Antimicrobial and Anti-Proliferative Effects of Skin Mucus Derived from Dasyatis pastinaca (Linnaeus, 1758).

abstract：:The carbonic anhydrase (CA, EC 4.2.1.1) superfamily of metalloenzymes catalyzes the hydration of carbon dioxide to bicarbonate and protons. The catalytically active form of these enzymes incorporates a metal hydroxide derivative, the formation of which is the rate-determining step of catalytic reaction, being affected...

journal_title：Marine drugs

authors： Perfetto R,Del Prete S,Vullo D,Sansone G,Barone CMA,Rossi M,Supuran CT,Capasso C

更新日期：2017-08-28 00:00:00

abstract：:Natural phenolic compounds are important classes of plant, microorganism, and algal secondary metabolites. They have well-documented beneficial biological activities. The marine environment is less explored than other environments but have huge potential for the discovery of new unique compounds with potential applica...

journal_title：Marine drugs

authors： Getachew AT,Jacobsen C,Holdt SL

更新日期：2020-07-27 00:00:00

abstract：:Seaweeds have attracted high interest in recent years due to their chemical and bioactive properties to find new molecules with valuable applications for humankind. Phenolic compounds are the group of metabolites with the most structural variation and the highest content in seaweeds. The most researched seaweed polyph...

journal_title：Marine drugs

authors： Cotas J,Leandro A,Monteiro P,Pacheco D,Figueirinha A,Gonçalves AMM,da Silva GJ,Pereira L

更新日期：2020-07-24 00:00:00

abstract：:A bioactivity guided study of a cf. Caldora penicillata species, collected during a 2013 expedition to the Pacific island of Saipan, Northern Mariana Islands (a commonwealth of the USA), led to the isolation of a new thiazoline-containing alkaloid, laucysteinamide A (1). Laucysteinamide A is a new monomeric analogue o...

journal_title：Marine drugs

authors： Zhang C,Naman CB,Engene N,Gerwick WH

更新日期：2017-04-14 00:00:00

abstract：:In this study, the extraction conditions of the crude polysaccharide from Cereus sinensis were optimized by response surface methodology. The optimum extraction conditions were: a ratio of raw material to water volume of 1:80 (g/mL); an extraction temperature of 72 °C; and an extraction time of 3 h. Then, a purified p...

journal_title：Marine drugs

authors： Wu J,Zhou X,Zhang M,Yao Y,Han J,Liu K

更新日期：2017-05-18 00:00:00

abstract：:To date, a number of mannose-specific lectins have been isolated and characterized from seaweeds, especially from red algae. In fact, man-specific seaweed lectins consist of different structural scaffolds harboring a single or a few carbohydrate-binding sites which specifically recognize mannose-containing glycans. De...

journal_title：Marine drugs

authors： Barre A,Simplicien M,Benoist H,Van Damme EJM,Rougé P

更新日期：2019-07-26 00:00:00

abstract：:Pectenotoxin-2 (PTX-2), which was first identified as a cytotoxic entity in marine sponges, has been reported to display significant cytotoxicity to human cancer cells where it inhibits mitotic separation and cytokinesis through the depolymerization of actin filaments. In the late stage of endoreduplication, the effec...

journal_title：Marine drugs

authors： Kim GY,Kim WJ,Choi YH

更新日期：2011-01-01 00:00:00

abstract：:Six new polyoxygenated cembrane-based diterpenoids, stellatumolides A⁻C (1⁻3), stellatumonins A and B (4 and 5), and stellatumonone (6), were isolated together with ten known related compounds (7⁻16) from the ethyl acetate (EtOAc) extract of soft coral Sarcophyton stellatum. The structures of the new compounds were es...

journal_title：Marine drugs

authors： Ahmed AF,Chen YW,Huang CY,Tseng YJ,Lin CC,Dai CF,Wu YC,Sheu JH

更新日期：2018-06-14 00:00:00

abstract：:A member of the marine streptomycete clade MAR4, Streptomyces sp. CNQ-509, has genetic potential for the biosynthesis of hybrid isoprenoids and produces several meroterpenoids such as naphterpin, nitropyrrolin and marinophenazine. Our research on the strain CNQ-509 led to the isolation of two new naphterpin derivative...

journal_title：Marine drugs

authors： Park JS,Kwon HC

更新日期：2018-03-12 00:00:00

abstract：:The goal of this work was to identify sequences encoding monooxygenase biocatalysts with novel features by in silico mining an assembled metagenomic dataset of polar and subpolar marine sediments. The targeted enzyme sequences were Baeyer-Villiger and bacterial cytochrome P450 monooxygenases (CYP153). These enzymes ha...

journal_title：Marine drugs

authors： Musumeci MA,Lozada M,Rial DV,Mac Cormack WP,Jansson JK,Sjöling S,Carroll J,Dionisi HM

更新日期：2017-04-09 00:00:00

abstract：:In this study, we aimed to illustrate the potential bio-effects of 3-bromo-4,5-dihydroxybenzaldehyde (3-BDB) on the antioxidant/cytoprotective enzyme heme oxygenase-1 (HO-1) in keratinocytes. The antioxidant effects of 3-BDB were examined via reverse transcription PCR, Western blotting, HO-1 activity assay, and immuno...

journal_title：Marine drugs

authors： Ryu YS,Fernando PDSM,Kang KA,Piao MJ,Zhen AX,Kang HK,Koh YS,Hyun JW

更新日期：2019-04-19 00:00:00

abstract：:The A. salmonicida A450 LPS O-antigen, encoded by the wbsalmo gene cluster, is exported through an ABC-2 transporter-dependent pathway. It represents the first example of an O-antigen LPS polysaccharide with three different monosaccharides in their repeating unit assembled by this pathway. Until now, only repeating un...

journal_title：Marine drugs

authors： Merino S,de Mendoza E,Canals R,Tomás JM

更新日期：2015-06-15 00:00:00

abstract：:Three new benzofuranoids, asperfuranoids A-C (1-3), two new phenylpropanoid derivatives (6 and 7), and nine known analogues (4, 5, and 8-14) were isolated from the liquid substrate fermentation cultures of the mangrove endopytic fungus Aspergillus sp. ZJ-68. The structures of the new compounds were determined by exten...

journal_title：Marine drugs

authors： Cai R,Jiang H,Zang Z,Li C,She Z

更新日期：2019-08-18 00:00:00

abstract：:The geographic position, highly fluctuating sea temperatures and hypersalinity make Persian Gulf an extreme environment. Although this unique environment has high biodiversity dominated by invertebrates, its potential in marine biodiscovery has largely remained untapped. Herein, we aimed at a detailed analysis of the ...

journal_title：Marine drugs

authors： Mohsenian Kouchaksaraee R,Moridi Farimani M,Li F,Nazemi M,Tasdemir D

更新日期：2020-07-16 00:00:00

abstract：:The nutritional and pharmaceutical values of long-chain polyunsaturated fatty acids (LC-PUFAs) such as arachidonic, eicosapentaenoic and docosahexaenoic acids have been well recognized. These LC-PUFAs are physiologically important compounds in bacteria and eukaryotes. Although little is known about the biosynthetic me...

journal_title：Marine drugs

authors： Yoshida K,Hashimoto M,Hori R,Adachi T,Okuyama H,Orikasa Y,Nagamine T,Shimizu S,Ueno A,Morita N

更新日期：2016-05-12 00:00:00

abstract：:Six regioisomers associated with the tricyclic core of thiaplakortones A-D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic core scaffolds presen...

journal_title：Marine drugs

authors： Schwartz BD,Coster MJ,Skinner-Adams TS,Andrews KT,White JM,Davis RA

更新日期：2015-09-15 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is a disease closely associated with obesity and diabetes. A prevalence of type 2 diabetes and a high body mass index in cryptogenic cirrhosis may imply that obesity leads to cirrhosis. Here, we examined the effects of an extract of Ecklonia cava, a brown algae, on the activation of...

journal_title：Marine drugs

authors： Yokogawa K,Matsui-Yuasa I,Tamura A,Terada M,Kojima-Yuasa A

更新日期：2011-12-01 00:00:00

abstract：:Global incidence of type 2 diabetes has escalated over the past few decades, necessitating a continued search for natural sources of enzyme inhibitors to offset postprandial hyperglycemia. The objective of this study was to evaluate coastal Alaskan seaweed inhibition of α-glucosidase and α-amylase, two carbolytic enzy...

journal_title：Marine drugs

authors： Kellogg J,Grace MH,Lila MA

更新日期：2014-10-22 00:00:00

abstract：:Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine invertebrates, including bivalves. No human intoxication has been repo...

journal_title：Marine drugs

authors： Delcourt N,Lagrange E,Abadie E,Fessard V,Frémy JM,Vernoux JP,Peyrat MB,Maignien T,Arnich N,Molgó J,Mattei C

更新日期：2019-07-20 00:00:00

abstract：:Two new guaiazulene-based analogues, ochracenoids A (1) and B (2), along with four known analogues (3-6), were isolated from the gorgonian Anthogorgia ochracea collected from the South China Sea. The planar structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configuration ...

journal_title：Marine drugs

authors： Zheng JJ,Shao CL,Chen M,Gan LS,Fang YC,Wang XH,Wang CY

更新日期：2014-03-14 00:00:00

abstract：:In this study, Spirulina maxima derived pectin nanoparticles (SmPNPs) were synthesized and multiple biological effects were investigated using in vitro and in vivo models. SmPNPs were not toxic to Raw 264.7 cells and zebrafish embryos up to 1 mg/mL and 200 µg/mL, respectively. SmPNPs upregulated Il 10, Cat, Sod 2, Def...

journal_title：Marine drugs

authors： Rajapaksha DC,Edirisinghe SL,Nikapitiya C,Dananjaya S,Kwun HJ,Kim CH,Oh C,Kang DH,De Zoysa M

更新日期：2020-11-07 00:00:00

abstract：:Water extracts and polysaccharides from Anabaena sp., Ecklonia sp., and Jania sp. were tested for their activity against the fungal plant pathogen Botrytis cinerea. Water extracts at 2.5, 5.0, and 10.0 mg/mL inhibited B. cinerea growth in vitro. Antifungal activity of polysaccharides obtained by N-cetylpyridinium brom...

journal_title：Marine drugs

authors： Righini H,Baraldi E,García Fernández Y,Martel Quintana A,Roberti R

更新日期：2019-05-20 00:00:00

abstract：:Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE) is a bromophenol isolated from marine algae. Previous reports have shown that BDDE possesses cytotoxic and antibacterial activity. In the present study, we demonstrate that BDDE displays broad-spectrum antifungal activities, especially on Botrytis cinerea. BDDE inhibit...

journal_title：Marine drugs

authors： Liu M,Wang G,Xiao L,Xu X,Liu X,Xu P,Lin X

更新日期：2014-06-27 00:00:00

abstract：:The 7-Acetylsinumaximol B (7-AB), a bioactive cembranoid, was originally discovered from aquaculture soft coral Sinularia sandensis. The current study investigated the anti-proliferative property of 7-AB towards the NCI-N87 human gastric cancer cell line. An MTT cell proliferative assay was applied to evaluate cell su...

journal_title：Marine drugs

authors： Tsai TC,Lai KH,Su JH,Wu YJ,Sheu JH

更新日期：2018-03-26 00:00:00

abstract：:TNF-related apoptosis-inducing ligand (TRAIL) is a tumor-selective apoptosis inducer and has been shown to be promising for treating various types of cancers. However, the application of TRAIL is greatly impeded by the resistance of cancer cells to its action. Studies show that overexpression of some critical pro-surv...

journal_title：Marine drugs

authors： Liu J,Ma L,Wu N,Liu G,Zheng L,Lin X

更新日期：2014-09-25 00:00:00

abstract：:Tetracenomycin X (Tcm X) has been reported to have antitumour activity in various cancers, but there have not been any studies on its activity with respect to lung cancer to date. Therefore, this study aims to investigate the anti-lung cancer activity of Tcm X. In this study, we found that tetracenomycin X showed anti...

journal_title：Marine drugs

authors： Qiao X,Gan M,Wang C,Liu B,Shang Y,Li Y,Chen S

更新日期：2019-01-18 00:00:00

abstract：:To date, studies describing myxobacterial secondary metabolites have been relatively scarce in comparison to those addressing actinobacterial secondary metabolites. This realization suggests the immense potential of myxobacteria as an intriguing source of secondary metabolites with unusual structural features and a wi...

journal_title：Marine drugs

authors： Zhang F,Braun DR,Rajski SR,DeMaria D,Bugni TS

更新日期：2019-12-12 00:00:00

abstract：:The aim of this research was to prepare and characterize alginate-chitosan mucoadhesive microparticles containing puerarin. The microparticles were prepared by an emulsification-internal gelatin method using a combination of chitosan and Ca2+ as cationic components and alginate as anions. Surface morphology, particle ...

journal_title：Marine drugs

authors： Hou JY,Gao LN,Meng FY,Cui YL

更新日期：2014-12-01 00:00:00

abstract：:The potential of marine natural products to become new drugs is vast; however, research is still in its infancy. The chemical and biological diversity of marine toxins is immeasurable and as such an extraordinary resource for the discovery of new drugs. With the rapid development of next-generation sequencing (NGS) an...

journal_title：Marine drugs

authors： Xie B,Huang Y,Baumann K,Fry BG,Shi Q

更新日期：2017-03-30 00:00:00

abstract：:In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS ...

journal_title：Marine drugs

authors： Lee DS,Ko W,Quang TH,Kim KS,Sohn JH,Jang JH,Ahn JS,Kim YC,Oh H

更新日期：2013-11-12 00:00:00