Microginins from a Microcystis sp. Bloom Material Collected from the Kishon Reservoir, Israel.

abstract：:Sea anemones are a remarkable source of active principles due to a decentralized venom system. New blood vessel growth or angiogenesis is a very promising target against cancer, but the few available antiangiogenic compounds have limited efficacy. In this study, a protein fraction, purified from tentacles of Anemonia ...

journal_title：Marine drugs

authors： Loret EP,Luis J,Nuccio C,Villard C,Mansuelle P,Lebrun R,Villard PH

更新日期：2018-04-19 00:00:00

abstract：:Sponge-associated bacteria have been mostly cultured from shallow water (≤30 m) sponges, whereas only few studies targeted specimens from below 30 m. This study assessed the cultivability of bacteria from two marine sponges Xestospongia muta and Agelas sventres collected from shallow (<30 m), upper mesophotic (30-60 m...

journal_title：Marine drugs

authors： Indraningrat AAG,Micheller S,Runderkamp M,Sauerland I,Becking LE,Smidt H,Sipkema D

更新日期：2019-10-11 00:00:00

abstract：:A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and catalytic properties. Homology models of the three-dimensional α-PsGal structure, ...

journal_title：Marine drugs

authors： Bakunina I,Slepchenko L,Anastyuk S,Isakov V,Likhatskaya G,Kim N,Tekutyeva L,Son O,Balabanova L

更新日期：2018-09-24 00:00:00

abstract：:The marine opisthobranch Scaphander lignarius has been analyzed in the systematic search for novel bioactive compounds in Arctic marine organisms using bioassay guided fractionation. A number of highly cytotoxic fractions were shown to contain mainly polyunsaturated fatty acids (PUFAs). Selected PUFAs were isolated an...

journal_title：Marine drugs

authors： Vasskog T,Andersen JH,Hansen E,Svenson J

更新日期：2012-12-01 00:00:00

abstract：:Marine biotoxin-contaminated seafood has caused thousands of poisonings worldwide this century. Given these threats, there is an increasing need for improved technologies that can be easily integrated into coastal monitoring programs. This study evaluates approaches for monitoring toxins associated with recurrent toxi...

journal_title：Marine drugs

authors： Hattenrath-Lehmann TK,Lusty MW,Wallace RB,Haynes B,Wang Z,Broadwater M,Deeds JR,Morton SL,Hastback W,Porter L,Chytalo K,Gobler CJ

更新日期：2018-01-13 00:00:00

abstract：:Spumigins are marine natural products derived from cyanobacteria Nodulariaspumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation of spumigins showed that spumigins with a (2S,4S)-4-methylproline...

journal_title：Marine drugs

authors： Žula A,Będziak I,Kikelj D,Ilaš J

更新日期：2018-10-27 00:00:00

abstract：:Microorganisms that inhabit unchartered unique soil such as in the highly saline and hot Red Sea lagoons on the Saudi Arabian coastline, represent untapped sources of potentially new bioactive compounds. In this study, a culture-dependent approach was applied to three types of sediments: mangrove mud (MN), microbial m...

journal_title：Marine drugs

authors： Al-Amoudi S,Essack M,Simões MF,Bougouffa S,Soloviev I,Archer JA,Lafi FF,Bajic VB

更新日期：2016-09-10 00:00:00

abstract：:The marine environment is known as a rich source of chemical structures with numerous beneficial health effects. Among marine organisms, marine algae have been identified as an under-exploited plant resource, although they have long been recognized as valuable sources of structurally diverse bioactive compounds. Prese...

journal_title：Marine drugs

authors： Pangestuti R,Kim SK

更新日期：2011-01-01 00:00:00

abstract：:In our search for bioactive metabolites from marine organisms, we have investigated the polar fraction of the organic extract of the Red Sea sponge Theonella swinhoei. Successive chromatographic separations and final HPLC purification of the potent antifungal fraction afforded a new bicyclic glycopeptide, theonellamid...

journal_title：Marine drugs

authors： Youssef DT,Shaala LA,Mohamed GA,Badr JM,Bamanie FH,Ibrahim SR

更新日期：2014-04-01 00:00:00

abstract：:Two new guaiazulene-based analogues, ochracenoids A (1) and B (2), along with four known analogues (3-6), were isolated from the gorgonian Anthogorgia ochracea collected from the South China Sea. The planar structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configuration ...

journal_title：Marine drugs

authors： Zheng JJ,Shao CL,Chen M,Gan LS,Fang YC,Wang XH,Wang CY

更新日期：2014-03-14 00:00:00

abstract：:When the aquaculture water environment deteriorates or the temperature rises, shrimp are susceptible to viral or bacterial infections, causing a large number of deaths. This study comprehensively evaluated the effects of the oral administration of a chitosan-gentamicin conjugate (CS-GT) after Litopenaeus vannamei were...

journal_title：Marine drugs

authors： Liang F,Li C,Hou T,Wen C,Kong S,Ma D,Sun C,Li S

更新日期：2020-08-10 00:00:00

abstract：:Numerous antimicrobial peptides (AMPs) from marine fish have been identified, isolated and characterized. These peptides act as host defense molecules that exert antimicrobial effects by targeting the lipopolysaccharide (LPS) of Gram-negative bacteria. The LPS-AMP interactions are driven by the biophysical properties ...

journal_title：Marine drugs

authors： Gopal R,Seo CH,Park Y

更新日期：2014-03-13 00:00:00

abstract：:The immunotoxic potential of domoic acid (DA), a well-characterized neurotoxin, has not been fully investigated. Phagocytosis and lymphocyte proliferation were evaluated following in vitro and in vivo exposure to assay direct vs indirect effects. Mice were injected intraperitoneally with a single dose of DA (2.5 micro...

journal_title：Marine drugs

authors： Levin M,Leibrecht H,Ryan J,Van Dolah F,De Guise S

更新日期：2008-01-01 00:00:00

abstract：:This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1-11 were evaluated for their in vitro cytotoxic activity...

journal_title：Marine drugs

authors： Boucle S,Melin C,Clastre M,Guillard J

更新日期：2015-01-19 00:00:00

abstract：:Immunotherapy takes advantage of the immune system to prevent, control, and eliminate neoplastic cells. The research in the field has already led to major breakthroughs to treat cancer. In this work, we describe a platform that integrates in vitro bioassays to test the immune response and direct antitumor effects for ...

journal_title：Marine drugs

authors： Gallo C,Barra G,Saponaro M,Manzo E,Fioretto L,Ziaco M,Nuzzo G,d'Ippolito G,De Palma R,Fontana A

更新日期：2020-11-29 00:00:00

abstract：:Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulat...

journal_title：Marine drugs

authors： Phan CS,Ng SY,Kim EA,Jeon YJ,Palaniveloo K,Vairappan CS

更新日期：2015-05-19 00:00:00

abstract：:PT-peptide is derived from the anti-lipopolysaccharide factor of the swimming crab Portunus trituberculatus. The peptide, consisting of 34 amino acids, contains a lipopolysaccharide binding domain. In this study, we investigated the effect of PT-peptide encapsulated in raw milk-derived extracellular vesicles (EVs), de...

journal_title：Marine drugs

authors： Lee BH,Chen BR,Huang CT,Lin CH

更新日期：2019-04-26 00:00:00

abstract：:Using theonellasterol as a novel FXR antagonist hit, we prepared a series of semi-synthetic derivatives in order to gain insight into the structural requirements for exhibiting antagonistic activity. These derivatives are characterized by modification at the exocyclic carbon-carbon double bond at C-4 and at the hydrox...

journal_title：Marine drugs

authors： Sepe V,Ummarino R,D'Auria MV,Taglialatela-Scafati O,Marino SD,D'Amore C,Renga B,Chini MG,Bifulco G,Nakao Y,Fusetani N,Fiorucci S,Zampella A

更新日期：2012-11-05 00:00:00

abstract：:In recent years, noteworthy research has been performed around lipids from microalgae. Among lipids, glycolipids (GLs) are quite abundant in microalgae and are considered an important source of fatty acids (FAs). GLs are rich in 16- and 18-carbon saturated and unsaturated fatty acids and often contain polyunsaturated ...

journal_title：Marine drugs

authors： da Costa E,Silva J,Mendonça SH,Abreu MH,Domingues MR

更新日期：2016-05-19 00:00:00

abstract：:A series of novel cyclic marinopyrroles were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-x(L), was evaluated using ELISA assays. Both atropisomers of marinopyrrole A (1) show similar potency. A tetrabromo congener 9 is t...

journal_title：Marine drugs

authors： Cheng C,Liu Y,Balasis ME,Simmons NL,Li J,Song H,Pan L,Qin Y,Nicolaou KC,Sebti SM,Li R

更新日期：2014-03-07 00:00:00

abstract：:Carrageenans are abundant and safe non-starch polysaccharides exerting their biological effects in living organisms. Apart from their known pro-inflammation properties and some pharmacological activity, carrageenans can also strongly bind and hold metal ions. This property can be used for creation of the new drugs for...

journal_title：Marine drugs

authors： Khotimchenko YS,Khozhaenko EV,Khotimchenko MY,Kolenchenko EA,Kovalev VV

更新日期：2010-04-01 00:00:00

abstract：:In this study, thirteen sponge-derived terpenoids, including five linear furanoterpenes: furospinulosin-1 (1), furospinulosin-2 (2), furospongin-1 (3), furospongin-4 (4), and demethylfurospongin-4 (5); four linear meroterpenes: 2-(hexaprenylmethyl)-2-methylchromenol (6), 4-hydroxy-3-octaprenylbenzoic acid (7), 4-hydro...

journal_title：Marine drugs

authors： Orhan I,Sener B,Kaiser M,Brun R,Tasdemir D

更新日期：2010-01-15 00:00:00

abstract：:The deterioration of bone formation is a leading cause of age-related bone disorders. Lack of bone formation is induced by decreased osteoblastogenesis. In this study, osteoblastogenesis promoting effects of algal phlorotannin, phlorofucofuroeckol A (PFF-A), were evaluated. PFF-A was isolated from brown alga Eckloniac...

journal_title：Marine drugs

authors： Oh JH,Ahn BN,Karadeniz F,Kim JA,Lee JI,Seo Y,Kong CS

更新日期：2019-09-21 00:00:00

abstract：:Agar, alginate, and carrageenans are high-value seaweed hydrocolloids, which are used as gelation and thickening agents in different food, pharmaceutical, and biotechnological applications. The annual global production of these hydrocolloids has recently reached 100,000 tons with a gross market value just above US$ 1....

journal_title：Marine drugs

authors： Rhein-Knudsen N,Ale MT,Meyer AS

更新日期：2015-05-27 00:00:00

abstract：:Overexpression of the global regulator LaeA in a marine-derived fungal strain of Penicillium dipodomyis YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-dihydrobislongiquinol...

journal_title：Marine drugs

authors： Yu J,Han H,Zhang X,Ma C,Sun C,Che Q,Gu Q,Zhu T,Zhang G,Li D

更新日期：2019-07-28 00:00:00

abstract：:Sea cucumbers belonging to echinoderm are traditionally used as tonic food in China and other Asian countries. They produce abundant biologically active triterpene glycosides. More than 300 triterpene glycosides have been isolated and characterized from various species of sea cucumbers, which are classified as holosta...

journal_title：Marine drugs

authors： Mondol MAM,Shin HJ,Rahman MA,Islam MT

更新日期：2017-10-17 00:00:00

abstract：:The marine ecosystem has been a key resource for secondary metabolites with promising biological roles. In the current study, bioassay-guided phytochemical investigations were carried out to assess the presence of enzyme inhibitory chemical constituents from the methanolic extract of marine green alga-Codium dwarkense...

journal_title：Marine drugs

authors： Ali L,Khan AL,Al-Kharusi L,Hussain J,Al-Harrasi A

更新日期：2015-07-14 00:00:00

abstract：:Polymeric 3-alkylpyridinium salts (poly-APS) present in the marine sponge Reniera sarai show a broad spectrum of biological activities. They are lytic to erythrocytes and various other mammalian cells, enabling the transfection of the latter with alien DNA. Furthermore, they show inhibitory effects to marine bacteria ...

journal_title：Marine drugs

authors： Turk T,Frangez R,Sepcić K

更新日期：2007-11-13 00:00:00

abstract：:The vast oceans of the world, which comprise a huge variety of unique ecosystems, are emerging as a rich and relatively untapped source of novel bioactive compounds with invaluable biotechnological and pharmaceutical potential. Evidence accumulated over the last decade has revealed that the diversity of marine microor...

journal_title：Marine drugs

authors： Reen FJ,Gutiérrez-Barranquero JA,Dobson AD,Adams C,O'Gara F

更新日期：2015-05-13 00:00:00

abstract：:The structures, names, bioactivities and references of 138 briarane-type diterpenoids, including 87 new compounds, are summarized in this review. All the briarane-type compounds mentioned in this review article were obtained from gorgonian corals including the genus Briareum, Dichotella, Junceella and Verrucella. Some...

journal_title：Marine drugs

authors： Sheu JH,Chen YH,Chen YH,Su YD,Chang YC,Su JH,Weng CF,Lee CH,Fang LS,Wang WH,Wen ZH,Wu YC,Sung PJ

更新日期：2014-04-10 00:00:00