Anticancer Activity of Fascaplysin against Lung Cancer Cell and Small Cell Lung Cancer Circulating Tumor Cell Lines.


:Lung cancer is a leading cause of tumor-associated mortality. Fascaplysin, a bis-indole of a marine sponge, exhibit broad anticancer activity as specific CDK4 inhibitor among several other mechanisms, and is investigated as a drug to overcome chemoresistance after the failure of targeted agents or immunotherapy. The cytotoxic activity of fascaplysin was studied using lung cancer cell lines, primary Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC) cells, as well as SCLC circulating tumor cell lines (CTCs). This compound exhibited high activity against SCLC cell lines (mean IC50 0.89 µM), as well as SCLC CTCs as single cells and in the form of tumorospheres (mean IC50 0.57 µM). NSCLC lines showed a mean IC50 of 1.15 µM for fascaplysin. Analysis of signal transduction mediators point to an ATM-triggered signaling cascade provoked by drug-induced DNA damage. Fascaplysin reveals at least an additive cytotoxic effect with cisplatin, which is the mainstay of lung cancer chemotherapy. In conclusion, fascaplysin shows high activity against lung cancer cell lines and spheroids of SCLC CTCs which are linked to the dismal prognosis of this tumor type. Derivatives of fascaplysin may constitute valuable new agents for the treatment of lung cancer.


Mar Drugs


Marine drugs


Rath B,Hochmair M,Plangger A,Hamilton G




Has Abstract


2018-10-14 00:00:00










  • Potential anti-HPV and related cancer agents from marine resources: an overview.

    abstract::Recently, the studies on the prevention and treatment of human papillomavirus (HPV) which is closely related to the cervical cancer and other genital diseases are attracting more and more attention all over the world. Marine-derived polysaccharides and other bioactive compounds have been shown to possess a variety of ...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Wang SX,Zhang XS,Guan HS,Wang W

    更新日期:2014-04-03 00:00:00

  • Bioaccessibility of Marine Carotenoids.

    abstract::The benefit of carotenoids to human health is undeniable and consequently, their use for this purpose is growing rapidly. Additionally, the nutraceutical properties of carotenoids have attracted attention of the food industry, especially in a new market area, the 'cosmeceuticals.' Marine organisms (microalgae, seaweed...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Viera I,Pérez-Gálvez A,Roca M

    更新日期:2018-10-22 00:00:00

  • The Immune Activity of PT-Peptide Derived from Anti-Lipopolysaccharide Factor of the Swimming Crab Portunus trituberculatus Is Enhanced when Encapsulated in Milk-Derived Extracellular Vesicles.

    abstract::PT-peptide is derived from the anti-lipopolysaccharide factor of the swimming crab Portunus trituberculatus. The peptide, consisting of 34 amino acids, contains a lipopolysaccharide binding domain. In this study, we investigated the effect of PT-peptide encapsulated in raw milk-derived extracellular vesicles (EVs), de...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lee BH,Chen BR,Huang CT,Lin CH

    更新日期:2019-04-26 00:00:00

  • Algal lectins as potential HIV microbicide candidates.

    abstract::The development and use of topical microbicides potentially offers an additional strategy to reduce the spread of the Human Immunodeficiency Virus (HIV). Carbohydrate-binding agents (CBAs) that show specificity for high mannose carbohydrates on the surface of the heavily glycosylated envelope of HIV are endowed with p...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Huskens D,Schols D

    更新日期:2012-07-01 00:00:00

  • Pretrichodermamides D-F from a Marine Algicolous Fungus Penicillium sp. KMM 4672.

    abstract::Three new epidithiodiketopiperazines pretrichodermamides D-F (1-3), together with the known N-methylpretrichodermamide B (4) and pretrichodermamide С (5), were isolated from the lipophilic extract of the marine algae-derived fungus Penicillium sp. KMM 4672. The structures of compounds 1-5 were determined based on spec...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Yurchenko AN,Smetanina OF,Ivanets EV,Kalinovsky AI,Khudyakova YV,Kirichuk NN,Popov RS,Bokemeyer C,von Amsberg G,Chingizova EA,Afiyatullov SSh,Dyshlovoy SA

    更新日期:2016-06-27 00:00:00

  • Microginins from a Microcystis sp. Bloom Material Collected from the Kishon Reservoir, Israel.

    abstract::During blooms, cyanobacteria produce diverse modified peptides. Among these are the microginins, which inhibit zinc-containing metalloproteases. Ten microginins, microginins KR767 (1), KR801(2), KR835 (3), KR785 (4), KR604 (5), KR638 (6), KR781 (7), KR815 (8), FR3 (9), and FR4 (10), were isolated from the extract of a...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lodin-Friedman A,Carmeli S

    更新日期:2018-03-02 00:00:00

  • Astaxanthin attenuates the apoptosis of retinal ganglion cells in db/db mice by inhibition of oxidative stress.

    abstract::Diabetic retinopathy is a common diabetic eye disease caused by changes in retinal ganglion cells (RGCs). It is an ocular manifestation of systemic disease, which affects up to 80% of all patients who have had diabetes for 10 years or more. The genetically diabetic db/db mouse, as a model of type-2 diabetes, shows dia...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Dong LY,Jin J,Lu G,Kang XL

    更新日期:2013-03-21 00:00:00

  • Pseudoceratonic Acid and Moloka'iamine Derivatives from the Red Sea Verongiid Sponge Pseudoceratina arabica.

    abstract::During an investigation of the chemistry of the Red Sea Verongiid sponge Pseudoceratina arabica, we discovered a small molecule, pseudoceratonic acid (1), along with the new moloka'iamine derivatives, ceratinines N (2), O (3), and the previously reported compounds moloka'iamine (4), hydroxymoloka'iamine (5) and cerati...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Shaala LA,Youssef DTA

    更新日期:2020-10-23 00:00:00

  • Antiproliferative Scalarane-Based Metabolites from the Red Sea Sponge Hyrtios erectus.

    abstract::Two new sesterterpenes analogs, namely, 12-acetoxy,16-epi-hyrtiolide (1) and 12β-acetoxy,16β-methoxy,20α-hydroxy-17-scalaren-19,20-olide (2), containing a scalarane-based framework along with seven previously reported scalarane-type sesterterpenes (3-9) have been isolated from the sponge Hyrtios erectus (order Dictyoc...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Elhady SS,Al-Abd AM,El-Halawany AM,Alahdal AM,Hassanean HA,Ahmed SA

    更新日期:2016-07-08 00:00:00

  • Gliotoxin isolated from marine fungus Aspergillus sp. induces apoptosis of human cervical cancer and chondrosarcoma cells.

    abstract::Gliotoxin, a secondary metabolite produced by marine fungus Aspergillus sp., possesses various biological activities including anticancer activity. However, the mechanism underlying gliotoxin-induced cytotoxicity on human cervical cancer (Hela) and human chondrosarcoma (SW1353) cells remains unclear. In this study, we...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Nguyen VT,Lee JS,Qian ZJ,Li YX,Kim KN,Heo SJ,Jeon YJ,Park WS,Choi IW,Je JY,Jung WK

    更新日期:2013-12-24 00:00:00

  • Antiviral lead compounds from marine sponges.

    abstract::Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. They are usually produced by functional enzyme c...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Sagar S,Kaur M,Minneman KP

    更新日期:2010-10-11 00:00:00

  • Butenolide Derivatives with α-Glucosidase Inhibitions from the Deep-Sea-Derived Fungus Aspergillus terreus YPGA10.

    abstract::Three new butenolide derivatives, namely aspernolides N-P (1-3), together with six known analogues (4-9), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 1-3 were determined on the basis of comprehensive analyses of the nuclear...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Cheng Z,Li Y,Liu W,Liu L,Liu J,Yuan W,Luo Z,Xu W,Li Q

    更新日期:2019-06-03 00:00:00

  • A Place to Call Home: An Analysis of the Bacterial Communities in Two Tethya rubra Samaai and Gibbons 2005 Populations in Algoa Bay, South Africa.

    abstract::Sponges are important sources of bioactive secondary metabolites. These compounds are frequently synthesized by bacterial symbionts, which may be recruited from the surrounding seawater or transferred to the sponge progeny by the parent. In this study, we investigated the bacterial communities associated with the spon...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Waterworth SC,Jiwaji M,Kalinski JJ,Parker-Nance S,Dorrington RA

    更新日期:2017-03-25 00:00:00

  • Cultivation of Sponge-Associated Bacteria from Agelas sventres and Xestospongia muta Collected from Different Depths.

    abstract::Sponge-associated bacteria have been mostly cultured from shallow water (≤30 m) sponges, whereas only few studies targeted specimens from below 30 m. This study assessed the cultivability of bacteria from two marine sponges Xestospongia muta and Agelas sventres collected from shallow (<30 m), upper mesophotic (30-60 m...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Indraningrat AAG,Micheller S,Runderkamp M,Sauerland I,Becking LE,Smidt H,Sipkema D

    更新日期:2019-10-11 00:00:00

  • Vasorelaxation, induced by Dictyota pulchella (Dictyotaceae), a brown alga, is mediated via inhibition of calcium influx in rats.

    abstract::This study aimed to investigate the cardiovascular effects elicited by Dictyota pulchella, a brown alga, using in vivo and in vitro approaches. In normotensive conscious rats, CH(2)Cl(2)/MeOH Extract (CME, 5, 10, 20 and 40 mg/kg) from Dictyota pulchella produced dose-dependent hypotension (-4 ± 1; -8 ± 2; -53 ± 8 and ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Queiroz TM,Machado NT,Furtado FF,Oliveira-Filho AA,Alustau MC,Figueiredo CS,Miranda GE,Barbosa-Filho JM,Braga VA,Medeiros IA

    更新日期:2011-01-01 00:00:00

  • Preclinical and Clinical Studies on Antioxidative, Antihypertensive and Cardioprotective Effect of Marine Proteins and Peptides-A Review.

    abstract::High seafood consumption has traditionally been linked to a reduced risk of cardiovascular diseases, mainly due to the lipid lowering effects of the long chained omega 3 fatty acids. However, fish and seafood are also excellent sources of good quality proteins and emerging documentation show that, upon digestion, thes...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Jensen IJ,Mæhre HK

    更新日期:2016-11-18 00:00:00

  • Reclamation of Marine Chitinous Materials for the Production of α-Glucosidase Inhibitors via Microbial Conversion.

    abstract::Six kinds of chitinous materials have been used as sole carbon/nitrogen (C/N) sources for producing α-glucosidase inhibitors (aGI) by Paenibacillus sp. TKU042. The aGI productivity was found to be highest in the culture supernatants using demineralized crab shell powder (deCSP) and demineralized shrimp shell powder (d...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Nguyen VB,Wang SL

    更新日期:2017-11-07 00:00:00

  • Pinnatoxins' Deleterious Effects on Cholinergic Networks: From Experimental Models to Human Health.

    abstract::Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine invertebrates, including bivalves. No human intoxication has been repo...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Delcourt N,Lagrange E,Abadie E,Fessard V,Frémy JM,Vernoux JP,Peyrat MB,Maignien T,Arnich N,Molgó J,Mattei C

    更新日期:2019-07-20 00:00:00

  • Discovery of new eunicellin-based diterpenoids from a Formosan soft coral Cladiella sp.

    abstract::A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Chen TH,Lu MC,Chang YC,Su YD,Chen YH,Lin NC,Fang LS,Wu YC,Sung PJ

    更新日期:2013-11-14 00:00:00

  • Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim.

    abstract::A series of novel marinopyrroles with sulfide and sulphone spacers were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Fluorescence-quenching (FQ) assays confirmed the direct binding of...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Cheng C,Liu Y,Balasis ME,Garner TP,Li J,Simmons NL,Berndt N,Song H,Pan L,Qin Y,Nicolaou KC,Gavathiotis E,Sebti SM,Li R

    更新日期:2014-07-29 00:00:00

  • 4-Acetoxydolastane diterpene from the Brazilian brown alga Canistrocarpus cervicornis as antileishmanial agent.

    abstract::Natural marine products have shown an interesting array of diverse and novel chemical structures with potent biological activities. Our study reports the antiproliferative assays of crude extracts, fraction and pure compound (4R,9S,14S)-4α-acetoxy-9β,14α-dihydroxydolast-1(15),7-diene (1) obtained from brown alga Canis...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Dos Santos AO,Britta EA,Bianco EM,Ueda-Nakamura T,Filho BP,Pereira RC,Nakamura CV

    更新日期:2011-01-01 00:00:00

  • Metabolomic Insights into Marine Phytoplankton Diversity.

    abstract::The democratization of sequencing technologies fostered a leap in our knowledge of the diversity of marine phytoplanktonic microalgae, revealing many previously unknown species and lineages. The evolutionary history of the diversification of microalgae can be inferred from the analysis of their genome sequences. Howev...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Marcellin-Gros R,Piganeau G,Stien D

    更新日期:2020-01-25 00:00:00

  • Nutritional Profiling and the Value of Processing By-Products from Gilthead Sea Bream (Sparus aurata).

    abstract::Fish processing industries generate a large volume of discards. In order to fulfil with the principles of a sustainable circular economy, it is necessary to maintain aquaculture by-products in the food chain through the production of high-value biomolecules that can be used as novel ingredients. In this study, we try ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Pateiro M,Munekata PES,Domínguez R,Wang M,Barba FJ,Bermúdez R,Lorenzo JM

    更新日期:2020-02-04 00:00:00

  • Marine-Inspired Bis-indoles Possessing Antiproliferative Activity against Breast Cancer; Design, Synthesis, and Biological Evaluation.

    abstract::Diverse indoles and bis-indoles extracted from marine sources have been identified as promising anticancer leads. Herein, we designed and synthesized novel bis-indole series 7a-f and 9a-h as Topsentin and Nortopsentin analogs. Our design is based on replacing the heterocyclic spacer in the natural leads by a more flex...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Eldehna WM,Hassan GS,Al-Rashood ST,Alkahtani HM,A Almehizia A,Al-Ansary GH

    更新日期:2020-04-02 00:00:00

  • Antimicrobial Peptide Arenicin-1 Derivative Ar-1-(C/A) as Complement System Modulator.

    abstract::Antimicrobial peptides (AMPs) are not only cytotoxic towards host pathogens or cancer cells but also are able to act as immunomodulators. It was shown that some human and non-human AMPs can interact with complement proteins and thereby modulate complement activity. Thus, AMPs could be considered as the base for comple...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Krenev IA,Umnyakova ES,Eliseev IE,Dubrovskii YA,Gorbunov NP,Pozolotin VA,Komlev AS,Panteleev PV,Balandin SV,Ovchinnikova TV,Shamova OV,Berlov MN

    更新日期:2020-12-10 00:00:00

  • Antimicrobial activity of the marine alkaloids, clathrodin and oroidin, and their synthetic analogues.

    abstract::Marine organisms produce secondary metabolites that may be valuable for the development of novel drug leads as such and can also provide structural scaffolds for the design and synthesis of novel bioactive compounds. The marine alkaloids, clathrodin and oroidin, which were originally isolated from sponges of the genus...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Zidar N,Montalvão S,Hodnik Ž,Nawrot DA,Žula A,Ilaš J,Kikelj D,Tammela P,Mašič LP

    更新日期:2014-02-14 00:00:00

  • Fucosterol from an Edible Brown Alga Ecklonia stolonifera Prevents Soluble Amyloid Beta-Induced Cognitive Dysfunction in Aging Rats.

    abstract::Fucosterol from edible brown seaweeds has various biological activities, including anti-inflammatory, anti-adipogenic, antiphotoaging, anti-acetylcholinesterase, and anti-beta-secretase 1 activities. However, little is known about its effects on soluble amyloid beta peptide (sAβ)-induced endoplasmic reticulum (ER) str...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Oh JH,Choi JS,Nam TJ

    更新日期:2018-10-05 00:00:00

  • Next Generation Sequencing of Actinobacteria for the Discovery of Novel Natural Products.

    abstract::Like many fields of the biosciences, actinomycete natural products research has been revolutionised by next-generation DNA sequencing (NGS). Hundreds of new genome sequences from actinobacteria are made public every year, many of them as a result of projects aimed at identifying new natural products and their biosynth...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Gomez-Escribano JP,Alt S,Bibb MJ

    更新日期:2016-04-13 00:00:00

  • Biotechnological Potential of Cold Adapted Pseudoalteromonas spp. Isolated from 'Deep Sea' Sponges.

    abstract::The marine genus Pseudoalteromonas is known for its versatile biotechnological potential with respect to the production of antimicrobials and enzymes of industrial interest. We have sequenced the genomes of three Pseudoalteromonas sp. strains isolated from different deep sea sponges on the Illumina MiSeq platform. The...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Borchert E,Knobloch S,Dwyer E,Flynn S,Jackson SA,Jóhannsson R,Marteinsson VT,O'Gara F,Dobson ADW

    更新日期:2017-06-19 00:00:00

  • Astaxanthin Inhibits PC-3 Xenograft Prostate Tumor Growth in Nude Mice.

    abstract::Prostate cancer (PCa), the most common malignancy in men, is a major cause of cancer deaths. A better understanding of the mechanisms that drive tumor initiation and progression may identify actionable targets to improve treatment of this patient group. As a dietary carotenoid, astaxanthin has been demonstrated to exe...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ni X,Yu H,Wang S,Zhang C,Shen S

    更新日期:2017-03-08 00:00:00