Abstract:
:Collagen is involved in the formation of complex fibrillar networks, providing the structural integrity of tissues. Its low immunogenicity and mechanical properties make this molecule a biomaterial that is extremely suitable for tissue engineering and regenerative medicine (TERM) strategies in human health issues. Here, for the first time, we performed a thorough screening of four different methods to obtain sponge collagenous fibrillar suspensions (FSs) from C. reniformis demosponge, which were then chemically, physically, and biologically characterized, in terms of protein, collagen, and glycosaminoglycans content, viscous properties, biocompatibility, and antioxidant activity. These four FSs were then tested for their capability to generate crosslinked or not thin sponge collagenous membranes (SCMs) that are suitable for TERM purposes. Two types of FSs, of the four tested, were able to generate SCMs, either from crosslinking or not, and showed good mechanical properties, enzymatic degradation resistance, water binding capacity, antioxidant activity, and biocompatibility on both fibroblast and keratinocyte cell cultures. Finally, our results demonstrate that it is possible to adapt the extraction procedure in order to alternatively improve the mechanical properties or the antioxidant performances of the derived biomaterial, depending on the application requirements, thanks to the versatility of C. reniformis extracellular matrix extracts.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Pozzolini M,Scarfì S,Gallus L,Castellano M,Vicini S,Cortese K,Gagliani MC,Bertolino M,Costa G,Giovine Mdoi
10.3390/md16040111subject
Has Abstractpub_date
2018-03-29 00:00:00issue
4issn
1660-3397pii
md16040111journal_volume
16pub_type
杂志文章相关文献
Marine Drugs文献大全abstract::Microorganisms that inhabit unchartered unique soil such as in the highly saline and hot Red Sea lagoons on the Saudi Arabian coastline, represent untapped sources of potentially new bioactive compounds. In this study, a culture-dependent approach was applied to three types of sediments: mangrove mud (MN), microbial m...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14090165
更新日期:2016-09-10 00:00:00
abstract::Long chain polyunsaturated fatty acids (LC-PUFAs) are important mediators in improving and maintaining human health over the total lifespan. One topic we especially focus on in this review is omega-3 LC-PUFA docosahexaenoic acid (DHA). Adequate DHA levels are essential during neurodevelopment and, in addition, benefic...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12126190
更新日期:2014-12-18 00:00:00
abstract::For a long time, fucoidan has been well known for its pharmacological activities, and recently low molecular weight fucoidan (LMF) has been used in food supplements and pharmaceutical products. In the present study, LMF was extracted from Laminaria japonica by enzyme hydrolysis. The toxicity of LMF in mouse and rat mo...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14070121
更新日期:2016-06-24 00:00:00
abstract::In 2011, a Diarrhetic Shellfish Poisoning (DSP) outbreak occurred in British Columbia (BC), Canada that was associated with cooked mussel consumption. This is the first reported DSP outbreak in BC. Investigation of ill individuals, traceback of product and laboratory testing for toxins were used in this investigation....
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11051669
更新日期:2013-05-21 00:00:00
abstract::In our current investigation, we evaluated the effect of Chlorella pyrenoidosa protein hydrolysate (CPPH) and Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) on calcium absorption and gut microbiota composition, as well as their in vivo regulatory mechanism in SD rats fed low-calcium diets. Potent ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17060348
更新日期:2019-06-11 00:00:00
abstract::Monostroma nitidum is a green single-cell layered algae that grows on the southwest coast of Japan. It is often used for salad ingredients, boiled tsukudani, soups, etc., due to its health benefits. M. nitidum is composed of many cell aggregates, and the various substances that fill the intercellular space are dietary...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18040228
更新日期:2020-04-24 00:00:00
abstract::The skin, the largest organ in humans, is exposed to major sources of outdoor air pollution, such as fine particulate matter with a diameter ≤ 2.5 µm (PM2.5). Diphlorethohydroxycarmalol (DPHC), a marine-based compound, possesses multiple activities including antioxidant effects. In the present study, we evaluated the ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17020095
更新日期:2019-02-01 00:00:00
abstract::TNF-related apoptosis-inducing ligand (TRAIL) is a tumor-selective apoptosis inducer and has been shown to be promising for treating various types of cancers. However, the application of TRAIL is greatly impeded by the resistance of cancer cells to its action. Studies show that overexpression of some critical pro-surv...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12095072
更新日期:2014-09-25 00:00:00
abstract::Despite intense efforts to develop non-cytotoxic anticancer treatments, effective agents are still not available. Therefore, novel apoptosis-inducing drug leads that may be developed into effective targeted cancer therapies are of interest to the cancer research community. Targeted cancer therapies affect specific abe...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md9091580
更新日期:2011-01-01 00:00:00
abstract::Chemical investigation of the marine soft coral Sarcophyton tenuispiculatum resulted in the isolation of a 1,4-dihydrobenzoquinone, sarcotenuhydroquinone (1), three new cembranoids, sarcotenusenes A‒C (2‒4), and ten previously reported metabolites 5-14. The chemical structures of all isolated metabolites were determin...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md19010008
更新日期:2020-12-27 00:00:00
abstract::The potential anti-tumor agent wentilactones were produced by a newly isolated marine fungus Aspergillus dimorphicus. This fungus was derived from deep-sea sediment and identified by polyphasic approach, combining phenotypic, molecular, and extrolite profiles. However, wentilactone production was detected only under s...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13117040
更新日期:2015-11-19 00:00:00
abstract::A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17020100
更新日期:2019-02-06 00:00:00
abstract::We have searched for special characteristics in growth, protein expression, fatty acids and volatile organic compounds (VOCs) in a local Phaeodactylum tricornutum Bohlin strain (Bergen Marine Biobank), by comparing it with a common accession strain (CCAP). Differences in growth and expressed proteins were detected bet...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14010009
更新日期:2015-12-30 00:00:00
abstract::Concerning the requirements of effective drug candidates to combat against high rising multidrug resistant pathogens, we isolated three new linear lipopeptides, gageostatins A-C (1-3), consisting of hepta-peptides and new 3-β-hydroxy fatty acids from the fermentation broth of a marine-derived bacterium Bacillus subtil...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12020871
更新日期:2014-01-31 00:00:00
abstract::Biologically active compounds with different modes of action, such as, antiproliferative, antioxidant, antimicrotubule, have been isolated from marine sources, specifically algae and cyanobacteria. Recently research has been focused on peptides from marine animal sources, since they have been found as secondary metabo...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md10050963
更新日期:2012-05-01 00:00:00
abstract::In aquatic microbial ecology, knowledge of the processes involved in the turnover of organic matter is of utmost importance to understand ecosystem functioning. Microorganisms are major players in the cycling of nutrients (nitrogen, phosphorus) and carbon, thanks to their enzymatic activities (leucine aminopeptidase, ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md8040916
更新日期:2010-03-29 00:00:00
abstract::Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 1-4 were characterized using comprehens...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15080260
更新日期:2017-08-19 00:00:00
abstract::Chemical investigation of the methanol extract of the Vietnamese marine sponge Ircinia echinata led to the isolation of six new 9α-hydroxy-5α,6α-epoxysterols: 5α,6α-epoxycholesta-7,22(E)-dien-3β,9α-diol (1), 5α,6α-epoxycholesta-7,24(28)-dien-3β,9α-diol (2), (24R)-5α,6α-epoxy-24-ethyl-cholesta-7-en-3β,9α-diol (3), 5α,6...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16110424
更新日期:2018-11-01 00:00:00
abstract::Natural O-alkyl-glycerolipids, also known as alkyl-ether-lipids (AEL), feature a long fatty alkyl chain linked to the glycerol unit by an ether bond. AEL are ubiquitously found in different tissues but, are abundant in shark liver oil, breast milk, red blood cells, blood plasma, and bone marrow. Only a few AEL are com...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040101
更新日期:2018-03-23 00:00:00
abstract::Six new polyoxygenated cembrane-based diterpenoids, stellatumolides A⁻C (1⁻3), stellatumonins A and B (4 and 5), and stellatumonone (6), were isolated together with ten known related compounds (7⁻16) from the ethyl acetate (EtOAc) extract of soft coral Sarcophyton stellatum. The structures of the new compounds were es...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16060210
更新日期:2018-06-14 00:00:00
abstract::The effect of gold nanoparticles (GNPs) synthesized in marine algae has been described in the context of skin, where they have shown potential benefit. Ecklonia stolonifera (ES) is a brown algae that belongs to the Laminariaceae family, and is widely used as a component of food and medicine due to its biological activ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18090433
更新日期:2020-08-19 00:00:00
abstract::Soft corals are common marine organisms that inhabit tropical and subtropical oceans. They are shown to be rich source of secondary metabolites with biological activities. In this work, soft corals from two geographical locations were investigated using ¹H-NMR spectroscopy coupled with multivariate statistical analysi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12041876
更新日期:2014-03-28 00:00:00
abstract::The red seaweed Pyropia yezoensis is an ideal research model for dissecting the molecular mechanisms underlying its robust acclimation to abiotic stresses in intertidal zones. Glycine betaine (GB) was an important osmolyte in maintaining osmotic balance and stabilizing the quaternary structure of complex proteins unde...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17010070
更新日期:2019-01-21 00:00:00
abstract::Several known sesquiterpenoid quinones and quinols (1-9), and kauamide (10), a new polyketide-peptide containing an 11-membered heterocycle, were isolated from the extracts of the Hawaiian marine sponge Dactylospongiaelegans. The planar structure of 10 was determined from spectroscopic analyses, and its relative and a...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17070423
更新日期:2019-07-19 00:00:00
abstract::A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolit...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13010128
更新日期:2014-12-29 00:00:00
abstract::The biosynthetic gene cluster for bisucaberin B (1, bsb gene cluster), an N-hydroxy-N-succinyl diamine (HSD)-based siderophore, was cloned from the marine bacterium Tenacibaculum mesophilum, originated from a marine sponge. The bsb gene cluster consists of six open reading frames (ORFs), in contrast to the four ORFs t...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16090342
更新日期:2018-09-19 00:00:00
abstract:BACKGROUND:Evaluation of the potential efficacy and safety of combination therapies for advanced soft tissue sarcomas (STS) has increased substantially after approval of trabectedin and pazopanib. Trabectedin's introduction in Europe in 2007 depended mainly on its activity in so-called L-sarcomas (liposarcoma and leiom...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13010379
更新日期:2015-01-13 00:00:00
abstract::The deterioration of bone formation is a leading cause of age-related bone disorders. Lack of bone formation is induced by decreased osteoblastogenesis. In this study, osteoblastogenesis promoting effects of algal phlorotannin, phlorofucofuroeckol A (PFF-A), were evaluated. PFF-A was isolated from brown alga Eckloniac...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17100543
更新日期:2019-09-21 00:00:00
abstract::Two new diphenyl ethers (1 and 2) and four new phenolic bisabolane sesquiterpenoids (3⁻6), together with five known related derivatives, were isolated from the culture of the endophytic fungus Aspergillus flavus QQSG-3 obtained from a fresh branch of Kandelia obobata, which was collected from Huizhou city in the provi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16090307
更新日期:2018-09-01 00:00:00
abstract::With the depletion of global fish stocks, caused by high demand and effective fishing techniques, alternative sources for long chain omega-3 fatty acids are required for human nutrition and aquaculture feeds. Recent research has focused on land-based cultivation of microalgae, the primary producers of omega-3 fatty ac...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12063381
更新日期:2014-06-04 00:00:00