Abstract：
:The immunomodulatory effect of triterpene glycoside cucumarioside A₂-2 (CA₂-2), isolated from the Far Eastern sea cucumber Cucumaria japonica, was compared with lipopolysaccharide (LPS) on mouse spleen. It has been shown that the intraperitoneal (i.p.) glycoside administration leads to increased spleen macrophage activating markers iba-1, IL-1β, iNOs, ROS and NO formation, with additional change of macrophage phenotype to M1. The mass spectrometry profiles of peptide/protein were obtained using MALDI-TOF-MS on the different parts of spleen sections isolated by laser mircodissection techniques. It was found that i.p. stimulation of animals with CA₂-2 leads to marked changes in the intensity of the characteristic peaks of spleen peptides/proteins, primarily in red pulp.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Pislyagin EA,Manzhulo IV,Gorpenchenko TY,Dmitrenok PS,Avilov SA,Silchenko AS,Wang YM,Aminin DLdoi
10.3390/md15110341subject
Has Abstractpub_date
2017-11-01 00:00:00issue
11issn
1660-3397pii
md15110341journal_volume
15pub_type
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