Design, synthesis and evaluation of new marine alkaloid-derived pentacyclic structures with anti-tumoral potency.

Abstract:

:This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1-11 were evaluated for their in vitro cytotoxic activity against different cancer cell lines and tested for their inhibitory activity against the human DNA topoisomerase II. The analysis by electrophoresis shows that the pentacycle 12 inhibits the topoisomerase II like doxorubicine at 100 µM. Compound 9 was found to have an interesting profile, having a cytotoxicity of 15, 15, 15 and 10 μM against Caco-2, HCT-116, Pc-3 and NCI cell lines respectively, without any noticeable toxicity against human fibroblast.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Boucle S,Melin C,Clastre M,Guillard J

doi

10.3390/md13010655

subject

Has Abstract

pub_date

2015-01-19 00:00:00

pages

655-65

issue

1

issn

1660-3397

pii

md13010655

journal_volume

13

pub_type

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