Extraction, Identification, Modification, and Antibacterial Activity of Histone from Immature Testis of Atlantic salmon.

abstract：:Cyclic imines are lipophilic marine toxins that bioaccumulate in seafood. Their structure comprises a cyclic-imino moiety, responsible for acute neurotoxicity in mice. Cyclic imines have not been linked yet to human poisonings and are not regulated in Europe, although the European Food Safety Authority requires more d...

journal_title：Marine drugs

authors： García-Altares M,Casanova A,Bane V,Diogène J,Furey A,de la Iglesia P

更新日期：2014-06-23 00:00:00

abstract：:Sea cucumbers belonging to echinoderm are traditionally used as tonic food in China and other Asian countries. They produce abundant biologically active triterpene glycosides. More than 300 triterpene glycosides have been isolated and characterized from various species of sea cucumbers, which are classified as holosta...

journal_title：Marine drugs

authors： Mondol MAM,Shin HJ,Rahman MA,Islam MT

更新日期：2017-10-17 00:00:00

abstract：:The crustacean processing industry produces large quantities of waste by-products (up to 70%). Such wastes could be used as raw materials for producing chitosan, a polysaccharide with a unique set of biochemical properties. However, the preparation methods and the long-term stability of chitosan-based products limit t...

journal_title：Marine drugs

authors： Bardakova KN,Akopova TA,Kurkov AV,Goncharuk GP,Butnaru DV,Burdukovskii VF,Antoshin AA,Farion IA,Zharikova TM,Shekhter AB,Yusupov VI,Timashev PS,Rochev YA

更新日期：2019-01-10 00:00:00

abstract：:A novel sesquiterpenoid, rumphellaoic acid A (1), was isolated from the gorgonian coral Rumphella antipathies, and was found to possess a carbon skeleton that was obtained for the first time from a natural sources. The structure of 1 was elucidated by spectroscopic methods and this compound and was found to exert a mo...

journal_title：Marine drugs

authors： Chung HM,Wang WH,Hwang TL,Fang LS,Wen ZH,Chen JJ,Wu YC,Sung PJ

更新日期：2014-12-04 00:00:00

abstract：:Chlorophenols (CPs) are environmental pollutants that are produced through various anthropogenic activities and introduced in the environment. Living organisms, including humans, are exposed to these toxic xenobiotics and suffer from adverse health effects. More specifically, 2,4-dichlorophenol (2,4-DCP) is released i...

journal_title：Marine drugs

authors： Nikolaivits E,Agrafiotis A,Termentzi A,Machera K,Le Goff G,Álvarez P,Chavanich S,Benayahu Y,Ouazzani J,Fokialakis N,Topakas E

更新日期：2019-09-30 00:00:00

abstract：:The authors wish to correct Figure 1 in this paper [1] to be as follows:[...]. ...

journal_title：Marine drugs

authors： Zhang G,Cheng G,Jia P,Jiao S,Feng C,Hu T,Liu H,Du Y

更新日期：2017-09-20 00:00:00

abstract：:In this review, we focus on processes, organs and systems targeted by the marine toxins yessotoxin (YTX), okadaic acid (OA) and palytoxin (PTX). The effects of YTX and their basis are analyzed from data collected in the mollusc Mytilus galloprovincialis, the annelid Enchytraeus crypticus, Swiss CD1 mice and invertebra...

journal_title：Marine drugs

authors： Franchini A,Malagoli D,Ottaviani E

更新日期：2010-03-16 00:00:00

abstract：:Most giant groupers in the market are derived from inbred stock. Inbreeding can cause trait depression, compromising the animals' fitness and disease resistance, obligating farmers to apply increased amounts of drugs. In order to solve this problem, a pedigree classification method is needed. Here, microsatellite and ...

journal_title：Marine drugs

authors： Kuo HC,Hsu HH,Chua CS,Wang TY,Chen YM,Chen TY

更新日期：2014-04-30 00:00:00

abstract：:Diabetes mellitus is a group of metabolic disorders of the endocrine system characterised by hyperglycaemia. Type II diabetes mellitus (T2DM) constitutes the majority of diabetes cases around the world and are due to unhealthy diet, sedentary lifestyle, as well as rise of obesity in the population, which warrants the ...

journal_title：Marine drugs

authors： Sharifuddin Y,Chin YX,Lim PE,Phang SM

更新日期：2015-08-21 00:00:00

abstract：:Natural marine products have shown an interesting array of diverse and novel chemical structures with potent biological activities. Our study reports the antiproliferative assays of crude extracts, fraction and pure compound (4R,9S,14S)-4α-acetoxy-9β,14α-dihydroxydolast-1(15),7-diene (1) obtained from brown alga Canis...

journal_title：Marine drugs

authors： Dos Santos AO,Britta EA,Bianco EM,Ueda-Nakamura T,Filho BP,Pereira RC,Nakamura CV

更新日期：2011-01-01 00:00:00

abstract：:Marine biotoxin-contaminated seafood has caused thousands of poisonings worldwide this century. Given these threats, there is an increasing need for improved technologies that can be easily integrated into coastal monitoring programs. This study evaluates approaches for monitoring toxins associated with recurrent toxi...

journal_title：Marine drugs

authors： Hattenrath-Lehmann TK,Lusty MW,Wallace RB,Haynes B,Wang Z,Broadwater M,Deeds JR,Morton SL,Hastback W,Porter L,Chytalo K,Gobler CJ

更新日期：2018-01-13 00:00:00

abstract：:Natural O-alkyl-glycerolipids, also known as alkyl-ether-lipids (AEL), feature a long fatty alkyl chain linked to the glycerol unit by an ether bond. AEL are ubiquitously found in different tissues but, are abundant in shark liver oil, breast milk, red blood cells, blood plasma, and bone marrow. Only a few AEL are com...

journal_title：Marine drugs

authors： Pinault M,Guimaraes C,Couthon H,Thibonnet J,Fontaine D,Chantôme A,Chevalier S,Besson P,Jaffrès PA,Vandier C

更新日期：2018-03-23 00:00:00

abstract：:Kelps are colonized by a wide range of microbial symbionts. Among them, endophytic fungi remain poorly studied, but recent studies evidenced yet their high diversity and their central role in algal defense against various pathogens. Thus, studying the metabolic expressions of kelp endophytes under different conditions...

journal_title：Marine drugs

authors： Vallet M,Meziane T,Thiney N,Prado S,Hubas C

更新日期：2020-07-22 00:00:00

abstract：:A novel tetranorditerpenoid, sinubatin A (1) (having an unprecedented carbon skeleton), a new norditerpenoid, sinubatin B (2) (a 4,5-epoxycaryophyllene possessing an unusual methylfuran moiety side chain), and a known diterpenoid, gibberosin J (3) were isolated from soft coral Sinulariananolobata. The structures of th...

journal_title：Marine drugs

authors： Hsu FY,Wang SK,Duh CY

更新日期：2018-01-24 00:00:00

abstract：:The vast oceans of the world, which comprise a huge variety of unique ecosystems, are emerging as a rich and relatively untapped source of novel bioactive compounds with invaluable biotechnological and pharmaceutical potential. Evidence accumulated over the last decade has revealed that the diversity of marine microor...

journal_title：Marine drugs

authors： Reen FJ,Gutiérrez-Barranquero JA,Dobson AD,Adams C,O'Gara F

更新日期：2015-05-13 00:00:00

abstract：:In tumor development, the degradation of heparan sulfate (HS) by heparanase (HPSE) is associated with cell-surface and extracellular matrix remodeling as well as the release of HS-bound signaling molecules, allowing cancer cell migration, invasion and angiogenesis. Because of their structural similarity with HS, sulfa...

journal_title：Marine drugs

authors： Groult H,Cousin R,Chot-Plassot C,Maura M,Bridiau N,Piot JM,Maugard T,Fruitier-Arnaudin I

更新日期：2019-02-27 00:00:00

abstract：:Ten new di-, tri- and tetrasulfated triterpene glycosides, psolusosides B1 (1), B2 (2), J (3), K (4), L (5), M (6), N (7), O (8), P (9), and Q (10), were isolated from the sea cucumber Psolus fabricii collected in the Sea of Okhotsk near the Kurile Islands. Structures of these glycosides were established by two-dimens...

journal_title：Marine drugs

authors： Silchenko AS,Kalinovsky AI,Avilov SA,Kalinin VI,Andrijaschenko PV,Dmitrenok PS,Popov RS,Chingizova EA

更新日期：2019-11-06 00:00:00

abstract：:Application of cytostatics in cancer patients' chemotherapy results in a number of side effects, including the inhibition of various parts of hematopoiesis. Two sulfated polysaccharides, fucoidan from the seaweed Chordaria flagelliformis (PS-Fuc) and fucosylated chondroitin sulfate from the sea cucumber Massinium magn...

journal_title：Marine drugs

authors： Anisimova N,Ustyuzhanina N,Bilan M,Donenko F,Usov A,Kiselevskiy M,Nifantiev N

更新日期：2017-09-30 00:00:00

abstract：:In our search for quorum-sensing (QS) disrupting molecules, 75 fungal isolates were recovered from reef organisms (endophytes), saline lakes and mangrove rhizosphere. Their QS inhibitory activity was evaluated in Chromobacterium violaceum CVO26. Four strains of endophytic fungi stood out for their potent activity at c...

journal_title：Marine drugs

authors： Martín-Rodríguez AJ,Reyes F,Martín J,Pérez-Yépez J,León-Barrios M,Couttolenc A,Espinoza C,Trigos A,Martín VS,Norte M,Fernández JJ

更新日期：2014-11-19 00:00:00

abstract：:The carbonic anhydrase (CA, EC 4.2.1.1) superfamily of metalloenzymes catalyzes the hydration of carbon dioxide to bicarbonate and protons. The catalytically active form of these enzymes incorporates a metal hydroxide derivative, the formation of which is the rate-determining step of catalytic reaction, being affected...

journal_title：Marine drugs

authors： Perfetto R,Del Prete S,Vullo D,Sansone G,Barone CMA,Rossi M,Supuran CT,Capasso C

更新日期：2017-08-28 00:00:00

abstract：:Seagrasses are high plants sharing adaptive metabolic features with both terrestrial plants and marine algae, resulting in a phytocomplex possibly endowed with interesting biological properties. The aim of this study is to evaluate the in vitro activities on skin cells of an ethanolic extract obtained from the leaves ...

journal_title：Marine drugs

authors： Cornara L,Pastorino G,Borghesi B,Salis A,Clericuzio M,Marchetti C,Damonte G,Burlando B

更新日期：2018-01-10 00:00:00

abstract：:For a long time, fucoidan has been well known for its pharmacological activities, and recently low molecular weight fucoidan (LMF) has been used in food supplements and pharmaceutical products. In the present study, LMF was extracted from Laminaria japonica by enzyme hydrolysis. The toxicity of LMF in mouse and rat mo...

journal_title：Marine drugs

authors： Hwang PA,Yan MD,Lin HT,Li KL,Lin YC

更新日期：2016-06-24 00:00:00

abstract：:Aurantiochytrium limacinum, a marine heterotrophic protist/microalga has shown interesting yields of docosahexaenoic acid (DHA) when cultured with different carbon sources: glucose, pure and crude glycerol. A complete study in a lab-scale fermenter allowed for the characterization and comparison of the growth kinetic ...

journal_title：Marine drugs

authors： Abad S,Turon X

更新日期：2015-12-05 00:00:00

abstract：:Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A-E (1-5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of th...

journal_title：Marine drugs

authors： Meng LH,Zhang P,Li XM,Wang BG

更新日期：2015-01-07 00:00:00

abstract：:Two new sesterterpenes analogs, namely, 12-acetoxy,16-epi-hyrtiolide (1) and 12β-acetoxy,16β-methoxy,20α-hydroxy-17-scalaren-19,20-olide (2), containing a scalarane-based framework along with seven previously reported scalarane-type sesterterpenes (3-9) have been isolated from the sponge Hyrtios erectus (order Dictyoc...

journal_title：Marine drugs

authors： Elhady SS,Al-Abd AM,El-Halawany AM,Alahdal AM,Hassanean HA,Ahmed SA

更新日期：2016-07-08 00:00:00

abstract：:Three new aryl alkaloids named suberitamides A-C (1-3), were isolated from an extract of the marine sponge Pseudosuberites sp. collected along the coast of North Carolina. Their planar structures were established by extensive nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis. To assign the challengi...

journal_title：Marine drugs

authors： Kim CK,Wang D,Wilson BAP,Saurí J,Voeller D,Lipkowitz S,O'Keefe BR,Gustafson KR

更新日期：2020-10-28 00:00:00

abstract：:Genome mining has become an increasingly powerful, scalable, and economically accessible tool for the study of natural product biosynthesis and drug discovery. However, there remain important biological and practical problems that can complicate or obscure biosynthetic analysis in genomic and metagenomic sequencing pr...

journal_title：Marine drugs

authors： Miller IJ,Chevrette MG,Kwan JC

更新日期：2017-06-06 00:00:00

abstract：:Fucoidan is a polysaccharide built from L-fucose molecules. The main source of this polysaccharide is the extracellular matrix of brown seaweed (Phaeophyta), but it can be also isolated from invertebrates such as sea urchins (Echinoidea) and sea cucumbers (Holothuroidea). Interest in fucoidan is related to its broad b...

journal_title：Marine drugs

authors： Citkowska A,Szekalska M,Winnicka K

更新日期：2019-08-05 00:00:00

abstract：:Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. They are usually produced by functional enzyme c...

journal_title：Marine drugs

authors： Sagar S,Kaur M,Minneman KP

更新日期：2010-10-11 00:00:00

abstract：:Two new indole-diterpenoids (1 and 2) and a new isocoumarin (3), along with the known β-aflatrem (4), paspalinine (5), leporin B (6), α-cyclopiazonic acid (7), iso-α-cyclopiazonic acid (8), ditryptophenaline (9), aflatoxin B1 (10), 7-O-acetylkojic acid (11) and kojic acid (12), were isolated from the fermentation brot...

journal_title：Marine drugs

authors： Sun K,Li Y,Guo L,Wang Y,Liu P,Zhu W

更新日期：2014-06-30 00:00:00