Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms.

Abstract:

:Fucoxanthin is a marine carotenoid exhibiting several health benefits. The anti-cancer effect of fucoxanthin and its deacetylated metabolite, fucoxanthinol, is well documented. In view of its potent anti-carcinogenic activity, the need to understand the underlying mechanisms has gained prominence. Towards achieving this goal, several researchers have carried out studies in various cell lines and in vivo and have deciphered that fucoxanthin exerts its anti-proliferative and cancer preventing influence via different molecules and pathways including the Bcl-2 proteins, MAPK, NFκB, Caspases, GADD45, and several other molecules that are involved in either cell cycle arrest, apoptosis, or metastasis. Thus, in addition to decreasing the frequency of occurrence and growth of tumours, fucoxanthin has a cytotoxic effect on cancer cells. Some studies show that this effect is selective, i.e., fucoxanthin has the capability to target cancer cells only, leaving normal physiological cells unaffected/less affected. Hence, fucoxanthin and its metabolites show great promise as chemotherapeutic agents in cancer.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Kumar SR,Hosokawa M,Miyashita K

doi

10.3390/md11125130

subject

Has Abstract

pub_date

2013-12-16 00:00:00

pages

5130-47

issue

12

issn

1660-3397

pii

md11125130

journal_volume

11

pub_type

杂志文章,评审
  • New Hydroquinone Monoterpenoid and Cembranoid-Related Metabolites from the Soft Coral Sarcophyton tenuispiculatum.

    abstract::Chemical investigation of the marine soft coral Sarcophyton tenuispiculatum resulted in the isolation of a 1,4-dihydrobenzoquinone, sarcotenuhydroquinone (1), three new cembranoids, sarcotenusenes A‒C (2‒4), and ten previously reported metabolites 5-14. The chemical structures of all isolated metabolites were determin...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md19010008

    authors: Huang TY,Huang CY,Chen SR,Weng JR,Tu TH,Cheng YB,Wu SH,Sheu JH

    更新日期:2020-12-27 00:00:00

  • A New Bioassay Platform Design for the Discovery of Small Molecules with Anticancer Immunotherapeutic Activity.

    abstract::Immunotherapy takes advantage of the immune system to prevent, control, and eliminate neoplastic cells. The research in the field has already led to major breakthroughs to treat cancer. In this work, we describe a platform that integrates in vitro bioassays to test the immune response and direct antitumor effects for ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md18120604

    authors: Gallo C,Barra G,Saponaro M,Manzo E,Fioretto L,Ziaco M,Nuzzo G,d'Ippolito G,De Palma R,Fontana A

    更新日期:2020-11-29 00:00:00

  • Core oligosaccharide of Plesiomonas shigelloides PCM 2231 (Serotype O17) lipopolysaccharide--structural and serological analysis.

    abstract::The herein presented complete structure of the core oligosaccharide of lipopolysaccharide (LPS) P. shigelloides Polish Collection of Microorganisms (PCM) 2231 (serotype O17) was investigated by (1)H, (13)C NMR spectroscopy, mass spectrometry, chemical analyses and serological methods. The core oligosaccharide is compo...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md11020440

    authors: Maciejewska A,Lukasiewicz J,Kaszowska M,Man-Kupisinska A,Jachymek W,Lugowski C

    更新日期:2013-02-06 00:00:00

  • Total Synthesis of Pulmonarin B and Design of Brominated Phenylacetic Acid/Tacrine Hybrids: Marine Pharmacophore Inspired Discovery of New ChE and Aβ Aggregation Inhibitors.

    abstract::A marine natural product, pulmonarin B (1), and a series of related tacrine hybrid analogues were synthesized and evaluated as cholinesterase (ChE) inhibitors. The in vitro ChE assay results revealed that 1 showed moderate dual acetylcholinesterase (AChE)/ butyrylcholinesterase (BChE) inhibitory activity, while the hy...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16090293

    authors: Cheng ZQ,Song JL,Zhu K,Zhang J,Jiang CS,Zhang H

    更新日期:2018-08-21 00:00:00

  • Penicillinolide A: a new anti-inflammatory metabolite from the marine fungus Penicillium sp. SF-5292.

    abstract::In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md11114510

    authors: Lee DS,Ko W,Quang TH,Kim KS,Sohn JH,Jang JH,Ahn JS,Kim YC,Oh H

    更新日期:2013-11-12 00:00:00

  • Nocapyrones: α- and γ-pyrones from a marine-derived Nocardiopsis sp.

    abstract::One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2-4 were found t...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md12074110

    authors: Kim Y,Ogura H,Akasaka K,Oikawa T,Matsuura N,Imada C,Yasuda H,Igarashi Y

    更新日期:2014-07-08 00:00:00

  • The Mucus of Actinia equina (Anthozoa, Cnidaria): An Unexplored Resource for Potential Applicative Purposes.

    abstract::The mucus produced by many marine organisms is a complex mixture of proteins and polysaccharides forming a weak watery gel. It is essential for vital processes including locomotion, navigation, structural support, heterotrophic feeding and defence against a multitude of environmental stresses, predators, parasites, an...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13085276

    authors: Stabili L,Schirosi R,Parisi MG,Piraino S,Cammarata M

    更新日期:2015-08-19 00:00:00

  • The effect of cholesterol on the long-range network of interactions established among sea anemone Sticholysin II residues at the water-membrane interface.

    abstract::Actinoporins are α-pore forming proteins with therapeutic potential, produced by sea anemones. Sticholysin II (StnII) from Stichodactyla helianthus is one of its most extensively characterized members. These proteins remain stably folded in water, but upon interaction with lipid bilayers, they oligomerize to form a po...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13041647

    authors: García-Linares S,Alm I,Maula T,Gavilanes JG,Slotte JP,Martínez-Del-Pozo Á

    更新日期:2015-03-25 00:00:00

  • MS/MS-Based Molecular Networking Approach for the Detection of Aplysiatoxin-Related Compounds in Environmental Marine Cyanobacteria.

    abstract::Certain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect aplysiatoxins pres...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16120505

    authors: Ding CYG,Pang LM,Liang ZX,Goh KKK,Glukhov E,Gerwick WH,Tan LT

    更新日期:2018-12-13 00:00:00

  • Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation.

    abstract::In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Starting from this scaf...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md12063091

    authors: Sepe V,Di Leva FS,D'Amore C,Festa C,De Marino S,Renga B,D'Auria MV,Novellino E,Limongelli V,D'Souza L,Majik M,Zampella A,Fiorucci S

    更新日期:2014-05-27 00:00:00

  • Butenolide Derivatives with α-Glucosidase Inhibitions from the Deep-Sea-Derived Fungus Aspergillus terreus YPGA10.

    abstract::Three new butenolide derivatives, namely aspernolides N-P (1-3), together with six known analogues (4-9), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 1-3 were determined on the basis of comprehensive analyses of the nuclear...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17060332

    authors: Cheng Z,Li Y,Liu W,Liu L,Liu J,Yuan W,Luo Z,Xu W,Li Q

    更新日期:2019-06-03 00:00:00

  • Isolation of a new natural product and cytotoxic and antimicrobial activities of extracts from fungi of Indonesian marine habitats.

    abstract::In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacter...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md9030294

    authors: Tarman K,Lindequist U,Wende K,Porzel A,Arnold N,Wessjohann LA

    更新日期:2011-02-25 00:00:00

  • Production of bioactive secondary metabolites by marine vibrionaceae.

    abstract::Bacteria belonging to the Vibrionaceae family are widespread in the marine environment. Today, 128 species of vibrios are known. Several of them are infamous for their pathogenicity or symbiotic relationships. Despite their ability to interact with eukaryotes, the vibrios are greatly underexplored for their ability to...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md9091440

    authors: Mansson M,Gram L,Larsen TO

    更新日期:2011-01-01 00:00:00

  • Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo.

    abstract::For a long time, fucoidan has been well known for its pharmacological activities, and recently low molecular weight fucoidan (LMF) has been used in food supplements and pharmaceutical products. In the present study, LMF was extracted from Laminaria japonica by enzyme hydrolysis. The toxicity of LMF in mouse and rat mo...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md14070121

    authors: Hwang PA,Yan MD,Lin HT,Li KL,Lin YC

    更新日期:2016-06-24 00:00:00

  • Effect of Methionine Oxidation and Substitution of α-Conotoxin TxID on α3β4 Nicotinic Acetylcholine Receptor.

    abstract::α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype. However, TxID is susceptible to modification due to it containing a methionine (Met) residue that easily forms m...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16060215

    authors: Ren J,Li R,Ning J,Zhu X,Zhangsun D,Wu Y,Luo S

    更新日期:2018-06-20 00:00:00

  • Terpenoids from the octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea).

    abstract::A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to dis...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md10020427

    authors: Lee CH,Kao CY,Kao SY,Chang CH,Su JH,Hwang TL,Kuo YH,Wen ZH,Sung PJ

    更新日期:2012-02-01 00:00:00

  • Sarcophyolides B-E, new cembranoids from the soft coral Sarcophyton elegans.

    abstract::Four new cembrane-type diterpenoids, sarcophyolides B-E (1-4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1-4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocraso...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md11093186

    authors: Xi Z,Bie W,Chen W,Liu D,van Ofwegen L,Proksch P,Lin W

    更新日期:2013-08-26 00:00:00

  • Azaspiracid shellfish poisoning: a review on the chemistry, ecology, and toxicology with an emphasis on human health impacts.

    abstract::Azaspiracids (AZA) are polyether marine toxins that accumulate in various shellfish species and have been associated with severe gastrointestinal human intoxications since 1995. This toxin class has since been reported from several countries, including Morocco and much of western Europe. A regulatory limit of 160 micr...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md20080004

    authors: Twiner MJ,Rehmann N,Hess P,Doucette GJ

    更新日期:2008-05-07 00:00:00

  • The Microbial Community of Tetrodotoxin-Bearing and Non-Tetrodotoxin-Bearing Ribbon Worms (Nemertea) from the Sea of Japan.

    abstract::A potent marine toxin, tetrodotoxin (TTX), found in a great variety of marine and some terrestrial species, leaves intriguing questions about its origin and distribution in marine ecosystems. TTX-producing bacteria were found in the cultivable microflora of many TTX-bearing hosts, thereby providing strong support for ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md18030177

    authors: Melnikova DI,Magarlamov TY

    更新日期:2020-03-23 00:00:00

  • The Protective Effects of Clams on Hypercholesterolemia in Late-Stage Triple-Transgenic Alzheimer's Diseased Mice Hearts.

    abstract::To investigate a high cholesterol diet in Alzheimer's disease (AD) mice, they were fed with (2% cholesterol) in five groups with a control group, AD mice group, AD mice plus Meretrix lusoria group, AD mice plus Geloina eros group, and, AD mice plus Corbicula fluminea group for three months, and treated with the fatty ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16080263

    authors: Hsieh YL,Teng HJ,Yeh YH,Hsieh CH,Huang CY

    更新日期:2018-08-01 00:00:00

  • Next Generation Sequencing of Actinobacteria for the Discovery of Novel Natural Products.

    abstract::Like many fields of the biosciences, actinomycete natural products research has been revolutionised by next-generation DNA sequencing (NGS). Hundreds of new genome sequences from actinobacteria are made public every year, many of them as a result of projects aimed at identifying new natural products and their biosynth...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md14040078

    authors: Gomez-Escribano JP,Alt S,Bibb MJ

    更新日期:2016-04-13 00:00:00

  • Optimization of Collagenase Production by Pseudoalteromonas sp. SJN2 and Application of Collagenases in the Preparation of Antioxidative Hydrolysates.

    abstract::Collagenases are the most important group of commercially-produced enzymes. However, even though biological resources are abundant in the sea, very few of these commercially popular enzymes are from marine sources, especially from marine bacteria. We optimized the production of marine collagenases by Pseudoalteromonas...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md15120377

    authors: Yang X,Xiao X,Liu D,Wu R,Wu C,Zhang J,Huang J,Liao B,He H

    更新日期:2017-12-04 00:00:00

  • Cereus sinensis Polysaccharide and Its Immunomodulatory Properties in Human Monocytic Cells.

    abstract::In this study, the extraction conditions of the crude polysaccharide from Cereus sinensis were optimized by response surface methodology. The optimum extraction conditions were: a ratio of raw material to water volume of 1:80 (g/mL); an extraction temperature of 72 °C; and an extraction time of 3 h. Then, a purified p...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md15050140

    authors: Wu J,Zhou X,Zhang M,Yao Y,Han J,Liu K

    更新日期:2017-05-18 00:00:00

  • Marine Compound 3-bromo-4,5-dihydroxybenzaldehyde Protects Skin Cells against Oxidative Damage via the Nrf2/HO-1 Pathway.

    abstract::In this study, we aimed to illustrate the potential bio-effects of 3-bromo-4,5-dihydroxybenzaldehyde (3-BDB) on the antioxidant/cytoprotective enzyme heme oxygenase-1 (HO-1) in keratinocytes. The antioxidant effects of 3-BDB were examined via reverse transcription PCR, Western blotting, HO-1 activity assay, and immuno...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17040234

    authors: Ryu YS,Fernando PDSM,Kang KA,Piao MJ,Zhen AX,Kang HK,Koh YS,Hyun JW

    更新日期:2019-04-19 00:00:00

  • Evidence of accelerated evolution and ectodermal-specific expression of presumptive BDS toxin cDNAs from Anemonia viridis.

    abstract::Anemonia viridis is a widespread and extensively studied Mediterranean species of sea anemone from which a large number of polypeptide toxins, such as blood depressing substances (BDS) peptides, have been isolated. The first members of this class, BDS-1 and BDS-2, are polypeptides belonging to the β-defensin fold fami...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md11114213

    authors: Nicosia A,Maggio T,Mazzola S,Cuttitta A

    更新日期:2013-10-30 00:00:00

  • Effect of Marine-Derived Ice-Binding Proteins on the Cryopreservation of Marine Microalgae.

    abstract::Ice-binding protein (IBPs) protect cells from cryo-injury during cryopreservation by inhibiting ice recrystallization (IR), which is a main cause of cell death. In the present study, we employed two IBPs, one, designated LeIBP from Arctic yeast, and the other, designated FfIBP from Antarctic sea ice bacterium, in the ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md15120372

    authors: Kim HJ,Koo BW,Kim D,Seo YS,Nam YK

    更新日期:2017-12-01 00:00:00

  • Functional metabolomics uncovers metabolic alterations associated to severe oxidative stress in MCF7 breast cancer cells exposed to ascididemin.

    abstract::Marine natural products are a source of promising agents for cancer treatment. However, there is a need to improve the evaluation of their mechanism of action in tumors. Metabolomics of the response to anti-tumor agents is a tool to reveal candidate biomarkers and metabolic targets. We used two-dimensional high-resolu...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md11103846

    authors: Morvan D

    更新日期:2013-10-11 00:00:00

  • Total Synthesis and Stereochemical Assignment of Nostosin B.

    abstract::Nostosins A and B were isolated from a hydrophilic extract of Nostoc sp. strain from Iran, which exhibits excellent tryps inhibitory activity. Nostosin A was the most potent natural tripeptide aldehyde as trypsin inhibitor up to now. Both R- and S-2-hydroxy-4-(4-hydroxy-phenyl) butanoic acid (Hhpba) were prepared and ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md15030058

    authors: Wang X,Feng J,Xu Z,Ye T,Meng Y,Zhang Z

    更新日期:2017-02-27 00:00:00

  • Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges.

    abstract::Natural phenolic compounds are important classes of plant, microorganism, and algal secondary metabolites. They have well-documented beneficial biological activities. The marine environment is less explored than other environments but have huge potential for the discovery of new unique compounds with potential applica...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md18080389

    authors: Getachew AT,Jacobsen C,Holdt SL

    更新日期:2020-07-27 00:00:00

  • Laminariales Host Does Impact Lipid Temperature Trajectories of the Fungal Endophyte Paradendryphiella salina (Sutherland.).

    abstract::Kelps are colonized by a wide range of microbial symbionts. Among them, endophytic fungi remain poorly studied, but recent studies evidenced yet their high diversity and their central role in algal defense against various pathogens. Thus, studying the metabolic expressions of kelp endophytes under different conditions...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md18080379

    authors: Vallet M,Meziane T,Thiney N,Prado S,Hubas C

    更新日期:2020-07-22 00:00:00