Abstract：
:Three new diphenyl ether derivatives-phomaethers A-C (1-3) and five known compounds-including a diphenyl ether analog, 2,3'-dihydroxy-4-methoxy-5',6-dimethyl diphenyl ether (4); and four isocoumarin derivatives, diaportinol (5), desmethyldiaportinol (6), citreoisocoumarinol (7), and citreoisocoumarin (8)-were isolated from a gorgonian-derived fungus Phoma sp. (TA07-1). Their structures were elucidated by extensive spectroscopic investigation. The absolute configurations of 1 and 2 were determined by acid hydrolysis reactions. It was the first report to discover the diphenyl glycoside derivatives from coral-derived fungi. Compounds 1, 3, and 4 showed selective strong antibacterial activity against five pathogenic bacteria with the minimum inhibiting concentration (MIC) values and minimum bactericidal concentration (MBC) values between 0.156 and 10.0 μM.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Shi T,Qi J,Shao CL,Zhao DL,Hou XM,Wang CYdoi
10.3390/md15060146subject
Has Abstractpub_date
2017-05-25 00:00:00issue
6issn
1660-3397pii
md15060146journal_volume
15pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Microalgae are promising sources for the sustainable production of compounds of interest for biotechnologies. Compared to higher plants, microalgae have a faster growth rate and can be grown in industrial photobioreactors. The microalgae biomass contains specific metabolites of high added value for biotechnology such ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16030076
更新日期：2018-02-28 00:00:00
abstract：:Astaxanthin is one of the strongest natural antioxidants and a red pigment occurring in nature. This C40 carotenoid is used in a broad range of applications such as a colorant in the feed industry, an antioxidant in cosmetics or as a supplement in human nutrition. Natural astaxanthin is on the rise and, hence, alterna...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17110621
更新日期：2019-10-31 00:00:00
abstract：:Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine invertebrates, including bivalves. No human intoxication has been repo...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17070425
更新日期：2019-07-20 00:00:00
abstract：:Two novel biscembranoids, sarelengans A and B (1 and 2), five new cembranoids, sarelengans C-G (3-7), along with two known cembranoids (8 and 9) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 wer...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15040085
更新日期：2017-03-23 00:00:00
abstract：:The methods to obtain chitooligosaccharides are tightly related to the physicochemical properties of the end products. Knowledge of these physicochemical characteristics is crucial to describing the biological functions of chitooligosaccharides. Chitooligosaccharides were prepared either in a single-step enzymatic hyd...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110430
更新日期：2018-11-02 00:00:00
abstract：:Two previously unreported citrinin dimer derivatives, penicitol D (1) and 1-epi-citrinin H1 (2), were isolated from the culture of a deep sea-derived fungus Penicillium citrinum NLG-S01-P1, together with 11 biogenetic related compounds (3⁻13). A plausible biogenetic pathway for compounds 2⁻4 was proposed. Their struct...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17010046
更新日期：2019-01-10 00:00:00
abstract：:The search for new biological sources of commercial value is a major goal for the sustainable management of natural resources. The huge amount of fishery by-catch or processing by-products continuously produced needs to be managed to avoid environmental problems and keep resource sustainability. Fishery by-products ca...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md18120622
更新日期：2020-12-07 00:00:00
abstract：:The effect of carrageenans on tomato chlorotic dwarf viroid (TCDVd) replication and symptom expression was studied. Three-week-old tomato plants were spray-treated with iota(ɩ)-, lambda(λ)-, and kappa(κ)-carrageenan at 1 g·L-1 and inoculated with TCDVd after 48 h. The λ-carrageenan significantly suppressed viroid symp...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13052875
更新日期：2015-05-08 00:00:00
abstract：:Sponges are important sources of bioactive secondary metabolites. These compounds are frequently synthesized by bacterial symbionts, which may be recruited from the surrounding seawater or transferred to the sponge progeny by the parent. In this study, we investigated the bacterial communities associated with the spon...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15040095
更新日期：2017-03-25 00:00:00
abstract：:Pseudomonas stutzeri 273 is a marine bacterium producing exopolysaccharide 273 (EPS273) with high anti-biofilm activity against P. aeruginosa PAO1. Here, the complete genome of P.stutzeri 273 was sequenced and the genome contained a circular 5.03 Mb chromosome. With extensive analysis of the genome, a genetic locus co...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15070218
更新日期：2017-07-10 00:00:00
abstract：:Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. However, one drawback of using this natural polysac...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md8041305
更新日期：2010-04-19 00:00:00
abstract：:A glycopeptide fraction (GPF) from internal organs of green sea urchins (Strongylocentrotus droebachiensis Müller, Strongylocentrotidae) has been reported to be an effective bronchitis treatment. In this study, we evaluated the pharmacokinetic and tissue distribution of GPF, following single and repeated intranasal (i...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17100577
更新日期：2019-10-11 00:00:00
abstract：:Sargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an ethanol extract from S. horneri (SHE) on immunoglobulin E (IgE)/bovine serum albumin (BSA)-mediated ac...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18120594
更新日期：2020-11-26 00:00:00
abstract：:Marine ecosystems are the most prevalent ecosystems on the planet, providing a diversity of living organisms and resources. The development of nanotechnology may provide solutions for utilizing these thousands of potential compounds as marine pharmaceuticals. Here, we designed a liposomal glycol chitosan formulation t...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17100581
更新日期：2019-10-12 00:00:00
abstract：:Protamine sulfate (PS) is a polycationic protein drug obtained from the sperm of fish, and is used to reverse the anticoagulant effect of unfractionated heparin (UFH). However, the interactions between PS, UFH, and platelets are still not clear. We measured the platelet numbers and collagen-induced aggregation, P-sele...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17090539
更新日期：2019-09-17 00:00:00
abstract：:Water extracts and polysaccharides from Anabaena sp., Ecklonia sp., and Jania sp. were tested for their activity against the fungal plant pathogen Botrytis cinerea. Water extracts at 2.5, 5.0, and 10.0 mg/mL inhibited B. cinerea growth in vitro. Antifungal activity of polysaccharides obtained by N-cetylpyridinium brom...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17050299
更新日期：2019-05-20 00:00:00
abstract：:A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020100
更新日期：2019-02-06 00:00:00
abstract：:Lung cancer is the leading cause of cancer mortality worldwide and non-small-cell lung cancer (NSCLC) is the most common type. Marine plants provide rich resources for anticancer drug discovery. Fucoxanthin (FX), a Laminaria japonica extract, has attracted great research interest for its antitumor activities. Accumula...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15020039
更新日期：2017-02-15 00:00:00
abstract：:Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and h...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15100251
更新日期：2017-09-26 00:00:00
abstract：:Sea anemones are a remarkable source of active principles due to a decentralized venom system. New blood vessel growth or angiogenesis is a very promising target against cancer, but the few available antiangiogenic compounds have limited efficacy. In this study, a protein fraction, purified from tentacles of Anemonia ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16040134
更新日期：2018-04-19 00:00:00
abstract：:The structures, names, bioactivities and references of 138 briarane-type diterpenoids, including 87 new compounds, are summarized in this review. All the briarane-type compounds mentioned in this review article were obtained from gorgonian corals including the genus Briareum, Dichotella, Junceella and Verrucella. Some...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md12042164
更新日期：2014-04-10 00:00:00
abstract：:Soft corals are common marine organisms that inhabit tropical and subtropical oceans. They are shown to be rich source of secondary metabolites with biological activities. In this work, soft corals from two geographical locations were investigated using ¹H-NMR spectroscopy coupled with multivariate statistical analysi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12041876
更新日期：2014-03-28 00:00:00
abstract：:In this study, sulfated polysaccharide-rich extracts were isolated from 22 tropical seaweeds (4 red, 11 brown, and 7 green) found in northeastern Brazil, and evaluated for the role of anticoagulant agents. Fifteen of the extracts showed anticoagulant activity, including all the extracts from green seaweeds. Udoteaflab...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17010005
更新日期：2018-12-21 00:00:00
abstract：:In this study, the extraction conditions of the crude polysaccharide from Cereus sinensis were optimized by response surface methodology. The optimum extraction conditions were: a ratio of raw material to water volume of 1:80 (g/mL); an extraction temperature of 72 °C; and an extraction time of 3 h. Then, a purified p...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15050140
更新日期：2017-05-18 00:00:00
abstract：:The development and use of topical microbicides potentially offers an additional strategy to reduce the spread of the Human Immunodeficiency Virus (HIV). Carbohydrate-binding agents (CBAs) that show specificity for high mannose carbohydrates on the surface of the heavily glycosylated envelope of HIV are endowed with p...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md10071476
更新日期：2012-07-01 00:00:00
abstract：:Cyclic imine toxins are neurotoxic, macrocyclic compounds produced by marine dinoflagellates. Mass spectrometric screenings of extracts from natural plankton assemblages revealed a high chemical diversity among this toxin class, yet only few toxins are structurally known. Here we report the structural characterization...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110446
更新日期：2018-11-14 00:00:00
abstract：:The immunomodulatory effect of triterpene glycoside cucumarioside A₂-2 (CA₂-2), isolated from the Far Eastern sea cucumber Cucumaria japonica, was compared with lipopolysaccharide (LPS) on mouse spleen. It has been shown that the intraperitoneal (i.p.) glycoside administration leads to increased spleen macrophage acti...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15110341
更新日期：2017-11-01 00:00:00
abstract：:The predatory marine gastropod Dicathais orbita has been the subject of a significant amount of biological and chemical research over the past five decades. Natural products research on D. orbita includes the isolation and identification of brominated indoles and choline esters as precursors of Tyrian purple, as well ...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md11041370
更新日期：2013-04-23 00:00:00
abstract：:A novel, cold-adapted, and acid-base stable manganese superoxide dismutase (Ps-Mn-SOD) was cloned from hadal sea cucumber Paelopatides sp. The dimeric recombinant enzyme exhibited approximately 60 kDa in molecular weight, expressed activity from 0 °C to 70 °C with an optimal temperature of 0 °C, and resisted wide pH v...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020084
更新日期：2019-02-01 00:00:00
abstract：:Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14010001
更新日期：2015-12-22 00:00:00
