Abstract：
:Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 1-4 were characterized using comprehensive spectroscopic analyses. The absolute configuration of 1 was determined by comparison of electronic circular dichroism (ECD) spectra with literature values used for the reported analogue, cyclopenicillone (5), which was not isolated in this research. Compound 1 was shown to scavenge 2,2-diphenyl-1-picrylhydrazyl free radicals, and decrease β-amyloid (Aβ) fibrillization in vitro. Moreover, 1 significantly reduced H₂O₂-induced neurotoxicity in SH-SY5Y cells. These findings suggested that compound 1, a newly discovered cyclopentenone, has moderate anti-oxidative, anti-Aβ fibrillization properties and neuroprotective effects, and might be a good free radical scavenger.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Fang F,Zhao J,Ding L,Huang C,Naman CB,He S,Wu B,Zhu P,Luo Q,Gerwick WH,Yan X,Wang Q,Zhang Z,Cui Wdoi
10.3390/md15080260subject
Has Abstractpub_date
2017-08-19 00:00:00issue
8issn
1660-3397pii
md15080260journal_volume
15pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Microalgae oil is an optimal feedstock for nutraceutical, pharmaceutical and biodiesel production, but its high levels of chlorophyll limit its large-scale application. To date, few effective approaches have been developed to remove chlorophyll from microalgae oil. The main purpose of this study was to present a prepr...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14090162
更新日期：2016-09-07 00:00:00
abstract：:The swim bladder of the croceine croaker (Pseudosciaena crocea) was believed to have good curative effects in various diseases, including amnesia, insomnia, dizziness, anepithymia, and weakness after giving birth, in traditional Chinese medicine. However, there is no research focusing on the antioxidant and anti-fatig...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14120221
更新日期：2016-12-13 00:00:00
abstract：:In this study, we aimed to illustrate the potential bio-effects of 3-bromo-4,5-dihydroxybenzaldehyde (3-BDB) on the antioxidant/cytoprotective enzyme heme oxygenase-1 (HO-1) in keratinocytes. The antioxidant effects of 3-BDB were examined via reverse transcription PCR, Western blotting, HO-1 activity assay, and immuno...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17040234
更新日期：2019-04-19 00:00:00
abstract：:A new compound containing a triene, a tetrahydropyran ring and glycine ester functionalities, restricticin B (1), together with four known compounds (2-5) were obtained from the EtOAc extract of the marine-derived fungus Penicillium janthinellum. The planar structure of 1 was determined by detailed analyses of MS, 1D ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18090465
更新日期：2020-09-14 00:00:00
abstract：:In 2011, a Diarrhetic Shellfish Poisoning (DSP) outbreak occurred in British Columbia (BC), Canada that was associated with cooked mussel consumption. This is the first reported DSP outbreak in BC. Investigation of ill individuals, traceback of product and laboratory testing for toxins were used in this investigation....
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11051669
更新日期：2013-05-21 00:00:00
abstract：:A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to dis...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10020427
更新日期：2012-02-01 00:00:00
abstract：:Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing infarct size and reinforcing antioxidant defenses. The aim of this work was to determine the combin...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13020838
更新日期：2015-02-04 00:00:00
abstract：:The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula). Kalkitoxin exhibited N-methyl-D-aspartate (NMDA)-mediated neurotoxicity and acted as an inhibitory ligand for voltage-sensitive sodium channels in cultured rat cerebellar granule ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13031552
更新日期：2015-03-20 00:00:00
abstract：:The genus Streptomyces produces secondary metabolic compounds that are rich in biological activity. Many of these compounds are genetically encoded by large secondary metabolism biosynthetic gene clusters (smBGCs) such as polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS) which are modular and can...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16020067
更新日期：2018-02-20 00:00:00
abstract：:A novel sesquiterpenoid, rumphellaoic acid A (1), was isolated from the gorgonian coral Rumphella antipathies, and was found to possess a carbon skeleton that was obtained for the first time from a natural sources. The structure of 1 was elucidated by spectroscopic methods and this compound and was found to exert a mo...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12125856
更新日期：2014-12-04 00:00:00
abstract：:Early acute kidney injury (AKI) is a devastating complication in critical burn patients, and it is associated with severe morbidity and mortality. The mechanism of AKI is multifactorial. Astaxanthin (ATX) is a natural compound that is widely distributed in marine organisms; it is a strong antioxidant and exhibits othe...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13042105
更新日期：2015-04-13 00:00:00
abstract：BACKGROUND:Parenteral nutrition is often a mandatory therapeutic strategy for cases of septicemia. Likewise, therapeutic application of anti-oxidants, anti-inflammatory therapy, and endotoxin lowering, by removal or inactivation, might be beneficial to ameliorate the systemic inflammatory response during the acute phas...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15030074
更新日期：2017-03-15 00:00:00
abstract：:Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16070218
更新日期：2018-06-25 00:00:00
abstract：:Monostroma nitidum is a green single-cell layered algae that grows on the southwest coast of Japan. It is often used for salad ingredients, boiled tsukudani, soups, etc., due to its health benefits. M. nitidum is composed of many cell aggregates, and the various substances that fill the intercellular space are dietary...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md18040228
更新日期：2020-04-24 00:00:00
abstract：:Hepatic fibrosis is an effusive wound healing process, characterized by an excessive deposition of extracellular matrix (ECM), as the consequence of chronic liver injury of any etiology. Current therapeutic repertoire for hepatic fibrosis is limited to withdrawal of the noxious agent, which is not always feasible. Hen...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13085201
更新日期：2015-08-18 00:00:00
abstract：:Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was first recognized in a human case study of temporal lobe epilepsy after the 1987 amnesic shellfish-poisoning event in Quebec, and was characterized as a chronic...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md12031185
更新日期：2014-03-06 00:00:00
abstract：:The small-spotted catshark is one of the most abundant elasmobranchs in the Northeastern Atlantic Ocean. Although its landings are devoted for human consumption, in general this species has low commercial value with high discard rates, reaching 100% in some European fisheries. The reduction of post-harvest losses (dis...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17010040
更新日期：2019-01-09 00:00:00
abstract：:Two new nitrogen-containing metabolites, designated hatsusamide A (1) and B (2), were isolated from a culture broth of Penicilliumsteckii FKJ-0213 together with the known compounds tanzawaic acid B (3) and trichodermamide C (4) by physicochemical (PC) screening. The structures of 1 and 2 were determined as a tanzawaic...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18100513
更新日期：2020-10-12 00:00:00
abstract：:Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide diversity in scaffolds, beyond the polysaccharide framework. While ...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17030170
更新日期：2019-03-16 00:00:00
abstract：:Chemical investigation on the soft coral Sarcophyton sp. collected from the South China Sea yielded three new polyhydroxylated steroids, compounds (1-3), together with seven known ones (4-10). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related kn...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11124788
更新日期：2013-12-02 00:00:00
abstract：:Thirteen nitrogen-containing molecules (1a/1b and 2-12) were isolated from the Indonesian sponge Acanthostrongylophora ingens, highlighting the richness of this organism as a source of alkaloids. Their structures were elucidated using one- and two-dimensional NMR spectroscopy and HR-ESI-MS, while the stereochemistry o...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17080472
更新日期：2019-08-15 00:00:00
abstract：:Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine invertebrates, including bivalves. No human intoxication has been repo...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17070425
更新日期：2019-07-20 00:00:00
abstract：:The present study investigated the effect of dietary astaxanthin (AX) on the growth performance, antioxidant parameters, and repair of hepatopancreas damage in Pacific white shrimp (Litopenaeus vannamei). To evaluate the hepatopancreas protective function of AX in shrimps, we compared the effect of five isonitrogenous...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18040218
更新日期：2020-04-17 00:00:00
abstract：:Mouse bioassay is the official testing method to quantify paralytic shellfish toxins (PSTs) in bivalves. A number of alternative analytical methods have been reported. Some methods have been evaluated by a single laboratory validation. Among the different types of methods, chemical analyses are capable of identifying ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9030466
更新日期：2011-03-22 00:00:00
abstract：:Two new guaiazulene-based analogues, ochracenoids A (1) and B (2), along with four known analogues (3-6), were isolated from the gorgonian Anthogorgia ochracea collected from the South China Sea. The planar structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configuration ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12031569
更新日期：2014-03-14 00:00:00
abstract：:For a long time, fucoidan has been well known for its pharmacological activities, and recently low molecular weight fucoidan (LMF) has been used in food supplements and pharmaceutical products. In the present study, LMF was extracted from Laminaria japonica by enzyme hydrolysis. The toxicity of LMF in mouse and rat mo...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14070121
更新日期：2016-06-24 00:00:00
abstract：:Aaptos is a genus of marine sponge which belongs to Suberitidae and is distributed in tropical and subtropical oceans. Bioactivity-guided fractionation of Aaptos sp. methanolic extract resulted in the isolation of aaptamine, demethyloxyaaptamine, and isoaaptamine. The cytotoxic activity of the isolated compounds was e...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16010018
更新日期：2018-01-09 00:00:00
abstract：:An alginate lyase-producing bacterial strain, Pseudoalteromonas sp. SM0524, was screened from marine rotten kelp. In an optimized condition, the production of alginate lyase from Pseudoalteromonas sp. SM0524 reached 62.6 U/mL, suggesting that strain SM0524 is a good producer of alginate lyases. The bifunctional algina...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9010109
更新日期：2011-01-21 00:00:00
abstract：:The benefit of carotenoids to human health is undeniable and consequently, their use for this purpose is growing rapidly. Additionally, the nutraceutical properties of carotenoids have attracted attention of the food industry, especially in a new market area, the 'cosmeceuticals.' Marine organisms (microalgae, seaweed...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md16100397
更新日期：2018-10-22 00:00:00
abstract：:To sustainably produce marine fish with a high lipid quality rich in omega-3 fatty acids, alternative sources of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are being identified. Moreover, the use of bioactive compounds that would stimulate the in vivo fatty acid synthesis, such as resveratrol (RV), wou...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100379
更新日期：2018-10-10 00:00:00
