Potential anti-HPV and related cancer agents from marine resources: an overview.


:Recently, the studies on the prevention and treatment of human papillomavirus (HPV) which is closely related to the cervical cancer and other genital diseases are attracting more and more attention all over the world. Marine-derived polysaccharides and other bioactive compounds have been shown to possess a variety of anti-HPV and related cancer activities. This paper will review the recent progress in research on the potential anti-HPV and related cancer agents from marine resources. In particular, it will provide an update on the anti-HPV actions of heparinoid polysaccharides and bioactive compounds present in marine organisms, as well as the therapeutic vaccines relating to marine organisms. In addition, the possible mechanisms of anti-HPV actions of marine bioactive compounds and their potential for therapeutic application will also be summarized in detail.


Mar Drugs


Marine drugs


Wang SX,Zhang XS,Guan HS,Wang W




Has Abstract


2014-04-03 00:00:00












  • Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegans.

    abstract::Two novel biscembranoids, sarelengans A and B (1 and 2), five new cembranoids, sarelengans C-G (3-7), along with two known cembranoids (8 and 9) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 wer...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Li W,Zou YH,Ge MX,Lou LL,Xu YS,Ahmed A,Chen YY,Zhang JS,Tang GH,Yin S

    更新日期:2017-03-23 00:00:00

  • Costatone C-A New Halogenated Monoterpene from the New Zealand Red Alga Plocamium angustum.

    abstract::Red algae of the genus Plocamium have been a rich source of halogenated monoterpenes. Herein, a new cyclic monoterpene, costatone C (7), was isolated from the extract of P. angustum collected in New Zealand, along with the previously reported (1E,5Z)-1,6-dichloro-2-methylhepta-1,5-dien-3-ol (8). Elucidation of the pla...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bracegirdle J,Sohail Z,Fairhurst MJ,Gerth ML,Zuccarello GC,Ali Hashmi M,Keyzers RA

    更新日期:2019-07-19 00:00:00

  • Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11.

    abstract::Overexpression of the global regulator LaeA in a marine-derived fungal strain of Penicillium dipodomyis YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-dihydrobislongiquinol...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Yu J,Han H,Zhang X,Ma C,Sun C,Che Q,Gu Q,Zhu T,Zhang G,Li D

    更新日期:2019-07-28 00:00:00

  • New Naphthoquinone Terpenoids from Marine Actinobacterium, Streptomyces sp. CNQ-509.

    abstract::A member of the marine streptomycete clade MAR4, Streptomyces sp. CNQ-509, has genetic potential for the biosynthesis of hybrid isoprenoids and produces several meroterpenoids such as naphterpin, nitropyrrolin and marinophenazine. Our research on the strain CNQ-509 led to the isolation of two new naphterpin derivative...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Park JS,Kwon HC

    更新日期:2018-03-12 00:00:00

  • Induction of apoptosis, G₀/G₁ phase arrest and microtubule disassembly in K562 leukemia cells by Mere15, a novel polypeptide from Meretrix meretrix Linnaeus.

    abstract::Mere15 is a novel polypeptide from Meretrix meretrix Linnaeus with cytotoxicity in solid cancer cells. In this study, we investigated its activity on human K562 chronic myelogenous leukemia cells. Mere15 inhibited the growth of K562 cells with IC₅₀ values of 38.2 μg/mL. Mere15 also caused concentration dependent induc...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Liu M,Zhao X,Zhao J,Xiao L,Liu H,Wang C,Cheng L,Wu N,Lin X

    更新日期:2012-11-21 00:00:00

  • Thalassospiramide G, a new γ-amino-acid-bearing peptide from the marine bacterium Thalassospira sp.

    abstract::In the chemical investigation of marine unicellular bacteria, a new peptide, thalassospiramide G (1), along with thalassospiramides A and D (2-3), was discovered from a large culture of Thalassospira sp. The structure of thalassospiramide G, bearing γ-amino acids, such as 4-amino-5-hydroxy-penta-2-enoic acid (AHPEA),...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Um S,Pyee Y,Kim EH,Lee SK,Shin J,Oh DC

    更新日期:2013-02-26 00:00:00

  • Recruitment of glycosyl hydrolase proteins in a cone snail venomous arsenal: further insights into biomolecular features of Conus venoms.

    abstract::Cone snail venoms are considered an untapped reservoir of extremely diverse peptides, named conopeptides, displaying a wide array of pharmacological activities. We report here for the first time, the presence of high molecular weight compounds that participate in the envenomation cocktail used by these marine snails. ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Violette A,Leonardi A,Piquemal D,Terrat Y,Biass D,Dutertre S,Noguier F,Ducancel F,Stöcklin R,Križaj I,Favreau P

    更新日期:2012-02-01 00:00:00

  • Carotenoid Profiling of a Red Seaweed Pyropia yezoensis: Insights into Biosynthetic Pathways in the Order Bangiales.

    abstract::Carotenoids are natural pigments that contribute to light harvesting and photo-protection in photosynthetic organisms. In this study, we analyzed the carotenoid profiles, including mono-hydroxy and epoxy-carotenoids, in the economically valuable red seaweed Pyropia yezoensis, to clarify the detailed biosynthetic and m...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Koizumi J,Takatani N,Kobayashi N,Mikami K,Miyashita K,Yamano Y,Wada A,Maoka T,Hosokawa M

    更新日期:2018-11-01 00:00:00

  • New Monoterpenoids and Polyketides from the Deep-Sea Sediment-Derived Fungus Aspergillus sydowii MCCC 3A00324.

    abstract::Chemical study of the secondary metabolites of a deep-sea-derived fungus Aspergillus sydowii MCCC 3A00324 led to the isolation of eleven compounds (1-11), including one novel (1) and one new (2) osmane-related monoterpenoids and two undescribed polyketides (3 and 4). The structures of the metabolites were determined b...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Niu S,Yang L,Chen T,Hong B,Pei S,Shao Z,Zhang G

    更新日期:2020-11-17 00:00:00

  • Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities.

    abstract::The review is devoted to the chemical diversity of steroids produced by soft corals and their determined and potential activities. There are about 200 steroids that belong to different types of steroids such as secosteroids, spirosteroids, epoxy- and peroxy-steroids, steroid glycosides, halogenated steroids, polyoxyge...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Ermolenko EV,Imbs AB,Gloriozova TA,Poroikov VV,Sikorskaya TV,Dembitsky VM

    更新日期:2020-12-02 00:00:00

  • Integrating Molecular Networking and 1H NMR Spectroscopy for Isolation of Bioactive Metabolites from the Persian Gulf Sponge Axinella sinoxea.

    abstract::The geographic position, highly fluctuating sea temperatures and hypersalinity make Persian Gulf an extreme environment. Although this unique environment has high biodiversity dominated by invertebrates, its potential in marine biodiscovery has largely remained untapped. Herein, we aimed at a detailed analysis of the ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Mohsenian Kouchaksaraee R,Moridi Farimani M,Li F,Nazemi M,Tasdemir D

    更新日期:2020-07-16 00:00:00

  • Penicillinolide A: a new anti-inflammatory metabolite from the marine fungus Penicillium sp. SF-5292.

    abstract::In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lee DS,Ko W,Quang TH,Kim KS,Sohn JH,Jang JH,Ahn JS,Kim YC,Oh H

    更新日期:2013-11-12 00:00:00

  • Cloning of the Bisucaberin B Biosynthetic Gene Cluster from the Marine Bacterium Tenacibaculum mesophilum, and Heterologous Production of Bisucaberin B.

    abstract::The biosynthetic gene cluster for bisucaberin B (1, bsb gene cluster), an N-hydroxy-N-succinyl diamine (HSD)-based siderophore, was cloned from the marine bacterium Tenacibaculum mesophilum, originated from a marine sponge. The bsb gene cluster consists of six open reading frames (ORFs), in contrast to the four ORFs t...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Fujita MJ,Goto Y,Sakai R

    更新日期:2018-09-19 00:00:00

  • Total Synthesis of Mycalisine B.

    abstract::The first total synthesis of the marine nucleoside Mycalisine B-a naturally occurring and structurally distinct 4,5-unsaturated 7-deazapurine nucleoside-has been accomplished in 10 linear steps with 27.5% overall yield from commercially available 1,2,3,5-tetra-O-acetyl-ribose and tetracyanoethylene. Key steps of the a...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ding H,Ruan Z,Kou P,Dong X,Bai J,Xiao Q

    更新日期:2019-04-14 00:00:00

  • Peridinin from the marine symbiotic dinoflagellate, Symbiodinium sp., regulates eosinophilia in mice.

    abstract::Peridinin and fucoxanthin, which are natural carotenoids isolated from a symbiotic dinoflagellate, Symbiodinium sp., and a brown alga, Petalonia fascia, respectively, were compared for inhibitory effects on delayed-type hypersensitivity in mice. The number of eosinophils at the site of inflammation and in peripheral b...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Onodera K,Konishi Y,Taguchi T,Kiyoto S,Tominaga A

    更新日期:2014-03-27 00:00:00

  • Antiviral lead compounds from marine sponges.

    abstract::Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. They are usually produced by functional enzyme c...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Sagar S,Kaur M,Minneman KP

    更新日期:2010-10-11 00:00:00

  • Sinulolides A-H, new cyclopentenone and butenolide derivatives from soft coral Sinularia sp.

    abstract::Eight new compounds, sinulolides A-H (1-8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were d...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Yang B,Wei X,Huang J,Lin X,Liu J,Liao S,Wang J,Zhou X,Wang L,Liu Y

    更新日期:2014-10-23 00:00:00

  • Biotechnological Production of Docosahexaenoic Acid Using Aurantiochytrium limacinum: Carbon Sources Comparison And Growth Characterization.

    abstract::Aurantiochytrium limacinum, a marine heterotrophic protist/microalga has shown interesting yields of docosahexaenoic acid (DHA) when cultured with different carbon sources: glucose, pure and crude glycerol. A complete study in a lab-scale fermenter allowed for the characterization and comparison of the growth kinetic ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Abad S,Turon X

    更新日期:2015-12-05 00:00:00

  • Co-processed chitin-mannitol as a new excipient for Oro-dispersible tablets.

    abstract::This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop-CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Daraghmeh N,Chowdhry BZ,Leharne SA,Al Omari MM,Badwan AA

    更新日期:2015-03-30 00:00:00

  • Caulerpa Cupressoides Var. Flabellata.

    abstract::Green seaweeds are rich sources of sulfated polysaccharides (SPs) with potential biomedical and nutraceutical applications. The aim of this work was to evaluate the immunostimulatory activity of SPs from the seaweed, Caulerpa cupressoides var. flabellata on murine RAW 264.7 macrophages. SPs were evaluated for their ab...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Barbosa JDS,Costa MSSP,Melo LFM,Medeiros MJC,Pontes DL,Scortecci KC,Rocha HAO

    更新日期:2019-02-09 00:00:00

  • Hyperoxia elevates adrenic acid peroxidation in marine fish and is associated with reproductive pheromone mediators.

    abstract::The development of oxidative stress in the marine ecosystem is a concurring concern in fish reproductive behavior. Marine fish being rich in polyunsaturated fatty acids (PUFA) are precursors of prostaglandin pheromone mediators but also vulnerable to lipid peroxidation. It is yet to be determined if hypoxia or hyperox...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Chung ML,Galano JM,Oger C,Durand T,Lee JC

    更新日期:2015-04-14 00:00:00

  • Sargassum horneri as a Functional Food Ameliorated IgE/BSA-Induced Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice.

    abstract::Sargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an ethanol extract from S. horneri (SHE) on immunoglobulin E (IgE)/bovine serum albumin (BSA)-mediated ac...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Han EJ,Kim HS,Sanjeewa KKA,Jung K,Jee Y,Jeon YJ,Fernando IPS,Ahn G

    更新日期:2020-11-26 00:00:00

  • Anti-Fatigue Effect by Peptide Fraction from Protein Hydrolysate of Croceine Croaker (Pseudosciaena crocea) Swim Bladder through Inhibiting the Oxidative Reactions including DNA Damage.

    abstract::The swim bladder of the croceine croaker (Pseudosciaena crocea) was believed to have good curative effects in various diseases, including amnesia, insomnia, dizziness, anepithymia, and weakness after giving birth, in traditional Chinese medicine. However, there is no research focusing on the antioxidant and anti-fatig...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Zhao YQ,Zeng L,Yang ZS,Huang FF,Ding GF,Wang B

    更新日期:2016-12-13 00:00:00

  • Seaweed Phenolics: From Extraction to Applications.

    abstract::Seaweeds have attracted high interest in recent years due to their chemical and bioactive properties to find new molecules with valuable applications for humankind. Phenolic compounds are the group of metabolites with the most structural variation and the highest content in seaweeds. The most researched seaweed polyph...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Cotas J,Leandro A,Monteiro P,Pacheco D,Figueirinha A,Gonçalves AMM,da Silva GJ,Pereira L

    更新日期:2020-07-24 00:00:00

  • Marine Bacteria, A Source for Alginolytic Enzyme to Disrupt Pseudomonas aeruginosa Biofilms.

    abstract::Pseudomonas aeruginosa biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one of the main components of its biofilm. Targeting this major biof...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Daboor SM,Raudonis R,Cohen A,Rohde JR,Cheng Z

    更新日期:2019-05-24 00:00:00

  • Bromotryptamine and Bromotyramine Derivatives from the Tropical Southwestern Pacific Sponge Narrabeena nigra.

    abstract::So far, the Futuna Islands located in the Central Indo-Pacific Ocean have not been inventoried for their diversity in marine sponges and associated chemical diversity. As part of the Tara Pacific expedition, the first chemical investigation of the sponge Narrabeena nigra collected around the Futuna Islands yielded 18 ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Miguel-Gordo M,Gegunde S,Calabro K,Jennings LK,Alfonso A,Genta-Jouve G,Vacelet J,Botana LM,Thomas OP

    更新日期:2019-05-30 00:00:00

  • Design, synthesis and evaluation of new marine alkaloid-derived pentacyclic structures with anti-tumoral potency.

    abstract::This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1-11 were evaluated for their in vitro cytotoxic activity...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Boucle S,Melin C,Clastre M,Guillard J

    更新日期:2015-01-19 00:00:00

  • Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation.

    abstract::Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-β peptide oligomers, which promote excessive mitochondrial reactive oxygen species (mROS) production and induce a sustained increase in cytoplasmic Ca2...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: García F,Lobos P,Ponce A,Cataldo K,Meza D,Farías P,Estay C,Oyarzun-Ampuero F,Herrera-Molina R,Paula-Lima A,Ardiles ÁO,Hidalgo C,Adasme T,Muñoz P

    更新日期:2020-06-26 00:00:00

  • Spiromastixones Inhibit Foam Cell Formation via Regulation of Cholesterol Efflux and Uptake in RAW264.7 Macrophages.

    abstract::Bioassay-guided evaluation shows that a deep sea-derived fungus, Spiromastix sp. MCCC 3A00308, possesses lipid-lowering activity. Chromatographic separation of a culture broth resulted in the isolation of 15 known depsidone-based analogues, labeled spiromastixones A-O (1-15). Each of these compounds was tested for its...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wu C,Chen R,Liu M,Liu D,Li X,Wang S,Niu S,Guo P,Lin W

    更新日期:2015-10-14 00:00:00

  • Anti-Diabetic Activity of 2,3,6-Tribromo-4,5-Dihydroxybenzyl Derivatives from Symphyocladia latiuscula through PTP1B Downregulation and α-Glucosidase Inhibition.

    abstract::The marine alga, Symphyocladia latiuscula (Harvey) Yamada, is a good source of bromophenols with numerous biological activities. This study aims to characterize the anti-diabetic potential of 2,3,6-tribromo-4,5-dihydroxybenzyl derivatives isolated from S. latiuscula via their inhibition of tyrosine phosphatase 1B (PTP...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Paudel P,Seong SH,Park HJ,Jung HA,Choi JS

    更新日期:2019-03-14 00:00:00