Abstract:
:Marine biotoxin-contaminated seafood has caused thousands of poisonings worldwide this century. Given these threats, there is an increasing need for improved technologies that can be easily integrated into coastal monitoring programs. This study evaluates approaches for monitoring toxins associated with recurrent toxin-producing Alexandrium and Dinophysis blooms on Long Island, NY, USA, which cause paralytic and diarrhetic shellfish poisoning (PSP and DSP), respectively. Within contrasting locations, the dynamics of pelagic Alexandrium and Dinophysis cell densities, toxins in plankton, and toxins in deployed blue mussels (Mytilus edulis) were compared with passive solid-phase adsorption toxin tracking (SPATT) samplers filled with two types of resin, HP20 and XAD-2. Multiple species of wild shellfish were also collected during Dinophysis blooms and used to compare toxin content using two different extraction techniques (single dispersive and double exhaustive) and two different toxin analysis assays (liquid chromatography/mass spectrometry and the protein phosphatase inhibition assay (PP2A)) for the measurement of DSP toxins. DSP toxins measured in the HP20 resin were significantly correlated (R² = 0.7-0.9, p < 0.001) with total DSP toxins in shellfish, but were detected more than three weeks prior to detection in deployed mussels. Both resins adsorbed measurable levels of PSP toxins, but neither quantitatively tracked Alexandrium cell densities, toxicity in plankton or toxins in shellfish. DSP extraction and toxin analysis methods did not differ significantly (p > 0.05), were highly correlated (R² = 0.98-0.99; p < 0.001) and provided complete recovery of DSP toxins from standard reference materials. Blue mussels (Mytilus edulis) and ribbed mussels (Geukensia demissa) were found to accumulate DSP toxins above federal and international standards (160 ng g-1) during Dinophysis blooms while Eastern oysters (Crassostrea virginica) and soft shell clams (Mya arenaria) did not. This study demonstrated that SPATT samplers using HP20 resin coupled with PP2A technology could be used to provide early warning of DSP, but not PSP, events for shellfish management.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Hattenrath-Lehmann TK,Lusty MW,Wallace RB,Haynes B,Wang Z,Broadwater M,Deeds JR,Morton SL,Hastback W,Porter L,Chytalo K,Gobler CJdoi
10.3390/md16010028subject
Has Abstractpub_date
2018-01-13 00:00:00issue
1issn
1660-3397pii
md16010028journal_volume
16pub_type
杂志文章相关文献
Marine Drugs文献大全abstract::When the aquaculture water environment deteriorates or the temperature rises, shrimp are susceptible to viral or bacterial infections, causing a large number of deaths. This study comprehensively evaluated the effects of the oral administration of a chitosan-gentamicin conjugate (CS-GT) after Litopenaeus vannamei were...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18080419
更新日期:2020-08-10 00:00:00
abstract::This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1-11 were evaluated for their in vitro cytotoxic activity...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13010655
更新日期:2015-01-19 00:00:00
abstract::Diabetes mellitus is a group of metabolic disorders of the endocrine system characterised by hyperglycaemia. Type II diabetes mellitus (T2DM) constitutes the majority of diabetes cases around the world and are due to unhealthy diet, sedentary lifestyle, as well as rise of obesity in the population, which warrants the ...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md13085447
更新日期:2015-08-21 00:00:00
abstract::Sargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an ethanol extract from S. horneri (SHE) on immunoglobulin E (IgE)/bovine serum albumin (BSA)-mediated ac...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18120594
更新日期:2020-11-26 00:00:00
abstract::A novel, cold-adapted, and acid-base stable manganese superoxide dismutase (Ps-Mn-SOD) was cloned from hadal sea cucumber Paelopatides sp. The dimeric recombinant enzyme exhibited approximately 60 kDa in molecular weight, expressed activity from 0 °C to 70 °C with an optimal temperature of 0 °C, and resisted wide pH v...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17020084
更新日期:2019-02-01 00:00:00
abstract::Polysaccharides extracted from marine algae have attracted much attention due to their biotechnological applications, including therapeutics, cosmetics, and mainly in agriculture and horticulture as biostimulants, biofertilizers, and stimulators of the natural defenses of plants. This study aimed to evaluate the abili...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18100521
更新日期:2020-10-19 00:00:00
abstract::Three new butenolide derivatives, namely aspernolides N-P (1-3), together with six known analogues (4-9), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 1-3 were determined on the basis of comprehensive analyses of the nuclear...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17060332
更新日期:2019-06-03 00:00:00
abstract::A chemical study of the ethyl acetate (EtOAc) extract from the deep-sea-derived fungus Penicilliumthomii YPGA3 led to the isolation of a new austalide meroterpenoid (1) and seven known analogues (28), two new labdane-type diterpenoids (9 and 10) and a known derivative (11). The structures of new compounds 1, 9, and 10...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18030164
更新日期:2020-03-16 00:00:00
abstract::The total syntheses of the marine-derived lipopeptide natural product fellutamide B and deoxy-fellutamides B, C, and D are reported. These compounds were accessed through a novel solid-phase synthetic strategy using Weinreb amide-derived resin. As part of the synthesis, a new enantioselective route to (3R)-hydroxy lau...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11072382
更新日期:2013-07-08 00:00:00
abstract::Mycothiazole, a polyketide metabolite isolated from the marine sponge Cacospongia mycofijiensis, is a potent inhibitor of metabolic activity and mitochondrial electron transport chain complex I in sensitive cells, but other cells are relatively insensitive to the drug. Sensitive cell lines (IC(50) 0.36-13.8 nM) includ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10040900
更新日期:2012-04-01 00:00:00
abstract::α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype. However, TxID is susceptible to modification due to it containing a methionine (Met) residue that easily forms m...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16060215
更新日期:2018-06-20 00:00:00
abstract::Azaspiracids (AZA) are polyether marine toxins that accumulate in various shellfish species and have been associated with severe gastrointestinal human intoxications since 1995. This toxin class has since been reported from several countries, including Morocco and much of western Europe. A regulatory limit of 160 micr...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md20080004
更新日期:2008-05-07 00:00:00
abstract::Climate change with increasing temperature and ocean acidification (OA) poses risks for marine ecosystems. According to Pörtner and Farrell, synergistic effects of elevated temperature and CO₂-induced OA on energy metabolism will narrow the thermal tolerance window of marine ectothermal animals. To test this hypothesi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md8082318
更新日期:2010-08-11 00:00:00
abstract::There is an urgent need for novel strategies to fight drug resistance and multi-drug resistance. As an alternative to the classic antibiotic therapy, attenuation of the bacteria virulence affecting their Quorum sensing (QS) system is a promising approach. Quorum sensing (QS) is a genetic regulation system that allows ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15030059
更新日期:2017-02-28 00:00:00
abstract::Sea cucumbers have been valued for many centuries as a tonic and functional food, dietary delicacies and important ingredients of traditional medicine in many Asian countries. An assortment of bioactive compounds has been described in sea cucumbers. The most important and abundant secondary metabolites from sea cucumb...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14080147
更新日期:2016-08-04 00:00:00
abstract::A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to dis...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10020427
更新日期:2012-02-01 00:00:00
abstract::Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures we...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13063567
更新日期:2015-06-05 00:00:00
abstract::Proteins from different fish species and different raw materials such as fish fillets and by-products have shown promising cardioprotective effects in rodents and humans, including effects on cholesterol metabolism. Blue whiting is used mainly to produce fish meal for the feed industry and during this production, a wa...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16050149
更新日期:2018-05-01 00:00:00
abstract::The deterioration of bone formation is a leading cause of age-related bone disorders. Lack of bone formation is induced by decreased osteoblastogenesis. In this study, osteoblastogenesis promoting effects of algal phlorotannin, phlorofucofuroeckol A (PFF-A), were evaluated. PFF-A was isolated from brown alga Eckloniac...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17100543
更新日期:2019-09-21 00:00:00
abstract::Red algae of the genus Plocamium have been a rich source of halogenated monoterpenes. Herein, a new cyclic monoterpene, costatone C (7), was isolated from the extract of P. angustum collected in New Zealand, along with the previously reported (1E,5Z)-1,6-dichloro-2-methylhepta-1,5-dien-3-ol (8). Elucidation of the pla...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17070418
更新日期:2019-07-19 00:00:00
abstract::Investigation of minor metabolites in the extracts of the red alga Sphaerococcus coronopifolius collected from the rocky coasts of Corfu Island in the Ionian Sea yielded two new diterpene alcohols, sphaerollanes I, and II (1, 2) featuring neodolabellane skeletons, and the new sphaeroane diterpene alcohol 16-hydroxy-9S...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md7020184
更新日期:2009-05-19 00:00:00
abstract::Biologically active compounds with different modes of action, such as, antiproliferative, antioxidant, antimicrotubule, have been isolated from marine sources, specifically algae and cyanobacteria. Recently research has been focused on peptides from marine animal sources, since they have been found as secondary metabo...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md10050963
更新日期:2012-05-01 00:00:00
abstract::In this study, we elucidated the inhibitory effect of fucoidan from marine brown algae on the lipid accumulation in differentiated 3T3-L1 adipocytes and its mechanism. The treatment of fucoidan in a dose-dependent manner was examined on lipid inhibition in 3T3-L1 cells by using Oil Red O staining. Fucoidan showed high...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md9081359
更新日期:2011-01-01 00:00:00
abstract::Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine invertebrates, including bivalves. No human intoxication has been repo...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md17070425
更新日期:2019-07-20 00:00:00
abstract::Oxidative stress contributes to chronic inflammatory processes implicated in aging, referred to as "inflamm-aging." In this study, the potential anti-inflammatory and anti-aging effects of a pigment-protein complex (PPC) from Chlorella pyrenoidosa were investigated using lipopolysaccharide (LPS)-stimulated RAW 264.7 m...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17100586
更新日期:2019-10-16 00:00:00
abstract::For a long time, fucoidan has been well known for its pharmacological activities, and recently low molecular weight fucoidan (LMF) has been used in food supplements and pharmaceutical products. In the present study, LMF was extracted from Laminaria japonica by enzyme hydrolysis. The toxicity of LMF in mouse and rat mo...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14070121
更新日期:2016-06-24 00:00:00
abstract::Nemerteans (ribbon worms) employ toxins to subdue their prey, but research thus far has focused on the small-molecule components of mucus secretions and few protein toxins have been characterized. We carried out a preliminary proteotranscriptomic analysis of putative toxins produced by the hoplonemertean Amphiporus la...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18080407
更新日期:2020-08-01 00:00:00
abstract::Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14010001
更新日期:2015-12-22 00:00:00
abstract::Fucosterol is an algae-derived unique phytosterol having several medicinal properties, including antioxidant, anti-inflammatory, anticholinesterase, neuroprotective, and so on. Accumulated evidence suggests a therapeutic promise of fucosterol in neurodegeneration; however, the in-depth pharmacological mechanism of its...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17110639
更新日期:2019-11-13 00:00:00
abstract::Seven new polyoxygenated steroids belonging to a new structural group of sponge steroids, gracilosulfates A-G (1-7), possessing 3β-O-sulfonato, 5β,6β epoxy (or 5(6)-dehydro), and 4β,23-dihydroxy substitution patterns as a common structural motif, were isolated from the marine sponge Haliclona gracilis. Their structure...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18090454
更新日期:2020-08-30 00:00:00