang T,Ren J,Liu X,Li Y

更新日期：2018-01-08 00:00:00

abstract：:Water extracts and polysaccharides from Anabaena sp., Ecklonia sp., and Jania sp. were tested for their activity against the fungal plant pathogen Botrytis cinerea. Water extracts at 2.5, 5.0, and 10.0 mg/mL inhibited B. cinerea growth in vitro. Antifungal activity of polysaccharides obtained by N-cetylpyridinium brom...

journal_title：Marine drugs

authors： Righini H,Baraldi E,García Fernández Y,Martel Quintana A,Roberti R

更新日期：2019-05-20 00:00:00

abstract：:Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus w...

journal_title：Marine drugs

authors： Zhang W,Sun T,Ma Z,Li Y

更新日期：2014-04-22 00:00:00

abstract：:Nosocomial infections and increasing multi-drug resistance caused by Acinetobacter baumannii have been recognized as emerging problems worldwide. Moreover, A. baumannii is able to colonize various abiotic materials and medical devices, making it difficult to eradicate and leading to ventilator-associated pneumonia, an...

journal_title：Marine drugs

authors： Tseng SP,Hung WC,Huang CY,Lin YS,Chan MY,Lu PL,Lin L,Sheu JH

更新日期：2016-07-29 00:00:00

abstract：:Gliotoxin, a secondary metabolite produced by marine fungus Aspergillus sp., possesses various biological activities including anticancer activity. However, the mechanism underlying gliotoxin-induced cytotoxicity on human cervical cancer (Hela) and human chondrosarcoma (SW1353) cells remains unclear. In this study, we...

journal_title：Marine drugs

authors： Nguyen VT,Lee JS,Qian ZJ,Li YX,Kim KN,Heo SJ,Jeon YJ,Park WS,Choi IW,Je JY,Jung WK

更新日期：2013-12-24 00:00:00

abstract：:Using theonellasterol as a novel FXR antagonist hit, we prepared a series of semi-synthetic derivatives in order to gain insight into the structural requirements for exhibiting antagonistic activity. These derivatives are characterized by modification at the exocyclic carbon-carbon double bond at C-4 and at the hydrox...

journal_title：Marine drugs

authors： Sepe V,Ummarino R,D'Auria MV,Taglialatela-Scafati O,Marino SD,D'Amore C,Renga B,Chini MG,Bifulco G,Nakao Y,Fusetani N,Fiorucci S,Zampella A

更新日期：2012-11-05 00:00:00

abstract：:In the current study, hemostatic compositions including a combination of chitosan and kaolin have been developed. Chitosan is a marine polysaccharide derived from chitins, a structural component in the shells of crustaceans. Both chitosan and kaolin have the ability to mediate a quick and efficient hemostatic effect f...

journal_title：Marine drugs

authors： Elsabahy M,Hamad MA

更新日期：2021-01-22 00:00:00

abstract：:Six regioisomers associated with the tricyclic core of thiaplakortones A-D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic core scaffolds presen...

journal_title：Marine drugs

authors： Schwartz BD,Coster MJ,Skinner-Adams TS,Andrews KT,White JM,Davis RA

更新日期：2015-09-15 00:00:00

abstract：:The role of the marine environment in the development of anticancer drugs has been widely reviewed, particularly in recent years. However, the innovation in terms of clinical benefits has not been duly emphasized, although there are important breakthroughs associated with the use of marine-derived anticancer agents th...

journal_title：Marine drugs

authors： Pereira RB,Evdokimov NM,Lefranc F,Valentão P,Kornienko A,Pereira DM,Andrade PB,Gomes NGM

更新日期：2019-06-02 00:00:00

abstract：:Fucoxanthin is a marine carotenoid exhibiting several health benefits. The anti-cancer effect of fucoxanthin and its deacetylated metabolite, fucoxanthinol, is well documented. In view of its potent anti-carcinogenic activity, the need to understand the underlying mechanisms has gained prominence. Towards achieving th...

journal_title：Marine drugs

authors： Kumar SR,Hosokawa M,Miyashita K

更新日期：2013-12-16 00:00:00

abstract：:A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to dis...

journal_title：Marine drugs

authors： Lee CH,Kao CY,Kao SY,Chang CH,Su JH,Hwang TL,Kuo YH,Wen ZH,Sung PJ

更新日期：2012-02-01 00:00:00

abstract：:Here we summarize the current knowledge on the transfer and accumulation of harmful algal bloom (HAB)-related toxins in cephalopods (octopods, cuttlefishes and squids). These mollusks have been reported to accumulate several HAB-toxins, namely domoic acid (DA, and its isomers), saxitoxin (and its derivatives) and paly...

journal_title：Marine drugs

authors： Lopes VM,Lopes AR,Costa P,Rosa R

更新日期：2013-09-06 00:00:00

abstract：:Lipid A is a fundamental Gram-negative outer membrane component and the essential element of lipopolysaccharide (endotoxin), a potent immunostimulatory molecule. This work describes the metabolic adaptation of the lipid A acyl structure by Psychrobacter cryohalolentis at various temperatures in its facultative psychro...

journal_title：Marine drugs

authors： Sweet CR,Watson RE,Landis CA,Smith JP

更新日期：2015-07-30 00:00:00

abstract：:Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing infarct size and reinforcing antioxidant defenses. The aim of this work was to determine the combin...

journal_title：Marine drugs

authors： Herrera EA,Farías JG,González-Candia A,Short SE,Carrasco-Pozo C,Castillo RL

更新日期：2015-02-04 00:00:00

abstract：:The potential anti-tumor agent wentilactones were produced by a newly isolated marine fungus Aspergillus dimorphicus. This fungus was derived from deep-sea sediment and identified by polyphasic approach, combining phenotypic, molecular, and extrolite profiles. However, wentilactone production was detected only under s...

journal_title：Marine drugs

authors： Xu R,Xu GM,Li XM,Li CS,Wang BG

更新日期：2015-11-19 00:00:00

abstract：:Domoic acid is a marine biotoxin associated with harmful algal blooms and is the causative agent of amnesic shellfish poisoning in marine animals and humans. It is also an excitatory amino acid analog to glutamate and kainic acid which acts through glutamate receptors eliciting a very rapid and potent neurotoxic respo...

journal_title：Marine drugs

authors： Gill SS,Hou Y,Ghane T,Pulido OM

更新日期：2008-02-14 00:00:00

abstract：:Six new bis(indole) alkaloids (1-6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A-D (1-4) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the...

journal_title：Marine drugs

authors： Park JS,Cho E,Hwang JY,Park SC,Chung B,Kwon OS,Sim CJ,Oh DC,Oh KB,Shin J

更新日期：2020-12-23 00:00:00

abstract：:Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus Penicillium griseofulvum. The structure of viridicatol was unambiguously established by X-ray diffraction analysis. In this study, a mouse model of ovalbumin-induced food allergy and the rat basophil leukemia (RBL)-2H3 cell model were establ...

journal_title：Marine drugs

authors： Shu Z,Liu Q,Xing C,Zhang Y,Zhou Y,Zhang J,Liu H,Cao M,Yang X,Liu G

更新日期：2020-10-16 00:00:00

abstract：:Tetracenomycin X (Tcm X) has been reported to have antitumour activity in various cancers, but there have not been any studies on its activity with respect to lung cancer to date. Therefore, this study aims to investigate the anti-lung cancer activity of Tcm X. In this study, we found that tetracenomycin X showed anti...

journal_title：Marine drugs

authors： Qiao X,Gan M,Wang C,Liu B,Shang Y,Li Y,Chen S

更新日期：2019-01-18 00:00:00

abstract：:The effect of carrageenans on tomato chlorotic dwarf viroid (TCDVd) replication and symptom expression was studied. Three-week-old tomato plants were spray-treated with iota(ɩ)-, lambda(λ)-, and kappa(κ)-carrageenan at 1 g·L-1 and inoculated with TCDVd after 48 h. The λ-carrageenan significantly suppressed viroid symp...

journal_title：Marine drugs

authors： Sangha JS,Kandasamy S,Khan W,Bahia NS,Singh RP,Critchley AT,Prithiviraj B

更新日期：2015-05-08 00:00:00

abstract：:Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer ce...

journal_title：Marine drugs

authors： Elmallah MI,Micheau O

更新日期：2015-11-13 00:00:00

abstract：:Three new aryl alkaloids named suberitamides A-C (1-3), were isolated from an extract of the marine sponge Pseudosuberites sp. collected along the coast of North Carolina. Their planar structures were established by extensive nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis. To assign the challengi...

journal_title：Marine drugs

authors： Kim CK,Wang D,Wilson BAP,Saurí J,Voeller D,Lipkowitz S,O'Keefe BR,Gustafson KR

更新日期：2020-10-28 00:00:00

abstract：:The marine alga, Symphyocladia latiuscula (Harvey) Yamada, is a good source of bromophenols with numerous biological activities. This study aims to characterize the anti-diabetic potential of 2,3,6-tribromo-4,5-dihydroxybenzyl derivatives isolated from S. latiuscula via their inhibition of tyrosine phosphatase 1B (PTP...

journal_title：Marine drugs

authors： Paudel P,Seong SH,Park HJ,Jung HA,Choi JS

更新日期：2019-03-14 00:00:00

abstract：:Kelps are colonized by a wide range of microbial symbionts. Among them, endophytic fungi remain poorly studied, but recent studies evidenced yet their high diversity and their central role in algal defense against various pathogens. Thus, studying the metabolic expressions of kelp endophytes under different conditions...

journal_title：Marine drugs

authors： Vallet M,Meziane T,Thiney N,Prado S,Hubas C

更新日期：2020-07-22 00:00:00

abstract：:The ability to produce an extracellular matrix and form multicellular communities is an adaptive behavior shared by many bacteria. In Bacillus subtilis, the model system for spore-forming bacteria, matrix production is one of the possible differentiation pathways that a cell can follow when vegetative growth is no lon...

journal_title：Marine drugs

authors： Di Luccia B,Riccio A,Vanacore A,Baccigalupi L,Molinaro A,Ricca E

更新日期：2015-10-21 00:00:00