Abstract：
:In this study, the extraction conditions of the crude polysaccharide from Cereus sinensis were optimized by response surface methodology. The optimum extraction conditions were: a ratio of raw material to water volume of 1:80 (g/mL); an extraction temperature of 72 °C; and an extraction time of 3 h. Then, a purified polysaccharide named Cereus sinensis polysaccharide-1 (CSP-1) was obtained from the crude polysaccharide by the Diethylaminoethyl cellulose-52 (DEAE-52) cellulose chromatography column and Sephadex G-100 column. The molecular weight and monosaccharide composition of CSP-1 was determined through Gel Permeation Chromatography (GPC) and Gas Chromatography-Mass Spectrometer (GS-MS), respectively. The results showed that CSP-1 with an average molecular weight of 56,335 Da was composed of l-(-)-Fucose, d-(+)-Mannose, d-Glucose and mainly possessed 1→2, 1→2, 6, 1→4, and 1→4, 6 of glycosyl linkages. The immunomodulatory activities of CSP-1 were also evaluated using lipopolysaccharide (LPS)-induced human monocytic (THP-1) cells. The results demonstrated that CSP-1 dose-dependently protected against LPS-induced toxicity, and CSP-1 significantly inhibited the Toll-like receptor 4 (TLR-4) mRNA, myeloid differentiation factor 88 (MyD88) mRNA and tumour necrosis factor receptor-associated factor-6 (TRAF-6) mRNA expression of the LPS-induced THP-1 cells, as well as suppressing reactive oxygen species (ROS) generation.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Wu J,Zhou X,Zhang M,Yao Y,Han J,Liu Kdoi
10.3390/md15050140subject
Has Abstractpub_date
2017-05-18 00:00:00issue
5issn
1660-3397pii
md15050140journal_volume
15pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. However, one drawback of using this natural polysac...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md8041305
更新日期：2010-04-19 00:00:00
abstract：:Chinese white dolphin (Sousa chinensis), also known as the Indo-Pacific humpback dolphin, has been classified as "Vulnerable" on the IUCN Red List of Threatened Species. It is a special cetacean species that lives in tropical and subtropical nearshore waters, with significant differences from other cetaceans. Here, we...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17090504
更新日期：2019-08-28 00:00:00
abstract：:Paralytic shellfish poisoning (PSP), due to saxitoxin and related compounds, typically results from the consumption of filter-feeding molluscan shellfish that concentrate toxins from marine dinoflagellates. In addition to these microalgal sources, saxitoxin and related compounds, referred to in this review as STXs, ar...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md20080015
更新日期：2008-06-10 00:00:00
abstract：:The venom of each Conus species consists of a diverse array of neurophysiologically active peptides, which are mostly unique to the examined species. In this study, we performed high-throughput transcriptome sequencing to extract and analyze putative conotoxin transcripts from the venom ducts of 3 vermivorous cone sna...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030193
更新日期：2019-03-26 00:00:00
abstract：:Sea anemones are a remarkable source of active principles due to a decentralized venom system. New blood vessel growth or angiogenesis is a very promising target against cancer, but the few available antiangiogenic compounds have limited efficacy. In this study, a protein fraction, purified from tentacles of Anemonia ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16040134
更新日期：2018-04-19 00:00:00
abstract：:Four 4-hydroxy-α-pyrones including three new ones named nipyrones A-C (1-3) together with one known analogue germicidin C (4) were discovered from a marine sponge-derived fungus Aspergillus niger cultivated in a solid rice culture. Their structures and absolute configurations were elucidated through a combination of s...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17060344
更新日期：2019-06-10 00:00:00
abstract：:In this review, we focus on processes, organs and systems targeted by the marine toxins yessotoxin (YTX), okadaic acid (OA) and palytoxin (PTX). The effects of YTX and their basis are analyzed from data collected in the mollusc Mytilus galloprovincialis, the annelid Enchytraeus crypticus, Swiss CD1 mice and invertebra...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md8030658
更新日期：2010-03-16 00:00:00
abstract：:Three new butenolide derivatives, namely aspernolides N-P (1-3), together with six known analogues (4-9), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 1-3 were determined on the basis of comprehensive analyses of the nuclear...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17060332
更新日期：2019-06-03 00:00:00
abstract：:The authors wish to correct Figure 1 in this paper [1] to be as follows:[...]. ...
journal_title：Marine drugs
pub_type： 杂志文章,已发布勘误
doi：10.3390/md15090292
更新日期：2017-09-20 00:00:00
abstract：:Terrosamycins A (1) and B (2), two polycyclic polyether natural products, were purified from the fermentation broth of Streptomyces sp. RKND004 isolated from Prince Edward Island sediment. The one strain-many compounds (OSMAC) approach coupled with UPLC-HRMS-based metabolomics screening led to the identification of th...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17060347
更新日期：2019-06-11 00:00:00
abstract：:Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer ce...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md13116884
更新日期：2015-11-13 00:00:00
abstract：:Hepatic fibrosis is an effusive wound healing process, characterized by an excessive deposition of extracellular matrix (ECM), as the consequence of chronic liver injury of any etiology. Current therapeutic repertoire for hepatic fibrosis is limited to withdrawal of the noxious agent, which is not always feasible. Hen...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13085201
更新日期：2015-08-18 00:00:00
abstract：:Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14010001
更新日期：2015-12-22 00:00:00
abstract：:In our current investigation, we evaluated the effect of Chlorella pyrenoidosa protein hydrolysate (CPPH) and Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) on calcium absorption and gut microbiota composition, as well as their in vivo regulatory mechanism in SD rats fed low-calcium diets. Potent ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17060348
更新日期：2019-06-11 00:00:00
abstract：:Fish oil is used in the production of feed for cultured fish owing to its high polyunsaturated fatty acid content (PUFA). The over-exploitation of fisheries and events like "El Niño" are reducing the fish oil supply. Some marine microorganisms are considered potentially as alternative fatty acid sources. This study as...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15120369
更新日期：2017-12-01 00:00:00
abstract：:A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (¹H NMR, ¹H-¹H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant acti...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10010200
更新日期：2012-01-01 00:00:00
abstract：:Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferat...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15110342
更新日期：2017-11-01 00:00:00
abstract：:Ovarian cancer is one of the prevalent gynecological cancers occurring in women. In particular, the efficiency of standard therapeutic methods decreases when recurrence and chemoresistance ensue. To assist standard anti-cancer agents in the cure of ovarian cancer, development and application of new compounds such as s...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17060331
更新日期：2019-06-03 00:00:00
abstract：:Infection with Helicobacter pylori is a critical cause of gastrointestinal diseases. A crucial host response associated with H. pylori infection includes gastric inflammation, which is characterized by a sustained recruitment of T-helper (Th) cells to the site of infection and distinct patterns of cytokine production....
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17070382
更新日期：2019-06-26 00:00:00
abstract：:In continuation of our search for drug leads from Red Sea sponges we have investigated the ethyl acetate fraction of the organic extract of the Red Sea sponge Hyrtios species. Bioassay-directed fractionation of the active fraction resulted into the identification of three new alkaloids, hyrtioerectines D-F (1-3). Hyrt...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11041061
更新日期：2013-03-28 00:00:00
abstract：BACKGROUND:Evaluation of the potential efficacy and safety of combination therapies for advanced soft tissue sarcomas (STS) has increased substantially after approval of trabectedin and pazopanib. Trabectedin's introduction in Europe in 2007 depended mainly on its activity in so-called L-sarcomas (liposarcoma and leiom...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13010379
更新日期：2015-01-13 00:00:00
abstract：:Dysregulation of the Wnt/β-catenin signaling pathway is involved in the development of human hepatocellular carcinoma and has thus emerged as a therapeutic target for this malignant tumor. In this study, we employed sensitive cell-based assays to identify aplykurodin A isolated from Aplysia kurodai as an antagonist of...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18040210
更新日期：2020-04-13 00:00:00
abstract：:Eight new compounds, sinulolides A-H (1-8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were d...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12105316
更新日期：2014-10-23 00:00:00
abstract：:Isolation of marine compounds from living invertebrates represents a major challenge for sustainable and environmentally friendly exploitation of marine bio-resources. To develop innovative technology to trap invertebrate compounds in the open sea, the proof of concept of a system combining external continuous circula...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16050152
更新日期：2018-05-06 00:00:00
abstract：:Gingival recession (GR) potentially leads to the exposure of tooth root to the oral cavity microenvironment and increases susceptibility to dental caries, dentin hypersensitivity, and other dental diseases. Even though many etiological factors were reported, the specific mechanism of GR is yet to be elucidated. Given ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030138
更新日期：2019-02-27 00:00:00
abstract：:The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter str...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md8122976
更新日期：2010-12-22 00:00:00
abstract：:Investigation of minor metabolites in the extracts of the red alga Sphaerococcus coronopifolius collected from the rocky coasts of Corfu Island in the Ionian Sea yielded two new diterpene alcohols, sphaerollanes I, and II (1, 2) featuring neodolabellane skeletons, and the new sphaeroane diterpene alcohol 16-hydroxy-9S...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md7020184
更新日期：2009-05-19 00:00:00
abstract：:Seaweeds have attracted high interest in recent years due to their chemical and bioactive properties to find new molecules with valuable applications for humankind. Phenolic compounds are the group of metabolites with the most structural variation and the highest content in seaweeds. The most researched seaweed polyph...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md18080384
更新日期：2020-07-24 00:00:00
abstract：:Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE) is a bromophenol isolated from marine algae. Previous reports have shown that BDDE possesses cytotoxic and antibacterial activity. In the present study, we demonstrate that BDDE displays broad-spectrum antifungal activities, especially on Botrytis cinerea. BDDE inhibit...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12073838
更新日期：2014-06-27 00:00:00
abstract：:Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine invertebrates, including bivalves. No human intoxication has been repo...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17070425
更新日期：2019-07-20 00:00:00
