Antimicrobial and Anti-Proliferative Effects of Skin Mucus Derived from Dasyatis pastinaca (Linnaeus, 1758).


:Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferative effects of skin mucus derived from Dasyatis pastinaca (Linnaeus, 1758). Our results showed that skin mucus exhibited a significant and specific antibacterial activity against Gram-negative bacteria but not against Gram-positive bacteria. Furthermore, we also observed a significant antifungal activity against some strains of Candida spp. Concerning anti-proliferative activity, we showed that fish mucus was specifically toxic for acute leukemia cells (HL60) with an inhibition of proliferation in a dose dependent manner (about 52% at 1000 μg/mL of fish skin mucous, FSM). Moreover, we did not observe effects in healthy cells, in neuroblastoma cells (SH-SY5Y), and multiple myeloma cell lines (MM1, U266). Finally, it exhibited strong expression and activity of chitinase which may be responsible, at least in part, for the aforementioned results.


Mar Drugs


Marine drugs


Fuochi V,Li Volti G,Camiolo G,Tiralongo F,Giallongo C,Distefano A,Petronio Petronio G,Barbagallo I,Viola M,Furneri PM,Di Rosa M,Avola R,Tibullo D




Has Abstract


2017-11-01 00:00:00










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    pub_type: 杂志文章


    authors: Hsu FY,Wang SK,Duh CY

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  • Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations.

    abstract::Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders. The (α3)2(β2)3 nAChR subunit arrangement comprises a pair of α3(+)β2(-) and β2(+)α3(-) interfaces, and a...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wen J,Adams DJ,Hung A

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    abstract::Chemical examination of the Taiwanese soft coral Sinularia triangular led to the isolation of five cembrane-based diterpenoids 1-5, including two new metabolites, triangulenes A (1) and B (2). The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly mass spec...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Su JH,Wen ZH

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  • Comparative Analysis of Culture Conditions for the Optimization of Carotenoid Production in Several Strains of the Picoeukaryote Ostreococcus.

    abstract::Microalgae are promising sources for the sustainable production of compounds of interest for biotechnologies. Compared to higher plants, microalgae have a faster growth rate and can be grown in industrial photobioreactors. The microalgae biomass contains specific metabolites of high added value for biotechnology such ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Guyon JB,Vergé V,Schatt P,Lozano JC,Liennard M,Bouget FY

    更新日期:2018-02-28 00:00:00

  • Isolation of a new natural product and cytotoxic and antimicrobial activities of extracts from fungi of Indonesian marine habitats.

    abstract::In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacter...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Tarman K,Lindequist U,Wende K,Porzel A,Arnold N,Wessjohann LA

    更新日期:2011-02-25 00:00:00

  • Protective Effect of Pyrogallol-Phloroglucinol-6,6-Bieckol from Ecklonia cava on Monocyte-Associated Vascular Dysfunction.

    abstract::Ecklonia cava (E. cava) can alleviate vascular dysfunction in diseases associated with poor circulation. E. cava contains various polyphenols with different functions, but few studies have compared the effects of these polyphenols. Here, we comparatively investigated four major compounds present in an ethanoic extract...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Oh S,Son M,Lee HS,Kim HS,Jeon YJ,Byun K

    更新日期:2018-11-09 00:00:00

  • Fishery Wastes as a Yet Undiscovered Treasure from the Sea: Biomolecules Sources, Extraction Methods and Valorization.

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    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Caruso G,Floris R,Serangeli C,Di Paola L

    更新日期:2020-12-07 00:00:00

  • Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells.

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    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Morgan JB,Liu Y,Coothankandaswamy V,Mahdi F,Jekabsons MB,Gerwick WH,Valeriote FA,Zhou YD,Nagle DG

    更新日期:2015-03-20 00:00:00

  • Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, a marine algae derived bromophenol, inhibits the growth of Botrytis cinerea and interacts with DNA molecules.

    abstract::Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE) is a bromophenol isolated from marine algae. Previous reports have shown that BDDE possesses cytotoxic and antibacterial activity. In the present study, we demonstrate that BDDE displays broad-spectrum antifungal activities, especially on Botrytis cinerea. BDDE inhibit...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Liu M,Wang G,Xiao L,Xu X,Liu X,Xu P,Lin X

    更新日期:2014-06-27 00:00:00

  • Aplisulfamines, new sulfoxide-containing metabolites from an aplidium tunicate: absolute stereochemistry at chiral sulfur and carbon atoms assigned through an original combination of spectroscopic and computational methods.

    abstract::Two new sulfoxide-containing metabolites, aplisulfamines A and B, have been isolated from an Aplidium sp. collected in the Bay of Naples. Their planar structure and geometry of a double bond were readily determined by using standard methods, mainly NMR spectroscopy. An original approach was used to assign the absolute...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Aiello A,Fattorusso E,Imperatore C,Luciano P,Menna M,Vitalone R

    更新日期:2012-01-01 00:00:00

  • Optimization of Growth and Carotenoid Production by Haloferax mediterranei Using Response Surface Methodology.

    abstract::Haloferax mediterranei produces C50 carotenoids that have strong antioxidant properties. The response surface methodology (RSM) tool helps to accurately analyze the most suitable conditions to maximize C50 carotenoids production by haloarchaea. The effects of temperature (15⁻50 °C), pH (4-10), and salinity (5⁻28% NaCl...

    journal_title:Marine drugs

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    authors: Montero-Lobato Z,Ramos-Merchante A,Fuentes JL,Sayago A,Fernández-Recamales Á,Martínez-Espinosa RM,Vega JM,Vílchez C,Garbayo I

    更新日期:2018-10-09 00:00:00

  • Natural Products from Cyanobacteria: Focus on Beneficial Activities.

    abstract::Cyanobacteria are photosynthetic microorganisms that colonize diverse environments worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their adaptation capacities and the diversity of natural products that they synthesize, support cyanobacterial success in colonization of their respective ec...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Demay J,Bernard C,Reinhardt A,Marie B

    更新日期:2019-05-30 00:00:00

  • New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis.

    abstract::A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolit...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lacret R,Oves-Costales D,Gómez C,Díaz C,de la Cruz M,Pérez-Victoria I,Vicente F,Genilloud O,Reyes F

    更新日期:2014-12-29 00:00:00

  • Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus.

    abstract::In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the cultur...

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    pub_type: 杂志文章


    authors: Wu DL,Li HJ,Smith DR,Jaratsittisin J,Xia-Ke-Er XF,Ma WZ,Guo YW,Dong J,Shen J,Yang DP,Lan WJ

    更新日期:2018-07-06 00:00:00

  • Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review.

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    pub_type: 杂志文章,评审


    authors: Shah SAA,Akhter N,Auckloo BN,Khan I,Lu Y,Wang K,Wu B,Guo YW

    更新日期:2017-11-10 00:00:00

  • Astaxanthin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells via Inhibition of Nf-Κb P65 and Wnt/Β-Catenin in Vitro.

    abstract::Hepatocellular carcinoma (HCC) is a malignant tumor that can cause systemic invasion; however, the exact etiology and molecular mechanism are unknown. Astaxanthin (ASX), a powerful antioxidant, has efficient anti-oxidant, anti-inflammatory, and other activities, and has great research prospects in cancer therapy. We s...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Li J,Dai W,Xia Y,Chen K,Li S,Liu T,Zhang R,Wang J,Lu W,Zhou Y,Yin Q,Abudumijiti H,Chen R,Zheng Y,Wang F,Lu J,Zhou Y,Guo C

    更新日期:2015-09-24 00:00:00

  • Thalassospiramide G, a new γ-amino-acid-bearing peptide from the marine bacterium Thalassospira sp.

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    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Um S,Pyee Y,Kim EH,Lee SK,Shin J,Oh DC

    更新日期:2013-02-26 00:00:00

  • Functional metabolomics uncovers metabolic alterations associated to severe oxidative stress in MCF7 breast cancer cells exposed to ascididemin.

    abstract::Marine natural products are a source of promising agents for cancer treatment. However, there is a need to improve the evaluation of their mechanism of action in tumors. Metabolomics of the response to anti-tumor agents is a tool to reveal candidate biomarkers and metabolic targets. We used two-dimensional high-resolu...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Morvan D

    更新日期:2013-10-11 00:00:00

  • Total Synthesis and Stereochemical Assignment of Nostosin B.

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    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wang X,Feng J,Xu Z,Ye T,Meng Y,Zhang Z

    更新日期:2017-02-27 00:00:00

  • Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells.

    abstract::Smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, was previously reported by us to induce erythroid differentiation and G1 phase arrest of K562 chronic myelogenous leukemia cells. In this study, we investigated the effect of smenospongine on the cell cycles of other le...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Kong D,Aoki S,Sowa Y,Sakai T,Kobayashi M

    更新日期:2008-01-01 00:00:00

  • Functional Genomics of the Aeromonas salmonicida Lipopolysaccharide O-Antigen and A-Layer from Typical and Atypical Strains.

    abstract::The A. salmonicida A450 LPS O-antigen, encoded by the wbsalmo gene cluster, is exported through an ABC-2 transporter-dependent pathway. It represents the first example of an O-antigen LPS polysaccharide with three different monosaccharides in their repeating unit assembled by this pathway. Until now, only repeating un...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Merino S,de Mendoza E,Canals R,Tomás JM

    更新日期:2015-06-15 00:00:00

  • Potential anti-HPV and related cancer agents from marine resources: an overview.

    abstract::Recently, the studies on the prevention and treatment of human papillomavirus (HPV) which is closely related to the cervical cancer and other genital diseases are attracting more and more attention all over the world. Marine-derived polysaccharides and other bioactive compounds have been shown to possess a variety of ...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Wang SX,Zhang XS,Guan HS,Wang W

    更新日期:2014-04-03 00:00:00

  • In vitro acylation of okadaic acid in the presence of various bivalves' extracts.

    abstract::The dinoflagellate Dinophysis spp. is responsible for diarrhetic shellfish poisoning (DSP). In the bivalves exposed to the toxic bloom of the dinoflagellate, dinophysistoxin 3 (DTX3), the 7-OH acylated form of either okadaic acid (OA) or DTX1, is produced. We demonstrated in vitro acylation of OA with palmitoyl CoA in...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Konoki K,Onoda T,Watanabe R,Cho Y,Kaga S,Suzuki T,Yotsu-Yamashita M

    更新日期:2013-01-29 00:00:00

  • Astaxanthin attenuates the apoptosis of retinal ganglion cells in db/db mice by inhibition of oxidative stress.

    abstract::Diabetic retinopathy is a common diabetic eye disease caused by changes in retinal ganglion cells (RGCs). It is an ocular manifestation of systemic disease, which affects up to 80% of all patients who have had diabetes for 10 years or more. The genetically diabetic db/db mouse, as a model of type-2 diabetes, shows dia...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Dong LY,Jin J,Lu G,Kang XL

    更新日期:2013-03-21 00:00:00

  • Cytotoxic Activity of Aplykurodin A Isolated From Aplysia kurodai against AXIN1-Mutated Hepatocellular Carcinoma Cells by Promoting Oncogenic β-Catenin Degradation.

    abstract::Dysregulation of the Wnt/β-catenin signaling pathway is involved in the development of human hepatocellular carcinoma and has thus emerged as a therapeutic target for this malignant tumor. In this study, we employed sensitive cell-based assays to identify aplykurodin A isolated from Aplysia kurodai as an antagonist of...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lee J,Zhou W,Na M,Oh S

    更新日期:2020-04-13 00:00:00

  • Biotransfer of β-N-methylamino-L-alanine (BMAA) in a eutrophicated freshwater lake.

    abstract::β-N-Methylamino-L-alanine (BMAA), a neurotoxic non-protein amino acid, plays a significant role as an environmental risk factor in neurodegenerative diseases, such as amyotrophic lateral sclerosis. BMAA producers occur globally, colonizing almost all habitats and represent species from distinct phytoplanktonic groups,...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lage S,Annadotter H,Rasmussen U,Rydberg S

    更新日期:2015-03-02 00:00:00

  • Deciphering Molecular Mechanism of the Neuropharmacological Action of Fucosterol through Integrated System Pharmacology and In Silico Analysis.

    abstract::Fucosterol is an algae-derived unique phytosterol having several medicinal properties, including antioxidant, anti-inflammatory, anticholinesterase, neuroprotective, and so on. Accumulated evidence suggests a therapeutic promise of fucosterol in neurodegeneration; however, the in-depth pharmacological mechanism of its...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Hannan MA,Dash R,Sohag AAM,Moon IS

    更新日期:2019-11-13 00:00:00

  • Fatty Acid Composition and Fatty Acid Associated Gene-Expression in Gilthead Sea Bream (Sparus aurata) are Affected by Low-Fish Oil Diets, Dietary Resveratrol, and Holding Temperature.

    abstract::To sustainably produce marine fish with a high lipid quality rich in omega-3 fatty acids, alternative sources of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are being identified. Moreover, the use of bioactive compounds that would stimulate the in vivo fatty acid synthesis, such as resveratrol (RV), wou...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Torno C,Staats S,Michl SC,de Pascual-Teresa S,Izquierdo M,Rimbach G,Schulz C

    更新日期:2018-10-10 00:00:00

  • Regional susceptibility to domoic acid in primary astrocyte cells cultured from the brain stem and hippocampus.

    abstract::Domoic acid is a marine biotoxin associated with harmful algal blooms and is the causative agent of amnesic shellfish poisoning in marine animals and humans. It is also an excitatory amino acid analog to glutamate and kainic acid which acts through glutamate receptors eliciting a very rapid and potent neurotoxic respo...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Gill SS,Hou Y,Ghane T,Pulido OM

    更新日期:2008-02-14 00:00:00

  • Molecular Targets of Active Anticancer Compounds Derived from Marine Sources.

    abstract::Over the past decades, a number of novel compounds, which are produced in the marine environment, have been found to exhibit the anticancer effects. This review focuses on molecular targets of marine-derived anticancer candidates in clinical and preclinical studies. They are kinases, transcription factors, histone dea...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Song X,Xiong Y,Qi X,Tang W,Dai J,Gu Q,Li J

    更新日期:2018-05-22 00:00:00