Abstract:
:Marine ecosystems are the most prevalent ecosystems on the planet, providing a diversity of living organisms and resources. The development of nanotechnology may provide solutions for utilizing these thousands of potential compounds as marine pharmaceuticals. Here, we designed a liposomal glycol chitosan formulation to load both doxorubicin (DOX) and rapamycin (RAPA), and then evaluated its therapeutic potential in a prepared drug-resistant cell model. We explored the stability of the drug delivery system by changing the physiological conditions and characterized its physicochemical properties. The electrostatic complexation between DOX-glycol chitosan and docosahexaenoic acid RAPA-liposomes (GC-DOX/RAPA ω-liposomes) was precisely regulated, resulting in particle size of 131.3 nm and zeta potential of -14.5 mV. The well-characterized structure of GC-DOX/RAPA ω-liposomes led to high loading efficiencies of 4.1% for DOX and 6.2% for RAPA. Also, GC-DOX/RAPA ω-liposomes exhibited high colloidal stability under physiological conditions and synergistic anti-cancer effects on DOX-resistant MDA-MB-231 cells, while showing pH-sensitive drug release behavior. Our results provided a viable example of marine pharmaceuticals with therapeutic potential for treating drug-resistant tumors using an efficient and safe drug delivery system.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Kim MW,Niidome T,Lee Rdoi
10.3390/md17100581subject
Has Abstractpub_date
2019-10-12 00:00:00issue
10issn
1660-3397pii
md17100581journal_volume
17pub_type
杂志文章相关文献
Marine Drugs文献大全abstract::Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide diversity in scaffolds, beyond the polysaccharide framework. While ...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md17030170
更新日期:2019-03-16 00:00:00
abstract::Concerning the requirements of effective drug candidates to combat against high rising multidrug resistant pathogens, we isolated three new linear lipopeptides, gageostatins A-C (1-3), consisting of hepta-peptides and new 3-β-hydroxy fatty acids from the fermentation broth of a marine-derived bacterium Bacillus subtil...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12020871
更新日期:2014-01-31 00:00:00
abstract::A series of novel marinopyrroles with sulfide and sulphone spacers were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Fluorescence-quenching (FQ) assays confirmed the direct binding of...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12084311
更新日期:2014-07-29 00:00:00
abstract::The geographic position, highly fluctuating sea temperatures and hypersalinity make Persian Gulf an extreme environment. Although this unique environment has high biodiversity dominated by invertebrates, its potential in marine biodiscovery has largely remained untapped. Herein, we aimed at a detailed analysis of the ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18070366
更新日期:2020-07-16 00:00:00
abstract::The swim bladder of the croceine croaker (Pseudosciaena crocea) was believed to have good curative effects in various diseases, including amnesia, insomnia, dizziness, anepithymia, and weakness after giving birth, in traditional Chinese medicine. However, there is no research focusing on the antioxidant and anti-fatig...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14120221
更新日期:2016-12-13 00:00:00
abstract::The role of the marine environment in the development of anticancer drugs has been widely reviewed, particularly in recent years. However, the innovation in terms of clinical benefits has not been duly emphasized, although there are important breakthroughs associated with the use of marine-derived anticancer agents th...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md17060329
更新日期:2019-06-02 00:00:00
abstract::Ten new di-, tri- and tetrasulfated triterpene glycosides, psolusosides B1 (1), B2 (2), J (3), K (4), L (5), M (6), N (7), O (8), P (9), and Q (10), were isolated from the sea cucumber Psolus fabricii collected in the Sea of Okhotsk near the Kurile Islands. Structures of these glycosides were established by two-dimens...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17110631
更新日期:2019-11-06 00:00:00
abstract::Microalgae are promising sources for the sustainable production of compounds of interest for biotechnologies. Compared to higher plants, microalgae have a faster growth rate and can be grown in industrial photobioreactors. The microalgae biomass contains specific metabolites of high added value for biotechnology such ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16030076
更新日期:2018-02-28 00:00:00
abstract::Collagenases are the most important group of commercially-produced enzymes. However, even though biological resources are abundant in the sea, very few of these commercially popular enzymes are from marine sources, especially from marine bacteria. We optimized the production of marine collagenases by Pseudoalteromonas...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15120377
更新日期:2017-12-04 00:00:00
abstract::Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferat...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15110342
更新日期:2017-11-01 00:00:00
abstract::The marine environment is host to unparalleled biological and chemical diversity, making it an attractive resource for the discovery of new therapeutics for a plethora of diseases. Compounds that are extracted from cyanobacteria are of special interest due to their unique structural scaffolds and capacity to produce p...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14010017
更新日期:2016-01-12 00:00:00
abstract::We test previous claims that the bacteria Vibrio alginolyticus produces tetrodotoxin (TTX) when living in symbiosis with the nemertean Lineus longissimus by a setup with bacteria cultivation for TTX production. Toxicity experiments on the shore crab, Carcinus maenas, demonstrated the presence of a paralytic toxin, but...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14040063
更新日期:2016-03-25 00:00:00
abstract::In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11114510
更新日期:2013-11-12 00:00:00
abstract::Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing infarct size and reinforcing antioxidant defenses. The aim of this work was to determine the combin...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13020838
更新日期:2015-02-04 00:00:00
abstract::Two novel biscembranoids, sarelengans A and B (1 and 2), five new cembranoids, sarelengans C-G (3-7), along with two known cembranoids (8 and 9) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 wer...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15040085
更新日期:2017-03-23 00:00:00
abstract::Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kerma...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15070219
更新日期:2017-07-11 00:00:00
abstract::Isolation of marine compounds from living invertebrates represents a major challenge for sustainable and environmentally friendly exploitation of marine bio-resources. To develop innovative technology to trap invertebrate compounds in the open sea, the proof of concept of a system combining external continuous circula...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16050152
更新日期:2018-05-06 00:00:00
abstract::In order to search for sulfated polysaccharides in different invertebrate connective tissues and to examine their biological activities, we have isolated three types of polysaccharides from the body wall of the three sea cucumbers Holothuria edulis, Apostichopus japonicas and Holothuria nobilis. The physicochemical pr...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11020399
更新日期:2013-02-05 00:00:00
abstract::Like many fields of the biosciences, actinomycete natural products research has been revolutionised by next-generation DNA sequencing (NGS). Hundreds of new genome sequences from actinobacteria are made public every year, many of them as a result of projects aimed at identifying new natural products and their biosynth...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14040078
更新日期:2016-04-13 00:00:00
abstract::Two strains of Azadinium poporum, one from the Korean West coast and the other from the North Sea, were mass cultured for isolation of new azaspiracids. Approximately 0.9 mg of pure AZA-36 (1) and 1.3 mg of pure AZA-37 (2) were isolated from the Korean (870 L) and North Sea (120 L) strains, respectively. The structure...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13116687
更新日期:2015-10-30 00:00:00
abstract::Marine sponges belonging to the phylum Porifera (Metazoa), evolutionarily the oldest animals are the single best source of marine natural products. The present review presents a comprehensive overview of the source, taxonomy, country of origin or geographical position, chemical class, and biological activity of sponge...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12084539
更新日期:2014-08-19 00:00:00
abstract::Sponges can provide potential drugs against many major world-wide occurring diseases. Despite the high potential of sponge derived drugs no sustainable production method has been developed. Thus far it is not fully understood why, when, where and how these metabolites are produced in sponges. For the near future sea-b...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md7040787
更新日期:2009-12-02 00:00:00
abstract::In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacter...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md9030294
更新日期:2011-02-25 00:00:00
abstract::Mexico is one of the three areas of the world with the greatest terrestrial and cultural biological diversity. The diversity of Mexican medicinal flora has been studied for a long time and several bioactive compounds have been isolated. The investigation of marine resources, and particularly the potential of Mexican m...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18010059
更新日期:2020-01-16 00:00:00
abstract::Mycothiazole, a polyketide metabolite isolated from the marine sponge Cacospongia mycofijiensis, is a potent inhibitor of metabolic activity and mitochondrial electron transport chain complex I in sensitive cells, but other cells are relatively insensitive to the drug. Sensitive cell lines (IC(50) 0.36-13.8 nM) includ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10040900
更新日期:2012-04-01 00:00:00
abstract::In recent years, due to an expansion of antibiotic-resistant microorganisms, there has been growing interest in biodegradable and antibacterial polymers that can be used in selected biomedical applications. The present work describes the synthesis of antimicrobial polylactide-copper alginate (PLA-ALG-Cu2+) composite f...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18120660
更新日期:2020-12-21 00:00:00
abstract::The nutritional and pharmaceutical values of long-chain polyunsaturated fatty acids (LC-PUFAs) such as arachidonic, eicosapentaenoic and docosahexaenoic acids have been well recognized. These LC-PUFAs are physiologically important compounds in bacteria and eukaryotes. Although little is known about the biosynthetic me...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14050094
更新日期:2016-05-12 00:00:00
abstract::We have searched for special characteristics in growth, protein expression, fatty acids and volatile organic compounds (VOCs) in a local Phaeodactylum tricornutum Bohlin strain (Bergen Marine Biobank), by comparing it with a common accession strain (CCAP). Differences in growth and expressed proteins were detected bet...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14010009
更新日期:2015-12-30 00:00:00
abstract::Oxidative stress contributes to chronic inflammatory processes implicated in aging, referred to as "inflamm-aging." In this study, the potential anti-inflammatory and anti-aging effects of a pigment-protein complex (PPC) from Chlorella pyrenoidosa were investigated using lipopolysaccharide (LPS)-stimulated RAW 264.7 m...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17100586
更新日期:2019-10-16 00:00:00
abstract::Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was first recognized in a human case study of temporal lobe epilepsy after the 1987 amnesic shellfish-poisoning event in Quebec, and was characterized as a chronic...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12031185
更新日期:2014-03-06 00:00:00