当前位置： SCI文献检索 > Marine Drugs期刊下所有文献 > Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, a marine algae derived bromophenol, inhibits the growth of Botrytis cinerea and interacts with DNA molecules.

Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, a marine algae derived bromophenol, inhibits the growth of Botrytis cinerea and interacts with DNA molecules.

Abstract：

:Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE) is a bromophenol isolated from marine algae. Previous reports have shown that BDDE possesses cytotoxic and antibacterial activity. In the present study, we demonstrate that BDDE displays broad-spectrum antifungal activities, especially on Botrytis cinerea. BDDE inhibits the growth of B. cinerea cultured on a solid medium of potato dextrose agar (PDA) as well as on the potato dextrose broth (PDB) medium. Moreover, BDDE decreases the incidence of fruit decay and severity of strawberries infected with B. cinerea. Further studies have revealed that BDDE decreases the germination rate and inhibits the mycelial growth of B. cinerea. The inhibition mechanisms are related to the disruption of the cell membrane integrity in B. cinerea spores and newly formed germ tubes. This study also suggests that BDDE possibly interacts with DNA via intercalation and minor groove binding. The studies provide evidence that BDDE has potential application in the control of gray mold after fruit harvest and the compound could serve as a candidate or lead template for rational drug design and for the development of antifungal agents.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Liu M,Wang G,Xiao L,Xu X,Liu X,Xu P,Lin X

doi

10.3390/md12073838

subject

Has Abstract

pub_date

2014-06-27 00:00:00

pages

3838-51

issue

7

issn

1660-3397

pii

md12073838

journal_volume

12

pub_type

杂志文章

相关文献

Marine Drugs文献大全
  • Ochracenoids A and B, guaiazulene-based analogues from gorgonian Anthogorgia ochracea collected from the South China Sea.

    abstract：:Two new guaiazulene-based analogues, ochracenoids A (1) and B (2), along with four known analogues (3-6), were isolated from the gorgonian Anthogorgia ochracea collected from the South China Sea. The planar structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configuration ...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md12031569

    authors： Zheng JJ,Shao CL,Chen M,Gan LS,Fang YC,Wang XH,Wang CY

    更新日期：2014-03-14 00:00:00

  • Metabolomic Insights into Marine Phytoplankton Diversity.

    abstract：:The democratization of sequencing technologies fostered a leap in our knowledge of the diversity of marine phytoplanktonic microalgae, revealing many previously unknown species and lineages. The evolutionary history of the diversification of microalgae can be inferred from the analysis of their genome sequences. Howev...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md18020078

    authors： Marcellin-Gros R,Piganeau G,Stien D

    更新日期：2020-01-25 00:00:00

  • Inhibitory effect of N,N-didesmethylgrossularine-1 on inflammatory cytokine production in lipopolysaccharide-stimulated RAW 264.7 cells.

    abstract：:N,N-Didesmethylgrossularine-1 (DDMG-1), a compound with a rare alpha-carboline structure, was isolated from an Indonesian ascidian Polycarpa aurata as responsible for the observed inhibitory activity against TNF-alpha production in lipopolysaccharide-stimulated murine macrophage-like RAW264.7 cells. DDMG-1 inhibited t...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md7040589

    authors： Oda T,Lee JS,Sato Y,Kabe Y,Sakamoto S,Handa H,Mangindaan RE,Namikoshi M

    更新日期：2009-11-17 00:00:00

  • Pyrogallol-Phloroglucinol-6,6-Bieckol from Ecklonia cava Attenuates Tubular Epithelial Cell (TCMK-1) Death in Hypoxia/Reoxygenation Injury.

    abstract：:The hypoxia/reoxygenation (H/R) injury causes serious complications after the blood supply to the kidney is stopped during surgery. The main mechanism of I/R injury is the release of high-mobility group protein B1 (HMGB1) from injured tubular epithelial cells (TEC, TCMK-1 cell), which triggers TLR4 or RAGE signaling, ...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md17110602

    authors： Son M,Oh S,Choi CH,Park KY,Son KH,Byun K

    更新日期：2019-10-24 00:00:00

  • Bacterial exopolysaccharides from extreme marine habitats: production, characterization and biological activities.

    abstract：:Many marine bacteria produce exopolysaccharides (EPS) as a strategy for growth, adhering to solid surfaces, and to survive adverse conditions. There is growing interest in isolating new EPS producing bacteria from marine environments, particularly from extreme marine environments such as deep-sea hydrothermal vents ch...

    journal_title：Marine drugs

    pub_type： 杂志文章,评审

    doi：10.3390/md8061779

    authors： Poli A,Anzelmo G,Nicolaus B

    更新日期：2010-06-03 00:00:00

  • A New Bioassay Platform Design for the Discovery of Small Molecules with Anticancer Immunotherapeutic Activity.

    abstract：:Immunotherapy takes advantage of the immune system to prevent, control, and eliminate neoplastic cells. The research in the field has already led to major breakthroughs to treat cancer. In this work, we describe a platform that integrates in vitro bioassays to test the immune response and direct antitumor effects for ...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md18120604

    authors： Gallo C,Barra G,Saponaro M,Manzo E,Fioretto L,Ziaco M,Nuzzo G,d'Ippolito G,De Palma R,Fontana A

    更新日期：2020-11-29 00:00:00

  • Mucoadhesive microparticles for gastroretentive delivery: preparation, biodistribution and targeting evaluation.

    abstract：:The aim of this research was to prepare and characterize alginate-chitosan mucoadhesive microparticles containing puerarin. The microparticles were prepared by an emulsification-internal gelatin method using a combination of chitosan and Ca2+ as cationic components and alginate as anions. Surface morphology, particle ...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md12125764

    authors： Hou JY,Gao LN,Meng FY,Cui YL

    更新日期：2014-12-01 00:00:00

  • 5-Episinuleptolide Decreases the Expression of the Extracellular Matrix in Early Biofilm Formation of Multi-Drug Resistant Acinetobacter baumannii.

    abstract：:Nosocomial infections and increasing multi-drug resistance caused by Acinetobacter baumannii have been recognized as emerging problems worldwide. Moreover, A. baumannii is able to colonize various abiotic materials and medical devices, making it difficult to eradicate and leading to ventilator-associated pneumonia, an...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md14080143

    authors： Tseng SP,Hung WC,Huang CY,Lin YS,Chan MY,Lu PL,Lin L,Sheu JH

    更新日期：2016-07-29 00:00:00

  • Mangrove Tirucallane- and Apotirucallane-Type Triterpenoids: Structure Diversity of the C-17 Side-Chain and Natural Agonists of Human Farnesoid/Pregnane⁻X⁻Receptor.

    abstract：:Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A⁻E (1⁻5) and agallochols A⁻D (6⁻9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10), were isolated from the mangrove plants Xylocarpus granatum, Xylocarpus moluccensis, and...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md16120488

    authors： Jiang ZP,Luan ZL,Liu RX,Zhang Q,Ma XC,Shen L,Wu J

    更新日期：2018-12-06 00:00:00

  • Seaweed Phenolics: From Extraction to Applications.

    abstract：:Seaweeds have attracted high interest in recent years due to their chemical and bioactive properties to find new molecules with valuable applications for humankind. Phenolic compounds are the group of metabolites with the most structural variation and the highest content in seaweeds. The most researched seaweed polyph...

    journal_title：Marine drugs

    pub_type： 杂志文章,评审

    doi：10.3390/md18080384

    authors： Cotas J,Leandro A,Monteiro P,Pacheco D,Figueirinha A,Gonçalves AMM,da Silva GJ,Pereira L

    更新日期：2020-07-24 00:00:00

  • Nine New Triterpene Glycosides, Magnumosides A₁-A₄, B₁, B₂, C₁, C₂ and C₄, from the Vietnamese Sea Cucumber Neothyonidium (=Massinium) magnum: Structures and Activities against Tumor Cells Independently and in Synergy with Radioactive Irradiation.

    abstract：:Nine new sulfated triterpene glycosides, magnumosides A₁ (1), A₂ (2), A₃ (3), A₄ (4), B₁ (5), B₂ (6), C₁ (7), C₂ (8) and C₄ (9) as well as a known colochiroside B₂ (10) have been isolated from the tropical Indo-West Pacific sea cucumber Neothynidium (=Massinium) magnum (Phyllophoridae, Dendrochirotida) collected in th...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md15080256

    authors： Silchenko AS,Kalinovsky AI,Avilov SA,Kalinin VI,Andrijaschenko PV,Dmitrenok PS,Chingizova EA,Ermakova SP,Malyarenko OS,Dautova TN

    更新日期：2017-08-16 00:00:00

  • Effects of long chain fatty acid synthesis and associated gene expression in microalga Tetraselmis sp.

    abstract：:With the depletion of global fish stocks, caused by high demand and effective fishing techniques, alternative sources for long chain omega-3 fatty acids are required for human nutrition and aquaculture feeds. Recent research has focused on land-based cultivation of microalgae, the primary producers of omega-3 fatty ac...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md12063381

    authors： Adarme-Vega TC,Thomas-Hall SR,Lim DK,Schenk PM

    更新日期：2014-06-04 00:00:00

  • Effects of Chitosan-Gentamicin Conjugate Supplement on Non-Specific Immunity, Aquaculture Water, Intestinal Histology and Microbiota of Pacific White Shrimp (Litopenaeus vannamei).

    abstract：:When the aquaculture water environment deteriorates or the temperature rises, shrimp are susceptible to viral or bacterial infections, causing a large number of deaths. This study comprehensively evaluated the effects of the oral administration of a chitosan-gentamicin conjugate (CS-GT) after Litopenaeus vannamei were...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md18080419

    authors： Liang F,Li C,Hou T,Wen C,Kong S,Ma D,Sun C,Li S

    更新日期：2020-08-10 00:00:00

  • Understanding nanocalcification: a role suggested for crystal ghosts.

    abstract：:The present survey deals with the initial stage of the calcification process in bone and other hard tissues, with special reference to the organic-inorganic relationship and the transformation that the early inorganic particles undergo as the process moves towards completion. Electron microscope studies clearly exclud...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md12074231

    authors： Bonucci E

    更新日期：2014-07-23 00:00:00

  • 24-Methyl-Cholesta-5,24(28)-Diene-3β,19-diol-7β-Monoacetate Inhibits Human Small Cell Lung Cancer Growth In Vitro and In Vivo via Apoptosis Induction.

    abstract：:24-methyl-cholesta-5,24(28)-diene-3β,19-diol-7β-monoacetate (MeCDDA) is a natural steroid compound isolated from a wild-type soft coral (Nephthea erecta). The present study aimed to investigate the anti-small cell lung cancer (SCLC) effects of MeCDDA in vitro and in vivo, as well as to elucidate its underlying mechani...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md15070210

    authors： Chung TW,Su JH,Lin CC,Li YR,Chao YH,Lin SH,Chan HL

    更新日期：2017-07-01 00:00:00

  • Increased Cell Detachment Ratio of Mesenchymal-Type Lung Cancer Cells on pH-Responsive Chitosan through the β3 Integrin.

    abstract：:Chitosan is sensitive to environmental pH values due to its electric property. This study investigates whether the pH-responsive chitosan assay can provide a simple method to evaluate the aggressive behavior of cancer cells with cell detachment ratio. The epithelial-mesenchymal transition (EMT) is induced with transfo...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md17120659

    authors： Yen CH,Young TH,Hsieh MC,Liao LJ,Huang TW

    更新日期：2019-11-23 00:00:00

  • Astaxanthin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells via Inhibition of Nf-Κb P65 and Wnt/Β-Catenin in Vitro.

    abstract：:Hepatocellular carcinoma (HCC) is a malignant tumor that can cause systemic invasion; however, the exact etiology and molecular mechanism are unknown. Astaxanthin (ASX), a powerful antioxidant, has efficient anti-oxidant, anti-inflammatory, and other activities, and has great research prospects in cancer therapy. We s...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md13106064

    authors： Li J,Dai W,Xia Y,Chen K,Li S,Liu T,Zhang R,Wang J,Lu W,Zhou Y,Yin Q,Abudumijiti H,Chen R,Zheng Y,Wang F,Lu J,Zhou Y,Guo C

    更新日期：2015-09-24 00:00:00

  • Cephalopod ink: production, chemistry, functions and applications.

    abstract：:One of the most distinctive and defining features of coleoid cephalopods-squid, cuttlefish and octopus-is their inking behavior. Their ink, which is blackened by melanin, but also contains other constituents, has been used by humans in various ways for millennia. This review summarizes our current knowledge of cephalo...

    journal_title：Marine drugs

    pub_type： 杂志文章,评审

    doi：10.3390/md12052700

    authors： Derby CD

    更新日期：2014-05-12 00:00:00

  • Natural product research in the Australian marine invertebrate Dicathais orbita.

    abstract：:The predatory marine gastropod Dicathais orbita has been the subject of a significant amount of biological and chemical research over the past five decades. Natural products research on D. orbita includes the isolation and identification of brominated indoles and choline esters as precursors of Tyrian purple, as well ...

    journal_title：Marine drugs

    pub_type： 杂志文章,评审

    doi：10.3390/md11041370

    authors： Benkendorff K

    更新日期：2013-04-23 00:00:00

  • Gracilosulfates A-G, Monosulfated Polyoxygenated Steroids from the Marine Sponge Haliclona gracilis.

    abstract：:Seven new polyoxygenated steroids belonging to a new structural group of sponge steroids, gracilosulfates A-G (1-7), possessing 3β-O-sulfonato, 5β,6β epoxy (or 5(6)-dehydro), and 4β,23-dihydroxy substitution patterns as a common structural motif, were isolated from the marine sponge Haliclona gracilis. Their structure...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md18090454

    authors： Shubina LK,Makarieva TN,Denisenko VA,Popov RS,Dyshlovoy SA,Grebnev BB,Dmitrenok PS,von Amsberg G,Stonik VA

    更新日期：2020-08-30 00:00:00

  • Characterization and cytotoxicity studies of the rare 21:4 n-7 acid and other polyunsaturated fatty acids from the marine opisthobranch Scaphander lignarius, isolated using bioassay guided fractionation.

    abstract：:The marine opisthobranch Scaphander lignarius has been analyzed in the systematic search for novel bioactive compounds in Arctic marine organisms using bioassay guided fractionation. A number of highly cytotoxic fractions were shown to contain mainly polyunsaturated fatty acids (PUFAs). Selected PUFAs were isolated an...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md10122676

    authors： Vasskog T,Andersen JH,Hansen E,Svenson J

    更新日期：2012-12-01 00:00:00

  • Anaerobic Digestion of Laminaria japonica Waste from Industrial Production Residues in Laboratory- and Pilot-Scale.

    abstract：:The cultivation of macroalgae to supply the biofuel, pharmaceutical or food industries generates a considerable amount of organic residue, which represents a potential substrate for biomethanation. Its use optimizes the total resource exploitation by the simultaneous disposal of waste biomaterials. In this study, we e...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md13095947

    authors： Barbot YN,Thomsen C,Thomsen L,Benz R

    更新日期：2015-09-18 00:00:00

  • Polyhydroxylated steroids from the South China Sea soft coral Sarcophyton sp. and their cytotoxic and antiviral activities.

    abstract：:Chemical investigation on the soft coral Sarcophyton sp. collected from the South China Sea yielded three new polyhydroxylated steroids, compounds (1-3), together with seven known ones (4-10). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related kn...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md11124788

    authors： Gong KK,Tang XL,Zhang G,Cheng CL,Zhang XW,Li PL,Li GQ

    更新日期：2013-12-02 00:00:00

  • Aurantoside K, a new antifungal tetramic acid glycoside from a Fijian marine sponge of the genus Melophlus.

    abstract：:A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (¹H NMR, ¹H-¹H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant acti...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md10010200

    authors： Kumar R,Subramani R,Feussner KD,Aalbersberg W

    更新日期：2012-01-01 00:00:00

  • New Mammalian Target of Rapamycin (mTOR) Modulators Derived from Natural Product Databases and Marine Extracts by Using Molecular Docking Techniques.

    abstract：:Mammalian target of rapamycin (mTOR) is a PI3K-related serine/threonine protein kinase that functions as a master regulator of cellular growth and metabolism, in response to nutrient and hormonal stimuli. mTOR functions in two distinct complexes-mTORC1 is sensitive to rapamycin, while, mTORC2 is insensitive to this dr...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md16100385

    authors： Ruiz-Torres V,Losada-Echeberría M,Herranz-López M,Barrajón-Catalán E,Galiano V,Micol V,Encinar JA

    更新日期：2018-10-15 00:00:00

  • A Collection of Bioactive Nitrogen-Containing Molecules from the Marine Sponge Acanthostrongylophora ingens.

    abstract：:Thirteen nitrogen-containing molecules (1a/1b and 2-12) were isolated from the Indonesian sponge Acanthostrongylophora ingens, highlighting the richness of this organism as a source of alkaloids. Their structures were elucidated using one- and two-dimensional NMR spectroscopy and HR-ESI-MS, while the stereochemistry o...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md17080472

    authors： Esposito G,Mai LH,Longeon A,Mangoni A,Durieu E,Meijer L,Van Soest R,Costantino V,Bourguet-Kondracki ML

    更新日期：2019-08-15 00:00:00

  • Anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of nitroastaxanthin and nitrolutein, the reaction products of astaxanthin and lutein with peroxynitrite.

    abstract：:Astaxanthin captured peroxynitrite to form nitroastaxanthins. 15-Nitroastaxanthin was a major reaction product of astaxanthin with peroxynitrite. Here, the anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of 15-nitroastaxanthin were investigated. In addition to astaxanthin, 15-nitroastaxanthin s...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md10061391

    authors： Maoka T,Tokuda H,Suzuki N,Kato H,Etoh H

    更新日期：2012-06-01 00:00:00

  • Cytotoxic Activity of Aplykurodin A Isolated From Aplysia kurodai against AXIN1-Mutated Hepatocellular Carcinoma Cells by Promoting Oncogenic β-Catenin Degradation.

    abstract：:Dysregulation of the Wnt/β-catenin signaling pathway is involved in the development of human hepatocellular carcinoma and has thus emerged as a therapeutic target for this malignant tumor. In this study, we employed sensitive cell-based assays to identify aplykurodin A isolated from Aplysia kurodai as an antagonist of...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md18040210

    authors： Lee J,Zhou W,Na M,Oh S

    更新日期：2020-04-13 00:00:00

  • Recently confirmed apoptosis-inducing lead compounds isolated from marine sponge of potential relevance in cancer treatment.

    abstract：:Despite intense efforts to develop non-cytotoxic anticancer treatments, effective agents are still not available. Therefore, novel apoptosis-inducing drug leads that may be developed into effective targeted cancer therapies are of interest to the cancer research community. Targeted cancer therapies affect specific abe...

    journal_title：Marine drugs

    pub_type： 杂志文章,评审

    doi：10.3390/md9091580

    authors： Essack M,Bajic VB,Archer JA

    更新日期：2011-01-01 00:00:00

  • Ceramide as a Target of Marine Triterpene Glycosides for Treatment of Human Myeloid Leukemia.

    abstract：:Acute myeloid leukemia (AML) is a heterogeneous myeloid clonal disorder exhibiting the accumulation of immature myeloid progenitors in the bone marrow and peripheral blood. Standard AML therapy requires intensive combination chemotherapy, which leads to significant treatment-related toxicity. The search for new, low t...

    journal_title：Marine drugs

    pub_type： 杂志文章,评审

    doi：10.3390/md14110205

    authors： Yun SH,Shin SW,Stonik VA,Park JI

    更新日期：2016-11-03 00:00:00