The Inhibitory Effect of Protamine on Platelets is Attenuated by Heparin without Inducing Thrombocytopenia in Rodents.


:Protamine sulfate (PS) is a polycationic protein drug obtained from the sperm of fish, and is used to reverse the anticoagulant effect of unfractionated heparin (UFH). However, the interactions between PS, UFH, and platelets are still not clear. We measured the platelet numbers and collagen-induced aggregation, P-selectin, platelet factor 4, β-thromboglobulin, prostacyclin metabolite, D-dimers, activated partial thromboplastin time, prothrombin time, anti-factor Xa, fibrinogen, thrombus weight and megakaryocytopoiesis in blood collected from mice and rats in different time points.. All of the groups were treated intravenously with vehicle, UFH, PS, or UFH with PS. We found a short-term antiplatelet activity of PS in mice and rats, and long-term platelet-independent antithrombotic activity in rats with electrically-induced thrombosis. The antiplatelet and antithrombotic potential of PS may contribute to bleeding risk in PS-overdosed patients. The inhibitory effect of PS on the platelets was attenuated by UFH without inducing thrombocytopenia. Treatment with UFH and PS did not affect the formation, number, or activation of platelets, or the thrombosis development in rodents.


Mar Drugs


Marine drugs


Miklosz J,Kalaska B,Kaminski K,Rusak M,Szczubialka K,Nowakowska M,Pawlak D,Mogielnicki A




Has Abstract


2019-09-17 00:00:00










  • Total Synthesis of Mycalisine B.

    abstract::The first total synthesis of the marine nucleoside Mycalisine B-a naturally occurring and structurally distinct 4,5-unsaturated 7-deazapurine nucleoside-has been accomplished in 10 linear steps with 27.5% overall yield from commercially available 1,2,3,5-tetra-O-acetyl-ribose and tetracyanoethylene. Key steps of the a...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ding H,Ruan Z,Kou P,Dong X,Bai J,Xiao Q

    更新日期:2019-04-14 00:00:00

  • Fucosterol from an Edible Brown Alga Ecklonia stolonifera Prevents Soluble Amyloid Beta-Induced Cognitive Dysfunction in Aging Rats.

    abstract::Fucosterol from edible brown seaweeds has various biological activities, including anti-inflammatory, anti-adipogenic, antiphotoaging, anti-acetylcholinesterase, and anti-beta-secretase 1 activities. However, little is known about its effects on soluble amyloid beta peptide (sAβ)-induced endoplasmic reticulum (ER) str...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Oh JH,Choi JS,Nam TJ

    更新日期:2018-10-05 00:00:00

  • Metabolomic Insights into Marine Phytoplankton Diversity.

    abstract::The democratization of sequencing technologies fostered a leap in our knowledge of the diversity of marine phytoplanktonic microalgae, revealing many previously unknown species and lineages. The evolutionary history of the diversification of microalgae can be inferred from the analysis of their genome sequences. Howev...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Marcellin-Gros R,Piganeau G,Stien D

    更新日期:2020-01-25 00:00:00

  • Virescenosides From the Holothurian-Associated Fungus Acremonium Striatisporum Kmm 4401.

    abstract::Ten new diterpene glycosides virescenosides Z9-Z18 (1-10) together with three known analogues (11-13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassiu...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Zhuravleva OI,Antonov AS,Oleinikova GK,Khudyakova YV,Popov RS,Denisenko VA,Pislyagin EA,Chingizova EA,Afiyatullov SS

    更新日期:2019-10-29 00:00:00

  • Bioactive compounds from the Red Sea marine sponge Hyrtios species.

    abstract::In continuation of our search for drug leads from Red Sea sponges we have investigated the ethyl acetate fraction of the organic extract of the Red Sea sponge Hyrtios species. Bioassay-directed fractionation of the active fraction resulted into the identification of three new alkaloids, hyrtioerectines D-F (1-3). Hyrt...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Youssef DT,Shaala LA,Asfour HZ

    更新日期:2013-03-28 00:00:00

  • Mucoadhesive microparticles for gastroretentive delivery: preparation, biodistribution and targeting evaluation.

    abstract::The aim of this research was to prepare and characterize alginate-chitosan mucoadhesive microparticles containing puerarin. The microparticles were prepared by an emulsification-internal gelatin method using a combination of chitosan and Ca2+ as cationic components and alginate as anions. Surface morphology, particle ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Hou JY,Gao LN,Meng FY,Cui YL

    更新日期:2014-12-01 00:00:00

  • Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones.

    abstract::The potential anti-tumor agent wentilactones were produced by a newly isolated marine fungus Aspergillus dimorphicus. This fungus was derived from deep-sea sediment and identified by polyphasic approach, combining phenotypic, molecular, and extrolite profiles. However, wentilactone production was detected only under s...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Xu R,Xu GM,Li XM,Li CS,Wang BG

    更新日期:2015-11-19 00:00:00

  • Brown Algae Padina sanctae-crucis Børgesen: A Potential Nutraceutical.

    abstract::Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and h...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Nogueira RBSS,Tomaz ACA,Pessoa DR,Xavier AL,Pita JCLR,Sobral MV,Pontes MLC,Pessôa HLF,Diniz MFFM,Miranda GEC,Vieira MAR,Marques MOM,Souza MFV,Cunha EVL

    更新日期:2017-09-26 00:00:00

  • Alkaloids from the mangrove-derived actinomycete Jishengella endophytica 161111.

    abstract::A new alkaloid, 2-(furan-2-yl)-6-(2S,3S,4-trihydroxybutyl)pyrazine (1), along with 12 known compounds, 2-(furan-2-yl)-5-(2S,3S,4-trihydroxybutyl)pyrazine (2), (S)-4-isobutyl-3-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbaldehyde (3), (S)-4-isopropyl-3-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbaldehyd...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wang P,Kong F,Wei J,Wang Y,Wang W,Hong K,Zhu W

    更新日期:2014-01-21 00:00:00

  • Extraction, Identification, Modification, and Antibacterial Activity of Histone from Immature Testis of Atlantic salmon.

    abstract::In the present study, histone from immature testis of Atlantic salmon was extracted and identified, and its antibacterial activity after enzymolysis was investigated. Histone extracted from Atlantic salmon (Salmo salar) testis using the acid extraction method was successfully identified by LC-MS/MS, and revealed signi...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Fu B,Lin H,Ramesh Pavase T,Mi N,Sui J

    更新日期:2020-02-26 00:00:00

  • Anti-Hepatocellular Carcinoma (HepG2) Activities of Monoterpene Hydroxy Lactones Isolated from the Marine Microalga Tisochrysis Lutea.

    abstract::Tisochrysis lutea is a marine haptophyte rich in omega-3 polyunsaturated fatty acids (e.g., docosahexaenoic acid (DHA)) and carotenoids (e.g., fucoxanthin). Because of the nutraceutical applications of these compounds, this microalga is being used in aquaculture to feed oyster and shrimp larvae. In our earlier report,...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Gangadhar KN,Rodrigues MJ,Pereira H,Gaspar H,Malcata FX,Barreira L,Varela J

    更新日期:2020-11-19 00:00:00

  • Clinical trial: marine lipid suppositories as laxatives.

    abstract:UNLABELLED:Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from ...

    journal_title:Marine drugs

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ormarsson OT,Geirsson T,Bjornsson ES,Jonsson T,Moller P,Loftsson T,Stefansson E

    更新日期:2012-09-01 00:00:00

  • Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum).

    abstract::Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures we...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ngokpol S,Suwakulsiri W,Sureram S,Lirdprapamongkol K,Aree T,Wiyakrutta S,Mahidol C,Ruchirawat S,Kittakoop P

    更新日期:2015-06-05 00:00:00

  • Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum.

    abstract::Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures of the new compoun...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Zhao M,Cheng S,Yuan W,Xi Y,Li X,Dong J,Huang K,Gustafson KR,Yan P

    更新日期:2016-06-03 00:00:00

  • Biotechnological Potential of Cold Adapted Pseudoalteromonas spp. Isolated from 'Deep Sea' Sponges.

    abstract::The marine genus Pseudoalteromonas is known for its versatile biotechnological potential with respect to the production of antimicrobials and enzymes of industrial interest. We have sequenced the genomes of three Pseudoalteromonas sp. strains isolated from different deep sea sponges on the Illumina MiSeq platform. The...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Borchert E,Knobloch S,Dwyer E,Flynn S,Jackson SA,Jóhannsson R,Marteinsson VT,O'Gara F,Dobson ADW

    更新日期:2017-06-19 00:00:00

  • Molecular Targets of Active Anticancer Compounds Derived from Marine Sources.

    abstract::Over the past decades, a number of novel compounds, which are produced in the marine environment, have been found to exhibit the anticancer effects. This review focuses on molecular targets of marine-derived anticancer candidates in clinical and preclinical studies. They are kinases, transcription factors, histone dea...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Song X,Xiong Y,Qi X,Tang W,Dai J,Gu Q,Li J

    更新日期:2018-05-22 00:00:00

  • Cyanobacterial Metabolite Calothrixins: Recent Advances in Synthesis and Biological Evaluation.

    abstract::The marine environment is host to unparalleled biological and chemical diversity, making it an attractive resource for the discovery of new therapeutics for a plethora of diseases. Compounds that are extracted from cyanobacteria are of special interest due to their unique structural scaffolds and capacity to produce p...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Xu S,Nijampatnam B,Dutta S,Velu SE

    更新日期:2016-01-12 00:00:00

  • Nine New Triterpene Glycosides, Magnumosides A₁-A₄, B₁, B₂, C₁, C₂ and C₄, from the Vietnamese Sea Cucumber Neothyonidium (=Massinium) magnum: Structures and Activities against Tumor Cells Independently and in Synergy with Radioactive Irradiation.

    abstract::Nine new sulfated triterpene glycosides, magnumosides A₁ (1), A₂ (2), A₃ (3), A₄ (4), B₁ (5), B₂ (6), C₁ (7), C₂ (8) and C₄ (9) as well as a known colochiroside B₂ (10) have been isolated from the tropical Indo-West Pacific sea cucumber Neothynidium (=Massinium) magnum (Phyllophoridae, Dendrochirotida) collected in th...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Silchenko AS,Kalinovsky AI,Avilov SA,Kalinin VI,Andrijaschenko PV,Dmitrenok PS,Chingizova EA,Ermakova SP,Malyarenko OS,Dautova TN

    更新日期:2017-08-16 00:00:00

  • Two New Terpenoids from Talaromyces purpurogenus.

    abstract::A new sesquiterpenoid 9,10-diolhinokiic acid (1) and a new diterpenoid roussoellol C (2), together with 4 known compounds, were isolated from the extracts of laboratory cultures of marine-derived fungus Talaromyces purpurogenus. 9,10-diolhinokiic acid is the first thujopsene-type sesquiterpenoid containing a 9,10-diol...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wang W,Wan X,Liu J,Wang J,Zhu H,Chen C,Zhang Y

    更新日期:2018-05-02 00:00:00

  • Fucus vesiculosus and Ascophyllum nodosum Ameliorate Liver Function by Reducing Diet-Induced Steatosis in Rats.

    abstract::The Asian coastal communities have used the brown seaweeds Fucus vesiculosus and Ascophyllum nodosum since ancient times. Recently, some in vitro and in vivo studies have demonstrated their abilities in reducing risk factors for metabolic syndrome. Here, we analyzed the protective effect of a phytocomplex extracted fr...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Gabbia D,Saponaro M,Sarcognato S,Guido M,Ferri N,Carrara M,De Martin S

    更新日期:2020-01-17 00:00:00

  • Antimicrobial and Anti-Proliferative Effects of Skin Mucus Derived from Dasyatis pastinaca (Linnaeus, 1758).

    abstract::Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferat...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Fuochi V,Li Volti G,Camiolo G,Tiralongo F,Giallongo C,Distefano A,Petronio Petronio G,Barbagallo I,Viola M,Furneri PM,Di Rosa M,Avola R,Tibullo D

    更新日期:2017-11-01 00:00:00

  • Antiviral activities of sulfated polysaccharides isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales).

    abstract::Water-soluble sulfated polysaccharides isolated from two red algae Sphaerococcus coronopifolius (Gigartinales, Sphaerococcaceae) and Boergeseniella thuyoides (Ceramiales, Rhodomelaceae) collected on the coast of Morocco inhibited in vitro replication of the Human Immunodeficiency Virus (HIV) at 12.5 μg/mL. In addition...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bouhlal R,Haslin C,Chermann JC,Colliec-Jouault S,Sinquin C,Simon G,Cerantola S,Riadi H,Bourgougnon N

    更新日期:2011-01-01 00:00:00

  • Vasorelaxation, induced by Dictyota pulchella (Dictyotaceae), a brown alga, is mediated via inhibition of calcium influx in rats.

    abstract::This study aimed to investigate the cardiovascular effects elicited by Dictyota pulchella, a brown alga, using in vivo and in vitro approaches. In normotensive conscious rats, CH(2)Cl(2)/MeOH Extract (CME, 5, 10, 20 and 40 mg/kg) from Dictyota pulchella produced dose-dependent hypotension (-4 ± 1; -8 ± 2; -53 ± 8 and ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Queiroz TM,Machado NT,Furtado FF,Oliveira-Filho AA,Alustau MC,Figueiredo CS,Miranda GE,Barbosa-Filho JM,Braga VA,Medeiros IA

    更新日期:2011-01-01 00:00:00

  • Butenolide Derivatives with α-Glucosidase Inhibitions from the Deep-Sea-Derived Fungus Aspergillus terreus YPGA10.

    abstract::Three new butenolide derivatives, namely aspernolides N-P (1-3), together with six known analogues (4-9), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 1-3 were determined on the basis of comprehensive analyses of the nuclear...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Cheng Z,Li Y,Liu W,Liu L,Liu J,Yuan W,Luo Z,Xu W,Li Q

    更新日期:2019-06-03 00:00:00

  • Ochracenoids A and B, guaiazulene-based analogues from gorgonian Anthogorgia ochracea collected from the South China Sea.

    abstract::Two new guaiazulene-based analogues, ochracenoids A (1) and B (2), along with four known analogues (3-6), were isolated from the gorgonian Anthogorgia ochracea collected from the South China Sea. The planar structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configuration ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Zheng JJ,Shao CL,Chen M,Gan LS,Fang YC,Wang XH,Wang CY

    更新日期:2014-03-14 00:00:00

  • A Saponification Method for Chlorophyll Removal from Microalgae Biomass as Oil Feedstock.

    abstract::Microalgae oil is an optimal feedstock for nutraceutical, pharmaceutical and biodiesel production, but its high levels of chlorophyll limit its large-scale application. To date, few effective approaches have been developed to remove chlorophyll from microalgae oil. The main purpose of this study was to present a prepr...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Li T,Xu J,Wu H,Wang G,Dai S,Fan J,He H,Xiang W

    更新日期:2016-09-07 00:00:00

  • Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A-D.

    abstract::Six regioisomers associated with the tricyclic core of thiaplakortones A-D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic core scaffolds presen...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Schwartz BD,Coster MJ,Skinner-Adams TS,Andrews KT,White JM,Davis RA

    更新日期:2015-09-15 00:00:00

  • Indole diterpenoids and isocoumarin from the fungus, Aspergillus flavus, isolated from the prawn, Penaeus vannamei.

    abstract::Two new indole-diterpenoids (1 and 2) and a new isocoumarin (3), along with the known β-aflatrem (4), paspalinine (5), leporin B (6), α-cyclopiazonic acid (7), iso-α-cyclopiazonic acid (8), ditryptophenaline (9), aflatoxin B1 (10), 7-O-acetylkojic acid (11) and kojic acid (12), were isolated from the fermentation brot...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Sun K,Li Y,Guo L,Wang Y,Liu P,Zhu W

    更新日期:2014-06-30 00:00:00

  • Borrelidins C-E: New Antibacterial Macrolides from a Saltern-Derived Halophilic Nocardiopsis sp.

    abstract::Chemical investigation of a halophilic actinomycete strain belonging to the genus Nocardiopsis inhabiting a hypersaline saltern led to the discovery of new 18-membered macrolides with nitrile functionality, borrelidins C-E (1-3), along with a previously reported borrelidin (4). The planar structures of borrelidins C-E...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Kim J,Shin D,Kim SH,Park W,Shin Y,Kim WK,Lee SK,Oh KB,Shin J,Oh DC

    更新日期:2017-06-06 00:00:00

  • Towards commercial production of sponge medicines.

    abstract::Sponges can provide potential drugs against many major world-wide occurring diseases. Despite the high potential of sponge derived drugs no sustainable production method has been developed. Thus far it is not fully understood why, when, where and how these metabolites are produced in sponges. For the near future sea-b...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Koopmans M,Martens D,Wijffels RH

    更新日期:2009-12-02 00:00:00