Abstract:
:Chemical investigation on the soft coral Sarcophyton sp. collected from the South China Sea yielded three new polyhydroxylated steroids, compounds (1-3), together with seven known ones (4-10). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related known compounds. All the isolates possessed the 3β,5α,6β-trihydroxylated steroidal nucleus. The cytotoxicities against selected HL-60, HeLa and K562 tumor cell lines and anti-H1N1 (Influenza A virus (IAV)) activities for the isolates were evaluated. Compounds 2, 3 and 5-8 exhibited potent activities against K562 cell lines with IC₅₀ values ranging from 6.4 to 10.3 μM. Compounds 1, 6-8 potently inhibited the growth of HL-60 tumor cell lines, and 6 also showed cytotoxicity towards HeLa cell lines. In addition, preliminary structure-activity relationships for the isolates are discussed. The OAc group at C-11 is proposed to be an important pharmacophore for their cytotoxicities in the 3β,5α,6β-triol steroids. Compounds 4 and 9 exhibited significant anti-H1N1 IAV activity with IC₅₀ values of 19.6 and 36.7 μg/mL, respectively.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Gong KK,Tang XL,Zhang G,Cheng CL,Zhang XW,Li PL,Li GQdoi
10.3390/md11124788subject
Has Abstractpub_date
2013-12-02 00:00:00pages
4788-98issue
12issn
1660-3397pii
md11124788journal_volume
11pub_type
杂志文章相关文献
Marine Drugs文献大全abstract::Mycosporine-like amino acids (MAAs) have gained considerable attention as highly active photoprotective candidates for human sunscreens. However, more studies are necessary to evaluate the extraction efficiency of these metabolites in solvents compatible with cosmetics and their subsequent analysis by HPLC. In the pre...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18010027
更新日期:2019-12-28 00:00:00
abstract::Astaxanthin (AXT), a xanthophyll carotenoid compound, has potent antioxidant, anti-inflammatory and neuroprotective properties. Neuroinflammation and oxidative stress are significant in the pathogenesis and development of Alzheimer's disease (AD). Here, we studied whether AXT could alleviate neuroinflammation, oxidati...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17020123
更新日期:2019-02-18 00:00:00
abstract::In the present study, histone from immature testis of Atlantic salmon was extracted and identified, and its antibacterial activity after enzymolysis was investigated. Histone extracted from Atlantic salmon (Salmo salar) testis using the acid extraction method was successfully identified by LC-MS/MS, and revealed signi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18030133
更新日期:2020-02-26 00:00:00
abstract::The authors wish to correct Figure 1 in this paper [1] to be as follows:[...]. ...
journal_title:Marine drugs
pub_type: 杂志文章,已发布勘误
doi:10.3390/md15090292
更新日期:2017-09-20 00:00:00
abstract::A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure⁻activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity against human prostate ca...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17010003
更新日期:2018-12-20 00:00:00
abstract::In tumor development, the degradation of heparan sulfate (HS) by heparanase (HPSE) is associated with cell-surface and extracellular matrix remodeling as well as the release of HS-bound signaling molecules, allowing cancer cell migration, invasion and angiogenesis. Because of their structural similarity with HS, sulfa...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030140
更新日期:2019-02-27 00:00:00
abstract::Astaxanthin captured peroxynitrite to form nitroastaxanthins. 15-Nitroastaxanthin was a major reaction product of astaxanthin with peroxynitrite. Here, the anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of 15-nitroastaxanthin were investigated. In addition to astaxanthin, 15-nitroastaxanthin s...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10061391
更新日期:2012-06-01 00:00:00
abstract::Natural O-alkyl-glycerolipids, also known as alkyl-ether-lipids (AEL), feature a long fatty alkyl chain linked to the glycerol unit by an ether bond. AEL are ubiquitously found in different tissues but, are abundant in shark liver oil, breast milk, red blood cells, blood plasma, and bone marrow. Only a few AEL are com...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040101
更新日期:2018-03-23 00:00:00
abstract::Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulat...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13053103
更新日期:2015-05-19 00:00:00
abstract::Nonalcoholic steatohepatitis (NASH) is a disease closely associated with obesity and diabetes. A prevalence of type 2 diabetes and a high body mass index in cryptogenic cirrhosis may imply that obesity leads to cirrhosis. Here, we examined the effects of an extract of Ecklonia cava, a brown algae, on the activation of...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md9122793
更新日期:2011-12-01 00:00:00
abstract::Domoic acid produced by marine algae has been shown to cause acute and chronic neurologic sequelae in Californian sea lions following acute or low-dose exposure. Histological findings in affected animals included a degenerative cardiomyopathy that was hypothesized to be caused by over-excitation of the glutamate recep...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md8051637
更新日期:2010-05-06 00:00:00
abstract::Being able to quantify ichthyotoxic metabolites from microalgae allows for the determination of ecologically-relevant concentrations that can be simulated in laboratory experiments, as well as to investigate bioaccumulation and degradation. Here, the ichthyotoxin karmitoxin, produced by Karlodinium armiger, was quanti...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15090278
更新日期:2017-08-31 00:00:00
abstract::Many cytotoxic compounds of therapeutic interest have been isolated from marine invertebrates, and some of them have been reported to be of microbial origin. Pyridoacridine alkaloids are the main compounds extracted from the ascidian Cystodytes dellechiajei. Here we describe the in vitro antiproliferative activity aga...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md503052
更新日期:2007-07-19 00:00:00
abstract::We performed a high-content screening (HCS) assay aiming to discover bioactive molecules with proteasome inhibitory activity. By structural elucidation, we identified six compounds purified from soft coral Clavularia flava, which potentiates proteasome inhibition. Chemical structure elucidation revealed they are dolab...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18010039
更新日期:2020-01-03 00:00:00
abstract::Metalloproteases are emerging as useful agents in the treatment of many diseases including arthritis, cancer, cardiovascular diseases, and fibrosis. Studies that could shed light on the metalloprotease pharmaceutical applications require the pure enzyme. Here, we reported the structure-based design and synthesis of th...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15010005
更新日期:2016-12-27 00:00:00
abstract::The present study investigated the effect of dietary astaxanthin (AX) on the growth performance, antioxidant parameters, and repair of hepatopancreas damage in Pacific white shrimp (Litopenaeus vannamei). To evaluate the hepatopancreas protective function of AX in shrimps, we compared the effect of five isonitrogenous...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18040218
更新日期:2020-04-17 00:00:00
abstract::Four new cembrane-type diterpenoids, sarcophyolides B-E (1-4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1-4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocraso...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11093186
更新日期:2013-08-26 00:00:00
abstract::D. salina is one of the recognized natural sources to produce beta-carotene, and an useful model for studying the role of inhibitors and enhancers of carotenogenesis. However there is little information in D. salina regarding whether the isoprenoid substrate can be influenced by stress factors (carotenogenic) or selec...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md7010045
更新日期:2009-01-01 00:00:00
abstract::The immunomodulatory effect of triterpene glycoside cucumarioside A₂-2 (CA₂-2), isolated from the Far Eastern sea cucumber Cucumaria japonica, was compared with lipopolysaccharide (LPS) on mouse spleen. It has been shown that the intraperitoneal (i.p.) glycoside administration leads to increased spleen macrophage acti...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15110341
更新日期:2017-11-01 00:00:00
abstract::Collagen is involved in the formation of complex fibrillar networks, providing the structural integrity of tissues. Its low immunogenicity and mechanical properties make this molecule a biomaterial that is extremely suitable for tissue engineering and regenerative medicine (TERM) strategies in human health issues. Her...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040111
更新日期:2018-03-29 00:00:00
abstract::Impaired wound healing is a major clinical problem in patients with diabetes and is the leading cause of lower limb amputation. This study is aimed to observe the effects of small molecule oligopeptides isolated from sea cucumber (SCCOPs) on the wound healing process in diabetic mice. Ninety db/db male mice were divid...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16010016
更新日期:2018-01-08 00:00:00
abstract::Omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs), such as eicosapentaenoic acid (EPA) (20:5n-3) and docosahexaenoic acid (DHA) (22:6n-3), are considered essential for human health. Microorganisms are the primary producers of omega-3 fatty acids in marine ecosystems, representing a sustainable source of these ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18020099
更新日期:2020-02-01 00:00:00
abstract::The total syntheses of the marine-derived lipopeptide natural product fellutamide B and deoxy-fellutamides B, C, and D are reported. These compounds were accessed through a novel solid-phase synthetic strategy using Weinreb amide-derived resin. As part of the synthesis, a new enantioselective route to (3R)-hydroxy lau...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11072382
更新日期:2013-07-08 00:00:00
abstract::Six new polyoxygenated cembrane-based diterpenoids, stellatumolides A⁻C (1⁻3), stellatumonins A and B (4 and 5), and stellatumonone (6), were isolated together with ten known related compounds (7⁻16) from the ethyl acetate (EtOAc) extract of soft coral Sarcophyton stellatum. The structures of the new compounds were es...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16060210
更新日期:2018-06-14 00:00:00
abstract::Magnetotactic bacteria (MTB) produce intracellular organelles called magnetosomes which are magnetic nanoparticles composed of magnetite (Fe3O4) or greigite (Fe3S4) enveloped by a lipid bilayer. The synthesis of a magnetosome is through a genetically controlled process in which the bacterium has control over the compo...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md13010389
更新日期:2015-01-16 00:00:00
abstract::Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030186
更新日期:2019-03-21 00:00:00
abstract::Fish oil is used in the production of feed for cultured fish owing to its high polyunsaturated fatty acid content (PUFA). The over-exploitation of fisheries and events like "El Niño" are reducing the fish oil supply. Some marine microorganisms are considered potentially as alternative fatty acid sources. This study as...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15120369
更新日期:2017-12-01 00:00:00
abstract::We have searched for special characteristics in growth, protein expression, fatty acids and volatile organic compounds (VOCs) in a local Phaeodactylum tricornutum Bohlin strain (Bergen Marine Biobank), by comparing it with a common accession strain (CCAP). Differences in growth and expressed proteins were detected bet...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14010009
更新日期:2015-12-30 00:00:00
abstract::One of the most distinctive and defining features of coleoid cephalopods-squid, cuttlefish and octopus-is their inking behavior. Their ink, which is blackened by melanin, but also contains other constituents, has been used by humans in various ways for millennia. This review summarizes our current knowledge of cephalo...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12052700
更新日期:2014-05-12 00:00:00
abstract::Fish consumption is a potential route of human exposure to the hepatotoxic microcystins, especially in lakes and reservoirs that routinely experience significant toxic Microcystis blooms. Understanding the rates of uptake and elimination for microcystins as well as the transfer efficiency into tissues of consumers are...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md9122553
更新日期:2011-12-01 00:00:00