Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636.

abstract：:There are numerous biologically active substances with novel structures and unique physiological functions in marine organisms. These substances are important sources of new lead compounds. Pelorol is a natural product isolated from marine organisms that possesses a novel structure with high bioactivity. In this paper...

journal_title：Marine drugs

authors： Luo Y,Chen H,Weng J,Lu G

更新日期：2016-06-21 00:00:00

abstract：:To sustainably produce marine fish with a high lipid quality rich in omega-3 fatty acids, alternative sources of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are being identified. Moreover, the use of bioactive compounds that would stimulate the in vivo fatty acid synthesis, such as resveratrol (RV), wou...

journal_title：Marine drugs

authors： Torno C,Staats S,Michl SC,de Pascual-Teresa S,Izquierdo M,Rimbach G,Schulz C

更新日期：2018-10-10 00:00:00

abstract：:The dinoflagellate Dinophysis spp. is responsible for diarrhetic shellfish poisoning (DSP). In the bivalves exposed to the toxic bloom of the dinoflagellate, dinophysistoxin 3 (DTX3), the 7-OH acylated form of either okadaic acid (OA) or DTX1, is produced. We demonstrated in vitro acylation of OA with palmitoyl CoA in...

journal_title：Marine drugs

authors： Konoki K,Onoda T,Watanabe R,Cho Y,Kaga S,Suzuki T,Yotsu-Yamashita M

更新日期：2013-01-29 00:00:00

abstract：:The aim of the present work was to load a Hibiscus sabdariffa (HS) hydroalcoholic extract into in situ gelling formulations for the treatment of oral mucositis and esophagitis. Such formulations, selected as the most promising options in a previous work of ours, were composed by κ-carrageenan (κ-CG), a sulfated marine...

journal_title：Marine drugs

authors： Vigani B,Rossi S,Gentile M,Sandri G,Bonferoni MC,Cavalloro V,Martino E,Collina S,Ferrari F

更新日期：2019-03-05 00:00:00

abstract：:Despite the increasing availability of new classes of cancer treatment, such as immune- and targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic drugs with improved pharmacological profiles that can also overcome drug resistant forms of cancer. In this study, we have identifi...

journal_title：Marine drugs

authors： Aldairi AF,Ogundipe OD,Pye DA

更新日期：2018-02-15 00:00:00

abstract：:A novel tetranorditerpenoid, sinubatin A (1) (having an unprecedented carbon skeleton), a new norditerpenoid, sinubatin B (2) (a 4,5-epoxycaryophyllene possessing an unusual methylfuran moiety side chain), and a known diterpenoid, gibberosin J (3) were isolated from soft coral Sinulariananolobata. The structures of th...

journal_title：Marine drugs

authors： Hsu FY,Wang SK,Duh CY

更新日期：2018-01-24 00:00:00

abstract：BACKGROUND:Parenteral nutrition is often a mandatory therapeutic strategy for cases of septicemia. Likewise, therapeutic application of anti-oxidants, anti-inflammatory therapy, and endotoxin lowering, by removal or inactivation, might be beneficial to ameliorate the systemic inflammatory response during the acute phas...

journal_title：Marine drugs

authors： Bonaterra GA,Driscoll D,Schwarzbach H,Kinscherf R

更新日期：2017-03-15 00:00:00

abstract：:Cone snail venoms are considered an untapped reservoir of extremely diverse peptides, named conopeptides, displaying a wide array of pharmacological activities. We report here for the first time, the presence of high molecular weight compounds that participate in the envenomation cocktail used by these marine snails. ...

journal_title：Marine drugs

authors： Violette A,Leonardi A,Piquemal D,Terrat Y,Biass D,Dutertre S,Noguier F,Ducancel F,Stöcklin R,Križaj I,Favreau P

更新日期：2012-02-01 00:00:00

abstract：:Cyanobacteria are a diverse group of Gram-negative bacteria that produce an array of secondary compounds with selective bioactivity against vertebrates, invertebrates, plants, microalgae, fungi, bacteria, viruses and cell lines. The aim of this study was to assess the toxic effects of aqueous, methanolic and hexane cr...

journal_title：Marine drugs

authors： Lopes VR,Fernández N,Martins RF,Vasconcelos V

更新日期：2010-03-05 00:00:00

abstract：:Soft corals are common marine organisms that inhabit tropical and subtropical oceans. They are shown to be rich source of secondary metabolites with biological activities. In this work, soft corals from two geographical locations were investigated using ¹H-NMR spectroscopy coupled with multivariate statistical analysi...

journal_title：Marine drugs

authors： He Q,Sun R,Liu H,Geng Z,Chen D,Li Y,Han J,Lin W,Du S,Deng Z

更新日期：2014-03-28 00:00:00

abstract：:Diabetes mellitus is a group of metabolic disorders of the endocrine system characterised by hyperglycaemia. Type II diabetes mellitus (T2DM) constitutes the majority of diabetes cases around the world and are due to unhealthy diet, sedentary lifestyle, as well as rise of obesity in the population, which warrants the ...

journal_title：Marine drugs

authors： Sharifuddin Y,Chin YX,Lim PE,Phang SM

更新日期：2015-08-21 00:00:00

abstract：:Diverse indoles and bis-indoles extracted from marine sources have been identified as promising anticancer leads. Herein, we designed and synthesized novel bis-indole series 7a-f and 9a-h as Topsentin and Nortopsentin analogs. Our design is based on replacing the heterocyclic spacer in the natural leads by a more flex...

journal_title：Marine drugs

authors： Eldehna WM,Hassan GS,Al-Rashood ST,Alkahtani HM,A Almehizia A,Al-Ansary GH

更新日期：2020-04-02 00:00:00

abstract：:A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolit...

journal_title：Marine drugs

authors： Lacret R,Oves-Costales D,Gómez C,Díaz C,de la Cruz M,Pérez-Victoria I,Vicente F,Genilloud O,Reyes F

更新日期：2014-12-29 00:00:00

abstract：:The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter str...

journal_title：Marine drugs

authors： Schulz S,Dickschat JS,Kunze B,Wagner-Dobler I,Diestel R,Sasse F

更新日期：2010-12-22 00:00:00

abstract：:Death-associated protein kinase 1 (DAPK1) expression induced by diverse death stimuli mediates apoptotic activity in various cancers, including ovarian cancer. In addition, mutual interaction between the tumor suppressor p53 and DAPK1 influences survival and death in several cancer cell lines. However, the exact role ...

journal_title：Marine drugs

authors： Park GB,Jeong JY,Kim D

更新日期：2019-07-12 00:00:00

abstract：:The marine nemertean Cephalothrix simula originates from the Pacific Ocean but in recent years has been discovered in northern Europe. The species has been associated with high levels of the marine neurotoxin Tetrodotoxin, traditionally associated with Pufferfish Poisoning. This study reports the first discovery of tw...

journal_title：Marine drugs

authors： Turner AD,Fenwick D,Powell A,Dhanji-Rapkova M,Ford C,Hatfield RG,Santos A,Martinez-Urtaza J,Bean TP,Baker-Austin C,Stebbing P

更新日期：2018-11-16 00:00:00

abstract：:It is proven that β-amyloid (Aβ) aggregates containing cross-β-sheet structures led to oxidative stress, neuroinflammation, and neuronal loss via multiple pathways. Therefore, reduction of Aβ neurotoxicity via inhibiting aggregation of Aβ or dissociating toxic Aβ aggregates into nontoxic forms might be effective thera...

journal_title：Marine drugs

authors： Zhu L,Li R,Jiao S,Wei J,Yan Y,Wang ZA,Li J,Du Y

更新日期：2020-09-25 00:00:00

abstract：:The cultivation of macroalgae to supply the biofuel, pharmaceutical or food industries generates a considerable amount of organic residue, which represents a potential substrate for biomethanation. Its use optimizes the total resource exploitation by the simultaneous disposal of waste biomaterials. In this study, we e...

journal_title：Marine drugs

authors： Barbot YN,Thomsen C,Thomsen L,Benz R

更新日期：2015-09-18 00:00:00

abstract：:Marine organisms produce secondary metabolites that may be valuable for the development of novel drug leads as such and can also provide structural scaffolds for the design and synthesis of novel bioactive compounds. The marine alkaloids, clathrodin and oroidin, which were originally isolated from sponges of the genus...

journal_title：Marine drugs

authors： Zidar N,Montalvão S,Hodnik Ž,Nawrot DA,Žula A,Ilaš J,Kikelj D,Tammela P,Mašič LP

更新日期：2014-02-14 00:00:00

abstract：:The marine opisthobranch Scaphander lignarius has been analyzed in the systematic search for novel bioactive compounds in Arctic marine organisms using bioassay guided fractionation. A number of highly cytotoxic fractions were shown to contain mainly polyunsaturated fatty acids (PUFAs). Selected PUFAs were isolated an...

journal_title：Marine drugs

authors： Vasskog T,Andersen JH,Hansen E,Svenson J

更新日期：2012-12-01 00:00:00

abstract：:Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing infarct size and reinforcing antioxidant defenses. The aim of this work was to determine the combin...

journal_title：Marine drugs

authors： Herrera EA,Farías JG,González-Candia A,Short SE,Carrasco-Pozo C,Castillo RL

更新日期：2015-02-04 00:00:00

abstract：:The present survey deals with the initial stage of the calcification process in bone and other hard tissues, with special reference to the organic-inorganic relationship and the transformation that the early inorganic particles undergo as the process moves towards completion. Electron microscope studies clearly exclud...

journal_title：Marine drugs

authors： Bonucci E

更新日期：2014-07-23 00:00:00

abstract：:Topical administration of drugs into the vagina can provide local therapy of vaginal infections, preventing the possible systemic side effects of the drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, and thus it can be utilized in ...

journal_title：Marine drugs

authors： Jøraholmen MW,Bhargava A,Julin K,Johannessen M,Škalko-Basnet N

更新日期：2020-01-31 00:00:00

abstract：:Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels. Recently we reported a high-throughput method to identify 215 conotoxin transcripts from the Chinese tubular cone snail, C. betulinus. Here, based ...

journal_title：Marine drugs

authors： Huang Y,Peng C,Yi Y,Gao B,Shi Q

更新日期：2017-07-18 00:00:00

abstract：:Marine ecosystems are the most prevalent ecosystems on the planet, providing a diversity of living organisms and resources. The development of nanotechnology may provide solutions for utilizing these thousands of potential compounds as marine pharmaceuticals. Here, we designed a liposomal glycol chitosan formulation t...

journal_title：Marine drugs

authors： Kim MW,Niidome T,Lee R

更新日期：2019-10-12 00:00:00

abstract：:Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 1-4 were characterized using comprehens...

journal_title：Marine drugs

authors： Fang F,Zhao J,Ding L,Huang C,Naman CB,He S,Wu B,Zhu P,Luo Q,Gerwick WH,Yan X,Wang Q,Zhang Z,Cui W

更新日期：2017-08-19 00:00:00

abstract：:The biosynthetic gene cluster for bisucaberin B (1, bsb gene cluster), an N-hydroxy-N-succinyl diamine (HSD)-based siderophore, was cloned from the marine bacterium Tenacibaculum mesophilum, originated from a marine sponge. The bsb gene cluster consists of six open reading frames (ORFs), in contrast to the four ORFs t...

journal_title：Marine drugs

authors： Fujita MJ,Goto Y,Sakai R

更新日期：2018-09-19 00:00:00

abstract：:The aim of this research was to prepare and characterize alginate-chitosan mucoadhesive microparticles containing puerarin. The microparticles were prepared by an emulsification-internal gelatin method using a combination of chitosan and Ca2+ as cationic components and alginate as anions. Surface morphology, particle ...

journal_title：Marine drugs

authors： Hou JY,Gao LN,Meng FY,Cui YL

更新日期：2014-12-01 00:00:00

abstract：:TNF-related apoptosis-inducing ligand (TRAIL) is a tumor-selective apoptosis inducer and has been shown to be promising for treating various types of cancers. However, the application of TRAIL is greatly impeded by the resistance of cancer cells to its action. Studies show that overexpression of some critical pro-surv...

journal_title：Marine drugs

authors： Liu J,Ma L,Wu N,Liu G,Zheng L,Lin X

更新日期：2014-09-25 00:00:00

abstract：:Lipid A is a fundamental Gram-negative outer membrane component and the essential element of lipopolysaccharide (endotoxin), a potent immunostimulatory molecule. This work describes the metabolic adaptation of the lipid A acyl structure by Psychrobacter cryohalolentis at various temperatures in its facultative psychro...

journal_title：Marine drugs

authors： Sweet CR,Watson RE,Landis CA,Smith JP

更新日期：2015-07-30 00:00:00