Production of bioactive secondary metabolites by marine vibrionaceae.


:Bacteria belonging to the Vibrionaceae family are widespread in the marine environment. Today, 128 species of vibrios are known. Several of them are infamous for their pathogenicity or symbiotic relationships. Despite their ability to interact with eukaryotes, the vibrios are greatly underexplored for their ability to produce bioactive secondary metabolites and studies have been limited to only a few species. Most of the compounds isolated from vibrios so far are non-ribosomal peptides or hybrids thereof, with examples of N-containing compounds produced independent of nonribosomal peptide synthetases (NRPS). Though covering a limited chemical space, vibrios produce compounds with attractive biological activities, including antibacterial, anticancer, and antivirulence activities. This review highlights some of the most interesting structures from this group of bacteria. Many compounds found in vibrios have also been isolated from other distantly related bacteria. This cosmopolitan occurrence of metabolites indicates a high incidence of horizontal gene transfer, which raises interesting questions concerning the ecological function of some of these molecules. This account underlines the pending potential for exploring new bacterial sources of bioactive compounds and the challenges related to their investigation.


Mar Drugs


Marine drugs


Mansson M,Gram L,Larsen TO




Has Abstract


2011-01-01 00:00:00












  • The deep-sea natural products, biogenic polyphosphate (Bio-PolyP) and biogenic silica (Bio-Silica), as biomimetic scaffolds for bone tissue engineering: fabrication of a morphogenetically-active polymer.

    abstract::Bone defects in human, caused by fractures/nonunions or trauma, gain increasing impact and have become a medical challenge in the present-day aging population. Frequently, those fractures require surgical intervention which ideally relies on autografts or suboptimally on allografts. Therefore, it is pressing and likew...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Wang X,Schröder HC,Feng Q,Draenert F,Müller WE

    更新日期:2013-03-08 00:00:00

  • Metabolomic Insights into Marine Phytoplankton Diversity.

    abstract::The democratization of sequencing technologies fostered a leap in our knowledge of the diversity of marine phytoplanktonic microalgae, revealing many previously unknown species and lineages. The evolutionary history of the diversification of microalgae can be inferred from the analysis of their genome sequences. Howev...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Marcellin-Gros R,Piganeau G,Stien D

    更新日期:2020-01-25 00:00:00

  • Chemical Diversity and Biological Activities of Marine Sponges of the Genus Suberea: A Systematic Review.

    abstract::Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: El-Demerdash A,Atanasov AG,Horbanczuk OK,Tammam MA,Abdel-Mogib M,Hooper JNA,Sekeroglu N,Al-Mourabit A,Kijjoa A

    更新日期:2019-02-12 00:00:00

  • Peridinin from the marine symbiotic dinoflagellate, Symbiodinium sp., regulates eosinophilia in mice.

    abstract::Peridinin and fucoxanthin, which are natural carotenoids isolated from a symbiotic dinoflagellate, Symbiodinium sp., and a brown alga, Petalonia fascia, respectively, were compared for inhibitory effects on delayed-type hypersensitivity in mice. The number of eosinophils at the site of inflammation and in peripheral b...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Onodera K,Konishi Y,Taguchi T,Kiyoto S,Tominaga A

    更新日期:2014-03-27 00:00:00

  • Anti-Diabetic Activity of 2,3,6-Tribromo-4,5-Dihydroxybenzyl Derivatives from Symphyocladia latiuscula through PTP1B Downregulation and α-Glucosidase Inhibition.

    abstract::The marine alga, Symphyocladia latiuscula (Harvey) Yamada, is a good source of bromophenols with numerous biological activities. This study aims to characterize the anti-diabetic potential of 2,3,6-tribromo-4,5-dihydroxybenzyl derivatives isolated from S. latiuscula via their inhibition of tyrosine phosphatase 1B (PTP...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Paudel P,Seong SH,Park HJ,Jung HA,Choi JS

    更新日期:2019-03-14 00:00:00

  • Preparation of calibration standards of N1-H paralytic shellfish toxin analogues by large-scale culture of cyanobacterium Anabaena circinalis (TA04).

    abstract::Mouse bioassay is the official testing method to quantify paralytic shellfish toxins (PSTs) in bivalves. A number of alternative analytical methods have been reported. Some methods have been evaluated by a single laboratory validation. Among the different types of methods, chemical analyses are capable of identifying ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Watanabe R,Suzuki T,Oshima Y

    更新日期:2011-03-22 00:00:00

  • Sea Cucumber Glycosides: Chemical Structures, Producing Species and Important Biological Properties.

    abstract::Sea cucumbers belonging to echinoderm are traditionally used as tonic food in China and other Asian countries. They produce abundant biologically active triterpene glycosides. More than 300 triterpene glycosides have been isolated and characterized from various species of sea cucumbers, which are classified as holosta...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Mondol MAM,Shin HJ,Rahman MA,Islam MT

    更新日期:2017-10-17 00:00:00

  • Different Antifungal Activity of Anabaena sp., Ecklonia sp., and Jania sp. against Botrytis cinerea.

    abstract::Water extracts and polysaccharides from Anabaena sp., Ecklonia sp., and Jania sp. were tested for their activity against the fungal plant pathogen Botrytis cinerea. Water extracts at 2.5, 5.0, and 10.0 mg/mL inhibited B. cinerea growth in vitro. Antifungal activity of polysaccharides obtained by N-cetylpyridinium brom...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Righini H,Baraldi E,García Fernández Y,Martel Quintana A,Roberti R

    更新日期:2019-05-20 00:00:00

  • From Marine Venoms to Drugs: Efficiently Supported by a Combination of Transcriptomics and Proteomics.

    abstract::The potential of marine natural products to become new drugs is vast; however, research is still in its infancy. The chemical and biological diversity of marine toxins is immeasurable and as such an extraordinary resource for the discovery of new drugs. With the rapid development of next-generation sequencing (NGS) an...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Xie B,Huang Y,Baumann K,Fry BG,Shi Q

    更新日期:2017-03-30 00:00:00

  • Synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and its inhibition of liver cancer characteristics in vitro and in vivo.

    abstract::Nanoparticle drug delivery (NDDS) is a novel system in which the drugs are delivered to the site of action by small particles in the nanometer range. Natural or synthetic polymers are used as vectors in NDDS, as they provide targeted, sustained release and biodegradability. Here, we used the chitosan and hepatoma cell...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Cheng M,Gao X,Wang Y,Chen H,He B,Xu H,Li Y,Han J,Zhang Z

    更新日期:2013-09-17 00:00:00

  • The Bacterial (Vibrio alginolyticus) Production of Tetrodotoxin in the Ribbon Worm Lineus longissimus-Just a False Positive?

    abstract::We test previous claims that the bacteria Vibrio alginolyticus produces tetrodotoxin (TTX) when living in symbiosis with the nemertean Lineus longissimus by a setup with bacteria cultivation for TTX production. Toxicity experiments on the shore crab, Carcinus maenas, demonstrated the presence of a paralytic toxin, but...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Strand M,Hedström M,Seth H,McEvoy EG,Jacobsson E,Göransson U,Andersson HS,Sundberg P

    更新日期:2016-03-25 00:00:00

  • Ubiquitin-Proteasome Modulating Dolabellanes and Secosteroids from Soft Coral Clavularia flava.

    abstract::We performed a high-content screening (HCS) assay aiming to discover bioactive molecules with proteasome inhibitory activity. By structural elucidation, we identified six compounds purified from soft coral Clavularia flava, which potentiates proteasome inhibition. Chemical structure elucidation revealed they are dolab...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Chiu CY,Ling XH,Wang SK,Duh CY

    更新日期:2020-01-03 00:00:00

  • Antimicrobial Peptide Arenicin-1 Derivative Ar-1-(C/A) as Complement System Modulator.

    abstract::Antimicrobial peptides (AMPs) are not only cytotoxic towards host pathogens or cancer cells but also are able to act as immunomodulators. It was shown that some human and non-human AMPs can interact with complement proteins and thereby modulate complement activity. Thus, AMPs could be considered as the base for comple...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Krenev IA,Umnyakova ES,Eliseev IE,Dubrovskii YA,Gorbunov NP,Pozolotin VA,Komlev AS,Panteleev PV,Balandin SV,Ovchinnikova TV,Shamova OV,Berlov MN

    更新日期:2020-12-10 00:00:00

  • Sea Cucumber Derived Type I Collagen: A Comprehensive Review.

    abstract::Collagen is the major fibrillar protein in most living organisms. Among the different types of collagen, type I collagen is the most abundant one in tissues of marine invertebrates. Due to the health-related risk factors and religious constraints, use of mammalian derived collagen has been limited. This triggers the s...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Senadheera TRL,Dave D,Shahidi F

    更新日期:2020-09-18 00:00:00

  • Improved Astaxanthin Production with Corynebacterium glutamicum by Application of a Membrane Fusion Protein.

    abstract::Astaxanthin is one of the strongest natural antioxidants and a red pigment occurring in nature. This C40 carotenoid is used in a broad range of applications such as a colorant in the feed industry, an antioxidant in cosmetics or as a supplement in human nutrition. Natural astaxanthin is on the rise and, hence, alterna...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Henke NA,Wendisch VF

    更新日期:2019-10-31 00:00:00

  • Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.

    abstract::Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulat...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Phan CS,Ng SY,Kim EA,Jeon YJ,Palaniveloo K,Vairappan CS

    更新日期:2015-05-19 00:00:00

  • Core oligosaccharide of Plesiomonas shigelloides PCM 2231 (Serotype O17) lipopolysaccharide--structural and serological analysis.

    abstract::The herein presented complete structure of the core oligosaccharide of lipopolysaccharide (LPS) P. shigelloides Polish Collection of Microorganisms (PCM) 2231 (serotype O17) was investigated by (1)H, (13)C NMR spectroscopy, mass spectrometry, chemical analyses and serological methods. The core oligosaccharide is compo...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Maciejewska A,Lukasiewicz J,Kaszowska M,Man-Kupisinska A,Jachymek W,Lugowski C

    更新日期:2013-02-06 00:00:00

  • Isoaaptamine Induces T-47D Cells Apoptosis and Autophagy via Oxidative Stress.

    abstract::Aaptos is a genus of marine sponge which belongs to Suberitidae and is distributed in tropical and subtropical oceans. Bioactivity-guided fractionation of Aaptos sp. methanolic extract resulted in the isolation of aaptamine, demethyloxyaaptamine, and isoaaptamine. The cytotoxic activity of the isolated compounds was e...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wu CF,Lee MG,El-Shazly M,Lai KH,Ke SC,Su CW,Shih SP,Sung PJ,Hong MC,Wen ZH,Lu MC

    更新日期:2018-01-09 00:00:00

  • Bromopyrrole alkaloids as lead compounds against protozoan parasites.

    abstract::In the present study, 13 bromopyrrole alkaloids, including the oroidin analogs hymenidin (2), dispacamide B (3) and dispacamide D (4), stevensine (5) and spongiacidin B (6), their derivatives lacking the imidazole ring bromoaldisin (7), longamide B (8) and longamide A (9), the dimeric oroidin derivatives sceptrin (10)...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Scala F,Fattorusso E,Menna M,Taglialatela-Scafati O,Tierney M,Kaiser M,Tasdemir D

    更新日期:2010-07-14 00:00:00

  • The Positive Role of Curcumin-Loaded Salmon Nanoliposomes on the Culture of Primary Cortical Neurons.

    abstract::Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Hasan M,Latifi S,Kahn CJF,Tamayol A,Habibey R,Passeri E,Linder M,Arab-Tehrany E

    更新日期:2018-06-25 00:00:00

  • Antihypertensive and Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Fish as Potential Cardioprotective Compounds.

    abstract::The term metabolic/cardiometabolic/insulin resistance syndrome could generally be defined as the co-occurrence of several risk factors inclusive of systemic arterial hypertension. Not only that organizations, such as the world health organization (WHO) have identified high blood pressure as one of the main risk factor...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Abachi S,Bazinet L,Beaulieu L

    更新日期:2019-10-29 00:00:00

  • Bromoperoxidase Producing Bacillus spp. Isolated from the Hypobranchial Glands of a Muricid Mollusc Are Capable of Tyrian Purple Precursor Biogenesis.

    abstract::The secondary metabolite Tyrian purple, also known as shellfish purple and royal purple, is a dye with historical importance for humans. The biosynthetic origin of Tyrian purple in Muricidae molluscs is not currently known. A possible role for symbiotic bacteria in the production of tyrindoxyl sulphate, the precursor ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ngangbam AK,Mouatt P,Smith J,Waters DLE,Benkendorff K

    更新日期:2019-05-03 00:00:00

  • Seaweed hydrocolloid production: an update on enzyme assisted extraction and modification technologies.

    abstract::Agar, alginate, and carrageenans are high-value seaweed hydrocolloids, which are used as gelation and thickening agents in different food, pharmaceutical, and biotechnological applications. The annual global production of these hydrocolloids has recently reached 100,000 tons with a gross market value just above US$ 1....

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Rhein-Knudsen N,Ale MT,Meyer AS

    更新日期:2015-05-27 00:00:00

  • Towards commercial production of sponge medicines.

    abstract::Sponges can provide potential drugs against many major world-wide occurring diseases. Despite the high potential of sponge derived drugs no sustainable production method has been developed. Thus far it is not fully understood why, when, where and how these metabolites are produced in sponges. For the near future sea-b...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Koopmans M,Martens D,Wijffels RH

    更新日期:2009-12-02 00:00:00

  • Preparation and characterization of antioxidant nanoparticles composed of chitosan and fucoidan for antibiotics delivery.

    abstract::In this study, we developed novel chitosan/fucoidan nanoparticles (CS/F NPs) using a simple polyelectrolyte self-assembly method and evaluated their potential to be antioxidant carriers. As the CS/F weight ratio was 5/1, the CS/F NPs were spherical and exhibited diameters of approximately 230-250 nm, as demonstrated b...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Huang YC,Li RY

    更新日期:2014-07-31 00:00:00

  • A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus).

    abstract::Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels. Recently we reported a high-throughput method to identify 215 conotoxin transcripts from the Chinese tubular cone snail, C. betulinus. Here, based ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Huang Y,Peng C,Yi Y,Gao B,Shi Q

    更新日期:2017-07-18 00:00:00

  • Bioactive Bis(indole) Alkaloids from a Spongosorites sp. Sponge.

    abstract::Six new bis(indole) alkaloids (1-6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A-D (1-4) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Park JS,Cho E,Hwang JY,Park SC,Chung B,Kwon OS,Sim CJ,Oh DC,Oh KB,Shin J

    更新日期:2020-12-23 00:00:00

  • Tetracenomycin X Exerts Antitumour Activity in Lung Cancer Cells through the Downregulation of Cyclin D1.

    abstract::Tetracenomycin X (Tcm X) has been reported to have antitumour activity in various cancers, but there have not been any studies on its activity with respect to lung cancer to date. Therefore, this study aims to investigate the anti-lung cancer activity of Tcm X. In this study, we found that tetracenomycin X showed anti...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Qiao X,Gan M,Wang C,Liu B,Shang Y,Li Y,Chen S

    更新日期:2019-01-18 00:00:00

  • Structure elucidation of new acetylated saponins, Lessoniosides A, B, C, D, and E, and non-acetylated saponins, Lessoniosides F and G, from the viscera of the sea cucumber Holothuria lessoni.

    abstract::Sea cucumbers produce numerous compounds with a wide range of chemical structural diversity. Among these, saponins are the most diverse and include sulfated, non-sulfated, acetylated and methylated congeners with different aglycone and sugar moieties. In this study, MALDI and ESI tandem mass spectrometry, in the posit...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bahrami Y,Franco CM

    更新日期:2015-01-16 00:00:00

  • Thalassospiramide G, a new γ-amino-acid-bearing peptide from the marine bacterium Thalassospira sp.

    abstract::In the chemical investigation of marine unicellular bacteria, a new peptide, thalassospiramide G (1), along with thalassospiramides A and D (2-3), was discovered from a large culture of Thalassospira sp. The structure of thalassospiramide G, bearing γ-amino acids, such as 4-amino-5-hydroxy-penta-2-enoic acid (AHPEA),...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Um S,Pyee Y,Kim EH,Lee SK,Shin J,Oh DC

    更新日期:2013-02-26 00:00:00