Chemical Diversity and Biological Activities of Marine Sponges of the Genus Suberea: A Systematic Review.

abstract：:Sea cucumbers produce numerous compounds with a wide range of chemical structural diversity. Among these, saponins are the most diverse and include sulfated, non-sulfated, acetylated and methylated congeners with different aglycone and sugar moieties. In this study, MALDI and ESI tandem mass spectrometry, in the posit...

journal_title：Marine drugs

authors： Bahrami Y,Franco CM

更新日期：2015-01-16 00:00:00

abstract：:Recently, the studies on the prevention and treatment of human papillomavirus (HPV) which is closely related to the cervical cancer and other genital diseases are attracting more and more attention all over the world. Marine-derived polysaccharides and other bioactive compounds have been shown to possess a variety of ...

journal_title：Marine drugs

authors： Wang SX,Zhang XS,Guan HS,Wang W

更新日期：2014-04-03 00:00:00

abstract：:In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS ...

journal_title：Marine drugs

authors： Lee DS,Ko W,Quang TH,Kim KS,Sohn JH,Jang JH,Ahn JS,Kim YC,Oh H

更新日期：2013-11-12 00:00:00

abstract：:Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increa...

journal_title：Marine drugs

authors： Shah SAA,Akhter N,Auckloo BN,Khan I,Lu Y,Wang K,Wu B,Guo YW

更新日期：2017-11-10 00:00:00

abstract：:Kelps are colonized by a wide range of microbial symbionts. Among them, endophytic fungi remain poorly studied, but recent studies evidenced yet their high diversity and their central role in algal defense against various pathogens. Thus, studying the metabolic expressions of kelp endophytes under different conditions...

journal_title：Marine drugs

authors： Vallet M,Meziane T,Thiney N,Prado S,Hubas C

更新日期：2020-07-22 00:00:00

abstract：:In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Starting from this scaf...

journal_title：Marine drugs

authors： Sepe V,Di Leva FS,D'Amore C,Festa C,De Marino S,Renga B,D'Auria MV,Novellino E,Limongelli V,D'Souza L,Majik M,Zampella A,Fiorucci S

更新日期：2014-05-27 00:00:00

abstract：:A new alkaloid, 2-(furan-2-yl)-6-(2S,3S,4-trihydroxybutyl)pyrazine (1), along with 12 known compounds, 2-(furan-2-yl)-5-(2S,3S,4-trihydroxybutyl)pyrazine (2), (S)-4-isobutyl-3-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbaldehyde (3), (S)-4-isopropyl-3-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbaldehyd...

journal_title：Marine drugs

authors： Wang P,Kong F,Wei J,Wang Y,Wang W,Hong K,Zhu W

更新日期：2014-01-21 00:00:00

abstract：:Marine biotoxin-contaminated seafood has caused thousands of poisonings worldwide this century. Given these threats, there is an increasing need for improved technologies that can be easily integrated into coastal monitoring programs. This study evaluates approaches for monitoring toxins associated with recurrent toxi...

journal_title：Marine drugs

authors： Hattenrath-Lehmann TK,Lusty MW,Wallace RB,Haynes B,Wang Z,Broadwater M,Deeds JR,Morton SL,Hastback W,Porter L,Chytalo K,Gobler CJ

更新日期：2018-01-13 00:00:00

abstract：:Microalgae are promising sources for the sustainable production of compounds of interest for biotechnologies. Compared to higher plants, microalgae have a faster growth rate and can be grown in industrial photobioreactors. The microalgae biomass contains specific metabolites of high added value for biotechnology such ...

journal_title：Marine drugs

authors： Guyon JB,Vergé V,Schatt P,Lozano JC,Liennard M,Bouget FY

更新日期：2018-02-28 00:00:00

abstract：:Monostroma nitidum is a green single-cell layered algae that grows on the southwest coast of Japan. It is often used for salad ingredients, boiled tsukudani, soups, etc., due to its health benefits. M. nitidum is composed of many cell aggregates, and the various substances that fill the intercellular space are dietary...

journal_title：Marine drugs

authors： Suzuki K,Terasawa M

更新日期：2020-04-24 00:00:00

abstract：:In the current study, hemostatic compositions including a combination of chitosan and kaolin have been developed. Chitosan is a marine polysaccharide derived from chitins, a structural component in the shells of crustaceans. Both chitosan and kaolin have the ability to mediate a quick and efficient hemostatic effect f...

journal_title：Marine drugs

authors： Elsabahy M,Hamad MA

更新日期：2021-01-22 00:00:00

abstract：:Here we summarize the current knowledge on the transfer and accumulation of harmful algal bloom (HAB)-related toxins in cephalopods (octopods, cuttlefishes and squids). These mollusks have been reported to accumulate several HAB-toxins, namely domoic acid (DA, and its isomers), saxitoxin (and its derivatives) and paly...

journal_title：Marine drugs

authors： Lopes VM,Lopes AR,Costa P,Rosa R

更新日期：2013-09-06 00:00:00

abstract：:Red algae of the genus Plocamium have been a rich source of halogenated monoterpenes. Herein, a new cyclic monoterpene, costatone C (7), was isolated from the extract of P. angustum collected in New Zealand, along with the previously reported (1E,5Z)-1,6-dichloro-2-methylhepta-1,5-dien-3-ol (8). Elucidation of the pla...

journal_title：Marine drugs

authors： Bracegirdle J,Sohail Z,Fairhurst MJ,Gerth ML,Zuccarello GC,Ali Hashmi M,Keyzers RA

更新日期：2019-07-19 00:00:00

abstract：:Cancer represents a set of more than 100 diseases, including malignant tumors from different locations. Strategies inducing differentiation have had limited success in the treatment of established cancers. Marine sponges are a biological reservoir of bioactive molecules, especially lectins. Several animal and plant le...

journal_title：Marine drugs

authors： Rabelo L,Monteiro N,Serquiz R,Santos P,Oliveira R,Oliveira A,Rocha H,Morais AH,Uchoa A,Santos E

更新日期：2012-04-01 00:00:00

abstract：:The present study investigated the effect of dietary astaxanthin (AX) on the growth performance, antioxidant parameters, and repair of hepatopancreas damage in Pacific white shrimp (Litopenaeus vannamei). To evaluate the hepatopancreas protective function of AX in shrimps, we compared the effect of five isonitrogenous...

journal_title：Marine drugs

authors： Yu Y,Liu Y,Yin P,Zhou W,Tian L,Liu Y,Xu D,Niu J

更新日期：2020-04-17 00:00:00

abstract：:Collagen has become a key-molecule in cell culture studies and in the tissue engineering field. Industrially, the principal sources of collagen are calf skin and bones which, however, could be associated to risks of serious disease transmission. In fact, collagen derived from alternative and riskless sources is requir...

journal_title：Marine drugs

authors： Benedetto CD,Barbaglio A,Martinello T,Alongi V,Fassini D,Cullorà E,Patruno M,Bonasoro F,Barbosa MA,Carnevali MD,Sugni M

更新日期：2014-09-24 00:00:00

abstract：:The venom of each Conus species consists of a diverse array of neurophysiologically active peptides, which are mostly unique to the examined species. In this study, we performed high-throughput transcriptome sequencing to extract and analyze putative conotoxin transcripts from the venom ducts of 3 vermivorous cone sna...

journal_title：Marine drugs

authors： Yao G,Peng C,Zhu Y,Fan C,Jiang H,Chen J,Cao Y,Shi Q

更新日期：2019-03-26 00:00:00

abstract：:This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop-CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll ...

journal_title：Marine drugs

authors： Daraghmeh N,Chowdhry BZ,Leharne SA,Al Omari MM,Badwan AA

更新日期：2015-03-30 00:00:00

abstract：:Ulvan lyases can degrade ulvan to oligosaccharides with potent biological activity. A new ulvan lyase gene, ALT3695, was identified in Alteromonas sp. A321. Soluble expression of ALT3695 was achieved in Escherichia coli BL21 (DE3). The 1314-bp gene encoded a protein with 437 amino acid residues. The amino acid sequenc...

journal_title：Marine drugs

authors： Gao J,Du C,Chi Y,Zuo S,Ye H,Wang P

更新日期：2019-10-08 00:00:00

abstract：:The methods to obtain chitooligosaccharides are tightly related to the physicochemical properties of the end products. Knowledge of these physicochemical characteristics is crucial to describing the biological functions of chitooligosaccharides. Chitooligosaccharides were prepared either in a single-step enzymatic hyd...

journal_title：Marine drugs

authors： Sánchez Á,Mengíbar M,Fernández M,Alemany S,Heras A,Acosta N

更新日期：2018-11-02 00:00:00

abstract：:In 2011, a Diarrhetic Shellfish Poisoning (DSP) outbreak occurred in British Columbia (BC), Canada that was associated with cooked mussel consumption. This is the first reported DSP outbreak in BC. Investigation of ill individuals, traceback of product and laboratory testing for toxins were used in this investigation....

journal_title：Marine drugs

authors： Taylor M,McIntyre L,Ritson M,Stone J,Bronson R,Bitzikos O,Rourke W,Galanis E,Outbreak Investigation Team.

更新日期：2013-05-21 00:00:00

abstract：:Domoic acid produced by marine algae has been shown to cause acute and chronic neurologic sequelae in Californian sea lions following acute or low-dose exposure. Histological findings in affected animals included a degenerative cardiomyopathy that was hypothesized to be caused by over-excitation of the glutamate recep...

journal_title：Marine drugs

authors： Gill S,Goldstein T,Situ D,Zabka TS,Gulland FM,Mueller RW

更新日期：2010-05-06 00:00:00

abstract：:Sea cucumbers belonging to echinoderm are traditionally used as tonic food in China and other Asian countries. They produce abundant biologically active triterpene glycosides. More than 300 triterpene glycosides have been isolated and characterized from various species of sea cucumbers, which are classified as holosta...

journal_title：Marine drugs

authors： Mondol MAM,Shin HJ,Rahman MA,Islam MT

更新日期：2017-10-17 00:00:00

abstract：:Natural O-alkyl-glycerolipids, also known as alkyl-ether-lipids (AEL), feature a long fatty alkyl chain linked to the glycerol unit by an ether bond. AEL are ubiquitously found in different tissues but, are abundant in shark liver oil, breast milk, red blood cells, blood plasma, and bone marrow. Only a few AEL are com...

journal_title：Marine drugs

authors： Pinault M,Guimaraes C,Couthon H,Thibonnet J,Fontaine D,Chantôme A,Chevalier S,Besson P,Jaffrès PA,Vandier C

更新日期：2018-03-23 00:00:00

abstract：:Carrageenans are abundant and safe non-starch polysaccharides exerting their biological effects in living organisms. Apart from their known pro-inflammation properties and some pharmacological activity, carrageenans can also strongly bind and hold metal ions. This property can be used for creation of the new drugs for...

journal_title：Marine drugs

authors： Khotimchenko YS,Khozhaenko EV,Khotimchenko MY,Kolenchenko EA,Kovalev VV

更新日期：2010-04-01 00:00:00

abstract：:The development of oxidative stress in the marine ecosystem is a concurring concern in fish reproductive behavior. Marine fish being rich in polyunsaturated fatty acids (PUFA) are precursors of prostaglandin pheromone mediators but also vulnerable to lipid peroxidation. It is yet to be determined if hypoxia or hyperox...

journal_title：Marine drugs

authors： Chung ML,Galano JM,Oger C,Durand T,Lee JC

更新日期：2015-04-14 00:00:00

abstract：:Being able to quantify ichthyotoxic metabolites from microalgae allows for the determination of ecologically-relevant concentrations that can be simulated in laboratory experiments, as well as to investigate bioaccumulation and degradation. Here, the ichthyotoxin karmitoxin, produced by Karlodinium armiger, was quanti...

journal_title：Marine drugs

authors： Andersen AJC,de Medeiros LS,Binzer SB,Rasmussen SA,Hansen PJ,Nielsen KF,Jørgensen K,Larsen TO

更新日期：2017-08-31 00:00:00

abstract：:Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulat...

journal_title：Marine drugs

authors： Phan CS,Ng SY,Kim EA,Jeon YJ,Palaniveloo K,Vairappan CS

更新日期：2015-05-19 00:00:00

abstract：:Smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, was previously reported by us to induce erythroid differentiation and G1 phase arrest of K562 chronic myelogenous leukemia cells. In this study, we investigated the effect of smenospongine on the cell cycles of other le...

journal_title：Marine drugs

authors： Kong D,Aoki S,Sowa Y,Sakai T,Kobayashi M

更新日期：2008-01-01 00:00:00

abstract：:Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders. The (α3)2(β2)3 nAChR subunit arrangement comprises a pair of α3(+)β2(-) and β2(+)α3(-) interfaces, and a...

journal_title：Marine drugs

authors： Wen J,Adams DJ,Hung A

更新日期：2020-07-03 00:00:00