Sarcophyolides B-E, new cembranoids from the soft coral Sarcophyton elegans.

abstract：:Two new guaiazulene-based analogues, ochracenoids A (1) and B (2), along with four known analogues (3-6), were isolated from the gorgonian Anthogorgia ochracea collected from the South China Sea. The planar structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configuration ...

journal_title：Marine drugs

authors： Zheng JJ,Shao CL,Chen M,Gan LS,Fang YC,Wang XH,Wang CY

更新日期：2014-03-14 00:00:00

abstract：:In this study, the extraction conditions of the crude polysaccharide from Cereus sinensis were optimized by response surface methodology. The optimum extraction conditions were: a ratio of raw material to water volume of 1:80 (g/mL); an extraction temperature of 72 °C; and an extraction time of 3 h. Then, a purified p...

journal_title：Marine drugs

authors： Wu J,Zhou X,Zhang M,Yao Y,Han J,Liu K

更新日期：2017-05-18 00:00:00

abstract：:Investigation of minor metabolites in the extracts of the red alga Sphaerococcus coronopifolius collected from the rocky coasts of Corfu Island in the Ionian Sea yielded two new diterpene alcohols, sphaerollanes I, and II (1, 2) featuring neodolabellane skeletons, and the new sphaeroane diterpene alcohol 16-hydroxy-9S...

journal_title：Marine drugs

authors： Smyrniotopoulos V,Vagias C,Roussis V

更新日期：2009-05-19 00:00:00

abstract：:Many marine bacteria produce exopolysaccharides (EPS) as a strategy for growth, adhering to solid surfaces, and to survive adverse conditions. There is growing interest in isolating new EPS producing bacteria from marine environments, particularly from extreme marine environments such as deep-sea hydrothermal vents ch...

journal_title：Marine drugs

authors： Poli A,Anzelmo G,Nicolaus B

更新日期：2010-06-03 00:00:00

abstract：:In tumor development, the degradation of heparan sulfate (HS) by heparanase (HPSE) is associated with cell-surface and extracellular matrix remodeling as well as the release of HS-bound signaling molecules, allowing cancer cell migration, invasion and angiogenesis. Because of their structural similarity with HS, sulfa...

journal_title：Marine drugs

authors： Groult H,Cousin R,Chot-Plassot C,Maura M,Bridiau N,Piot JM,Maugard T,Fruitier-Arnaudin I

更新日期：2019-02-27 00:00:00

abstract：:Pseudomonas aeruginosa biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one of the main components of its biofilm. Targeting this major biof...

journal_title：Marine drugs

authors： Daboor SM,Raudonis R,Cohen A,Rohde JR,Cheng Z

更新日期：2019-05-24 00:00:00

abstract：:Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus w...

journal_title：Marine drugs

authors： Zhang W,Sun T,Ma Z,Li Y

更新日期：2014-04-22 00:00:00

abstract：:The purpose of this study is to elucidate both the chemical and conformational structure of an unfractionated fucoidan extracted from brown seaweed Turbinaria ornata collected at Nha-trang bay, Vietnam. Electrospray ionization mass spectrometry (ESI-MS) was used for determining the chemical structure and small angle X...

journal_title：Marine drugs

authors： Thanh TT,Tran VT,Yuguchi Y,Bui LM,Nguyen TT

更新日期：2013-07-12 00:00:00

abstract：:Marine organisms produce secondary metabolites that may be valuable for the development of novel drug leads as such and can also provide structural scaffolds for the design and synthesis of novel bioactive compounds. The marine alkaloids, clathrodin and oroidin, which were originally isolated from sponges of the genus...

journal_title：Marine drugs

authors： Zidar N,Montalvão S,Hodnik Ž,Nawrot DA,Žula A,Ilaš J,Kikelj D,Tammela P,Mašič LP

更新日期：2014-02-14 00:00:00

abstract：:To date, a number of mannose-specific lectins have been isolated and characterized from seaweeds, especially from red algae. In fact, man-specific seaweed lectins consist of different structural scaffolds harboring a single or a few carbohydrate-binding sites which specifically recognize mannose-containing glycans. De...

journal_title：Marine drugs

authors： Barre A,Simplicien M,Benoist H,Van Damme EJM,Rougé P

更新日期：2019-07-26 00:00:00

abstract：:The first total synthesis of the marine nucleoside Mycalisine B-a naturally occurring and structurally distinct 4,5-unsaturated 7-deazapurine nucleoside-has been accomplished in 10 linear steps with 27.5% overall yield from commercially available 1,2,3,5-tetra-O-acetyl-ribose and tetracyanoethylene. Key steps of the a...

journal_title：Marine drugs

authors： Ding H,Ruan Z,Kou P,Dong X,Bai J,Xiao Q

更新日期：2019-04-14 00:00:00

abstract：:Collagen is involved in the formation of complex fibrillar networks, providing the structural integrity of tissues. Its low immunogenicity and mechanical properties make this molecule a biomaterial that is extremely suitable for tissue engineering and regenerative medicine (TERM) strategies in human health issues. Her...

journal_title：Marine drugs

authors： Pozzolini M,Scarfì S,Gallus L,Castellano M,Vicini S,Cortese K,Gagliani MC,Bertolino M,Costa G,Giovine M

更新日期：2018-03-29 00:00:00

abstract：:Four new xanthene derivatives, penicixanthenes A-D (1-4), and one known compound 5 were isolated from a marine mangrove endophytic fungus Penicillium sp. JY246 that was obtained from the stem of Ceriops tagal. Their structures were determined by detailed NMR, MS spectroscopic data, modified Mosher's method, and calcul...

journal_title：Marine drugs

authors： Bai M,Zheng CJ,Nong XH,Zhou XM,Luo YP,Chen GY

更新日期：2019-11-20 00:00:00

abstract：:Microalgae oil is an optimal feedstock for nutraceutical, pharmaceutical and biodiesel production, but its high levels of chlorophyll limit its large-scale application. To date, few effective approaches have been developed to remove chlorophyll from microalgae oil. The main purpose of this study was to present a prepr...

journal_title：Marine drugs

authors： Li T,Xu J,Wu H,Wang G,Dai S,Fan J,He H,Xiang W

更新日期：2016-09-07 00:00:00

abstract：:The vast oceans of the world, which comprise a huge variety of unique ecosystems, are emerging as a rich and relatively untapped source of novel bioactive compounds with invaluable biotechnological and pharmaceutical potential. Evidence accumulated over the last decade has revealed that the diversity of marine microor...

journal_title：Marine drugs

authors： Reen FJ,Gutiérrez-Barranquero JA,Dobson AD,Adams C,O'Gara F

更新日期：2015-05-13 00:00:00

abstract：:Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 1-4 were characterized using comprehens...

journal_title：Marine drugs

authors： Fang F,Zhao J,Ding L,Huang C,Naman CB,He S,Wu B,Zhu P,Luo Q,Gerwick WH,Yan X,Wang Q,Zhang Z,Cui W

更新日期：2017-08-19 00:00:00

abstract：:Two new diphenyl ethers (1 and 2) and four new phenolic bisabolane sesquiterpenoids (3⁻6), together with five known related derivatives, were isolated from the culture of the endophytic fungus Aspergillus flavus QQSG-3 obtained from a fresh branch of Kandelia obobata, which was collected from Huizhou city in the provi...

journal_title：Marine drugs

authors： Wu Y,Chen Y,Huang X,Pan Y,Liu Z,Yan T,Cao W,She Z

更新日期：2018-09-01 00:00:00

abstract：:Pseudopterosins and pseudopteroxazole are intriguing marine natural products that possess notable antimicrobial activity with a commensurate lack of cytotoxicity. New semi-synthetic pseudopteroxazoles, pseudopteroquinoxalines and pseudopterosin congeners along with simple synthetic mimics of the terpene skeleton were ...

journal_title：Marine drugs

authors： McCulloch MW,Haltli B,Marchbank DH,Kerr RG

更新日期：2012-08-01 00:00:00

abstract：:In this study, we aimed to illustrate the potential bio-effects of 3-bromo-4,5-dihydroxybenzaldehyde (3-BDB) on the antioxidant/cytoprotective enzyme heme oxygenase-1 (HO-1) in keratinocytes. The antioxidant effects of 3-BDB were examined via reverse transcription PCR, Western blotting, HO-1 activity assay, and immuno...

journal_title：Marine drugs

authors： Ryu YS,Fernando PDSM,Kang KA,Piao MJ,Zhen AX,Kang HK,Koh YS,Hyun JW

更新日期：2019-04-19 00:00:00

abstract：:A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure⁻activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity against human prostate ca...

journal_title：Marine drugs

authors： Matsubara T,Yokoya M,Sirimangkalakitti N,Saito N

更新日期：2018-12-20 00:00:00

abstract：:Global incidence of type 2 diabetes has escalated over the past few decades, necessitating a continued search for natural sources of enzyme inhibitors to offset postprandial hyperglycemia. The objective of this study was to evaluate coastal Alaskan seaweed inhibition of α-glucosidase and α-amylase, two carbolytic enzy...

journal_title：Marine drugs

authors： Kellogg J,Grace MH,Lila MA

更新日期：2014-10-22 00:00:00

abstract：:The marine alga, Symphyocladia latiuscula (Harvey) Yamada, is a good source of bromophenols with numerous biological activities. This study aims to characterize the anti-diabetic potential of 2,3,6-tribromo-4,5-dihydroxybenzyl derivatives isolated from S. latiuscula via their inhibition of tyrosine phosphatase 1B (PTP...

journal_title：Marine drugs

authors： Paudel P,Seong SH,Park HJ,Jung HA,Choi JS

更新日期：2019-03-14 00:00:00

abstract：:The skin, the largest organ in humans, is exposed to major sources of outdoor air pollution, such as fine particulate matter with a diameter ≤ 2.5 µm (PM2.5). Diphlorethohydroxycarmalol (DPHC), a marine-based compound, possesses multiple activities including antioxidant effects. In the present study, we evaluated the ...

journal_title：Marine drugs

authors： Zhen AX,Piao MJ,Hyun YJ,Kang KA,Madushan Fernando PDS,Cho SJ,Ahn MJ,Hyun JW

更新日期：2019-02-01 00:00:00

abstract：:The potential of marine natural products to become new drugs is vast; however, research is still in its infancy. The chemical and biological diversity of marine toxins is immeasurable and as such an extraordinary resource for the discovery of new drugs. With the rapid development of next-generation sequencing (NGS) an...

journal_title：Marine drugs

authors： Xie B,Huang Y,Baumann K,Fry BG,Shi Q

更新日期：2017-03-30 00:00:00

abstract：:In this study, as part of our continuous search for environmentally-friendly antifoulants from natural resources, subergorgic acid (SA) was identified from the gorgonian coral Subergorgia suberosa, demonstrating non-toxic, significant inhibitory effects (EC50 1.25 μg/mL, LC50 > 25 μg/mL) against the settlement of Bala...

journal_title：Marine drugs

authors： Zhang J,Ling W,Yang Z,Liang Y,Zhang L,Guo C,Wang K,Zhong B,Xu S,Xu Y

更新日期：2019-02-06 00:00:00

abstract：:The Asian coastal communities have used the brown seaweeds Fucus vesiculosus and Ascophyllum nodosum since ancient times. Recently, some in vitro and in vivo studies have demonstrated their abilities in reducing risk factors for metabolic syndrome. Here, we analyzed the protective effect of a phytocomplex extracted fr...

journal_title：Marine drugs

authors： Gabbia D,Saponaro M,Sarcognato S,Guido M,Ferri N,Carrara M,De Martin S

更新日期：2020-01-17 00:00:00

abstract：:A series of novel marinopyrroles with sulfide and sulphone spacers were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Fluorescence-quenching (FQ) assays confirmed the direct binding of...

journal_title：Marine drugs

authors： Cheng C,Liu Y,Balasis ME,Garner TP,Li J,Simmons NL,Berndt N,Song H,Pan L,Qin Y,Nicolaou KC,Gavathiotis E,Sebti SM,Li R

更新日期：2014-07-29 00:00:00

abstract：:Although oncolytic viruses provide attractive vehicles for cancer treatment, their adverse effects are largely ignored. In this work, rat C6 glioblastoma cells were subcutaneously xenografted into mice, and a thymidine kinase-deficient oncolytic vaccinia virus (oncoVV) induced severe toxicity in this model. However, o...

journal_title：Marine drugs

authors： Li G,Mei S,Cheng J,Wu T,Luo J

更新日期：2018-04-26 00:00:00

abstract：:β-N-Methylamino-L-alanine (BMAA), a neurotoxic non-protein amino acid, plays a significant role as an environmental risk factor in neurodegenerative diseases, such as amyotrophic lateral sclerosis. BMAA producers occur globally, colonizing almost all habitats and represent species from distinct phytoplanktonic groups,...

journal_title：Marine drugs

authors： Lage S,Annadotter H,Rasmussen U,Rydberg S

更新日期：2015-03-02 00:00:00

abstract：:The Antarctic sponge Dendrilla antarctica is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted in the generation of a small chemical library containing diterpenoid secondary metabolites with bioactivity in an infectious disease screening campaign focused...

journal_title：Marine drugs

authors： Bory A,Shilling AJ,Allen J,Azhari A,Roth A,Shaw LN,Kyle DE,Adams JH,Amsler CD,McClintock JB,Baker BJ

更新日期：2020-06-23 00:00:00