Ceramide as a Target of Marine Triterpene Glycosides for Treatment of Human Myeloid Leukemia.

Abstract:

:Acute myeloid leukemia (AML) is a heterogeneous myeloid clonal disorder exhibiting the accumulation of immature myeloid progenitors in the bone marrow and peripheral blood. Standard AML therapy requires intensive combination chemotherapy, which leads to significant treatment-related toxicity. The search for new, low toxic marine agents, inducing the generation of ceramide in leukemic cells is a new approach to improve the therapy of leukemia. This review focuses on the metabolism of sphingolipids, the role of ceramide in treating leukemia, and the antitumor activity, related to ceramide metabolism, of some marine metabolites, particularly stichoposides, triterpene glycosides extracted from sea cucumbers of the family Stichopodiidae.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Yun SH,Shin SW,Stonik VA,Park JI

doi

10.3390/md14110205

subject

Has Abstract

pub_date

2016-11-03 00:00:00

issue

11

issn

1660-3397

pii

md14110205

journal_volume

14

pub_type

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