Abstract:
:The aim of the present work was to load a Hibiscus sabdariffa (HS) hydroalcoholic extract into in situ gelling formulations for the treatment of oral mucositis and esophagitis. Such formulations, selected as the most promising options in a previous work of ours, were composed by κ-carrageenan (κ-CG), a sulfated marine polymer able to gelify in presence of saliva ions, hydroxypropyl cellulose (HPC), used as mucoadhesive agent, and CaCl₂, salt able to enhance the interaction κ-CG/saliva ions. HS extract, which is rich in phytochemicals such as polyphenols, polysaccharides and organic acids, was selected due to its antioxidant and anti-inflammatory properties. For HS extraction, three different methodologies (maceration, Ultrasound Assisted Extraction (UAE) and Microwave Assisted Extraction (MAE)) were compared in terms of extraction yield and extract antioxidant activity, revealing that MAE was the best procedure. Rheological and mucoadhesive properties of HS-loaded formulations were investigated. Such formulations were characterized by a low viscosity at 25 °C, guaranteeing an easy administration, a proper in situ gelation behavior and marked elastic and mucoadhesive properties at 37 °C, functional to a protective action towards the damaged mucosa. Finally, the biocompatibility and the proliferative effect of HS-loaded formulations, as well as their antioxidant and anti-inflammatory properties, were proved in vitro on human dermal fibroblasts.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Vigani B,Rossi S,Gentile M,Sandri G,Bonferoni MC,Cavalloro V,Martino E,Collina S,Ferrari Fdoi
10.3390/md17030153subject
Has Abstractpub_date
2019-03-05 00:00:00issue
3issn
1660-3397pii
md17030153journal_volume
17pub_type
杂志文章相关文献
Marine Drugs文献大全abstract::Astaxanthin is one of the strongest natural antioxidants and a red pigment occurring in nature. This C40 carotenoid is used in a broad range of applications such as a colorant in the feed industry, an antioxidant in cosmetics or as a supplement in human nutrition. Natural astaxanthin is on the rise and, hence, alterna...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17110621
更新日期:2019-10-31 00:00:00
abstract::To date, studies describing myxobacterial secondary metabolites have been relatively scarce in comparison to those addressing actinobacterial secondary metabolites. This realization suggests the immense potential of myxobacteria as an intriguing source of secondary metabolites with unusual structural features and a wi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17120698
更新日期:2019-12-12 00:00:00
abstract::Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferat...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15110342
更新日期:2017-11-01 00:00:00
abstract::The democratization of sequencing technologies fostered a leap in our knowledge of the diversity of marine phytoplanktonic microalgae, revealing many previously unknown species and lineages. The evolutionary history of the diversification of microalgae can be inferred from the analysis of their genome sequences. Howev...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18020078
更新日期:2020-01-25 00:00:00
abstract::Oceans have shown to be a remarkable source of natural products. The biological properties of many of these compounds have helped to produce great advances in medicinal chemistry. Within them, marine natural products containing an oxepanyl ring are present in a great variety of algae, sponges, fungus and corals and sh...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md15110361
更新日期:2017-11-15 00:00:00
abstract::Lipid A is a fundamental Gram-negative outer membrane component and the essential element of lipopolysaccharide (endotoxin), a potent immunostimulatory molecule. This work describes the metabolic adaptation of the lipid A acyl structure by Psychrobacter cryohalolentis at various temperatures in its facultative psychro...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13084701
更新日期:2015-07-30 00:00:00
abstract::PT-peptide is derived from the anti-lipopolysaccharide factor of the swimming crab Portunus trituberculatus. The peptide, consisting of 34 amino acids, contains a lipopolysaccharide binding domain. In this study, we investigated the effect of PT-peptide encapsulated in raw milk-derived extracellular vesicles (EVs), de...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17050248
更新日期:2019-04-26 00:00:00
abstract::Three new epidithiodiketopiperazines pretrichodermamides D-F (1-3), together with the known N-methylpretrichodermamide B (4) and pretrichodermamide С (5), were isolated from the lipophilic extract of the marine algae-derived fungus Penicillium sp. KMM 4672. The structures of compounds 1-5 were determined based on spec...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14070122
更新日期:2016-06-27 00:00:00
abstract::Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18020084
更新日期:2020-01-27 00:00:00
abstract::Three new aryl alkaloids named suberitamides A-C (1-3), were isolated from an extract of the marine sponge Pseudosuberites sp. collected along the coast of North Carolina. Their planar structures were established by extensive nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis. To assign the challengi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18110536
更新日期:2020-10-28 00:00:00
abstract::Gut microbiota has been proved to be an indispensable link between nutrient excess and metabolic syndrome, and chitin oligosaccharide (NACOS) has displayed therapeutic effects on multiple diseases such as cancer and gastritis. In this study, we aim to confirm whether NACOS can ameliorate high-fat diet (HFD)-induced me...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16020066
更新日期:2018-02-19 00:00:00
abstract::The skin, the largest organ in humans, is exposed to major sources of outdoor air pollution, such as fine particulate matter with a diameter ≤ 2.5 µm (PM2.5). Diphlorethohydroxycarmalol (DPHC), a marine-based compound, possesses multiple activities including antioxidant effects. In the present study, we evaluated the ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17020095
更新日期:2019-02-01 00:00:00
abstract::Topical administration of drugs into the vagina can provide local therapy of vaginal infections, preventing the possible systemic side effects of the drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, and thus it can be utilized in ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18020096
更新日期:2020-01-31 00:00:00
abstract::In recent years, noteworthy research has been performed around lipids from microalgae. Among lipids, glycolipids (GLs) are quite abundant in microalgae and are considered an important source of fatty acids (FAs). GLs are rich in 16- and 18-carbon saturated and unsaturated fatty acids and often contain polyunsaturated ...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14050101
更新日期:2016-05-19 00:00:00
abstract::Omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs), such as eicosapentaenoic acid (EPA) (20:5n-3) and docosahexaenoic acid (DHA) (22:6n-3), are considered essential for human health. Microorganisms are the primary producers of omega-3 fatty acids in marine ecosystems, representing a sustainable source of these ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18020099
更新日期:2020-02-01 00:00:00
abstract::Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing infarct size and reinforcing antioxidant defenses. The aim of this work was to determine the combin...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13020838
更新日期:2015-02-04 00:00:00
abstract::Chemical investigation of the methanol extract of the Vietnamese marine sponge Ircinia echinata led to the isolation of six new 9α-hydroxy-5α,6α-epoxysterols: 5α,6α-epoxycholesta-7,22(E)-dien-3β,9α-diol (1), 5α,6α-epoxycholesta-7,24(28)-dien-3β,9α-diol (2), (24R)-5α,6α-epoxy-24-ethyl-cholesta-7-en-3β,9α-diol (3), 5α,6...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16110424
更新日期:2018-11-01 00:00:00
abstract::Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increa...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md15110354
更新日期:2017-11-10 00:00:00
abstract::Eight new compounds, sinulolides A-H (1-8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were d...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12105316
更新日期:2014-10-23 00:00:00
abstract::The present study investigated the effect of dietary astaxanthin (AX) on the growth performance, antioxidant parameters, and repair of hepatopancreas damage in Pacific white shrimp (Litopenaeus vannamei). To evaluate the hepatopancreas protective function of AX in shrimps, we compared the effect of five isonitrogenous...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18040218
更新日期:2020-04-17 00:00:00
abstract::The development of oxidative stress in the marine ecosystem is a concurring concern in fish reproductive behavior. Marine fish being rich in polyunsaturated fatty acids (PUFA) are precursors of prostaglandin pheromone mediators but also vulnerable to lipid peroxidation. It is yet to be determined if hypoxia or hyperox...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13042215
更新日期:2015-04-14 00:00:00
abstract::In this review, we focus on processes, organs and systems targeted by the marine toxins yessotoxin (YTX), okadaic acid (OA) and palytoxin (PTX). The effects of YTX and their basis are analyzed from data collected in the mollusc Mytilus galloprovincialis, the annelid Enchytraeus crypticus, Swiss CD1 mice and invertebra...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md8030658
更新日期:2010-03-16 00:00:00
abstract::This work aimed at improving the targeting and cytotoxicity of simvastatin (SMV) against colon cancer cells. SMV was encapsulated in chitosan polymers, followed by eudragit S100 microparticles. The release of SMV double coated microparticles was dependent on time and pH. At pH 7.4 maximum release was observed for 6 h....
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18040226
更新日期:2020-04-24 00:00:00
abstract::The marine environment is host to unparalleled biological and chemical diversity, making it an attractive resource for the discovery of new therapeutics for a plethora of diseases. Compounds that are extracted from cyanobacteria are of special interest due to their unique structural scaffolds and capacity to produce p...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14010017
更新日期:2016-01-12 00:00:00
abstract::A series of novel marinopyrroles with sulfide and sulphone spacers were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Fluorescence-quenching (FQ) assays confirmed the direct binding of...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12084311
更新日期:2014-07-29 00:00:00
abstract::Dysregulation of the Wnt/β-catenin signaling pathway is involved in the development of human hepatocellular carcinoma and has thus emerged as a therapeutic target for this malignant tumor. In this study, we employed sensitive cell-based assays to identify aplykurodin A isolated from Aplysia kurodai as an antagonist of...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18040210
更新日期:2020-04-13 00:00:00
abstract::Four new cembrane-type diterpenoids, sarcophyolides B-E (1-4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1-4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocraso...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11093186
更新日期:2013-08-26 00:00:00
abstract::Chondroitinase (ChSase), a type of glycosaminoglycan (GAG) lyase, can degrade chondroitin sulfate (CS) to unsaturate oligosaccharides, with various functional activities. In this study, ChSase AC II from a newly isolated marine bacterium Arthrobacter sp. CS01 was cloned, expressed in Pichia pastoris X33, purified, and...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030185
更新日期:2019-03-20 00:00:00
abstract::Polymeric 3-alkylpyridinium salts (poly-APS) present in the marine sponge Reniera sarai show a broad spectrum of biological activities. They are lytic to erythrocytes and various other mammalian cells, enabling the transfection of the latter with alien DNA. Furthermore, they show inhibitory effects to marine bacteria ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:
更新日期:2007-11-13 00:00:00
abstract::Two strains of Azadinium poporum, one from the Korean West coast and the other from the North Sea, were mass cultured for isolation of new azaspiracids. Approximately 0.9 mg of pure AZA-36 (1) and 1.3 mg of pure AZA-37 (2) were isolated from the Korean (870 L) and North Sea (120 L) strains, respectively. The structure...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13116687
更新日期:2015-10-30 00:00:00