Abstract：
:Cone snails produce a distinctive repertoire of venom peptides that are used both as a defense mechanism and also to facilitate the immobilization and digestion of prey. These peptides target a wide variety of voltage- and ligand-gated ion channels, which make them an invaluable resource for studying the properties of these ion channels in normal and diseased states, as well as being a collection of compounds of potential pharmacological use in their own right. Examples include the United States Food and Drug Administration (FDA) approved pharmaceutical drug, Ziconotide (Prialt(®); Elan Pharmaceuticals, Inc.) that is the synthetic equivalent of the naturally occurring ω-conotoxin MVIIA, whilst several other conotoxins are currently being used as standard research tools and screened as potential therapeutic drugs in pre-clinical or clinical trials. These developments highlight the importance of driving conotoxin-related research. A PubMed query from 1 January 2007 to 31 August 2011 combined with hand-curation of the retrieved articles allowed for the collation of 98 recently identified conotoxins with therapeutic potential which are selectively discussed in this review. Protein sequence similarity analysis tentatively assigned uncharacterized conotoxins to predicted functional classes. Furthermore, conotoxin therapeutic potential for neurodegenerative disorders (NDD) was also inferred.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Essack M,Bajic VB,Archer JAdoi
10.3390/md10061244subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1244-65issue
6issn
1660-3397pii
marinedrugs-10-01244journal_volume
10pub_type
杂志文章,评审相关文献
Marine Drugs文献大全abstract：:The secondary metabolite Tyrian purple, also known as shellfish purple and royal purple, is a dye with historical importance for humans. The biosynthetic origin of Tyrian purple in Muricidae molluscs is not currently known. A possible role for symbiotic bacteria in the production of tyrindoxyl sulphate, the precursor ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17050264
更新日期：2019-05-03 00:00:00
abstract：:A chemical study of the ethyl acetate (EtOAc) extract from the deep-sea-derived fungus Penicilliumthomii YPGA3 led to the isolation of a new austalide meroterpenoid (1) and seven known analogues (28), two new labdane-type diterpenoids (9 and 10) and a known derivative (11). The structures of new compounds 1, 9, and 10...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18030164
更新日期：2020-03-16 00:00:00
abstract：:Smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, was previously reported by us to induce erythroid differentiation and G1 phase arrest of K562 chronic myelogenous leukemia cells. In this study, we investigated the effect of smenospongine on the cell cycles of other le...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md20080023
更新日期：2008-01-01 00:00:00
abstract：:Four new xanthene derivatives, penicixanthenes A-D (1-4), and one known compound 5 were isolated from a marine mangrove endophytic fungus Penicillium sp. JY246 that was obtained from the stem of Ceriops tagal. Their structures were determined by detailed NMR, MS spectroscopic data, modified Mosher's method, and calcul...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17120649
更新日期：2019-11-20 00:00:00
abstract：:A glycopeptide fraction (GPF) from internal organs of green sea urchins (Strongylocentrotus droebachiensis Müller, Strongylocentrotidae) has been reported to be an effective bronchitis treatment. In this study, we evaluated the pharmacokinetic and tissue distribution of GPF, following single and repeated intranasal (i...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17100577
更新日期：2019-10-11 00:00:00
abstract：:Sponges can provide potential drugs against many major world-wide occurring diseases. Despite the high potential of sponge derived drugs no sustainable production method has been developed. Thus far it is not fully understood why, when, where and how these metabolites are produced in sponges. For the near future sea-b...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md7040787
更新日期：2009-12-02 00:00:00
abstract：:Accurate characterization of biomass constituents is a crucial aspect of research in the biotechnological application of natural products. Here we report an efficient, fast and reproducible method for the identification and quantitation of fatty acids and complex lipids (triacylglycerols, glycolipids, phospholipids) i...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11103742
更新日期：2013-09-30 00:00:00
abstract：:High seafood consumption has traditionally been linked to a reduced risk of cardiovascular diseases, mainly due to the lipid lowering effects of the long chained omega 3 fatty acids. However, fish and seafood are also excellent sources of good quality proteins and emerging documentation show that, upon digestion, thes...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14110211
更新日期：2016-11-18 00:00:00
abstract：:Pseudopterosins and pseudopteroxazole are intriguing marine natural products that possess notable antimicrobial activity with a commensurate lack of cytotoxicity. New semi-synthetic pseudopteroxazoles, pseudopteroquinoxalines and pseudopterosin congeners along with simple synthetic mimics of the terpene skeleton were ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10081711
更新日期：2012-08-01 00:00:00
abstract：:Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11082882
更新日期：2013-08-13 00:00:00
abstract：:Marine cyanobacteria, notably those from tropical regions, are a rich source of bioactive secondary metabolites. Tropical marine cyanobacteria often grow to high densities in the environment, allowing direct isolation of many secondary metabolites from field-collected material. However, in temperate environments cultu...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11041316
更新日期：2013-04-22 00:00:00
abstract：:In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11114510
更新日期：2013-11-12 00:00:00
abstract：:Here we summarize the current knowledge on the transfer and accumulation of harmful algal bloom (HAB)-related toxins in cephalopods (octopods, cuttlefishes and squids). These mollusks have been reported to accumulate several HAB-toxins, namely domoic acid (DA, and its isomers), saxitoxin (and its derivatives) and paly...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md11093381
更新日期：2013-09-06 00:00:00
abstract：:AIDS is a pandemic responsible for more than 35 million deaths. The emergence of resistant mutations due to drug use is the biggest cause of treatment failure. Marine organisms are sources of different molecules, some of which offer promising HIV-1 reverse transcriptase (RT) inhibitory activity, such as the diterpenes...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11114127
更新日期：2013-10-29 00:00:00
abstract：:Domoic acid produced by marine algae has been shown to cause acute and chronic neurologic sequelae in Californian sea lions following acute or low-dose exposure. Histological findings in affected animals included a degenerative cardiomyopathy that was hypothesized to be caused by over-excitation of the glutamate recep...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md8051637
更新日期：2010-05-06 00:00:00
abstract：:The marine nemertean Cephalothrix simula originates from the Pacific Ocean but in recent years has been discovered in northern Europe. The species has been associated with high levels of the marine neurotoxin Tetrodotoxin, traditionally associated with Pufferfish Poisoning. This study reports the first discovery of tw...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110452
更新日期：2018-11-16 00:00:00
abstract：:The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter str...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md8122976
更新日期：2010-12-22 00:00:00
abstract：:Microalgae represent a source of bio-active compounds such as carotenoids with potent anti-inflammatory and antioxidant properties. We aimed to investigate the effects of fucoxanthin (FX) in both in vitro and in vivo skin models. Firstly, its anti-inflammatory activity was evaluated in LPS-stimulated THP-1 macrophages...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100378
更新日期：2018-10-10 00:00:00
abstract：:Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulat...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13053103
更新日期：2015-05-19 00:00:00
abstract：:Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14010001
更新日期：2015-12-22 00:00:00
abstract：:Marine derived cyclo(Gly-l-Ser-l-Pro-l-Glu) was selected as a lead to evaluate antitumor-antibiotic activity. Histidine was chosen to replace the serine residue to form cyclo(Gly-l-His-l-Pro-l-Glu). Cyclic tetrapeptides (CtetPs) were then synthesized using a solution phase method, and subjected to antitumor and antibi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13053029
更新日期：2015-05-15 00:00:00
abstract：:Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus w...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12042308
更新日期：2014-04-22 00:00:00
abstract：:The effect of gold nanoparticles (GNPs) synthesized in marine algae has been described in the context of skin, where they have shown potential benefit. Ecklonia stolonifera (ES) is a brown algae that belongs to the Laminariaceae family, and is widely used as a component of food and medicine due to its biological activ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18090433
更新日期：2020-08-19 00:00:00
abstract：:Peridinin and fucoxanthin, which are natural carotenoids isolated from a symbiotic dinoflagellate, Symbiodinium sp., and a brown alga, Petalonia fascia, respectively, were compared for inhibitory effects on delayed-type hypersensitivity in mice. The number of eosinophils at the site of inflammation and in peripheral b...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12041773
更新日期：2014-03-27 00:00:00
abstract：:An anti-fibrotic compound produced by Streptomycesn xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis. The compound, N-[[3,4-dihydro-3S-hydroxy-2S-methyl-2-(4'R-methyl-3'S-pentenyl)-2H-1-benzopyran-6-yl]carbonyl]-threonine (1), was isolated from crude extracts...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10030639
更新日期：2012-03-01 00:00:00
abstract：:Three new diphenyl ether derivatives-phomaethers A-C (1-3) and five known compounds-including a diphenyl ether analog, 2,3'-dihydroxy-4-methoxy-5',6-dimethyl diphenyl ether (4); and four isocoumarin derivatives, diaportinol (5), desmethyldiaportinol (6), citreoisocoumarinol (7), and citreoisocoumarin (8)-were isolated...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15060146
更新日期：2017-05-25 00:00:00
abstract：:Monostroma nitidum is a green single-cell layered algae that grows on the southwest coast of Japan. It is often used for salad ingredients, boiled tsukudani, soups, etc., due to its health benefits. M. nitidum is composed of many cell aggregates, and the various substances that fill the intercellular space are dietary...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md18040228
更新日期：2020-04-24 00:00:00
abstract：:Four new cembrane-type diterpenoids, sarcophyolides B-E (1-4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1-4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocraso...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11093186
更新日期：2013-08-26 00:00:00
abstract：:In this study, the extraction conditions of the crude polysaccharide from Cereus sinensis were optimized by response surface methodology. The optimum extraction conditions were: a ratio of raw material to water volume of 1:80 (g/mL); an extraction temperature of 72 °C; and an extraction time of 3 h. Then, a purified p...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15050140
更新日期：2017-05-18 00:00:00
abstract：:Polysaccharides extracted from marine algae have attracted much attention due to their biotechnological applications, including therapeutics, cosmetics, and mainly in agriculture and horticulture as biostimulants, biofertilizers, and stimulators of the natural defenses of plants. This study aimed to evaluate the abili...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18100521
更新日期：2020-10-19 00:00:00
