Abstract：
:Two new nitrogen-containing metabolites, designated hatsusamide A (1) and B (2), were isolated from a culture broth of Penicilliumsteckii FKJ-0213 together with the known compounds tanzawaic acid B (3) and trichodermamide C (4) by physicochemical (PC) screening. The structures of 1 and 2 were determined as a tanzawaic acid B-trichodermamide C hybrid structure and a new analog of aspergillazines, respectively. The absolute configuration of 1 was determined by comparing the values of tanzawaic acid B and trichodermamide C in the literatures, such as 1H-nuclear magnetic resonance (1H-NMR) data and optical rotation, after hydrolysis of 1. Compounds 1-4 were evaluated for cytotoxicity and anti-malarial activities. Compounds 1 and 3 exhibited weak anti-malarial activity at half-maximal inhibitory concentration (IC50) values of 27.2 and 78.5 µM against the K1 strain, and 27.9 and 79.2 µM against the FCR3 strain of Plasmodium falciparum, respectively. Furthermore, 1 exhibited cytotoxicity against HeLa S3, A549, Panc1, HT29 and H1299 cells, with IC50 values of 15.0, 13.7, 12.9, 6.8, and 18.7 μM, respectively.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Matsuo H,Hokari R,Ishiyama A,Iwatsuki M,Higo M,Nonaka K,Nagano Y,Takahashi Y,Ōmura S,Nakashima Tdoi
10.3390/md18100513subject
Has Abstractpub_date
2020-10-12 00:00:00issue
10issn
1660-3397pii
md18100513journal_volume
18pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Six regioisomers associated with the tricyclic core of thiaplakortones A-D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic core scaffolds presen...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13095784
更新日期：2015-09-15 00:00:00
abstract：:Astaxanthin captured peroxynitrite to form nitroastaxanthins. 15-Nitroastaxanthin was a major reaction product of astaxanthin with peroxynitrite. Here, the anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of 15-nitroastaxanthin were investigated. In addition to astaxanthin, 15-nitroastaxanthin s...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10061391
更新日期：2012-06-01 00:00:00
abstract：:Nemerteans (ribbon worms) employ toxins to subdue their prey, but research thus far has focused on the small-molecule components of mucus secretions and few protein toxins have been characterized. We carried out a preliminary proteotranscriptomic analysis of putative toxins produced by the hoplonemertean Amphiporus la...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18080407
更新日期：2020-08-01 00:00:00
abstract：:Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders. The (α3)2(β2)3 nAChR subunit arrangement comprises a pair of α3(+)β2(-) and β2(+)α3(-) interfaces, and a...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18070349
更新日期：2020-07-03 00:00:00
abstract：:Oceans have shown to be a remarkable source of natural products. The biological properties of many of these compounds have helped to produce great advances in medicinal chemistry. Within them, marine natural products containing an oxepanyl ring are present in a great variety of algae, sponges, fungus and corals and sh...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md15110361
更新日期：2017-11-15 00:00:00
abstract：:In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11114510
更新日期：2013-11-12 00:00:00
abstract：:In this study, thirteen sponge-derived terpenoids, including five linear furanoterpenes: furospinulosin-1 (1), furospinulosin-2 (2), furospongin-1 (3), furospongin-4 (4), and demethylfurospongin-4 (5); four linear meroterpenes: 2-(hexaprenylmethyl)-2-methylchromenol (6), 4-hydroxy-3-octaprenylbenzoic acid (7), 4-hydro...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md8010047
更新日期：2010-01-15 00:00:00
abstract：:There are numerous biologically active substances with novel structures and unique physiological functions in marine organisms. These substances are important sources of new lead compounds. Pelorol is a natural product isolated from marine organisms that possesses a novel structure with high bioactivity. In this paper...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14060118
更新日期：2016-06-21 00:00:00
abstract：:Gingival recession (GR) potentially leads to the exposure of tooth root to the oral cavity microenvironment and increases susceptibility to dental caries, dentin hypersensitivity, and other dental diseases. Even though many etiological factors were reported, the specific mechanism of GR is yet to be elucidated. Given ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030138
更新日期：2019-02-27 00:00:00
abstract：:For a long time, fucoidan has been well known for its pharmacological activities, and recently low molecular weight fucoidan (LMF) has been used in food supplements and pharmaceutical products. In the present study, LMF was extracted from Laminaria japonica by enzyme hydrolysis. The toxicity of LMF in mouse and rat mo...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14070121
更新日期：2016-06-24 00:00:00
abstract：:A chemical study of the ethyl acetate (EtOAc) extract from the deep-sea-derived fungus Penicilliumthomii YPGA3 led to the isolation of a new austalide meroterpenoid (1) and seven known analogues (28), two new labdane-type diterpenoids (9 and 10) and a known derivative (11). The structures of new compounds 1, 9, and 10...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18030164
更新日期：2020-03-16 00:00:00
abstract：:The marine environment is known as a rich source of chemical structures with numerous beneficial health effects. Among marine organisms, marine algae have been identified as an under-exploited plant resource, although they have long been recognized as valuable sources of structurally diverse bioactive compounds. Prese...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md9050803
更新日期：2011-01-01 00:00:00
abstract：:Carotenoids are lipid-soluble pigments that are produced in some plants, algae, fungi, and bacterial species, which accounts for their orange and yellow hues. Carotenoids are powerful antioxidants thanks to their ability to quench singlet oxygen, to be oxidized, to be isomerized, and to scavenge free radicals, which p...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md13106226
更新日期：2015-09-30 00:00:00
abstract：:Three new epidithiodiketopiperazines pretrichodermamides D-F (1-3), together with the known N-methylpretrichodermamide B (4) and pretrichodermamide С (5), were isolated from the lipophilic extract of the marine algae-derived fungus Penicillium sp. KMM 4672. The structures of compounds 1-5 were determined based on spec...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14070122
更新日期：2016-06-27 00:00:00
abstract：:Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kerma...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15070219
更新日期：2017-07-11 00:00:00
abstract：:Fucoidan is a polysaccharide built from L-fucose molecules. The main source of this polysaccharide is the extracellular matrix of brown seaweed (Phaeophyta), but it can be also isolated from invertebrates such as sea urchins (Echinoidea) and sea cucumbers (Holothuroidea). Interest in fucoidan is related to its broad b...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17080458
更新日期：2019-08-05 00:00:00
abstract：:Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14010001
更新日期：2015-12-22 00:00:00
abstract：:The present study is focused on the intestinal absorption of sea cucumber saponins. We determined the pharmacokinetic characteristics and bioavailability of Echinoside A and Holotoxin A₁; the findings indicated that the bioavailability of Holotoxin A₁ was lower than Echinoside A. We inferred that the differences in ch...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14060114
更新日期：2016-06-17 00:00:00
abstract：:We test previous claims that the bacteria Vibrio alginolyticus produces tetrodotoxin (TTX) when living in symbiosis with the nemertean Lineus longissimus by a setup with bacteria cultivation for TTX production. Toxicity experiments on the shore crab, Carcinus maenas, demonstrated the presence of a paralytic toxin, but...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14040063
更新日期：2016-03-25 00:00:00
abstract：:Two new sesterterpenes analogs, namely, 12-acetoxy,16-epi-hyrtiolide (1) and 12β-acetoxy,16β-methoxy,20α-hydroxy-17-scalaren-19,20-olide (2), containing a scalarane-based framework along with seven previously reported scalarane-type sesterterpenes (3-9) have been isolated from the sponge Hyrtios erectus (order Dictyoc...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14070130
更新日期：2016-07-08 00:00:00
abstract：:The development and use of topical microbicides potentially offers an additional strategy to reduce the spread of the Human Immunodeficiency Virus (HIV). Carbohydrate-binding agents (CBAs) that show specificity for high mannose carbohydrates on the surface of the heavily glycosylated envelope of HIV are endowed with p...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md10071476
更新日期：2012-07-01 00:00:00
abstract：:Sponges can provide potential drugs against many major world-wide occurring diseases. Despite the high potential of sponge derived drugs no sustainable production method has been developed. Thus far it is not fully understood why, when, where and how these metabolites are produced in sponges. For the near future sea-b...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md7040787
更新日期：2009-12-02 00:00:00
abstract：:Water extracts and polysaccharides from Anabaena sp., Ecklonia sp., and Jania sp. were tested for their activity against the fungal plant pathogen Botrytis cinerea. Water extracts at 2.5, 5.0, and 10.0 mg/mL inhibited B. cinerea growth in vitro. Antifungal activity of polysaccharides obtained by N-cetylpyridinium brom...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17050299
更新日期：2019-05-20 00:00:00
abstract：:Three myxobacterial strains, designated SWB004, SWB005 and SWB006, were obtained from beach sand samples from the Pacific Ocean and the North Sea. The strains were cultivated in salt water containing media and subjected to studies to determine their taxonomic status, the presence of genes for the biosynthesis of polyk...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md8092466
更新日期：2010-09-03 00:00:00
abstract：:A novel tetranorditerpenoid, sinubatin A (1) (having an unprecedented carbon skeleton), a new norditerpenoid, sinubatin B (2) (a 4,5-epoxycaryophyllene possessing an unusual methylfuran moiety side chain), and a known diterpenoid, gibberosin J (3) were isolated from soft coral Sinulariananolobata. The structures of th...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16020040
更新日期：2018-01-24 00:00:00
abstract：:Lung cancer is a leading cause of tumor-associated mortality. Fascaplysin, a bis-indole of a marine sponge, exhibit broad anticancer activity as specific CDK4 inhibitor among several other mechanisms, and is investigated as a drug to overcome chemoresistance after the failure of targeted agents or immunotherapy. The c...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100383
更新日期：2018-10-14 00:00:00
abstract：:To sustainably produce marine fish with a high lipid quality rich in omega-3 fatty acids, alternative sources of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are being identified. Moreover, the use of bioactive compounds that would stimulate the in vivo fatty acid synthesis, such as resveratrol (RV), wou...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100379
更新日期：2018-10-10 00:00:00
abstract：:To investigate a high cholesterol diet in Alzheimer's disease (AD) mice, they were fed with (2% cholesterol) in five groups with a control group, AD mice group, AD mice plus Meretrix lusoria group, AD mice plus Geloina eros group, and, AD mice plus Corbicula fluminea group for three months, and treated with the fatty ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16080263
更新日期：2018-08-01 00:00:00
abstract：:Using theonellasterol as a novel FXR antagonist hit, we prepared a series of semi-synthetic derivatives in order to gain insight into the structural requirements for exhibiting antagonistic activity. These derivatives are characterized by modification at the exocyclic carbon-carbon double bond at C-4 and at the hydrox...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10112448
更新日期：2012-11-05 00:00:00
abstract：:The methods to obtain chitooligosaccharides are tightly related to the physicochemical properties of the end products. Knowledge of these physicochemical characteristics is crucial to describing the biological functions of chitooligosaccharides. Chitooligosaccharides were prepared either in a single-step enzymatic hyd...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110430
更新日期：2018-11-02 00:00:00
