Abstract：
:β-N-Methylamino-L-alanine (BMAA), a neurotoxic non-protein amino acid, plays a significant role as an environmental risk factor in neurodegenerative diseases, such as amyotrophic lateral sclerosis. BMAA producers occur globally, colonizing almost all habitats and represent species from distinct phytoplanktonic groups, i.e., cyanobacteria, diatoms, and dinoflagellates. Bioaccumulation of BMAA in invertebrate and vertebrate organisms has also been registered around the globe. In the Baltic Sea, BMAA has been detected in several commercial fish species, raising the question of the bioaccumulation of BMAA in Swedish limnic systems. Here we find the presence of BMAA in water samples from Lake Finjasjön and identify its bioaccumulation patterns in both plankti-benthivorous and piscivorous fish, according to fish species, total weight, gender, and season of collection. For the first time, a large number of fish individuals were used in order to draw conclusions on BMAA bioaccumulation in a closed ecological community based on a statistical approach. We may, therefore, conclude that feeding patterns (plankti-benthivorous) and increased age of fish may lead to a higher tissue concentration of BMAA.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Lage S,Annadotter H,Rasmussen U,Rydberg Sdoi
10.3390/md13031185subject
Has Abstractpub_date
2015-03-02 00:00:00pages
1185-201issue
3issn
1660-3397pii
md13031185journal_volume
13pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Astaxanthin is one of the strongest natural antioxidants and a red pigment occurring in nature. This C40 carotenoid is used in a broad range of applications such as a colorant in the feed industry, an antioxidant in cosmetics or as a supplement in human nutrition. Natural astaxanthin is on the rise and, hence, alterna...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17110621
更新日期：2019-10-31 00:00:00
abstract：:Carotenoids are natural pigments that contribute to light harvesting and photo-protection in photosynthetic organisms. In this study, we analyzed the carotenoid profiles, including mono-hydroxy and epoxy-carotenoids, in the economically valuable red seaweed Pyropia yezoensis, to clarify the detailed biosynthetic and m...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110426
更新日期：2018-11-01 00:00:00
abstract：:Ulvan lyases can degrade ulvan to oligosaccharides with potent biological activity. A new ulvan lyase gene, ALT3695, was identified in Alteromonas sp. A321. Soluble expression of ALT3695 was achieved in Escherichia coli BL21 (DE3). The 1314-bp gene encoded a protein with 437 amino acid residues. The amino acid sequenc...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17100568
更新日期：2019-10-08 00:00:00
abstract：:In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Starting from this scaf...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12063091
更新日期：2014-05-27 00:00:00
abstract：:Anemonia viridis is a widespread and extensively studied Mediterranean species of sea anemone from which a large number of polypeptide toxins, such as blood depressing substances (BDS) peptides, have been isolated. The first members of this class, BDS-1 and BDS-2, are polypeptides belonging to the β-defensin fold fami...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11114213
更新日期：2013-10-30 00:00:00
abstract：:Water-soluble sulfated polysaccharides isolated from two red algae Sphaerococcus coronopifolius (Gigartinales, Sphaerococcaceae) and Boergeseniella thuyoides (Ceramiales, Rhodomelaceae) collected on the coast of Morocco inhibited in vitro replication of the Human Immunodeficiency Virus (HIV) at 12.5 μg/mL. In addition...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9071187
更新日期：2011-01-01 00:00:00
abstract：:Fish processing industries generate a large volume of discards. In order to fulfil with the principles of a sustainable circular economy, it is necessary to maintain aquaculture by-products in the food chain through the production of high-value biomolecules that can be used as novel ingredients. In this study, we try ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18020101
更新日期：2020-02-04 00:00:00
abstract：:Overexpression of the global regulator LaeA in a marine-derived fungal strain of Penicillium dipodomyis YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-dihydrobislongiquinol...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17080446
更新日期：2019-07-28 00:00:00
abstract：:A series of novel cyclic marinopyrroles were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-x(L), was evaluated using ELISA assays. Both atropisomers of marinopyrrole A (1) show similar potency. A tetrabromo congener 9 is t...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12031335
更新日期：2014-03-07 00:00:00
abstract：:Paralytic shellfish poisoning (PSP), due to saxitoxin and related compounds, typically results from the consumption of filter-feeding molluscan shellfish that concentrate toxins from marine dinoflagellates. In addition to these microalgal sources, saxitoxin and related compounds, referred to in this review as STXs, ar...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md20080015
更新日期：2008-06-10 00:00:00
abstract：:Diverse indoles and bis-indoles extracted from marine sources have been identified as promising anticancer leads. Herein, we designed and synthesized novel bis-indole series 7a-f and 9a-h as Topsentin and Nortopsentin analogs. Our design is based on replacing the heterocyclic spacer in the natural leads by a more flex...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18040190
更新日期：2020-04-02 00:00:00
abstract：:The purpose of this study was to develop a pharmaceutical formulation containing fatty acid extract rich in free omega-3 fatty acids such as eicosapentaenoic acid and docosahexaenoic acid for topical use. Although the health benefits of cod liver oil and other fish oils taken orally as a dietary supplement have been a...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14060105
更新日期：2016-06-01 00:00:00
abstract：:Three new benzofuranoids, asperfuranoids A-C (1-3), two new phenylpropanoid derivatives (6 and 7), and nine known analogues (4, 5, and 8-14) were isolated from the liquid substrate fermentation cultures of the mangrove endopytic fungus Aspergillus sp. ZJ-68. The structures of the new compounds were determined by exten...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17080478
更新日期：2019-08-18 00:00:00
abstract：:Carrageenans are abundant and safe non-starch polysaccharides exerting their biological effects in living organisms. Apart from their known pro-inflammation properties and some pharmacological activity, carrageenans can also strongly bind and hold metal ions. This property can be used for creation of the new drugs for...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md8041106
更新日期：2010-04-01 00:00:00
abstract：:The aim of the present work was to load a Hibiscus sabdariffa (HS) hydroalcoholic extract into in situ gelling formulations for the treatment of oral mucositis and esophagitis. Such formulations, selected as the most promising options in a previous work of ours, were composed by κ-carrageenan (κ-CG), a sulfated marine...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030153
更新日期：2019-03-05 00:00:00
abstract：:The small-spotted catshark is one of the most abundant elasmobranchs in the Northeastern Atlantic Ocean. Although its landings are devoted for human consumption, in general this species has low commercial value with high discard rates, reaching 100% in some European fisheries. The reduction of post-harvest losses (dis...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17010040
更新日期：2019-01-09 00:00:00
abstract：:Most giant groupers in the market are derived from inbred stock. Inbreeding can cause trait depression, compromising the animals' fitness and disease resistance, obligating farmers to apply increased amounts of drugs. In order to solve this problem, a pedigree classification method is needed. Here, microsatellite and ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12052397
更新日期：2014-04-30 00:00:00
abstract：:Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders. The (α3)2(β2)3 nAChR subunit arrangement comprises a pair of α3(+)β2(-) and β2(+)α3(-) interfaces, and a...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18070349
更新日期：2020-07-03 00:00:00
abstract：:Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increa...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md15110354
更新日期：2017-11-10 00:00:00
abstract：:In the chemical investigation of marine unicellular bacteria, a new peptide, thalassospiramide G (1), along with thalassospiramides A and D (2-3), was discovered from a large culture of Thalassospira sp. The structure of thalassospiramide G, bearing γ-amino acids, such as 4-amino-5-hydroxy-penta-2-enoic acid (AHPEA),...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11030611
更新日期：2013-02-26 00:00:00
abstract：:Collagenases are the most important group of commercially-produced enzymes. However, even though biological resources are abundant in the sea, very few of these commercially popular enzymes are from marine sources, especially from marine bacteria. We optimized the production of marine collagenases by Pseudoalteromonas...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15120377
更新日期：2017-12-04 00:00:00
abstract：:To sustainably produce marine fish with a high lipid quality rich in omega-3 fatty acids, alternative sources of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are being identified. Moreover, the use of bioactive compounds that would stimulate the in vivo fatty acid synthesis, such as resveratrol (RV), wou...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100379
更新日期：2018-10-10 00:00:00
abstract：:In this review, we focus on processes, organs and systems targeted by the marine toxins yessotoxin (YTX), okadaic acid (OA) and palytoxin (PTX). The effects of YTX and their basis are analyzed from data collected in the mollusc Mytilus galloprovincialis, the annelid Enchytraeus crypticus, Swiss CD1 mice and invertebra...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md8030658
更新日期：2010-03-16 00:00:00
abstract：:Global incidence of type 2 diabetes has escalated over the past few decades, necessitating a continued search for natural sources of enzyme inhibitors to offset postprandial hyperglycemia. The objective of this study was to evaluate coastal Alaskan seaweed inhibition of α-glucosidase and α-amylase, two carbolytic enzy...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12105277
更新日期：2014-10-22 00:00:00
abstract：:In the current study, hemostatic compositions including a combination of chitosan and kaolin have been developed. Chitosan is a marine polysaccharide derived from chitins, a structural component in the shells of crustaceans. Both chitosan and kaolin have the ability to mediate a quick and efficient hemostatic effect f...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md19020050
更新日期：2021-01-22 00:00:00
abstract：:In this study, sulfated polysaccharide-rich extracts were isolated from 22 tropical seaweeds (4 red, 11 brown, and 7 green) found in northeastern Brazil, and evaluated for the role of anticoagulant agents. Fifteen of the extracts showed anticoagulant activity, including all the extracts from green seaweeds. Udoteaflab...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17010005
更新日期：2018-12-21 00:00:00
abstract：:The role of the marine environment in the development of anticancer drugs has been widely reviewed, particularly in recent years. However, the innovation in terms of clinical benefits has not been duly emphasized, although there are important breakthroughs associated with the use of marine-derived anticancer agents th...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17060329
更新日期：2019-06-02 00:00:00
abstract：:Carotenoids are lipid-soluble pigments that are produced in some plants, algae, fungi, and bacterial species, which accounts for their orange and yellow hues. Carotenoids are powerful antioxidants thanks to their ability to quench singlet oxygen, to be oxidized, to be isomerized, and to scavenge free radicals, which p...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md13106226
更新日期：2015-09-30 00:00:00
abstract：:The tropical marine cyanobacterium Moorena bouillonii occupies a large geographic range across the Indian and Western Tropical Pacific Oceans and is a prolific producer of structurally unique and biologically active natural products. An ensemble of computational approaches, including the creation of the ORCA (Objectiv...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18100515
更新日期：2020-10-14 00:00:00
abstract：:Cone snails produce a distinctive repertoire of venom peptides that are used both as a defense mechanism and also to facilitate the immobilization and digestion of prey. These peptides target a wide variety of voltage- and ligand-gated ion channels, which make them an invaluable resource for studying the properties of...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md10061244
更新日期：2012-06-01 00:00:00
