Abstract：
:This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1-11 were evaluated for their in vitro cytotoxic activity against different cancer cell lines and tested for their inhibitory activity against the human DNA topoisomerase II. The analysis by electrophoresis shows that the pentacycle 12 inhibits the topoisomerase II like doxorubicine at 100 µM. Compound 9 was found to have an interesting profile, having a cytotoxicity of 15, 15, 15 and 10 μM against Caco-2, HCT-116, Pc-3 and NCI cell lines respectively, without any noticeable toxicity against human fibroblast.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Boucle S,Melin C,Clastre M,Guillard Jdoi
10.3390/md13010655subject
Has Abstractpub_date
2015-01-19 00:00:00pages
655-65issue
1issn
1660-3397pii
md13010655journal_volume
13pub_type
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