Abstract:
:Acute myeloid leukemia (AML) is a heterogeneous myeloid clonal disorder exhibiting the accumulation of immature myeloid progenitors in the bone marrow and peripheral blood. Standard AML therapy requires intensive combination chemotherapy, which leads to significant treatment-related toxicity. The search for new, low toxic marine agents, inducing the generation of ceramide in leukemic cells is a new approach to improve the therapy of leukemia. This review focuses on the metabolism of sphingolipids, the role of ceramide in treating leukemia, and the antitumor activity, related to ceramide metabolism, of some marine metabolites, particularly stichoposides, triterpene glycosides extracted from sea cucumbers of the family Stichopodiidae.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Yun SH,Shin SW,Stonik VA,Park JIdoi
10.3390/md14110205subject
Has Abstractpub_date
2016-11-03 00:00:00issue
11issn
1660-3397pii
md14110205journal_volume
14pub_type
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