Abstract：
:Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A⁻E (1⁻5) and agallochols A⁻D (6⁻9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10), were isolated from the mangrove plants Xylocarpus granatum, Xylocarpus moluccensis, and Excoecaria agallocha. The structures of these compounds were established by HR-ESIMS and extensive one-dimensional (1D) and two-dimensional (2D) NMR investigations. The absolute configurations of 1 and 2 were unequivocally determined by single-crystal X-ray diffraction analyses, conducted with Cu Kα radiation; whereas those of 4, 6⁻8 were assigned by a modified Mosher's method and the comparison of experimental electronic circular dichroism (ECD) spectra. Most notably, 5, 6, 7, and 9 displayed potent activation effects on farnesoid⁻X⁻receptor (FXR) at the concentration of 10.0 μM; 10 exhibited very significant agonistic effects on pregnane⁻X⁻receptor (PXR) at the concentration of 10.0 nM.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Jiang ZP,Luan ZL,Liu RX,Zhang Q,Ma XC,Shen L,Wu Jdoi
10.3390/md16120488subject
Has Abstractpub_date
2018-12-06 00:00:00issue
12issn
1660-3397pii
md16120488journal_volume
16pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Water extracts and polysaccharides from Anabaena sp., Ecklonia sp., and Jania sp. were tested for their activity against the fungal plant pathogen Botrytis cinerea. Water extracts at 2.5, 5.0, and 10.0 mg/mL inhibited B. cinerea growth in vitro. Antifungal activity of polysaccharides obtained by N-cetylpyridinium brom...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17050299
更新日期：2019-05-20 00:00:00
abstract：:Aurantiochytrium limacinum, a marine heterotrophic protist/microalga has shown interesting yields of docosahexaenoic acid (DHA) when cultured with different carbon sources: glucose, pure and crude glycerol. A complete study in a lab-scale fermenter allowed for the characterization and comparison of the growth kinetic ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13127064
更新日期：2015-12-05 00:00:00
abstract：:Marine organisms produce secondary metabolites that may be valuable for the development of novel drug leads as such and can also provide structural scaffolds for the design and synthesis of novel bioactive compounds. The marine alkaloids, clathrodin and oroidin, which were originally isolated from sponges of the genus...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12020940
更新日期：2014-02-14 00:00:00
abstract：:Food protein hydrolysates are known to exhibit angiotensin converting enzyme (ACE) inhibitory properties and can be used as a novel functional food for prevention of hypertension. This study evaluated the ACE inhibitory potentials of Actinopyga lecanora proteolysate (ALP) in vivo. The pre-fed rats with ALP at various ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14100176
更新日期：2016-09-30 00:00:00
abstract：:In our search for bioactive metabolites from marine organisms, we have investigated the polar fraction of the organic extract of the Red Sea sponge Theonella swinhoei. Successive chromatographic separations and final HPLC purification of the potent antifungal fraction afforded a new bicyclic glycopeptide, theonellamid...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12041911
更新日期：2014-04-01 00:00:00
abstract：:In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Starting from this scaf...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12063091
更新日期：2014-05-27 00:00:00
abstract：:Most giant groupers in the market are derived from inbred stock. Inbreeding can cause trait depression, compromising the animals' fitness and disease resistance, obligating farmers to apply increased amounts of drugs. In order to solve this problem, a pedigree classification method is needed. Here, microsatellite and ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12052397
更新日期：2014-04-30 00:00:00
abstract：:In the present study, histone from immature testis of Atlantic salmon was extracted and identified, and its antibacterial activity after enzymolysis was investigated. Histone extracted from Atlantic salmon (Salmo salar) testis using the acid extraction method was successfully identified by LC-MS/MS, and revealed signi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18030133
更新日期：2020-02-26 00:00:00
abstract：:Green seaweeds are rich sources of sulfated polysaccharides (SPs) with potential biomedical and nutraceutical applications. The aim of this work was to evaluate the immunostimulatory activity of SPs from the seaweed, Caulerpa cupressoides var. flabellata on murine RAW 264.7 macrophages. SPs were evaluated for their ab...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020105
更新日期：2019-02-09 00:00:00
abstract：:Certain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect aplysiatoxins pres...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16120505
更新日期：2018-12-13 00:00:00
abstract：:Oxylipins such as polyunsaturated aldehydes (PUAs) and hydroxyacids (HEPEs) are signaling molecules derived from the oxidation of polyunsaturated fatty acids. They are common in diatoms that constitute a major group of microalgae in freshwater and oceanic ecosystems. Although HEPEs represent the most common oxylipins ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030144
更新日期：2019-03-01 00:00:00
abstract：:It is proven that β-amyloid (Aβ) aggregates containing cross-β-sheet structures led to oxidative stress, neuroinflammation, and neuronal loss via multiple pathways. Therefore, reduction of Aβ neurotoxicity via inhibiting aggregation of Aβ or dissociating toxic Aβ aggregates into nontoxic forms might be effective thera...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18100488
更新日期：2020-09-25 00:00:00
abstract：:The dinoflagellate Prorocentrum belizeanum is responsible for the production of several toxins involved in the red tide phenomenon known as Diarrhetic Shellfish Poisoning (DSP). In this paper we report on the biosynthetic origin of an okadaic acid water-soluble ester derivative, DTX5c, on the basis of the spectroscopi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10102234
更新日期：2012-10-01 00:00:00
abstract：:The Asian coastal communities have used the brown seaweeds Fucus vesiculosus and Ascophyllum nodosum since ancient times. Recently, some in vitro and in vivo studies have demonstrated their abilities in reducing risk factors for metabolic syndrome. Here, we analyzed the protective effect of a phytocomplex extracted fr...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18010062
更新日期：2020-01-17 00:00:00
abstract：:A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020100
更新日期：2019-02-06 00:00:00
abstract：:The cultivation of macroalgae to supply the biofuel, pharmaceutical or food industries generates a considerable amount of organic residue, which represents a potential substrate for biomethanation. Its use optimizes the total resource exploitation by the simultaneous disposal of waste biomaterials. In this study, we e...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13095947
更新日期：2015-09-18 00:00:00
abstract：:Pseudomonas stutzeri 273 is a marine bacterium producing exopolysaccharide 273 (EPS273) with high anti-biofilm activity against P. aeruginosa PAO1. Here, the complete genome of P.stutzeri 273 was sequenced and the genome contained a circular 5.03 Mb chromosome. With extensive analysis of the genome, a genetic locus co...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15070218
更新日期：2017-07-10 00:00:00
abstract：:Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. They are usually produced by functional enzyme c...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md8102619
更新日期：2010-10-11 00:00:00
abstract：:Although oncolytic viruses provide attractive vehicles for cancer treatment, their adverse effects are largely ignored. In this work, rat C6 glioblastoma cells were subcutaneously xenografted into mice, and a thymidine kinase-deficient oncolytic vaccinia virus (oncoVV) induced severe toxicity in this model. However, o...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16050141
更新日期：2018-04-26 00:00:00
abstract：:Tuberculosis is the leading cause of death due to infectious disease worldwide. There is an urgent need for more effective compounds against this pathogen to control the disease. Investigation of the anti-mycobacterial activity of a deep-water sponge of the genus Plakina revealed the presence of a new steroidal alkalo...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17120707
更新日期：2019-12-16 00:00:00
abstract：:Several known sesquiterpenoid quinones and quinols (1-9), and kauamide (10), a new polyketide-peptide containing an 11-membered heterocycle, were isolated from the extracts of the Hawaiian marine sponge Dactylospongiaelegans. The planar structure of 10 was determined from spectroscopic analyses, and its relative and a...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17070423
更新日期：2019-07-19 00:00:00
abstract：:Diabetic retinopathy is a common diabetic eye disease caused by changes in retinal ganglion cells (RGCs). It is an ocular manifestation of systemic disease, which affects up to 80% of all patients who have had diabetes for 10 years or more. The genetically diabetic db/db mouse, as a model of type-2 diabetes, shows dia...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11030960
更新日期：2013-03-21 00:00:00
abstract：:In this study, the extraction conditions of the crude polysaccharide from Cereus sinensis were optimized by response surface methodology. The optimum extraction conditions were: a ratio of raw material to water volume of 1:80 (g/mL); an extraction temperature of 72 °C; and an extraction time of 3 h. Then, a purified p...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15050140
更新日期：2017-05-18 00:00:00
abstract：:A green extraction process using only water was proposed for the simultaneous extraction of alginate and bioactive compounds from Laminaria ochroleuca. Operation was carried out during non-isothermal heating up to maximal temperatures over the range of 70 °C to 100 °C. Once separated, the alginate and the crude extrac...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18070336
更新日期：2020-06-27 00:00:00
abstract：:In this study, we elucidated the inhibitory effect of fucoidan from marine brown algae on the lipid accumulation in differentiated 3T3-L1 adipocytes and its mechanism. The treatment of fucoidan in a dose-dependent manner was examined on lipid inhibition in 3T3-L1 cells by using Oil Red O staining. Fucoidan showed high...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9081359
更新日期：2011-01-01 00:00:00
abstract：:The A. salmonicida A450 LPS O-antigen, encoded by the wbsalmo gene cluster, is exported through an ABC-2 transporter-dependent pathway. It represents the first example of an O-antigen LPS polysaccharide with three different monosaccharides in their repeating unit assembled by this pathway. Until now, only repeating un...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13063791
更新日期：2015-06-15 00:00:00
abstract：:Vaginal infections are associated with high recurrence, which is often due to a lack of efficient treatment of complex vaginal infections comprised of several types of pathogens, especially fungi and bacteria. Chitosan, a mucoadhesive polymer with known antifungal effect, could offer a great improvement in vaginal the...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15030064
更新日期：2017-03-04 00:00:00
abstract：:Recently, the studies on the prevention and treatment of human papillomavirus (HPV) which is closely related to the cervical cancer and other genital diseases are attracting more and more attention all over the world. Marine-derived polysaccharides and other bioactive compounds have been shown to possess a variety of ...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md12042019
更新日期：2014-04-03 00:00:00
abstract：:The authors wish to correct Figure 1 in this paper [1] to be as follows:[...]. ...
journal_title：Marine drugs
pub_type： 杂志文章,已发布勘误
doi：10.3390/md15090292
更新日期：2017-09-20 00:00:00
abstract：:Bacteria belonging to the Vibrionaceae family are widespread in the marine environment. Today, 128 species of vibrios are known. Several of them are infamous for their pathogenicity or symbiotic relationships. Despite their ability to interact with eukaryotes, the vibrios are greatly underexplored for their ability to...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md9091440
更新日期：2011-01-01 00:00:00
