Abstract：
:To date, studies describing myxobacterial secondary metabolites have been relatively scarce in comparison to those addressing actinobacterial secondary metabolites. This realization suggests the immense potential of myxobacteria as an intriguing source of secondary metabolites with unusual structural features and a wide array of biological activities. Marine-derived myxobacteria are especially attractive due to their unique biosynthetic gene clusters, although they are more difficult to handle than terrestrial myxobacteria. Here, we report the discovery of two new pyrazinone-type molecules, enhypyrazinones A and B, from a marine-derived myxobacterium Enhygromyxa sp. Their structures were elucidated by HRESIMS and comprehensive NMR data analyses. Compounds 1 and 2, which contain a rare trisubstituted-pyrazinone core, represent a unique class of molecules from Enhygromyxa sp.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Zhang F,Braun DR,Rajski SR,DeMaria D,Bugni TSdoi
10.3390/md17120698subject
Has Abstractpub_date
2019-12-12 00:00:00issue
12issn
1660-3397pii
md17120698journal_volume
17pub_type
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