4-Acetoxydolastane diterpene from the Brazilian brown alga Canistrocarpus cervicornis as antileishmanial agent.


:Natural marine products have shown an interesting array of diverse and novel chemical structures with potent biological activities. Our study reports the antiproliferative assays of crude extracts, fraction and pure compound (4R,9S,14S)-4α-acetoxy-9β,14α-dihydroxydolast-1(15),7-diene (1) obtained from brown alga Canistrocarpus cervicornis showing the antileishmanial activity. We showed that 1 had a dose-dependent activity during 72 h of treatment, exhibiting IC(50) of 2.0 μg/mL, 12.0 μg/mL, and 4.0 μg/mL for promastigote, axenic amastigote and intracellular amastigote forms of Leishmania amazonensis, respectively. A cytotoxicity assay showed that the action of the isolated compound 1 was 93.0 times less toxic to the macrophage than to the protozoan. Additionally, compound 1 induced ultrastructural changes, including extensive mitochondrial damage; decrease in Rh123 fluorescence, suggesting interference with the mitochondrial membrane potential; and lipid peroxidation in parasite cells. The use of 1 from C. cervicornis against L. amazonensis parasites might be of great interest as a future alternative to the development of new antileishmanial drugs.


Mar Drugs


Marine drugs


Dos Santos AO,Britta EA,Bianco EM,Ueda-Nakamura T,Filho BP,Pereira RC,Nakamura CV




Has Abstract


2011-01-01 00:00:00












  • Fatty Acid Composition and Fatty Acid Associated Gene-Expression in Gilthead Sea Bream (Sparus aurata) are Affected by Low-Fish Oil Diets, Dietary Resveratrol, and Holding Temperature.

    abstract::To sustainably produce marine fish with a high lipid quality rich in omega-3 fatty acids, alternative sources of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are being identified. Moreover, the use of bioactive compounds that would stimulate the in vivo fatty acid synthesis, such as resveratrol (RV), wou...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Torno C,Staats S,Michl SC,de Pascual-Teresa S,Izquierdo M,Rimbach G,Schulz C

    更新日期:2018-10-10 00:00:00

  • Costatone C-A New Halogenated Monoterpene from the New Zealand Red Alga Plocamium angustum.

    abstract::Red algae of the genus Plocamium have been a rich source of halogenated monoterpenes. Herein, a new cyclic monoterpene, costatone C (7), was isolated from the extract of P. angustum collected in New Zealand, along with the previously reported (1E,5Z)-1,6-dichloro-2-methylhepta-1,5-dien-3-ol (8). Elucidation of the pla...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bracegirdle J,Sohail Z,Fairhurst MJ,Gerth ML,Zuccarello GC,Ali Hashmi M,Keyzers RA

    更新日期:2019-07-19 00:00:00

  • Optimization of Collagenase Production by Pseudoalteromonas sp. SJN2 and Application of Collagenases in the Preparation of Antioxidative Hydrolysates.

    abstract::Collagenases are the most important group of commercially-produced enzymes. However, even though biological resources are abundant in the sea, very few of these commercially popular enzymes are from marine sources, especially from marine bacteria. We optimized the production of marine collagenases by Pseudoalteromonas...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Yang X,Xiao X,Liu D,Wu R,Wu C,Zhang J,Huang J,Liao B,He H

    更新日期:2017-12-04 00:00:00

  • Phylogenetic identification of fungi isolated from the marine sponge Tethya aurantium and identification of their secondary metabolites.

    abstract::Fungi associated with the marine sponge Tethya aurantium were isolated and identified by morphological criteria and phylogenetic analyses based on internal transcribed spacer (ITS) regions. They were evaluated with regard to their secondary metabolite profiles. Among the 81 isolates which were characterized, members o...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wiese J,Ohlendorf B,Blümel M,Schmaljohann R,Imhoff JF

    更新日期:2011-01-01 00:00:00

  • Shrimp lipids: a source of cancer chemopreventive compounds.

    abstract::Shrimp is one of the most popular seafoods worldwide, and its lipids have been studied for biological activity in both, muscle and exoskeleton. Free fatty acids, triglycerides, carotenoids, and other lipids integrate this fraction, and some of these compounds have been reported with cancer chemopreventive activities. ...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: López-Saiz CM,Suárez-Jiménez GM,Plascencia-Jatomea M,Burgos-Hernández A

    更新日期:2013-10-16 00:00:00

  • Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, a marine algae derived bromophenol, inhibits the growth of Botrytis cinerea and interacts with DNA molecules.

    abstract::Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE) is a bromophenol isolated from marine algae. Previous reports have shown that BDDE possesses cytotoxic and antibacterial activity. In the present study, we demonstrate that BDDE displays broad-spectrum antifungal activities, especially on Botrytis cinerea. BDDE inhibit...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Liu M,Wang G,Xiao L,Xu X,Liu X,Xu P,Lin X

    更新日期:2014-06-27 00:00:00

  • Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from Chlorella Pyrenoidosa.

    abstract::Oxidative stress contributes to chronic inflammatory processes implicated in aging, referred to as "inflamm-aging." In this study, the potential anti-inflammatory and anti-aging effects of a pigment-protein complex (PPC) from Chlorella pyrenoidosa were investigated using lipopolysaccharide (LPS)-stimulated RAW 264.7 m...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Zhang R,Chen J,Mao X,Qi P,Zhang X

    更新日期:2019-10-16 00:00:00

  • Brown Algae Padina sanctae-crucis Børgesen: A Potential Nutraceutical.

    abstract::Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and h...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Nogueira RBSS,Tomaz ACA,Pessoa DR,Xavier AL,Pita JCLR,Sobral MV,Pontes MLC,Pessôa HLF,Diniz MFFM,Miranda GEC,Vieira MAR,Marques MOM,Souza MFV,Cunha EVL

    更新日期:2017-09-26 00:00:00

  • Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones.

    abstract::The potential anti-tumor agent wentilactones were produced by a newly isolated marine fungus Aspergillus dimorphicus. This fungus was derived from deep-sea sediment and identified by polyphasic approach, combining phenotypic, molecular, and extrolite profiles. However, wentilactone production was detected only under s...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Xu R,Xu GM,Li XM,Li CS,Wang BG

    更新日期:2015-11-19 00:00:00

  • New Invasive Nemertean Species (Cephalothrix Simula) in England with High Levels of Tetrodotoxin and a Microbiome Linked to Toxin Metabolism.

    abstract::The marine nemertean Cephalothrix simula originates from the Pacific Ocean but in recent years has been discovered in northern Europe. The species has been associated with high levels of the marine neurotoxin Tetrodotoxin, traditionally associated with Pufferfish Poisoning. This study reports the first discovery of tw...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Turner AD,Fenwick D,Powell A,Dhanji-Rapkova M,Ford C,Hatfield RG,Santos A,Martinez-Urtaza J,Bean TP,Baker-Austin C,Stebbing P

    更新日期:2018-11-16 00:00:00

  • Sinulolides A-H, new cyclopentenone and butenolide derivatives from soft coral Sinularia sp.

    abstract::Eight new compounds, sinulolides A-H (1-8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were d...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Yang B,Wei X,Huang J,Lin X,Liu J,Liao S,Wang J,Zhou X,Wang L,Liu Y

    更新日期:2014-10-23 00:00:00

  • Natural product research in the Australian marine invertebrate Dicathais orbita.

    abstract::The predatory marine gastropod Dicathais orbita has been the subject of a significant amount of biological and chemical research over the past five decades. Natural products research on D. orbita includes the isolation and identification of brominated indoles and choline esters as precursors of Tyrian purple, as well ...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Benkendorff K

    更新日期:2013-04-23 00:00:00

  • Optimization of Growth and Carotenoid Production by Haloferax mediterranei Using Response Surface Methodology.

    abstract::Haloferax mediterranei produces C50 carotenoids that have strong antioxidant properties. The response surface methodology (RSM) tool helps to accurately analyze the most suitable conditions to maximize C50 carotenoids production by haloarchaea. The effects of temperature (15⁻50 °C), pH (4-10), and salinity (5⁻28% NaCl...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Montero-Lobato Z,Ramos-Merchante A,Fuentes JL,Sayago A,Fernández-Recamales Á,Martínez-Espinosa RM,Vega JM,Vílchez C,Garbayo I

    更新日期:2018-10-09 00:00:00

  • New lobane and cembrane diterpenes from two comorian soft corals.

    abstract::Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fr...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bonnard I,Jhaumeer-Laulloo SB,Bontemps N,Banaigs B,Aknin M

    更新日期:2010-02-23 00:00:00

  • Absorption and Transport of Sea Cucumber Saponins from Apostichopus japonicus.

    abstract::The present study is focused on the intestinal absorption of sea cucumber saponins. We determined the pharmacokinetic characteristics and bioavailability of Echinoside A and Holotoxin A₁; the findings indicated that the bioavailability of Holotoxin A₁ was lower than Echinoside A. We inferred that the differences in ch...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Li S,Wang Y,Jiang T,Wang H,Yang S,Lv Z

    更新日期:2016-06-17 00:00:00

  • Biotransfer of β-N-methylamino-L-alanine (BMAA) in a eutrophicated freshwater lake.

    abstract::β-N-Methylamino-L-alanine (BMAA), a neurotoxic non-protein amino acid, plays a significant role as an environmental risk factor in neurodegenerative diseases, such as amyotrophic lateral sclerosis. BMAA producers occur globally, colonizing almost all habitats and represent species from distinct phytoplanktonic groups,...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lage S,Annadotter H,Rasmussen U,Rydberg S

    更新日期:2015-03-02 00:00:00

  • Pharmacokinetics of Jaspine B and Enhancement of Intestinal Absorption of Jaspine B in the Presence of Bile Acid in Rats.

    abstract::We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal absorption, distribution, metabolism, and excretion of Jaspine B in rats. The oral bioavailability of Jaspine B was 6.2%, but it decreased to 1.6% in bile-depleted rats and increased to 41.2% (normal) and 23.5% (bile-depleted)...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Choi MK,Lee J,Nam SJ,Kang YJ,Han Y,Choi K,Choi YA,Kwon M,Lee D,Song IS

    更新日期:2017-09-01 00:00:00

  • Cloning of the Bisucaberin B Biosynthetic Gene Cluster from the Marine Bacterium Tenacibaculum mesophilum, and Heterologous Production of Bisucaberin B.

    abstract::The biosynthetic gene cluster for bisucaberin B (1, bsb gene cluster), an N-hydroxy-N-succinyl diamine (HSD)-based siderophore, was cloned from the marine bacterium Tenacibaculum mesophilum, originated from a marine sponge. The bsb gene cluster consists of six open reading frames (ORFs), in contrast to the four ORFs t...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Fujita MJ,Goto Y,Sakai R

    更新日期:2018-09-19 00:00:00

  • Topical Formulation Comprising Fatty Acid Extract from Cod Liver Oil: Development, Evaluation and Stability Studies.

    abstract::The purpose of this study was to develop a pharmaceutical formulation containing fatty acid extract rich in free omega-3 fatty acids such as eicosapentaenoic acid and docosahexaenoic acid for topical use. Although the health benefits of cod liver oil and other fish oils taken orally as a dietary supplement have been a...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ilievska B,Loftsson T,Hjalmarsdottir MA,Asgrimsdottir GM

    更新日期:2016-06-01 00:00:00

  • Anti-Fatigue Effect by Peptide Fraction from Protein Hydrolysate of Croceine Croaker (Pseudosciaena crocea) Swim Bladder through Inhibiting the Oxidative Reactions including DNA Damage.

    abstract::The swim bladder of the croceine croaker (Pseudosciaena crocea) was believed to have good curative effects in various diseases, including amnesia, insomnia, dizziness, anepithymia, and weakness after giving birth, in traditional Chinese medicine. However, there is no research focusing on the antioxidant and anti-fatig...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Zhao YQ,Zeng L,Yang ZS,Huang FF,Ding GF,Wang B

    更新日期:2016-12-13 00:00:00

  • Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives.

    abstract::Marine sponges belonging to the phylum Porifera (Metazoa), evolutionarily the oldest animals are the single best source of marine natural products. The present review presents a comprehensive overview of the source, taxonomy, country of origin or geographical position, chemical class, and biological activity of sponge...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Mehbub MF,Lei J,Franco C,Zhang W

    更新日期:2014-08-19 00:00:00

  • Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim.

    abstract::A series of novel marinopyrroles with sulfide and sulphone spacers were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Fluorescence-quenching (FQ) assays confirmed the direct binding of...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Cheng C,Liu Y,Balasis ME,Garner TP,Li J,Simmons NL,Berndt N,Song H,Pan L,Qin Y,Nicolaou KC,Gavathiotis E,Sebti SM,Li R

    更新日期:2014-07-29 00:00:00

  • Design, synthesis and evaluation of new marine alkaloid-derived pentacyclic structures with anti-tumoral potency.

    abstract::This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1-11 were evaluated for their in vitro cytotoxic activity...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Boucle S,Melin C,Clastre M,Guillard J

    更新日期:2015-01-19 00:00:00

  • Potential anti-HPV and related cancer agents from marine resources: an overview.

    abstract::Recently, the studies on the prevention and treatment of human papillomavirus (HPV) which is closely related to the cervical cancer and other genital diseases are attracting more and more attention all over the world. Marine-derived polysaccharides and other bioactive compounds have been shown to possess a variety of ...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Wang SX,Zhang XS,Guan HS,Wang W

    更新日期:2014-04-03 00:00:00

  • Synthesis and Evaluation of Spumigin Analogues Library with Thrombin Inhibitory Activity.

    abstract::Spumigins are marine natural products derived from cyanobacteria Nodulariaspumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation of spumigins showed that spumigins with a (2S,4S)-4-methylproline...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Žula A,Będziak I,Kikelj D,Ilaš J

    更新日期:2018-10-27 00:00:00

  • Algal lectins as potential HIV microbicide candidates.

    abstract::The development and use of topical microbicides potentially offers an additional strategy to reduce the spread of the Human Immunodeficiency Virus (HIV). Carbohydrate-binding agents (CBAs) that show specificity for high mannose carbohydrates on the surface of the heavily glycosylated envelope of HIV are endowed with p...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Huskens D,Schols D

    更新日期:2012-07-01 00:00:00

  • Identification and characterization of an anti-fibrotic benzopyran compound isolated from mangrove-derived Streptomyces xiamenensis.

    abstract::An anti-fibrotic compound produced by Streptomycesn xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis. The compound, N-[[3,4-dihydro-3S-hydroxy-2S-methyl-2-(4'R-methyl-3'S-pentenyl)-2H-1-benzopyran-6-yl]carbonyl]-threonine (1), was isolated from crude extracts...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Xu MJ,Liu XJ,Zhao YL,Liu D,Xu ZH,Lang XM,Ao P,Lin WH,Yang SL,Zhang ZG,Xu J

    更新日期:2012-03-01 00:00:00

  • Marine Natural Products from the Yucatan Peninsula.

    abstract::Mexico is one of the three areas of the world with the greatest terrestrial and cultural biological diversity. The diversity of Mexican medicinal flora has been studied for a long time and several bioactive compounds have been isolated. The investigation of marine resources, and particularly the potential of Mexican m...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Pech-Puch D,Pérez-Povedano M,Lenis-Rojas OA,Rodríguez J,Jiménez C

    更新日期:2020-01-16 00:00:00

  • Fucus vesiculosus and Ascophyllum nodosum Ameliorate Liver Function by Reducing Diet-Induced Steatosis in Rats.

    abstract::The Asian coastal communities have used the brown seaweeds Fucus vesiculosus and Ascophyllum nodosum since ancient times. Recently, some in vitro and in vivo studies have demonstrated their abilities in reducing risk factors for metabolic syndrome. Here, we analyzed the protective effect of a phytocomplex extracted fr...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Gabbia D,Saponaro M,Sarcognato S,Guido M,Ferri N,Carrara M,De Martin S

    更新日期:2020-01-17 00:00:00

  • Total Synthesis of Pulmonarin B and Design of Brominated Phenylacetic Acid/Tacrine Hybrids: Marine Pharmacophore Inspired Discovery of New ChE and Aβ Aggregation Inhibitors.

    abstract::A marine natural product, pulmonarin B (1), and a series of related tacrine hybrid analogues were synthesized and evaluated as cholinesterase (ChE) inhibitors. The in vitro ChE assay results revealed that 1 showed moderate dual acetylcholinesterase (AChE)/ butyrylcholinesterase (BChE) inhibitory activity, while the hy...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Cheng ZQ,Song JL,Zhu K,Zhang J,Jiang CS,Zhang H

    更新日期:2018-08-21 00:00:00